Category: alcohols-buliding-blocks

Adding a certain compound to certain chemical reactions, such as: 42514-50-1, 3-Amino-3-methylbutan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 42514-50-1, blongs to alcohols-buliding-blocks compound. name: 3-Amino-3-methylbutan-1-ol

Step 2: Synthesis of benzyl 3-[(4-hydroxy-2-methylbutan-2-yl)amino]-4- nitrobenzoate A stirred solution of benzyl 3-fluoro-4-nitrobenzoate (2.67 g, 9.69 mmol) and 3-amino-3- methylbutan-l-ol (1.00 g, 9.69 mmol) in acetonitrile (20 mL) containing potassium carbonate (1.34 g, 9.69 mmol) is heated to 80 C for 16 h. The solvent is evaporated, water (100 mL) is added, and the mixture is extracted with EtOAc (3 x 100 mL). The combined organic layers are dried (MgS04), concentrated and purified by flash chromatography in heptanes/EtOAc to afford the title compound (395 mg, 1.10 mmol).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,42514-50-1, its application will become more common.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOYER, Stephen, James; BURKE, Jennifer; GUO, Xin; KIRRANE JR., Thomas, Martin; SNOW, Roger, John; ZHANG, Yunlong; WO2011/71725; (2011); A1;,
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Reference of 109-83-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 109-83-1, name is 2-(Methylamino)ethanol, molecular formula is C3H9NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-fluoro benzaldehyde in dry DMSO (35ml) (5.0g, 40.29mmol) and 2- To a stirred solution of (methylamino) ethanol (3.63g, 48.34mmol), under an argon atmosphere K2CO3 ( 6.68g, 48.34mmol) was added. The reaction mixture was then heated for 3 days at 120 . Then added to the reaction mixture which was cooled in water (400ml), and extracted with EtOAc (7 × 100ml). The combined organic layers were washed with brine (2 × 100ml), dried (Na2SO4), the solvent was removed under reduced pressure to give an oil of high viscosity orange. Which solidified slowly at room temperature. This solid was dissolved in DCM (40ml) and then a yellow solid precipitated by adding the solution to hexanes (200 ml), was collected yellow solid by filtration under vacuum. Recrystallization from toluene, the title compound (4.47g, 62%) was obtained as small yellow thin plate material.

According to the analysis of related databases, 109-83-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; WISTA LABORATORIES LIMITED; KEMP, STEVEN JOHN; STOREY, LYNDA JANE; STOREY, JOHN MERVYN DAVID; RICKARD, JANET; HARRINGTON, CHARLES ROBERT; WISCHIK, CLAUDE MICHEL; CLUNAS, SCOTT; HEINRICH, TOBIAS KERST; (269 pag.)JP5667058; (2015); B2;,
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Electric Literature of 109-83-1, Adding some certain compound to certain chemical reactions, such as: 109-83-1, name is 2-(Methylamino)ethanol,molecular formula is C3H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 109-83-1.

Triethylamine (80 mmol) was added to a solution of the amino alcohol (35 mmol) in MC (200 ml) and the mixture was cooled to 00C using an ice bath. The sulfonyl chloride (32 mmol) was then added and the mixture was stirred at RT for 3 h. After addition of 0.5 M HCI (100 ml), the organic phase was separated off, washed with water, dried over Na2SO4 and filtered and the solvent was removed in vacuo. The crude product was used in the next stage without further purification

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 109-83-1, 2-(Methylamino)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GRUeNENTHAL GMBH; WO2009/109364; (2009); A1;,
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Related Products of 10488-69-4 , The common heterocyclic compound, 10488-69-4, name is Ethyl 4-chloro-3-hydroxybutanoate, molecular formula is C6H11ClO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 1; [60] 61.5 g (1.626 mol) of sodium borohydride was dissolved in 694 mL of toluene, and52 g (1.626 mol) of methanol was added drop wise at room temperature for 1 hour. Subsequently, 300 g (1.807 mol, 99.3percent ee) of ethyl (S)-4-chloro-3-hydroxybutyrate was added, and stirring was performed at room temperature for 12 hours. The reaction mixture was cooled below 100C and, after adding 183 g of 36percent HCl dropwise, the solvent was removed by distillation under reduced pressure below 400C. Using 800 mL of methanol, concentration under reduced pressure was performed for 3 times below 40 C. 800 mL of dichloromethane was added to the resultant residue. After filtering off solid inorganic materials and removing the solvent under reduced pressure, 220 g of (S )-4-chloro-l,3-butanediol was obtained as oil (yield = 98percent).

The synthetic route of 10488-69-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RSTECH CORPORATION; WO2008/93955; (2008); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 187731-65-3, name is (2-Amino-4-methoxyphenyl)methanol. A new synthetic method of this compound is introduced below., Quality Control of (2-Amino-4-methoxyphenyl)methanol

Synthesis of 2-amino-4-methoxybenzaldehyde. A mixture of (2-amino-4-methoxyphenyl)methanol (20 g, 131.0 mmol) and manganese oxide (68 g, 786.0 mmol) in dichioromethane (300 mL) was stuffed at RT overnight. LCMS showed the reaction was completed. The solid was filtered off, and the filtrate was concentrated. The residuewas purified by silica gel chromatography (petroleum ether:ethyl acetate = 6:1) to give the title compound (7 g, 35%) as a yellow solid. MS (ES+) C8H9N02 requires: 151, found: 152 [M + H].

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 187731-65-3, (2-Amino-4-methoxyphenyl)methanol.

Reference:
Patent; BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.; WO2014/11900; (2014); A2;,
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Adding a certain compound to certain chemical reactions, such as: 4654-39-1, 2-(4-Bromophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 4654-39-1, blongs to alcohols-buliding-blocks compound. Quality Control of 2-(4-Bromophenyl)ethanol

Example 1.60: Preparation of Intermediate 4-Bromophenethyl Methanesulfonate. 4-Bromophenethyl alcohol (38.9 g, 193 mmol) was dissolved in DCM (193 mL).Triethylamine (40.4 mL, 290 mmol) was added and the mixture was cooled in an ice bath. Methanesulfonyl chloride (18 mL, 232 mmol) was added dropwise via an addition funnel. The ice bath was removed and the mixture was stirred for 30 min. The reaction mixture was diluted with DCM (200 mL), washed with 1 M HCl twice (100 mL each), followed by brine, saturated sodium bicarbonate, and brine. The organic phase was dried with sodium sulfate and filtered. The solvent was removed under reduced pressure to give the title compound (54.0 g) in quantitative yield. 1H NMR (400 MHz, CDCl3) delta ppm 2.89 (s, 3 H), 3.02 (t, J = 6.82 Hz, 2 H), 4.40 (t, J= 6.82 Hz, 2 H), 7.03 – 7.17 (m, 2 H), 7.43 – 7.47 (m, 2 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4654-39-1, its application will become more common.

Reference:
Patent; ARENA PHARMACEUTICALS, INC.; WO2009/105206; (2009); A1;,
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Reference of 16308-92-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16308-92-2, name is (2,4-Dimethylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a suspension of benzyl alcohol (1.1 g, 0.0101 mol), aniline (0.94 g, 0.0101 mol), and ethyl vinyl ether (0.728 g, 0.0101 mol) in a mixture of EtOAc:DMSO (6.0: 2.0 mL) was added T3P (2.0 mmol, 50% solution in ethyl acetate) at 0oC, and the resulting mixture was stirred at room temperature for 45 h. Progress of the reaction was monitored by TLC. The reaction mass was concentrated, the obtained residue was neutralized with 10% NaHCO3 solution, and then extracted with ethyl acetate (2 x 20 mL), the combined organic phase was washed with water and brine solution, and dried over anhydrous sodium sulphate. The organic phase was evaporated and the crude product was purified by column chromatography using silica gel mesh 100-200 (15% EtOAc in hexanes).

According to the analysis of related databases, 16308-92-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Narasimhamurthy, Kereyagalahally H.; Chandrappa, Siddappa; Kumar, Kothanahally S. Sharath; Swaroop, Toreshettahally R.; Rangappa, Kanchugarakoppal S.; Chemistry Letters; vol. 42; 9; (2013); p. 1073 – 1075;,
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Application of 1777-82-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1777-82-8 as follows.

The reactants used were 2,4-dichlorobenzyl alcohol (i.e., R1 in the formula (I) was ortho, with two Cl) 1.0 mmol(177.0 mg), the experimental method and procedure were the same as in Example 1, ammonia water (1.8 mol / L) 5.0 mL, and the amount of catalyst cuprous bromide was5 mol% (7.2 mg), TEMPO was used in an amount of 5 mol% (7.8 mg), the reaction temperature was 80 C, the reaction time was 24 h, and the crude productPurification by column chromatography (petroleum ether: ethyl acetate = 10: 1) gave the pure title product, yielded 166.8 mg yield 97%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1777-82-8, its application will become more common.

Reference:
Patent; Zhejiang University of Technology; Zhang Guofu; Zhao Yiyong; Zhang Guihua; Ding Chengrong; Yu Yidong; Lv Jinghui; (10 pag.)CN106866326; (2017); A;,
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Synthetic Route of 1562-00-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1562-00-1 as follows.

Example A; 31 g of (E)-10-pentafluorosulfanyldec-9-enecarbonyl chloride, prepared as in Example 1, are dissolved in 100 g of THF, 2-hydroxyethanesulfonic acid Na salt (15 g) and triethylamine (10 g) are added, and the mixture is stirred at 30 C. for 6 hrs.In order to isolate the product, the mixture is added to ice/methyl tert-butyl ether, the water phase is extracted with this solvent, and all org. phases are evaporated. Ethanol and then 1.2 equivalents of sodium hydroxide are added. The mixture is warmed briefly, and, after cooling, the crystals formed are isolated and dried.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1562-00-1, its application will become more common.

Reference:
Patent; MERCK PATENT GMBH; US2009/264525; (2009); A1;,
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Adding a certain compound to certain chemical reactions, such as: 2919-23-5, Cyclobutanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2919-23-5, blongs to alcohols-buliding-blocks compound. Recommanded Product: 2919-23-5

To a solution of N-Boc-L-alanine (4: 15.5 g, 81.9 mmol) in dichloromethane (300 ml), DCC (16.9 g, 81.9 mmol)was added at 0C and 5 min later, cyclobutanol (3: 5.6 g, 78.0 mmol) and DMAP (2.0 g, 16.4 mmol). The mixture wasstirred overnight evaporated in vacuum , and the residue was treated with ethyl acetate (300 ml). The residue was filteredoff and washed with ethyl acetate. The filtrate was washed with a 5% solution of citric acid (2 x 100 ml), a saturatedNaHCO3 solution (2 x 100 ml), and brine, dried over Na2SO4, and evaporated in vacuum to afford 19.6 g (98 %) of(S)-cyclobutyl 2-(tert-butoxycarbonylamino)-propanoate (5) as a white powder. 1H NMR (400 MHz, DMSO-d6) delta 7.22(d, J = 7.2 Hz, 0.85H), 6.87 (m, 0.15H), 4.89 (p, J = 7.2 Hz, 1H), 3.94 (m, 1H), 2.26 (m, 2H), 1.98 (m, 2H), 1.74 (m, 1H),1.59 (m, 1H), 1.38 (s, 7.5H), 1.34 (brs, 1.5H), 1.22 (d, J = 7.2Hz, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2919-23-5, its application will become more common.

Reference:
Patent; Alla Chem, LLC; Ivachtchenko, Alexandre Vasilievich; Ivashchenko, Andrey Alexandrovich; Ivachtchenko, Alena Alexandrovna; Savchuk, Nikolay Filippovich; IVACHTCHENKO, Alexandr Vasilievich; MITKIN, Oleg Dmitrievich; (24 pag.)EP3400946; (2018); A1;,
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