tianli, Author at Alcohols-buliding-blocks

Haviv, Fortuna et al. published their research in Journal of Medicinal Chemistry in 1983 | CAS: 1122-71-0

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 6-Methyl-2-pyridinemethanol

2-[(Phenylthio)methyl]pyridine derivatives: new antiinflammatory agents was written by Haviv, Fortuna;DeNet, Robert W.;Michaels, Raymond J.;Ratajczyk, James D.;Carter, George W.;Young, Patrick R.. And the article was included in Journal of Medicinal Chemistry in 1983.Recommanded Product: 6-Methyl-2-pyridinemethanol This article mentions the following:

The title compounds I (R = H, Br, Cl, F, Me, NH₂, OMe, etc., R¹ = H, Cl, OH, Me, OMe, Ph, etc.) and related compounds as the HCl salts, prepared mostly by the reaction of 2-picolyl chloride [4377-33-7] or 2-(hydroxymethyl)pyridine [586-98-1] with the appropriate mercaptol either in 48% HBr under reflux or in the presence of NaOEt in EtOH at room temperature, were investigated as inflammation inhibitors in rat. I (R = H, Br, Cl, F, or NO₂ and R¹ = H) were effective inhibitors of immune complex induced inflammation as represented by the rat reverse passive Arthus reaction. 2-[[(4-bromophenyl)thio]methyl]pyridine (I; R = Br, R¹ = H) [83782-10-9] also inhibited both exudate formation and cellular accumulation in the more conventional carrageenin pleural test, whereas indomethacin inhibited only exudate volume in this model. Structure-activity relations are discussed. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Recommanded Product: 6-Methyl-2-pyridinemethanol).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Yu’s team published research in Xiandai Zhenduan Yu Zhiliao in 32 | CAS: 58551-69-2

Xiandai Zhenduan Yu Zhiliao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C18H28N2O7, SDS of cas: 58551-69-2.

Zhu, Yu published the artcileClinical observation of oxytocin combined with hemabate in the treatment of postpartum hemorrhage after cesarean section, SDS of cas: 58551-69-2, the publication is Xiandai Zhenduan Yu Zhiliao (2021), 32(1), 28-29, database is CAplus.

This article discusses the clin. efficacy of oxytocin combined with hemabate in the treatment of post-cesarean hemorrhage. Oxytocin combined with hemabate treatment can improve the oxidative stress index and coagulation index in patients with post-cesarean hemorrhage, thereby improving the therapeutic effect.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Jin-ling’s team published research in Xiandai Zhenduan Yu Zhiliao in 24 | CAS: 58551-69-2

Zhu, Jin-ling published the artcileEvaluation and analysis of application of carboprost in obstetrics and gynecology, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Xiandai Zhenduan Yu Zhiliao (2013), 24(9), 1993-1994, database is CAplus.

60 Placenta previa lying-in women receiving cesarean section in our hospital in 2012-2013 were randomly divided into observation group and control group. The women in the observation group were given carboprost before placental expulsion, and the women in the control group were given carboprost after placental expulsion. The cesarean operation time and blood loss of the patients of the two groups were comparatively analyzed. Results: The maternal operative time and blood loss of the patients in the observation group were significantly different from those of the control group (P < 0.05), and were statistically significant. Administration of carboprost tromethamine before placental expulsion can shorten operation time, reduce blood loss and has important application value in clin.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Xiao-yan’s team published research in Zhongguo Fuyou Baojian in 32 | CAS: 58551-69-2

Zhongguo Fuyou Baojian published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C10H15ClO3S, Quality Control of 58551-69-2.

Zhou, Xiao-yan published the artcileEffectiveness and safety of carboprost tromethamine in prevention and treatment of bleeding during cesarean section in high-risk parturients, Quality Control of 58551-69-2, the publication is Zhongguo Fuyou Baojian (2017), 32(22), 5539-5541, database is CAplus.

Objective: The article explored the effectiveness and safety of preventive intrauterine injection of carboprost tromethamine in the prevention and treatment of bleeding during cesarean section in high-risk parturients. Methods: The article selected 381 women with high-risk factors for postpartum hemorrhage during cesarean section admitted to the obstetrics department of Sichuan Provincial Maternity and Child Health Hospital from Jan. 2015 to Dec. 2016 as the research objects. They were divided according to the uterine body injection of uterine contraction drugs. 3 groups, each with 127 cases. Women in the control group were given 20 IU of oxytocin plus 500mL of compound sodium chloride i.v. infusion immediately after the fetus was delivered; study group 1 was given 20 IU of oxytocin plus 500mL of compound sodium chloride i.v. infusion immediately after the fetus was delivered 250 Î¼g carprost tromethamine was injected into the uterus; study group 2 immediately after the fetus was delivered, 250 Î¼g carprost tromethamine was injected into the uterus. The article compares the clin. treatment effect, operation time, intraoperative and postoperative blood loss, incidence of postpartum hemorrhage, hemostasis of postpartum hemorrhage and adverse reactions among the three groups of women. Results: The total effective rate of the control group was significantly lower than that of study group 1 and study group 2, and the difference was statistically significant (P < 0.05); the total effective rate of study group 1 and study group 2 was compared, and the difference was not statistically significant (P > 0.05). There was no statistically significant difference in the operation time between the three groups of women (P > 0.05). In the control group, the amount of bleeding and the incidence of postpartum hemorrhage during operation, 2h, 24h after operation were significantly higher than that of study group 1 and study group 2, and the differences were statistically significant (all P < 0.05); study group 1 during operation and 2h after operation Compared with study group 2, the amount of bleeding and the incidence of postpartum hemorrhage at 24h were not statistically significant (P > 0.05). The use of therapeutic uterine contractions in study group 1 and study group 2 was significantly less than that of control group, and the differences were statistically significant (P < 0.05). A total of 29 cases of adverse reactions occurred in all parturients, with an incidence of 22.83%. The incidence of adverse reactions in the control group, study group 1, and study group 2 were 3.94%, 11.18%, and 7.09%, resp. Conclusion: Carprost tromethamine was effective in preventing and treating high-risk parturientsâ?bleeding during cesarean section, and it was worthy of clin. application.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Jing’s team published research in Xin Zhongyi in 53 | CAS: 23828-92-4

Xin Zhongyi published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C11H10ClNO, Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Zhou, Jing published the artcileClinical comparative study between Xiao′er feike granules and ambroxol hydrochloride syrup for chronic cough in children, Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Xin Zhongyi (2021), 53(5), 120-123, database is CAplus.

Objective: To compare and analyze the clin. application value of Xiao′er Feike granules and ambroxol hydrochloride syrup in the treatment of chronic cough in children. Methods: A total of 200 children with chronic cough were divided into the study group and the control group, 100 cases each, by digital parity. Based on the routine treatment, the control group was addnl. treated with ambroxol hydrochloride syrup, and the study group was addnl. treated with Xiao′er Feike granules. After two weeks of treatment, the clin. symptoms and signs in the two groups and the clin. effect were evaluated, and the immune function. Results: The total effective rate in the study group of 93.00% was higher than what was 67.00% in the control group, which was statistically significant (P<0.05). Before treatment, the difference in the comparison of Chinese medicine syndrome scores between the two groups was no significant (P>0.05). After treatment, the Chinese medicine syndrome scores in the two groups were decreased and the scores was statistically significant between the study group and the control group (P<0.05). The cough relief time and cough disappearance time in the study group were earlier, what were statistically significant, than those in the control group (P<0.05). There was no significant difference before treatment in the comparison of the levels of CD4⁺, CD8⁺, CD4⁺/CD8⁺ between all groups (P>0.05). After treatment, the levels of CD8⁺ in the two groups were increased and the level of the study group was greater than that of the control group;the levels of CD4⁺ and CD4⁺/CD8⁺ were decreased and the level of the study group were greater, which was statistically significant, than those in the control group (P<0.05). Conclusion: Compared with ambroxol hydrochloride syrup, Xiao′er Feike granules is more beneficial to improving the clin. effect, relieving the clin. symptoms and improving the immune resistance of children.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhong, Wen-qu’s team published research in Xiandai Zhenduan Yu Zhiliao in 25 | CAS: 58551-69-2

Zhong, Wen-qu published the artcileComparison of efficacy of hemabate and oxytocin in prevention of high-risk cesarean section postpartum hemorrhage, COA of Formula: C25H47NO8, the publication is Xiandai Zhenduan Yu Zhiliao (2014), 25(19), 4421-4422, database is CAplus.

82 Cases of patients with high-risk cesarean section postpartum hemorrhage were divided into observation group and control group, 41 cases in each group. The observation group received i.m. injection of hemabate, and the control group received i.m. injection of oxytocin after cesarean section. The amount of bleeding 2 h after surgery, amount of bleeding 2 h after surgery and bleeding rate of observation group were 212.6 ± 57.8 mL, 298.6 ± 71.4 mL and 17.1%, and those of control group were 358.7 ± 62.5 mL, 459.7 ± 86.3ml and 41.5%. The incidence of adverse reactions of observation group was 4.88%, and that of control group was 19.51%. The differences of all the data between groups were statistically significant (P < 0.05 or P < 0.01). Compared with traditional drugs, hemabate can effectively control bleeding amount and bleeding rate in preventing high-risk cesarean section postpartum hemorrhage, has high drug safety and is recommended to be used in clinic.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Yongju’s team published research in Sichuan Yixue in 35 | CAS: 58551-69-2

Sichuan Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C8H5F3N4, SDS of cas: 58551-69-2.

Zhang, Yongju published the artcileTreatment of atonic postpartum hemorrhage with carboprost tromethamine, SDS of cas: 58551-69-2, the publication is Sichuan Yixue (2014), 35(3), 356-358, database is CAplus.

Objective: To observe curative effect of carboprost tromethamine (Hemabate) for controlling atonic postpartum hemorrhage. Methods: A retrospective anal. was undertaken on 87 cases of atonic postpartum hemorrhage which were treated with Hemabate, and 87 cases which didn′t use Hemabate were regarded as controlled group. Results: The hemorrhage was successfully controlled immediately after administration of Hemabate in 69 of 87cases. The total effective rate was 96.5%, four cases failed and two were performed hysterectomy. Conclusion: Hemabate appeared very effective for treatment of severe atonic postpartum hemorrhage. It also has the characters of convenience, safety, quick and high performance. It should be used actively at the early stage of postpartum hemorrhage.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Xiang-mei’s team published research in Zhongguo Weisheng Jianyan Zazhi in 24 | CAS: 526-98-7

Zhongguo Weisheng Jianyan Zazhi published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C5H7NO, Formula: C6H10O7.

Zhang, Xiang-mei published the artcileIdentification of vitamin C precursor 2-keto-L-gulonic acid, Formula: C6H10O7, the publication is Zhongguo Weisheng Jianyan Zazhi (2014), 24(10), 1399-1400, database is CAplus.

The objective of this paper was to establish the method system for identification of 2-keto-L-gulonic acid (2-KLG) in fermentation broth, and to distinguish 2-KLG from its byproducts (5-DKG and 2-DKG). The standard substance and fermentation product samples were analyzed by thin layer chromatog.(TLC), HPLC and m.p. determination, then the results were compared to confirm the consistency of the three methods in identification of 2-KLG. The TLC results indicated that the Rf value, color and size of chromatogram were concordant between fermentation product and the standard substance of 2-KLG. HPLC results showed that the fermentation product exhibited concordant retention time (8 min), m.p.(170 °C or so) and pH value with standard substance of 2-KLG, but different from 2-DKG and 5-DKG. This method system could identify the existence of 2-KLG in unknown fermentation products, with great significance in screening of new strains of 2-KLG from further fermentation of D-glucose.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Lan’s team published research in Yixue Zongshu in 20 | CAS: 58551-69-2

Yixue Zongshu published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C7H6Cl2, HPLC of Formula: 58551-69-2.

Zhang, Lan published the artcileClinical observation of uterine suture combining with carboprost tromethamine injection treatment for uterine atony postpartum hemorrhage, HPLC of Formula: 58551-69-2, the publication is Yixue Zongshu (2014), 20(10), 1901-1902, database is CAplus.

The clin. value of uterine suture combined with carboprost tromethamine on uterine atony postpartum hemorrhage was investigated. A total of 60 cases of uterine atony postpartum hemorrhage from Jiangyou Second People’s Hospital during Jun. 2012 and Aug. 2013 were randomly divided into two groups, control group (30 cases) received routine uterine suture, observation group (30 cases) received uterine suture combined with carboprost tromethamine treatment. The estradiol, FSH (FSH), hot flashes score, endometrial thickness and proportions of bleeding time (â?2 h, > 2 h), bleeding amount (500-1,000 mL, â?1,000 mL) of the two groups were observed The level of estradiol of the observation group was higher than the control group, the endometrial thickness bigger than the control group, FSH, hot flash scores were lower than the control group, with statistically significant differences. The proportion of bleeding time â?2 h and the bleeding amount of 500-1,000 mL of the observation group was significantly higher than the control group, with statistically significant difference. The use of uterine suture combined with carboprost tromethamine on uterine atony postpartum hemorrhage could effectively improve the clin. symptoms, and reduce the bleeding amount and time, further promotion of the treatment should be done to improve the medical service level.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Yahui’s team published research in Green Chemistry in 23 | CAS: 608534-44-7

Green Chemistry published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C12H14O, Application In Synthesis of 608534-44-7.

Zhang, Yahui published the artcileSelective electrocatalytic hydroboration of aryl alkenes, Application In Synthesis of 608534-44-7, the publication is Green Chemistry (2021), 23(4), 1691-1699, database is CAplus.

Organoboron compounds are powerful precursors of value-added organic compounds in synthetic chem., and transition metal-catalyzed borylation has always been dominant. To avoid toxic reagents and costs associated with metal catalysts, simpler, more economical and effective approaches for delivering organoborons are highly desirable. Here, without the use of any metal catalysts, a CH₃CN-involved electrochem. borylation reaction is reported with alkenes and HBpin as substrates. The site-selectivity is realized to achieve mono- or di-functional borylation of an unsaturated bond by regulating the proportion of HBpin. In addition, the success of gram-scale experiments and versatile conversions confirms the potential applications of this strategy in industrial synthesis. The vital auxiliary role of N,N-diisopropylethylamine (DIEA) in the process of acetonitrile electrolysis is disclosed in the mechanism study. The proposed new strategy provides a generic platform for the discovery of addnl. challenging electrochem. systems for hydrogenation reactions.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts