Author: tianli

Weber, Lothar published the artcileSynthetic, structural, photophysical and computational studies of π-conjugated bis- and tris-1,3,2-benzodiazaboroles and related bis(boryl) dithiophenes, Safety of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Dalton Transactions (2009), 1339-1351, database is CAplus and MEDLINE.

π-Conjugated systems with two and three 1,3-diethyl-1,3,2-benzodiazaborolyl end-groups were synthesized in 58-91% yields using established 1,3,2-diazaborole methodologies. The bis(diazaborolyl) compounds contain thiophene -2,5-C₄H₂S- (2a), dithiophene -5,5′-(2,2′-C₄H₂S)₂– (2b), phenylene -1,4-C₆H₄– (2c), biphenylene -4,4′-(1,1′-(C₆H₄)₂)- (2d) and dioctylfluorene -2,7-(9,9-(C₈H₇)₂C₁₁H₆)- (2e) bridges. The three-way linkers in the tris(diazaborolyl) assemblies contain a central phenylene unit -1,3,5-C₆H₃– linked to the borolyl end groups via thiophene -2,5-C₄H₂S- (3a), directly bonded (3b) or via phenylene -1,4-C₆H₄– (3c) units. Mol. structures of 2a, 2b, 2c, 3a, 3b and 3c were determined by x-ray crystallog. studies. These borolylated systems show intense blue/violet luminescence with Stokes shifts of 6200-9500 cm^-1 and quantum yields of 0.33 to 0.98. The absorption maxima (296-351 nm) of these assemblies are reproduced well by TD-DFT computations (B3LYP/6-31G^*), and arise from strong, low energy HOMO-LUMO transitions. From MO computations on optimized geometries of these diazaborolyl systems, the LUMO is located mainly on the thiophene/benzene bridge (66-92%) while the HOMO is largely benzodiazaborolyl in character (53-83%). The S₁←S₀ absorption bands are thus assigned to π(diazaborolyl)-π^*(thiophene/benzene) transitions. Computations on related bis(boryl) dithiophenes [with diarylboryl e.g. Ph₂B, Mes₂B, (C₆F₅)₂B and FMes₂B (Mes = 2,4,6-Me₃C₆H₂; FMes = 2,4,6-(CF₃)₃C₆H₂), dioxaborolyl and other diazaborolyl groups] reveal strong, low energy UV-visible absorption bands arising from π(thiophene)-π^*(thiophene) transitions, with increasing B participation in the LUMO of the diarylboryl and especially the highly fluorinated systems.

Dalton Transactions published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C5H9IO2, Safety of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Spichal, Lukas published the artcileThe purine derivative PI-55 blocks cytokinin action via receptor inhibition, Synthetic Route of 1122579-42-3, the publication is FEBS Journal (2009), 276(1), 244-253, database is CAplus and MEDLINE.

One of several potential approaches to study mechanisms of action of biol. active compounds is to develop their agonists and antagonists. In the present study, we report the identification of the first known mol. antagonizing the activity of the plant hormone cytokinin at the receptor level. This compound, 6-(2-hydroxy-3-methylbenzylamino)purine, designated PI-55 in the present study, is structurally closely related to cytokinin 6-benzylaminopyrine, but substitutions at specific positions of the aromatic side chain strongly diminished its cytokinin activity and conferred antagonistic properties. PI-55 competitively inhibited the binding of the natural ligand trans-zeatin to the Arabidopsis cytokinin receptors cytokinin response 1 (CRE1)/Arabidopsis histidine kinase (AHK) 4 and AHK3 and repressed induction of the cytokinin response gene ARR5:GUS. Genetic anal. revealed that CRE1/AHK4 is the primary target of PI-55. Cytokinin bioassays also demonstrated the anticytokinin effect of PI-55 in several other species. Furthermore, we show that PI-55 accelerated the germination of Arabidopsis seeds and promoted the root growth and formation of lateral roots, thus phenocopying the known consequences of a lowered cytokinin status and demonstrating its potential to inhibit cytokinin perception in planta. PI-55 is the first example for the targeted development of a cytokinin antagonist and represents an initial step for the preparation of cytokinin antagonists with broad activity and reduced agonistic properties.

FEBS Journal published new progress about 1122579-42-3. 1122579-42-3 belongs to alcohols-buliding-blocks, auxiliary class 5.6_Aromatics,Purines, name is 2-(((9H-Purin-6-yl)amino)methyl)-6-methylphenol, and the molecular formula is C8H5F3O3, Synthetic Route of 1122579-42-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Conant, J. B. published the artcileSuperacid solutions. IV. Determination of the strength of weak bases and pseudo bases in glacial acetic acid solution, Recommanded Product: 9-Phenyl-9H-xanthen-9-ol, the publication is Journal of the American Chemical Society (1930), 4436-50, database is CAplus.

cf. C. A. 22, 4035. A spectrophotometric study has been made of the acid-base equilibrium in solutions of crystal violet in buffered glacial AcOH solutions The extinction coefficient was measured at intervals of 10 mμ from 470 to 680. Data are given for the fundamentals chosen for the violet, green and yellow forms; also for the dissociation constants of crystal violet from spectrophotometric data at 25° in urea-H₂SO₄, urea-HClO₄ and acetoxime-H₂SO₄ buffers. The change of pK’₁ for crystal violet with change in ionic strength is shown in the form of curves; this effect is very marked; the total change of pK’₁ from the limiting value at μ = 0 to √μ = 0.5 is about 2.6 p_H units. In the more concentrated solutions there are sp. effects depending on the nature of the neutral salt. These effects are larger than the corresponding effects in H₂O because of the low dielec. constants of AcOH; the natures of both the cation and anion of the neutral salt are important. An electrometric study of weak bases and pseudo bases in glacial AcOH reveals the large effect of changing ionic strength, also noted in the spectrophotometric study. The following apparent pK’ values for pseudo bases at 25° in glacial AcOH are reported (bases in 0.05 M solution titrated with H₂SO₄ μ = 0.2 with Me₃NHSO₃C₆H₄Ne-p): Ph₃COH -1.47; C₁₀H₇CPh₂OH -1.25; (MeOC₆H₄)₂CHOH -1.14; MeOC₆H₄CPh₂OH -0.59; phenylxanthanol 1.91; dinaphthoxanthanol. 2.40 MeOC₆H₄)₃COH, 2.56. The effect of added H₂O on the apparent constants of a number of weak pseudo bases is reported. A method is outlined for obtaining significant values for the relative basicity of the “halochromic carbinols.”

Journal of the American Chemical Society published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Recommanded Product: 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rodygin, Konstantin S. published the artcileA Green and Sustainable Route to Carbohydrate Vinyl Ethers for Accessing Bioinspired Materials with a Unique Microspherical Morphology, COA of Formula: C12H20O6, the publication is ChemSusChem (2018), 11(1), 292-298, database is CAplus and MEDLINE.

Synthesizing chems. and materials from renewable sources is one of the main aims of modern science. Carbohydrates represent excellent renewable natural raw materials that are ecofriendly, inexpensive, and biol. compatible. A green procedure has been developed for the vinylation of carbohydrates by using readily available calcium carbide. Various carbohydrates were utilized as starting materials, resulting in mono-, di-, and tetravinyl ethers in high to excellent yields (81-92 %). The synthesized biobased vinyl ethers were utilized as monomers in free radical and cationic polymerizations A unique combination of a smooth surface and intrinsic microcompartments was achieved in the synthesized materials. Two types of biobased materials were prepared involving microspheres and intrinsic hollow compartments in polymers. SEM with built-in ion beam cutting was applied to reveal the spatial hierarchical structures in 3D space.

ChemSusChem published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, COA of Formula: C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wentworth, Anita D. published the artcileA Soluble Polymer-Supported Triflating Reagent: A High-Throughput Synthetic Approach to Aryl and Enol Triflates, Formula: C4H4OS, the publication is Organic Letters (2000), 2(4), 477-480, database is CAplus and MEDLINE.

The high-yielding synthesis and application of the first example of a polymer-supported reagent for the preparation of trifluoromethanesulfonates (triflates), 4-(F₃CSO₂)₂NC₆H₄(OCH₂CH₂)_nOC₆H₄N(SO₂CF₃)₂, is described. This new reagent efficiently triflates aryl alcs. and lithium enolates in high yield (>90%). A simple precipitation and filtration to remove the excess reagent and byproduct facilitate purification of the triflate products. The PEG-supported approach is highly efficient, as the PEG-supported byproduct can be quant. recovered and recycled into reagent.

Organic Letters published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C7H8BFO2, Formula: C4H4OS.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dong, Hui published the artcileClinical efficacy of atomizing inhalation of ambroxol hydrochloride in treatment of chronic bronchitis in elderly patients, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Latin American Journal of Pharmacy (2019), 38(7), 1284-1289, database is CAplus.

This study aimed to investigate the clin. efficacy of atomizing inhalation of ambroxol hydrochloride in treatment of chronic bronchitis in elderly patients. Four hundred elderly patients with chronic bronchitis were randomly divided into control and observation group, which received conventional treatment and atomizing inhalation of ambroxol hydrochloride based on conventional treatment, resp. After treatment, compared with control group, in observation group the disappearance time of clin. symptoms was decreased (P < 0.05), the total effective rate was increased (P < 0.01), the lung function, life quality and daily activity ability were improved (P < 0.05), the serum IL-2 level was increased (P < 0.05), and the serum IL-6 and TNF-α levels were decreased (P < 0.05). There was no significant difference of adverse reaction between two groups (P > 0.05). Atomizing inhalation of ambroxol hydrochloride can quickly and effectively alleviate the clin. symptoms of chronic bronchitis in elderly patients.

Latin American Journal of Pharmacy published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cao, Zhan-fang published the artcileIn situ nano-Fe₃O₄/triisopropanolamine functionalized graphene oxide composites to enhance Pb²⁺ ions removal, Application of Triisopropanolamine, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (2019), 209-217, database is CAplus.

In this work, a kind of magnetic graphene oxide composite material (TI/GO@Fe₃O₄) for Pb²⁺ removal was successfully synthesized through in situ growth method. Briefly, metal ions (Fe³⁺) were fixed on GO surface by oxygen-containing functional groups and acted as growth centers of Fe₃O₄. Furthermore, the surface of GO and Fe₃O₄ nanoparticles were strengthened by the triisopropanolamine and its oxidnation products (TI), which can promote the removal of Pb²⁺ ions. The mass percentage of Fe₃O₄ particles in TI/GO@Fe₃O₄ was 54.31% by EDS datas. Average particle size of TI/GO@Fe₃O₄ is 19.03 nm. The adsorption experiments indicated that the adsorption capacity of TI/GO@Fe₃O₄ can reach 461.00 mg/g under optimized conditions (10 mg TI/GO@Fe₃O₄, 50 mL 500 mg/L Pb²⁺, pH 5.0, 293 K, 120 min). The XPS anal. results indicated that the TI/GO@Fe₃O₄ can adsorb the Pb²⁺ through the complexation between nitrogen and oxygen-containing functional groups and Pb²⁺ ions. Hence, the composite material is a superior material for the adsorption of Pb²⁺. Moreover, the synthesized adsorbent can be recycled by magnet quickly after adsorption.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Application of Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Meng, Zhong-Lei published the artcileSynthesis of Terpineol from Alpha-Pinene Catalyzed by α-Hydroxy Acids, Quality Control of 90-64-2, the publication is Molecules (2022), 27(3), 1126, database is CAplus and MEDLINE.

We report the use of five alpha-hydroxy acids (citric, tartaric, mandelic, lactic and glycolic acids) as catalysts in the synthesis of terpineol from alpha-pinene. The study found that the hydration rate of pinene was slow when only catalyzed by alpha-hydroxyl acids. Ternary composite catalysts, composed of AHAs, phosphoric acid, and acetic acid, had a good catalytic performance. The reaction step was hydrolysis of the intermediate terpinyl acetate, which yielded terpineol. The optimal reaction conditions were as follows: alpha-pinene, acetic acid, water, citric acid, and phosphoric acid, at a mass ratio of 1:2.5:1:(0.1-0.05):0.05, a reaction temperature of 70°C, and a reaction time of 12-15 h. The conversion of alpha-pinene was 96%, the content of alpha-terpineol was 46.9%, and the selectivity of alpha-terpineol was 48.1%. In addition, the catalytic performance of monolayer graphene oxide and its composite catalyst with citric acid was studied, with acetic acid used as an additive.

Molecules published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Quality Control of 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rojanasakul, Yon published the artcileAntisense inhibition of silica-induced tumor necrosis factor in alveolar macrophages, Recommanded Product: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, the publication is Journal of Biological Chemistry (1997), 272(7), 3910-3914, database is CAplus and MEDLINE.

Tumor necrosis factor-α (TNFα) has been shown to play an important role in the pathogenesis of silicotic fibrosis. In this study, antisense oligonucleotides targeted to TNFα mRNA were used to inhibit silica-induced TNFα gene expression in alveolar macrophages. To achieve macrophage-specific oligonucleotide delivery, a mol. conjugate consisting of mannosylated polylysine that exploits endocytosis via the macrophage mannose receptor was used. Complexes were formed between the mannosylated polylysine and oligonucleotides and added to the cells in the presence of silica. Enzyme-linked immunoadsorbent assay showed that the complex consisting of the conjugate and antisense oligomer effectively inhibited TNFα production, whereas the oligomer alone had much less effect. Reverse transcriptase-polymerase chain reaction anal. revealed that the reduction in TNFα secretion was associated with specific ablation of targeted TNFα mRNA. The conjugate alone or conjugate complexed with inverted or sense sequence oligonucleotide had no effect. The promoting effect of the conjugate on antisense activity was shown to be due to enhance cellular uptake of the oligomer via mannose receptor-mediated endocytosis. Cells lacking mannose receptors showed no susceptibility to the conjugate treatment. These results indicate that effective and selective inhibition of macrophage TNFα expression can be achieved using the antisense mannosylated polylysine system.

Journal of Biological Chemistry published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Recommanded Product: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Karsai, Syrus published the artcileComparison of novel aluminium lactate versus aluminium chloride-based antiperspirant in excessive axillary perspiration: First prospective cohort study, Product Details of C5H12O2, the publication is Dermatologic Therapy (2021), 34(4), e15020, database is CAplus and MEDLINE.

Aluminum chloride-based antiperspirants are an effective topical therapeutic option for mild to moderate states of excessive perspiration. Its use is primarily limited by the occurrence of skin irritation, especially in sensitive skin types. The objective of this study was to compare the antiperspirant efficacy and tolerability of a novel antiperspirant with 12.5% aluminum lactate, and a 12.5% aluminum chloride-based antiperspirant. This cohort study was conducted as a two-sided self-assessment comparison between both preparations in healthy volunteers to generate selfcare-related data. Almost half of the participants stated that aluminum chloride was more efficacious than aluminum lactate; 22% stated aluminum lactate was more efficacious than aluminum chloride; 28% observed no difference in the efficacy of both preparations (p = 0.04). However, 88% described greater tolerability with aluminum lactate (p < 0.0001). In this study, aluminum lactate showed significantly greater tolerability than aluminum chloride, although the latter tended to show slightly greater efficacy.

Dermatologic Therapy published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Product Details of C5H12O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts