Author: tianli

Zhao, Hongyi published the artcileEfficient and stereoselective one-pot synthesis of benzo[b]oxazolo[3,4-d][1,4]oxazin-1-ones, Recommanded Product: 4,5-Difluoro-2-nitrophenol, the publication is RSC Advances (2020), 10(40), 24037-24044, database is CAplus and MEDLINE.

An efficient and mild one-pot convergent synthesis protocol has been developed for benzo[b]oxazolo[3,4-d][1,4]oxazin-1-one derivatives through the Mitsunobu reaction and sequential cyclization. Various tricyclic fused benzoxazinyl-oxazolidinones (20 examples) were obtained in good to excellent yields and high enantioselectivities with facile operation. Furthermore, four stereoisomers were afforded resp. in high ee values (>97.8%) via using different chiral 2,3-epoxy-4-trityloxybutanol. This methodol. has been applied to the synthesis of key intermediates of drug candidates.

RSC Advances published new progress about 55346-97-9. 55346-97-9 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Nitro Compound,Benzene,Phenol, name is 4,5-Difluoro-2-nitrophenol, and the molecular formula is C24H29N5O3, Recommanded Product: 4,5-Difluoro-2-nitrophenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Kaisu published the artcileEffect of hypophysin combined with carboprost tromethamine in treatment of post-partum hemorrhage induced by uterine inertia, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Jianyan Yixue Yu Linchuang (2016), 13(20), 2872-2873, database is CAplus.

Objective: To investigate the effect of hypophysin combined with carboprost tromethamine in treatment of post-partum hemorrhage induced by uterine inertia. Methods: From Mar. 2014 to Aug. 2015, 92 patients with postpartum hemorrhage induced by uterine inertia were randomly divided into control group (46 cases), given combined treatment of hypophysin and oxytocin, and study group (46 cases), further given carboprost Tromethamine on the basis of control group. The postpartum bleeding time, amounts of postpartum blood loss, incidence rate of hysterectomy and fetal mortality rate were compared between the two groups. Results: The amounts of postpartum blood loss at 0.5, 2 and 24 h after delivery, postpartum bleeding time, incidence rate of hysterectomy and fetal mortality rate of study group were significantly lower than those of control group (P < 0.05). Conclusion: Hypophysin combined with carboprost tromethamine might be with significant curative effect in the treatment of post-partum hemorrhage induced by uterine inertia.

Jianyan Yixue Yu Linchuang published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C14H31NO2, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Peng, Fang-liang published the artcileClinical observation of carboprost tromethamine and oxytocin in the treatment of postpartum hemorrhage, Application In Synthesis of 58551-69-2, the publication is Zhongguo Yaofang (2014), 25(32), 3015-3017, database is CAplus.

This paper is to observe clin. efficacy and safety of carboprost tromethamine and oxytocin in the treatment of postpartum hemorrhage. 60 Delivery women with postpartum hemorrhage were randomly divided into control group and observation group. In control group, women undergoing natural labor were given i.m. injection of oxytocin 20 u after delivery of fetus, and women undergoing caesarean section were given intrauterine injection of oxytocin 20 u after delivery of fetus; then all of them received i.v. dripping of oxytocin 20 u added into 5% glucose solution 500 mL, and i.v. injection of oxytocin was given repeatedly and oral dose of misoprostol was given 600 mg if necessary, qd. Observation group was addnl. given intrauterine injection of carboprost tromethamine 0.25 mg on the basis of control group, and repeated injection was given if necessary; total daily dose could not be more than 2.0 mg and medication interval was more than 15 min. The clin. efficacy, the intensity of uterine contraction, hemostatic rates of patients with different amount of bleeding at different time and ADR were observed in 2 groups. The total effective rate, the intensity of uterine contraction hemostatic rates of patients with different amount of bleeding 5, 10 and 15 min after medication in observation group were significantly higher than those in control group, and there were statistical significances(P<0.05); there was no statistical significance in the incidence of ADR between 2 groups(P>0.05). Carboprost tromethamine and oxytocin are more effective and safer than oxytocin alone in the treatment of postpartum hemorrhage.

Zhongguo Yaofang published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Application In Synthesis of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhuang, Yaping published the artcileSystemic analysis of 150 kinds of tablet, Synthetic Route of 3818-50-6, the publication is Yaoxue Tongbao (1982), 17(6), 332-5, database is CAplus.

Marquis reagent, modified Dragendorff reagent, Folin reagent, ammonium vanadate-H₂SO₄ reagent, Ehrlich’s reagent, Froehde reagent and 8 other test reagents were used in the identification of âˆ?50 different tablets.

Yaoxue Tongbao published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C14H14O5S, Synthetic Route of 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Peng, Jingjing published the artcileDesign, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y₁ receptor antagonists, Application of 2-Morpholinoethanol, the publication is European Journal of Medicinal Chemistry (2018), 302-310, database is CAplus and MEDLINE.

A novel series of 2-(phenoxyaryl)-3-urea derivatives I [R¹ = H, Me; R² = n-Bu, 4-F₃COC₆H₄, 5-methoxycarbonyl-2-thienyl, etc.; X = CH, N] were designed, synthesized and biol. evaluated for their anti-thrombotic activity and antiplatelet aggregation study. Most of compounds exhibited good inhibition against P2Y₁ receptor among them, compounds I [R¹ = H, Me; R² = 2-methylcyclohexyl, 2-adamantyl, 4-F₃COC₆H₄; X = N] demonstrated good P2Y₁ receptor antagonistic potency in vitro (IC₅₀ = 0.62 μM, 0.82 μM, and 0.21 μM, resp.). Four compounds I [R¹ = H, Me; R² = 4-methylcyclohexyl, 4-F₃COC₆H₄, 5-ethoxycarbonyl-2-thienyl, 5-benzyloxycarbonyl-2-thienyl, etc.; X = N] showed good antiplatelet activity. The possible binding modes of compounds with P2Y₁ receptor were also explored by mol. docking simulation. The docking studies demonstrated that compound I [R¹ = Me; R² = 4-F₃COC₆H₄; X = N] interacted well with Phe119 through hydrophobic interaction and modestly improved the P2Y₁ receptor antagonistic activity.

European Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Application of 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Truax, Valarie M. published the artcileDiscovery of Tetrahydroisoquinoline-Based CXCR4 Antagonists, Synthetic Route of 6346-09-4, the publication is ACS Medicinal Chemistry Letters (2013), 4(11), 1025-1030, database is CAplus and MEDLINE.

A de novo hit-to-lead effort involving the redesign of benzimidazole-containing antagonists of the CXCR4 receptor resulted in the discovery of a novel series of 1,2,3,4-tetrahydroisoquinoline (TIQ) analogs. In general, this series of compounds show good potencies (3-650 nM) in assays involving CXCR4 function, including both inhibition of attachment of X4 HIV-1_IIIB virus in MAGI-CCR5/CXCR4 cells and inhibition of calcium release in Chem-1 cells. Series profiling permitted the identification of TIQ-(R)-stereoisomer I as a potent and selective CXCR4 antagonist lead candidate with a promising in vitro profile. The drug-like properties of I were determined in ADME in vitro studies, revealing low metabolic liability potential. Further in vivo evaluations included pharmacokinetic experiments in rats and mice, where I was shown to have oral bioavailability (F = 63%) and resulted in the mobilization of white blood cells (WBCs) in a dose-dependent manner.

ACS Medicinal Chemistry Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C7H6Cl2O, Synthetic Route of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Yumei published the artcileAnti-inflammatory and anti-asthmatic effects of TMDCT decoction in eosinophilic asthma through Treg/ Th17 balance, HPLC of Formula: 621-37-4, the publication is Frontiers in Pharmacology (2022), 819728, database is CAplus and MEDLINE.

Tuo-Min-Ding-Chuan decoction (TMDCT) is a Traditional Chinese Medicine (TCM) formula consisting of twelve herbs that can relieve the symptoms and treat allergic asthma. Yet, the underlying mechanism of action is still unclear. In this study, we investigated the effect of TMDCT in regulating Treg/Th17 cells immune balance and explored potential metabolic and gut biomarkers associated with Treg and Th17 cells in eosinophilic asthma mice treated by TMDCT. We found that TMDCT increases Treg cells percentage and decreases Th17 cells percentage in the ovalbumin (OVA) -induced eosinophilic asthma mice model. Furthermore, Imidazoleacetic acid, DL-glutamine, L-pyroglutamic acid, 2-deoxy-D-glucose were preliminary identified as biomarkers in plasma metabolites treated by TMDCT, meanwhile genus Desulfovibrio, genus Butyricimonas and genus Prevotella 9 were preliminary identified as gut microbiota biomarkers after TMDCT treatment. These results provide an exptl. foundation for the treatment of allergic asthma with Chinese herbal compounds

Frontiers in Pharmacology published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C37H30ClIrOP2, HPLC of Formula: 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hariri, Ali published the artcileMolecular imaging of oxidative stress using an LED-based photoacoustic imaging system, Recommanded Product: 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, the publication is Scientific Reports (2019), 9(1), 1-10, database is CAplus and MEDLINE.

LED-based photoacoustic imaging has practical value in that it is affordable and rugged; however, this technol. has largely been confined to anat. imaging with limited applications into functional or mol. imaging. Here, we report mol. imaging reactive oxygen and nitrogen species (RONS) with a near-IR (NIR) absorbing small mol. (CyBA) and LED-based photoacoustic imaging equipment. CyBA produces increasing photoacoustic signal in response to peroxynitrite (ONOO^–) and hydrogen peroxide (H₂O₂) with photoacoustic signal increases of 3.54 and 4.23-fold at 50μM of RONS at 700 nm, resp. CyBA is insensitive to OCl^–, NO, NO₂^–, NO₃^–, tBuOOH, O₂^–, C₄H₉O , HNO, and OH, but can detect ONOO^– in whole blood and plasma. CyBA was then used to detect endogenous RONS in macrophage RAW 246.7 cells as well as a rodent model; these results were confirmed with fluorescence microscopy. Importantly, CyB suffers photobleaching under a Nd:YAG laser but the signal decrease is <2% with the low-power LED-based photoacoustic system and the same radiant exposure time. To the best of our knowledge, this is the first report to describe mol. imaging with an LED-based photoacoustic scanner. This study not only reveals the sensitive photoacoustic detection of RONS but also highlights the utility of LED-based photoacoustic imaging.

Scientific Reports published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Recommanded Product: 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yuan, Bo published the artcileDevelopment and validation of a micro-QuEChERS method with high-throughput enhanced matrix removal followed with UHPLC-QqQ-MS/MS for analysis of raspberry ketone-related phenolic compounds in adipose tissues, SDS of cas: 621-37-4, the publication is Talanta (2021), 122716, database is CAplus and MEDLINE.

Raspberry ketone (RK) is a major flavor compound in red raspberries, and it has been marketed as a popular weight-loss dietary supplement with high potential in accumulating in fatty tissues. However, challenges in extracting and characterizing RK and its associated phenolic compounds in fatty tissues persist due to the complex matrix effect. In this work, we reported a high-throughput sample preparation method for RK and 25 related phenolic compounds in white adipose tissues using an improved micro-scale QuEChERS (quick, efficient, cheap, easy, rugged and safe) approach with enhanced matrix removal (EMR)-lipid cleanup in 96-well plates, followed by UHPLC-QqQ-MS/MS anal. The absolute recovery was 73-105% at the extraction step, and achieved 71-96% at the EMR cleanup step. The EMR cleanup removed around 66% of total lipids in the acetonitrile extract as profiled by UHPLC-QTOF-MS/MS. The innovative introduction of a reversed-phase C18 sorbent into the extract significantly improved the analytes′ recovery during SpeedVac drying. The final accuracy achieved 80-120% for most analytes. Overall, this newly developed and validated method could serve as a powerful tool for analyzing RK and related phenolic compounds in fatty tissues.

Talanta published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C10H11N3O3S, SDS of cas: 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yuan, Bo published the artcileUHPLC-QqQ-MS/MS method development and validation with statistical analysis: Determination of raspberry ketone metabolites in mice plasma and brain, SDS of cas: 621-37-4, the publication is Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences (2020), 122146, database is CAplus and MEDLINE.

Raspberry ketone (RK) (4-(4-hydroxyphenyl)-2-butanone) is the major compound responsible for the characteristic aroma of red raspberries, and has long been used com. as a flavoring agent and recently as a weight loss supplement. A targeted UHPLC-QqQ-MS/MS method was developed and validated for anal. of RK and 25 associated metabolites in mouse plasma and brain. Dispersion and projection anal. and central composite design were used for method optimization. Random effect anal. of variance was applied for validation inference and variation partition. Within this framework, repeatability, a broader sense of precision, was calculated as fraction of accuracy variance, reflecting instrumental imprecision, compound degradation and carry-over effects. Multivariate correlation anal. and principle component anal. were conducted, revealing underlying association among the manifold of method traits. R programming was engaged in streamlined statistical anal. and data visualization. Two particular phenomena, the analytes’ background existence in the enzyme solution used for phase II metabolites deconjugation, and the noted lability of analytes in pure solvent at 4° vs. elevated stability in biomatrices, were found critical to method development and validation. The approach for the method development and validation provided a foundation for experiments that examine RK metabolism and bioavailability.

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C11H15BO4, SDS of cas: 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts