Category: alcohols-buliding-blocks

Adding a certain compound to certain chemical reactions, such as: 221285-25-2, (2-Amino-6-fluorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 221285-25-2, blongs to alcohols-buliding-blocks compound. Quality Control of (2-Amino-6-fluorophenyl)methanol

EXAMPLE 39-fluoro-2,3-bis(2-methoxyethoxy)-8H-quinazolino[4,3-b]quinazoline mesylate (V-3)4-chloro-6,7-bis(2-methoxyethoxy)quinazoline (3.12 g, 10 mmol) and 2-amino-6-fluoro-benzyl alcohol (1.41 g, 10 mmol) were dissolved in 20 ml isopropanol to form a solution, and 0.55 ml of concentrated hydrochloric acid was added dropwise to the solution.The reaction was carried out according to General Method Ito obtain a white solid intermediate M-3 (3.92 g, 85.96percent).M-3 (2.27 g, 5 mmol) was dissolved in 15 ml toluene, and cooled in an ice bath.Triethylamine (15 mmol) and methanesulfonyl chloride (20 mmol) were added to the reaction mixture dropwise sequentially.The reaction lasted for 7 h at room temperature.Water (30 ml) was added to the reaction mixture, and the reaction mixture was extracted by dichloromethane three times.The organic phase was combined, washed with water three times, then washed with saturated NaCl solution three times, and dried by anhydrous sodium sulfate.The solution was filtered to obtain a filtrate, which was concentrated under vacuum to obtain the crude product as a light yellow solid, which was recrystallized by ethanol or separated by column chromatography to obtain a white solid V-3′ (1.76 g, 88.22percent).The white solid V-3′ (2 mmol) obtained above was dissolved in hot ethanol, and methanesulfonic acid (2 mmol) was added dropwise into the ethanol solution.The solution was refluxed for 30 min, cooled and precipitated to obtain the compound V-3.MS(ESI):[M+H]+=400.1H-NMR(400 MHz,CDCl3) deltappm: 3.44(s,6H), 3.85(m,4H), 4.26(m,2H), 4.41(m,2H), 5.61(s,2H), 7.12(s,1H), 7.18-7.30(m,3H), 7.6(8s,1H), 8.32(s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,221285-25-2, its application will become more common.

Reference:
Patent; Li, Jianqi; Zhang, Zixue; Xie, Peng; Zhang, Qingwei; US2011/288086; (2011); A1;,
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Reference of 115-20-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 115-20-8, name is Trichloroethanol. This compound has unique chemical properties. The synthetic route is as follows.

Step A: Synthesis of O-(2,2,2-trichloroethyl) phosphoric dichloride A solution of 52.3 g (0.35 mole) of 2,2,2-trichloroethanol and 53.7 g (0.35 mole) of phosphorous oxychloride in 150 ml of toluene was cooled to -10 C. To this solution, under nitrogen, 27.7 g (0.35 mole) of pyridine was added dropwise while maintaining the temperature at -10 C. Upon completion of addition the temperature was allowed to rise to ambient conditions, and the mixture was stirred overnight. The solid was filtered from the reaction mixture and the toluene evaporated under vacuum. The liquid residue was distilled, yielding the following fractions:

According to the analysis of related databases, 115-20-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; FMC Corporation; US4457923; (1984); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 10160-28-8, name is Non-8-yn-1-ol. A new synthetic method of this compound is introduced below., Computed Properties of C9H16O

Example 2Part A: Synthesis of Pentadeca-8,10-diyn-l-olTo a stirred solution of 1-iodo-hex-l-yne (6.2 g, 29.80 mmol) and non-8-yn-l-ol (2.46 g, 17.53 mmol) in pyrrolidine (50 ml) under an argon atmosphere, was added copper(I) iodide (2.98 mmol, 0.57 g). After stirring at room temperature for 30 min, the mixture was hydrolysed with a saturated aqueous solution of ammonium chloride and extracted with diethyl ether. The organic extract was dried over MgSO4 and the solvent was removed in vacuo. Column chromatography (SiO2, EtOAc-hexane: 2:1) gave 3.35 g (15.19 mmol, 87 %) of pure pentadeca-8,10-diyn-l-ol. 1H-NMR (CDCl3, 400 MHz): delta[ppm] = 0.89 (3H, t, J = 7.3 Hz)5 1.26 – 1.62 (14H, m), 2.24 (4H, t, J = 6.6 Hz), 3.62 (2H, t, J = 7.0 Hz)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 10160-28-8, Non-8-yn-1-ol.

Reference:
Patent; COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION; WO2008/31157; (2008); A1;,
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Electric Literature of 2566-44-1, Adding some certain compound to certain chemical reactions, such as: 2566-44-1, name is 2-Cyclopropylethanol,molecular formula is C5H10O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2566-44-1.

To a solution of oxalyl chloride (7.4 mL, 87 mmol) in DCM (100 mL) was added DMSO (12.4 mL, 174 mmol) dropwise at -78C and the solution was stirred at -78C for 15 minutes, then to the reaction solution was added cyclopropyl ethylalcohol (5 g, 58 mmol, dissolved in DCM lOmL). After being stirred at -78C for 1 hour, to the reaction solution was added TEA (40.4 ml, 290 mmol). The reaction solution was allowed to warm to room temperature and stirred for another 30 minutes. The reaction was quenched with water (50 ml) and extracted with DCM (50 mL) three times. The organic phase was combined, washed with saturated NH4CI solution, water and brine, and dried over anhydrous Na2SO4. The organic layer was concentrated and the residue was fractionally distilled to give 2-cyclopropylacetaldehyde (compound 23a) 1.3 g as a colorless oil. Compound 23a: 1H NMR (400 MHz, DMSO-d6) delta ppm: 9.64 – 9.76 (m, 1 H), 2.28 – 2.37 (m, 2 H), 0.89 – 0.98 (m, 1 H), 0.51 (dd, J = 8.16, 1.63 Hz, 2 H), 0.14 (dd, J = 4.83, 1.44 Hz, 2 H).

According to the analysis of related databases, 2566-44-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FENG, Song; LIU, Haixia; WU, Guolong; YUN, Hongying; CHEN, Dongdong; LI, Chao; (102 pag.)WO2016/55553; (2016); A1;,
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Adding a certain compound to certain chemical reactions, such as: 3562-73-0, 1-(4-Biphenylyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 3562-73-0, blongs to alcohols-buliding-blocks compound. SDS of cas: 3562-73-0

General procedure: Alcohol 3 (0.5 mmol) and NaBr(102.9 mg, 1 mmol) were dissolved in DMSO (1 mL), and then H2SO4 was added tothe solution under air at room temperature, and then the mixture were stirred at 60 Cfor 24 h. After cooling down to room temperature, the mixture were diluted withwater (10 mL) and extracted with EA (3 × 10 mL). The combined extracts werewashed with a saturated solution of NaCl (15 mL), dried over MgSO4, and evaporatedin vacuo. The residue was purified by chromatography on silica gel (petroleumether/ethyl acetate) to afford the bromohydrin 4.

The synthetic route of 3562-73-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ai, Lingsheng; Wang, Weijin; Wei, Jialiang; Li, Qing; Song, Song; Jiao, Ning; Synlett; vol. 30; 4; (2019); p. 437 – 441;,
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Adding a certain compound to certain chemical reactions, such as: 148043-73-6, 4,4,5,5,5-Pentafluoropentan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 148043-73-6, blongs to alcohols-buliding-blocks compound. Recommanded Product: 148043-73-6

4-Bromo-3-methylbenzylalcohol (4) A solution of methyl 4-bromo-3-methylbenzoate (2.0 g, 8.7 mmol) in dry THF (10 mL) was added to an ice-cooled suspension of lithium aluminiumhydride (400 mg, 10.4 mmol) in dry THF (30 mL). After addition, the mixture was warmed to room temperature and then stirred for 3 h. The excess lithium aluminiumhydride was quenched by successive addition of water (0.4 mL), 15percent NaOHaq (0.4 mL), and water (1.2 mL) under ice cooling. The insoluble material appeared was removed by filtration (celite), and the precipitate was washed by AcOEt (20 mL*5). The combined filtrates were washed with brine (50 mL) and then dried over Na2SO4. The solvent was evaporated, and the obtained product (1.6 g, 100percent) was used for next step without further purification. 1H-NMR (CDCl3, 400 MHz): delta7.53 (1H, d, J=8.1 Hz), 7.26 (1H, d, J=1.5 Hz), 6.40 (1H, dd, J=8.1, 1.5 Hz), 4.68 (2H, s), 2.44 (3H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,148043-73-6, its application will become more common.

Reference:
Patent; CHANG, Christopher J.; VAN DE BITTNER, Genevieve V.; HIRAYAMA, Tasuku; CHAN, Jefferson; US2014/51863; (2014); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 28539-02-8, name is 1-(Hydroxymethyl)benzotriazole, the common compound, a new synthetic route is introduced below. Recommanded Product: 28539-02-8

To tert-butyl ((1S,2S)-2-aminocyclohexyl)carbamate (17-1, 500 mg, 2.33 mmol) in EtOH (30 mL) was added (1H-benzo[d][1,2,3]triazol-1-yl)methanol (17-2, 750 mg, 4.67 mmol) and the resulting mixture was stirred for 3 h. Sodium borohydride (265 mg, 7.00 mmol) was then added and stirring was continued overnight. The reaction mixture was concentrated and then quenched with water. The aqueous phase was extracted with DCM (*3) and the combined organic phases were dried over Na2SO4, filtered, and concentrated. The crude residue was purified by reverse phase RP-C18 column chromatography column eluting with 10 to 100% MeCN in water with 0.1% NH4OH as a modifier to provide the product 25-1 (250 mg, 1.03 mmol, 44% yield) as a white solid. MS [M+H]+=243.2.

The synthetic route of 28539-02-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Novartis AG; BECKWITH, Rohan Eric John; BONAZZI, Simone; CERNIJENKO, Artiom; MA, Fupeng; WARE, Nathaniel F.; US2020/16143; (2020); A1;,
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Synthetic Route of 6214-44-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6214-44-4, name is (4-Ethoxyphenyl)methanol, molecular formula is C9H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: All oxidation experiments are performed in a 120mL autoclave equipped with the magnetic stirring and temperature control. A typical procedure for the oxidation of benzyl alcohol is as follows: 1.08g (10.0mmol) of benzyl alcohol, 0.0156g (0.1mmol) of TEMPO, 0.274g (0.5mmol) of CAN, 0.0690g (1.0mmol) of NaNO2, additive in suitable amount and 10mL of H2O were charged into the reactor, and the atmosphere inside is replaced with oxygen after the reactor is sealed. Then, pure oxygen is charged to 0.3MPa at room temperature. In the following, the autoclave is heated to 80C under stirring, and then kept for 2h. After reaction, the autoclave was cooled to room temperature and excess gas was purged. The mixture was transferred into a flask, in which the reactor was washed with CH2Cl2 for 3-5 times in order to transfer completely. Next, the products are extracted with 6mL CH2Cl2 three times. The obtained products were analyzed with internal standard technique by GC with a flame ionization detector (all products were determined on GC-MS with an Agilent 6890N GC/5973 MS detector).

According to the analysis of related databases, 6214-44-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Yan, Yongtao; Tong, Xinli; Wang, Kaixuan; Bai, Xueqin; Catalysis Communications; vol. 43; (2014); p. 112 – 115;,
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Electric Literature of 7287-82-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7287-82-3, name is 1-(2-Methylphenyl)ethanol, molecular formula is C9H12O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: In a flask under argon atmosphere, iridium catalyst 5 (0.50 or 1.0 mol %), sodium hydroxide (0.50 or 1.0 mol %), water (2 mL), and alcohol (2.0 mmol) were placed. The mixture was stirred under vigorous reflux (temperature of the oil bath was set at 140 C) for 20-96 h. After cooling to room temperature, water (4 mL) was added and the mixture was transferred to a separate funnel. Extraction of the organic compounds with dichloromethane (15 mL x 3), dehydration with sodium sulfate, followed by evaporation under vacuum gave crude mixture. For entries 2-11,the conversion of starting alcohol and the yield of ketone were determined by 1H NMR analysis in chloroform-d using triphenylmethane as an internal standard. For entries 1 and 12-14, the conversion of starting alcohol and the yield of ketone were determined by GC analysis using biphenyl as an internal standard. For entries 2-8, 10, and 11, the product was isolated by silica-gel column chromatography (eluent:ethyl acetate/ hexane).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7287-82-3, 1-(2-Methylphenyl)ethanol.

Reference:
Article; Toyomura, Kazuki; Fujita, Ken-Ichi; Chemistry Letters; vol. 46; 6; (2017); p. 808 – 810;,
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Application of 172023-97-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.172023-97-1, name is (3-Bromo-5-(trifluoromethyl)phenyl)methanol, molecular formula is C8H6BrF3O, molecular weight is 255.03, as common compound, the synthetic route is as follows.

[3-amino-5-(trifluoromethyl)phenyl]methanol (900 mg, 4.71 mmol) (Step A, Example 24) was suspended in CHBr3 (9 mL), and t-butyl nitrite (600 muL, 5.04 mmol) was added dropwise by syringe. The reaction was heated slowly to 80C and was maintained at this temperature for 10 minutes. The reaction was then cooled to room temperature, diluted with hexanes (50 mL), loaded on a silica gel column, and purified with 100% hexanes to 20% EtOAc/hexanes (2 columns) to afford [3-bromo-5- (trifluoromethyl) phenyl] methanol. Rf= 0.31 (25% EtOAc/hexanes). ‘H NMR (CDC13, 500 MHz) No. 7.71 (s, 1H), 7.68 (s, 1H), 7.56 (s, 1H), 4.76 (d, J = 5.5 Hz, 2H), 1.86 (t, J = 5.7 Hz, 1H). Step B: 3-Bromo-5-(trifluoromethyl)benzaldehyde A solution of [3-bromo-5-(trifluoromethyl)phenyl]methanol (409 mg, 1.61 mmol) in CH2Cl2 (25 mL) was cooled to 0C and then Dess-Martin periodinane (1.02 g, 2.41 mmol) was added. The reaction was stirred at 0 C for 30 minutes and then warmed to room temperature. After stirring at room temperature for thirty minutes, the reaction was poured into IN NaOH (25 mL). The mixture was extracted with EtOAc (100 mL), and the organic extracts were washed with IN NaOH (25 mL), then brine (25 mL), dried over Na2S04, filtered, and concentrated. Purification by flash chromatography with 25% EtOAc/hexanes afforded 3-bromo-5- (trifluoromethyl)benzaldehyde. 0.60 (25% EtOAc/hexanes). ‘H NMR (CDCI3, 500 MHz) 8 10.02 (s, 1H), 8.20 (s, 1H), 8.07 (s, 1H), 8.02 (s, 1H).

The chemical industry reduces the impact on the environment during synthesis 172023-97-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK & CO., INC.; WO2005/100298; (2005); A1;,
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