Author: tianli

Gershbein, Leon L. published the artcileAction of drugs and chemical agents on rat liver regeneration, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Drug and Chemical Toxicology (1977) (1985), 8(3), 125-43, database is CAplus and MEDLINE.

A large number (> 270) of drugs, chems., and other agents were tested for their effects on the regeneration of liver in hepatectomized rats. Seven anticonvulsants, 4 antiinflammatory drugs, 4 sedatives-hypnotics, the antipyretic-analgesic aminopyrine  [58-15-1], the antifungal griseofulvin  [126-07-8], a uricosuric, a muscle relaxant, a hydrocholeretic, an antihypertensive, and a thyroid inhibitor were hepatotrophic. Most the remaining drugs were inactive in this screening, whereas a few suppressed liver regeneration.

Drug and Chemical Toxicology (1977) published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Marciniec, Bogdan published the artcileSilylation of silanols with vinylsilanes catalyzed by a ruthenium complex, Name: Triisopropylsilanol, the publication is Tetrahedron Letters (2008), 49(8), 1310-1313, database is CAplus.

A new ruthenium complex-catalyzed O-silylation of silanols with vinylsilanes leading to siloxane bond formation with the evolution of ethylene is described. A maximum conversion of silanol is reached using an excess of vinylsilane which also yields the product of the homo-coupling of the latter. Under the optimum conditions, when a vinylsilane with at least one ethoxy substituent is used, the reaction gives exclusively unsym. siloxanes.

Tetrahedron Letters published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Name: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hreczycho, Grzegorz published the artcileA new selective approach to unsymmetrical siloxanes and germasiloxanes via O-metalation of silanols with 2-methylallylsilanes and 2-methylallylgermanes, Recommanded Product: Triisopropylsilanol, the publication is New Journal of Chemistry (2011), 35(12), 2743-2746, database is CAplus.

A scandium(iii) trifluoromethanesulfonate-catalyzed O-metalation of silanols with 2-methylallylsilanes and 2-methylallylgermanes leading to siloxane or germasiloxane bond formation under mild conditions with evolution of isobutylene is described.

New Journal of Chemistry published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Recommanded Product: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Marko, Monika published the artcileReal-life efficiency and safety comparison study of emollient ointment based on glycerophosphoinositol (GPI) salt of choline and other emollient products in patients with atopic dermatitis, Application In Synthesis of 70445-33-9, the publication is Journal of Dermatological Treatment (2022), 33(2), 999-1010, database is CAplus and MEDLINE.

Introduction The aim of this study was to investigate the effectiveness and safety of emollient preparations in comparison with the emollient ointment containing glycerophosphoinositol salt of choline in patients with atopic dermatitis (AD). Methods In a ‘real-life’ study, 300 patients with moderate AD were age-stratified and divided into two groups: patients applying GPI emollient and the comparator. We evaluated the effectiveness of AD treatment using: Eczema Area and Severity Index (EASI), Three Item Severity (TIS), Visual Analog Scale (VAS) and Four-Item Itch Questionnaire. Results The GPI emollient was superior in reduction AD symptoms in children: VAS (-2.58 ± 0.25), TIS (-2.22 ± 0.22), EASI (-15.27 ± 1.77), and adults: VAS (-2.42 ± 0.19), TIS (-2.22 ± 0.17), EASI (-13.22 ± 1.53), as compared to the other emollient in children: VAS (-0.67 ± 0.19), TIS (0.47 ± 0.19), EASI (-3.71 ± 1.01) and adults: VAS (-0.86 ± 0.09), TIS (0.77 ± 0.09), EASI (-2.95 ± 0.46), p < .001. Similar results were observed in Four Item Itch Questionnaire. Conclusion Both emollients showed good safety and tolerance profile and reduced AD symptoms. The GPI emollient seems to be more slightly effective in reducing AD symptoms as compared to the other com. available emollient.

Journal of Dermatological Treatment published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Application In Synthesis of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Manna, Subal Chandra published the artcileStructure and magnetic characterization of tetranuclear closed/double-open cubane core, and 1D polynuclear copper(II) complexes, Name: 2-Aminobutan-1-ol, the publication is Journal of Solid State Chemistry (2019), 378-385, database is CAplus.

Three copper(II) complexes namely [Cu₄(L¹)₄]·0.5(H₂O) (1), [Cu₄(L²)₂(HL²)₂(H₂O)₂](sq)·H₂O (2) and {[Cu₂(L²)₂(tp)]·(H₂O)}_n (3) (H₂L¹ = [(E)-2-((1-hydroxybutan-2-ylimino)methyl)phenol], H₂L² = [(E)-2-((1-hydroxybutan-2-ylimino)methyl)-6-methoxyphenol], sq = squarate and tp = terephthalate ion) were characterized by structure determination and magnetic anal. Both 1 and 2 are tetranuclear Cu₄O₄ species with closed cubane core and double-open cubane like core structure, resp. However, complex 3 is a 1D polymeric chain, where Schiff base chelated dinuclear copper units are linked through terephthalate ions. C-H…π interactions among the 1D polymeric chains form a 2D supramol. architecture. Variable temperature magnetic property study indicates overall antiferromagnetic exchange coupling in all complexes.

Journal of Solid State Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Name: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chatzopoulou, Maria published the artcileDecreasing acidity in a series of aldose reductase inhibitors: 2-Fluoro-4-(1H-pyrrol-1-yl)phenol as a scaffold for improved membrane permeation, COA of Formula: C10H9NO, the publication is Bioorganic & Medicinal Chemistry (2014), 22(7), 2194-2207, database is CAplus and MEDLINE.

Targeting long-term diabetic complications, as well as inflammatory pathologies, aldose reductase inhibitors (ARIs) have been gaining attention over the years. In the present work, in order to address the poor membrane permeation of previously reported ARIs, derivatives of N-phenylpyrrole, bearing groups with putative pK_a ≥ 7.4, were synthesized and evaluated for aldose reductase inhibitory activity. The 2-fluorophenol group proved the most promising moiety, and further modifications were explored. The most active compound was identified as a submicromolar inhibitor (IC₅₀ = 0.443 μM), was also selective against the homologous enzyme aldehyde reductase. Cross-docking revealed that the above mentioned compound displays a peculiar interaction network that may be responsible for high affinity. Physicochem. profiling of it showed a pK_a of 7.64, rendering it less than 50% ionized in the physiol. pH range, with potentially favorable membrane permeation. The latter was supported from the successful inhibition of sorbitol formation in rat lenses and the ability to permeate rat jejunum.

Bioorganic & Medicinal Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, COA of Formula: C10H9NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Roy, Ekta published the artcileCarbon dot/TAT peptide co-conjugated bubble nanoliposome for multicolor cell imaging, nuclear-targeted delivery, and chemo/photothermal synergistic therapy, Product Details of C9H21NO3, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2017), 144-157, database is CAplus.

A pioneering nucleus-targeting dual-functional thermosensitive bubble-generating liposome as drug carrier has been developed with conjugated cell penetrating peptide and photothermal agent (CDs) for multi-color cell imaging and combination (chemo- and photothermal) therapy of cancer, using doxorubicin as drug mol. The liposome was prepared by ‘inhouse’ synthesized precursors mols., to reduce the cost of production in comparison to the earlier reported liposomes. This drug carrier was proposed to target nucleus of the cancer cells, owing to specific and selective cell-penetrating property of TAT, followed by burst but stable drug release due to decomposition of bubble forming agent present inside the liposome core, by being subjected to near-IR (NIR) irradiation (i.e. photothermal conversion of radiation to heat). The in-vitro temperature and/or NIR-triggered release study indicated that liposome was sensitive towards heat and able to generate the sufficient temperature of 68 °C in the presence of NIR-laser source. The in vivo experiment was also performed to explore the NIR-responsive hyperthermia in the mice body. The as prepared bubble containing liposome-based drug delivery system exhibits superior stability, no drug leakage and enhanced in vitro and in vivo drug delivery with efficient cancer cell killing via combination therapy. The multicolor fluorescence obtained via CDs improves the accuracy of the cell imaging study as well as works as a key component for photothermal treatment of cancer. The results obtained in the study demonstrated that the designed smart drug carrier have great potential in the field of cancer theragnosis i.e. imaging, targeted drug delivery, and treatment.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Product Details of C9H21NO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Frankowski, Kevin J. published the artcileDiscovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis, Category: alcohols-buliding-blocks, the publication is Journal of Medicinal Chemistry (2022), 65(12), 8303-8331, database is CAplus and MEDLINE.

A high-throughput, high-content assay was developed to identify novel small mols. that selectively reduce PNC prevalence in cancer cells. The pyrrolopyrimidine series able to reduce PNC prevalence in PC3M cancer cells at submicromolar concentrations without affecting cell viability was identified and further optimized. Structure-activity relationship exploration of the structural elements necessary for activity resulted in the discovery of several potent compounds Anal. of in vitro drug-like properties led to the discovery of the bioavailable analog, metarrestin, which has shown potent antimetastatic activity with improved survival in rodent models and is currently being evaluated in a first-in-human phase 1 clin. trial.

Journal of Medicinal Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Frankowski, Kevin J. published the artcileDiscovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis, Application of 4,4-Diethoxybutan-1-amine, the publication is Journal of Medicinal Chemistry (2022), 65(12), 8303-8331, database is CAplus and MEDLINE.

A high-throughput, high-content assay was developed to identify novel small mols. that selectively reduce PNC prevalence in cancer cells. The pyrrolopyrimidine series able to reduce PNC prevalence in PC3M cancer cells at submicromolar concentrations without affecting cell viability was identified and further optimized. Structure-activity relationship exploration of the structural elements necessary for activity resulted in the discovery of several potent compounds Anal. of in vitro drug-like properties led to the discovery of the bioavailable analog, metarrestin, which has shown potent antimetastatic activity with improved survival in rodent models and is currently being evaluated in a first-in-human phase 1 clin. trial.

Journal of Medicinal Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Application of 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gollapelli, Krishna Kumar published the artcileRh(I)-catalyzed stereoselective desymmetrization of prochiral cyclohexadienones via highly exo-selective Huisgen-type [3 + 2] cycloaddition, COA of Formula: C9H12O, the publication is Chemical Science (2021), 12(4), 1544-1550, database is CAplus and MEDLINE.

A Rh(I)-catalyzed highly stereoselective desymmetrization of 2-alkynylbenzaldehyde-tethered cyclohexadienones triggered by intramol. Huisgen-type [3 + 2] cycloaddition was developed. This method enables convergent construction of complex epoxy-bridged polycyclic ring systems with five contiguous stereocenters with excellent exo-selectivity and broad substrate scope. The highly atom-economical process involves 6-endo-dig cyclization of carbonyl oxygen onto an activated alkyne resulting in a highly reactive metal-benzopyrylium intermediate, which readily undergoes intramol. [3 + 2] annulation/hydration. Asym. induction was also achieved for the first time in Rh(I)-catalyzed 1,3-dipolar cycloaddition using an easily accessible chiral diene as the ligand.

Chemical Science published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, COA of Formula: C9H12O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts