Author: tianli

Agarwal, Sameer published the artcileDiscovery of a Potent and Orally Efficacious TGR5 Receptor Agonist, SDS of cas: 23351-09-9, the publication is ACS Medicinal Chemistry Letters (2016), 7(1), 51-55, database is CAplus and MEDLINE.

TGR5 is a G protein-coupled receptor (GPCR), activation of which promotes secretion of glucagon-like peptide-1 (GLP-1) and modulates insulin secretion. The 2-thio-imidazole derivative 6g was identified as a novel, potent, and selective TGR5 agonist (hTGR5 EC₅₀ = 57 pM, mTGR5 = 62 pM) with a favorable pharmacokinetic profile. The compound 6g was found to have potent glucose lowering effects in vivo during an oral glucose tolerance test in DIO C57 mice with ED₅₀ of 7.9 mg/kg and ED₉₀ of 29.2 mg/kg.

ACS Medicinal Chemistry Letters published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, SDS of cas: 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bleehen, S. S. published the artcileDepigmentation of skin with 4-sisopropylcatechol, mercaptoamines, and other compounds, Computed Properties of 1139-46-4, the publication is Journal of Investigative Dermatology (1968), 50(2), 103-17, database is CAplus and MEDLINE.

Thirty-three compounds including thiols, mercaptoamines, catechol, catechol derivatives, and quinones were tested for their depigmenting potency and irritant effect on the skin of guinea pigs. These compounds, in concentrations ranging from 1 to 10%, were applied topically to the epilated skin of the back and the unepilated skin of the ear of black guinea pigs; 4-isopropylcatechol (4-IPC) was the most potent depigmenting agent, and the depigmentation occurred only in the treated areas. When used in low concentrations (1-3%), 4-IPC did not irritate the skin. Evidence obtained by light and electron microscopy indicated that 4-IPC markedly reduced the population of the melanocytes in the epidermis. The few remaining melanocytes were rendered degenerative, and those found had only a few melanized melanosomes. Cutaneous depigmentation by 4-IPC apparently results from a selective action on melanocytes; they are either destroyed or inactivated.

Journal of Investigative Dermatology published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Computed Properties of 1139-46-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Patel, Rashmin B. published the artcileBox-Behnken Experimental Design Aided Optimization of Stability Indicating HPTLC-Based Assay Method: Application in Pharmaceutical Dosage form Containing Model Drugs-Roxithromycin and Ambroxol Hydrochloride, Application of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Analytical Chemistry Letters (2019), 9(6), 816-834, database is CAplus.

The objective of this study was to apply Design of Experiment (DoE) concept for development of stability indicating high-performance thin-layer chromatog. (HPTLC) method for assay of model drugs (Roxithromycin (ROXTM) and Ambroxol hydrochloride (AMBRX)) in marketed tablet formulations followed by validation of developed HPTLC method as per ICHQ2(R1). Box-Behnken exptl. design was applied to optimize chromatog. conditions and their effects on retardation factor (Rf) value. The developed HPTLC method was validated for specificity, linearity, accuracy, precision, and robustness. The ROXTM (Rf 0.42) and AMBRX (Rf 0.75) were well separated (Rs 2.06) from each other and from their resp. degradation products on HPTLC plate using optimized chromatog. conditions. The developed method was successfully validated and statistical anal. proved that the method is sensitive, specific (peak purity > 0.9999 for both ROXTM and AMBRX), accurate (98.59-101.14% and 99.96-101.76%, ROXTM and AMBRX, resp.) and precise (% RSD >1.0 for both ROXTM and AMBRX). The developed HPTLC method have advantages over reported methods in being robust and able to determine the model drugs and degradation products with sensitivity, selectivity and short anal. time using simple mobile phase.

Analytical Chemistry Letters published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rastogi, Supriya published the artcileAllergic contact dermatitis to personal care products and topical medications in adults with atopic dermatitis, COA of Formula: C11H24O3, the publication is Journal of the American Academy of Dermatology (2018), 79(6), 1028-1033.e6, database is CAplus and MEDLINE.

Atopic dermatitis (AD) is associated with skin-barrier disruption, immune dysregulation, and application of emollients and topical medications that might predispose a person toward developing allergic contact dermatitis. To determine the predictors of allergic contact dermatitis and relevant allergens in AD. A retrospective chart review was performed for 502 adults (age ≥18 years) who were patch tested to an expanded allergen series during 2014-2017. Overall, 108 (21.5%) had current AD and 109 (21.7%) had past AD. Patients with and without current AD had similar proportions of any pos. (+, ++, or +++ 80 [74.1%] vs 254 [64.5%], resp., chi-squared P = .06); strong-pos. (++ and +++ 34 [31.5%] vs 102 [25.9%], resp., P = .25); and irritant (56 [51.9%] vs 188 [47.7%], resp., P = .45) patch-test reactions. AD patients had significantly higher rates of pos. reactions to ingredients in their personal care products and topical medications, including fragrance mix II (P = .04), lanolin (P = .03), bacitracin (P = .04), cinnamal (P = .02), budesonide (P = .01), tixocortol (P = .02), and chlorhexidine (P = .001); relevance was established in >90% of these reactions. Polysensitization occurred more commonly in patients with AD than without (35 [32.4%] vs 75 [19.0%]; P = .01). Study was performed at a single center. AD patients had more pos. patch-test reactions to ingredients in their personal care products, topical steroids, and antibiotics.

Journal of the American Academy of Dermatology published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, COA of Formula: C11H24O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Adeshra, Shreya D. published the artcileDevelopment and validation of three novel UV spectrophotometric methods for simultaneous estimation of efonidipine hydrochloride ethanolate and telmisartan in their synthetic mixture and its comparison using ANOVA, SDS of cas: 111011-76-8, the publication is Journal of Medicinal and Chemical Sciences (2021), 4(2), 145-153, database is CAplus.

Efonidipine hydrochloride ethanolate and telmisartan combination is used for to treat hypertension treatment and under clin. phase 4 study. It is necessary to develop suitable quality control methods for rapid and accurate determination of these drugs. Three simple, accurate, sensitive, precise and economical UV spectrophotometric methods (A, B and C) have been developed for simultaneous estimation of efonidipine hydrochloride ethanolate and telmisartan in their synthetic mixture Method (A) is based on the first order derivative spectrophotometric method at zero crossing wavelength. In this method the zero crossing zero-crossing point of efonidipine hydrochloride ethanolate is 326 nm and for telmisartan is 272 nm. The linearity was obtained in the concentration range of 8-20 μg/mL for efonidipine hydrochloride ethanolate and 16-40 μg/mL for telmisartan using methanol as a solvent. Method (B) is based on absorbance correction method, method; it was performed at 347 nm for efonidipine hydrochloride ethanolate and at 296 nm for telmisartan. Method (C) is based on dual wavelength method developed using absorbance difference at 242.5 nm and 257.5 nm for efonidipine hydrochloride ethanolate and 244.5 nm and 287 nm for telmisartan. The accuracy and precision of the methods were determined assessed and validated statistically. All the methods showed revealed good reproducibility and recovery. The three methods were compared using one way ANOVA. All methods were found to be rapid, specific, precise and accurate and these methods require no preliminary separation and found no interferences from the tablet excipients so it can be used for routine anal. of both drugs in quality control laboratories

Journal of Medicinal and Chemical Sciences published new progress about 111011-76-8. 111011-76-8 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is 2-(Benzyl(phenyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate ethanol hydrochloride, and the molecular formula is C36H45ClN3O8P, SDS of cas: 111011-76-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ricciardi, Maria published the artcileFirst Attempt of Glycidol-to-Monoalkyl Glyceryl Ethers Conversion by Acid Heterogeneous Catalysis: Synthesis and Simplified Sustainability Assessment, Name: 3-((2-Ethylhexyl)oxy)propane-1,2-diol, the publication is ChemSusChem (2018), 11(11), 1829-1837, database is CAplus and MEDLINE.

The selective preparation of monoalkylglyceryl ethers (MAGEs) is a task for researchers owing to their broad range of applications. In this work, green feedstocks such as glycidol and alcs. were used to prepare MAGEs under mild reaction conditions (80 °C, 3 h, 0.5 mol % catalyst) in the presence of acid heterogeneous catalysts. Nafion shows the best performances in terms of conversion and selectivity to MAGES and also high stability. A comparison of the environmental performances with the most consolidated pathway from glycerol has shown that the usage of glycidol (recovered as a value-added product from Epicerol process) and Nafion leads to a lower impact on ecosystems. In addition, results achieved from a simplified socio-economic anal. show that the innovative route here proposed has potential (at the laboratory scale) of enhancing potential gains and of reducing the social implications resulting from externalities associated with environmental impacts (e.g., CO₂ equivalents).

ChemSusChem published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Name: 3-((2-Ethylhexyl)oxy)propane-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ricciardi, Maria published the artcileGlycidol, a Valuable Substrate for the Synthesis of Monoalkyl Glyceryl Ethers: A Simplified Life Cycle Approach, Related Products of alcohols-buliding-blocks, the publication is ChemSusChem (2017), 10(10), 2291-2300, database is CAplus and MEDLINE.

The disposal of any waste by recovering it within the production plant represents the ultimate goal of every biorefinery. In this scenario, the selective preparation of monoalkyl glyceryl ethers (MAGEs) starting from glycidol, obtained as byproduct in the epichlorohydrin production plant, represents a very promising strategy. Here, we report the synthesis of MAGEs through the reaction of glycidol with alcs. catalyzed by a green homogeneous Lewis acids catalyst, such as Bi^III triflate, under very mild reaction conditions. To evaluate the green potential of the proposed alternative, a simplified life cycle assessment (LCA) approach was followed by comparing the environmental performance of the proposed innovative route to prepare MAGEs with that of the most investigated pathway from glycerol. A considerable reduction of all impact categories considered was observed in our exptl. conditions, suggesting that the glycidol-to-MAGEs route can be a valuable integration to the glycerol-to-MAGEs chain. Thanks to the use of primary data within the LCA model, the results achieved are a very good approximation of the real case.

ChemSusChem published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bolis, Serena published the artcileA core copolymer approach to improve the gain properties of a red-emitting molecule, Application of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Chemical Communications (Cambridge, United Kingdom) (2013), 49(100), 11761-11763, database is CAplus and MEDLINE.

The authors report a new approach to improve the gain characteristics of a red-emitting based mol. The insertion of the active dye between two polymeric arms prevents the inter-mol. interactions deleterious for the gain. By the ultra-fast pump-probe technique the authors found an efficient energy transfer between the polymer and dye. High gain in the nanosecond timescale regime was proved.

Chemical Communications (Cambridge, United Kingdom) published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Application of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bolis, Serena published the artcileUltrafast study of inter- and intrachain energy transfer in a core-polymer, Formula: C20H28B2O4S2, the publication is Journal of Polymer Science, Part B: Polymer Physics (2018), 56(13), 965-969, database is CAplus.

Interchain interactions can play a pos. role in reaching amplified spontaneous emission in an interesting core-polymer system where the donor (side chains) and the acceptor (core) are chem. linked together. Different degree of interchain interactions modifies the photophys. characteristics of the polymer. By means of transient absorption spectroscopy we show that the stimulated emission from the core decreases passing from solid state to concentrated solution and it is almost absent in the diluted solution The conformational rearrangements of the core-polymer chain in solution limits the efficiency of the intrachain Foerster energy transfer mechanism. The free chain rotations decrease the exciton hopping along the conjugated chains, the ratio between donor and acceptor moieties in the polymer, and change the relative orientation of the transition dipoles of the donor and acceptor causing a strong decrease of energy transfer efficiency and subsequently of the gain. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2018.

Journal of Polymer Science, Part B: Polymer Physics published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Formula: C20H28B2O4S2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bredikhina, Z. A. published the artcileNew approach to nonracemic 1-alkylamino-3-aryloxypropan-2-ols belonging to β-blockers via cyclic sulfites, Application of 4-Morpholino-1,2,5-thiadiazol-3-ol, the publication is Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya) (2001), 50(3), 436-439, database is CAplus.

Nonracemic β-blockers, viz., (S)-propranolol and (S)-timolol, were prepared from (S)-glycidol in three steps consisting in the reaction with SOCl₂ followed by the reaction of the resulting (4S)-4-chloromethyl-2-oxo-1,3,2-dioxathiolanes with the corresponding phenol and the final cleavage of (4R)-aryloxymethyl sulfites under the action of amines in DMF.

Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya) published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C6H9N3O2S, Application of 4-Morpholino-1,2,5-thiadiazol-3-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts