Author: tianli

Adding a certain compound to certain chemical reactions, such as: 112513-79-8, 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-7-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-7-ol, blongs to alcohols-buliding-blocks compound. Quality Control of 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-7-ol

A solution of racemic 6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-7-ol (30 mg), isopropenyl acetate (24-240 mul, 1-30 eq.) and NOV435 (30 mg) in 3.0 mL of solvent (toluene, acetonitrile, tetrahydrofuran or terc-buthyl methyl ester) was stirred gently at 35 C for 7 h in a 4 mL vial. Samples were collected after 3 and 7 h and were directly analyzed by chiral GC for ee of the product and reagent. Conversion (C) was calculated as C = eer/(eer + eep) and enantiomeric ratio (E) was calculated as E = ln[1 – C(1 + eep)]/ln[1 – C(1 – eep)].

The synthetic route of 112513-79-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; De Miranda, Amanda S.; Gomes, Juliana C.; Rodrigues Jr., Manoel T.; Costa, Ingrid C.R.; Almeida, Wanda P.; Lopes, Raquel De O.; Miranda, Leandro S.M.; Coelho, Fernando; De Souza, Rodrigo O.M.A.; Journal of Molecular Catalysis B: Enzymatic; vol. 91; (2013); p. 77 – 80;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 115-20-8, name is Trichloroethanol. A new synthetic method of this compound is introduced below., COA of Formula: C2H3Cl3O

3alpha-Hydroxy-7-oxo-5beta-cholanoic acid (39.0 g, 100 mmol),beta,beta,beta-Trichloroethanol (16.4 g, 110 mmol)Soluble in 150 ml of methylene chlorideStir and cool to 0C.DCC (dicyclohexylcarbodiimide) (24.7 g) was slowly added dropwise.120mmol) dichloromethane solution,After dripping, the reaction was incubated for 6 hours.Filtered, concentrated under reduced pressure, recrystallized from acetonitrile, filtered,Trichloroethyl 3alpha-hydroxy-7-oxo-5beta-cholanoic acid (50.4 g, yield 86.7%) was obtained.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 115-20-8, Trichloroethanol.

Reference:
Patent; Hangzhou Heze Pharmaceutical Technology Co., Ltd.; Ni Sheng; Yang Zhenghe; Chen Jie; Cai Liefeng; Zhou Yinglei; Zhou Liang; Chen Hongxiang; (23 pag.)CN107383139; (2017); A;,
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Adding a certain compound to certain chemical reactions, such as: 16545-68-9, Cyclopropanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of Cyclopropanol, blongs to alcohols-buliding-blocks compound. Safety of Cyclopropanol

Step 6: N-methyl-7-cyclopropoxy-6-nitro-1,2,3,4-tetrahydroisoquinoline N-methyl-7-fluoro-6-nitro-1,2,3,4-tetrahydroisoquinoline (150mg, 0.72mmol), sodium tert-butoxide (83mg, 0.86mmol) and N, N-dimethylformamide (5mL) were added to a 25ml reaction flask under nitrogen protection. The reaction was stirred for 10 minutes at 0C, and added with cyclopropanol (54mg, 0.93mmol) in N, N-dimethylformamide (5mL) solution. The reaction was stirred and reacted for 1 hour at 0C. After completion of the reaction, ethyl acetate and water were added to the reaction solution, and the reaction solution was extracted with ethyl acetate twice additionally. The combined organic phase was washed with saturated brine, dried and concentrated. The obtained crude product was separated and purified by column chromatography (silica gel column, eluent: ethyl acetate/petroleum ether, gradient: 0?50%) to obtain the title compound (140mg, 79%). (MS: [M+1] 249.1)

The synthetic route of 16545-68-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Beijing Pearl Biotechnology Limited Liability Company; DONG, Jiaqiang; ZHONG, Boyu; YUAN, Hongbin; SHI, Quan; CHU, Shaosong; ZHANG, Deyi; ZHANG, Ruihao; (219 pag.)EP3150592; (2017); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6338-55-2, name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol, molecular formula is C6H15NO3, molecular weight is 149.1882, as common compound, the synthetic route is as follows.HPLC of Formula: C6H15NO3

A solutionof 2-[2-(2-aminoethoxy)ethoxy]ethanol (0.41 g, 2.75 mmol, 1.1 eq.) and Et3N (660 L, 4.75mmol, 1.9 eq.) in methanol (15 mL) was stirred at 30C for 1 h. NBD-Cl (0.5 g, 2.50 mmol, 1eq.) was added and the reaction was stirred in the dark for 16 h at 30C. Insoluble material wasremoved by filtration, and the filtrate was dried. The resulting solid was dissolved in H2O (5mL) and purified on a sephadex LH-20 column, eluting with H2O to give the product as anorange solid (0.33 g, 1.05 mmol, 42% yield).LRMS (ESI-): m/z calculated 311.10 ([M-H]-), found 311.18 ([M-H]-), (ESI+): m/z calculated335.27 ([M+Na]+), found 335.09 ([M+Na]+); HRMS (ESI+): m/z calculated 335.09621([M+Na]+) for C12H16N4O6Na, found 335.09650 ([M+Na]+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6338-55-2, 2-(2-(2-Aminoethoxy)ethoxy)ethanol, and friends who are interested can also refer to it.

Reference:
Article; Glenister, Alexandra; Simone, Michela I.; Hambley, Trevor W.; PLoS ONE; vol. 14; 7; (2019);,
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Synthetic Route of 7397-62-8, Adding some certain compound to certain chemical reactions, such as: 7397-62-8, name is Butyl 2-hydroxyacetate,molecular formula is C6H12O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7397-62-8.

175.16 g (99%) of o-cresol and 214.10 g (99%) of n-butyl glycolate,And the catalyst Mo2P5-MCM-48 (Mo2P5 and MCM-48 mass ratio of 25:100) 1.32g was put into the reaction rectification apparatus, mixed and stirred, and the temperature was raised to 120 C, and the reaction was carried out for 3 hours.When the top of the column is substantially anhydrous, the reaction is completed, the temperature is lowered to room temperature, the catalyst is filtered off, and the filtrate is distilled to recover 64.85 g of o-cresol.a mixture of 48.94 g of n-butyl glycolate, 118.54 g,The product obtained n-butyl tolyloxyacetate 223.82g, purity 98.9%,The yield was 99.2% based on phenol.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7397-62-8, Butyl 2-hydroxyacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shandong Runbo Biological Technology Co., Ltd.; Sun Guoqing; Hou Yongsheng; Chi Zhilong; Zhang Liguo; Hu Yishan; (13 pag.)CN108947839; (2018); A;,
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Related Products of 2568-33-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2568-33-4, name is 3-Methylbutane-1,3-diol. This compound has unique chemical properties. The synthetic route is as follows.

Step 1. Preparation of 3-hydroxy-3-methylbutyl 4-methylbenzenesulfonate To a solution of 3-methylbutane-l,3-diol (1.00 g, 9.60 mmol) in pyridine (10 mL) at 0 C was added -toluenesulfonyl chloride (2.014 g, 10.56 mmol). The reaction mixture was stirred for 16 h while allowing the reaction mixture to slowly warm up to room temperature by dissipation of the ice-water bath. The mixture was transferred to a separatory funnel containing ethyl acetate (100 mL). The organic layer was washed with 1 N HQ (3 x 50 mL). The organic layer was then washed with saturated aHC03 solution (50 mL), brine (50 mL), dried over MgS04, filtered, and concentrated. The product was purified by column chromatography on silica gel (30%? 50% ethyl acetate in hexanes; 220 g column) to afford 3-hydroxy-3-methylbutyl 4-methylbenzenesulfonate (2.03 g, 7.86 mmol, 82% yield) as a colorless oil: XH NMR (400MHz, CHLOROFORM- d) delta 7.85 – 7.78 (m, 2H), 7.37 (dd, J=8.5, 0.8 Hz, 2H), 4.23 (t, J=6.9 Hz, 2H), 2.47 (s, 3H), 1.88 (t, J=6.9 Hz, 2H), 1.24 (s, 6H); LC/MS: The product did not ionize, tR = 1.78 min (method 2-1).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2568-33-4, 3-Methylbutane-1,3-diol.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; SIT, Sing-Yuen; CHEN, Yan; CHEN, Jie; SWIDORSKI, Jacob; VENABLES, Brian Lee; SIN, Ny; MEANWELL, Nicholas A.; REGUEIRO-REN, Alicia; HARTZ, Richard A.; XU, Li; LIU, Zheng; WO2015/157483; (2015); A1;,
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Reference of 355-80-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 355-80-6, name is 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, molecular formula is C5H4F8O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A solution of 2-chloro-1,3,2-dioxaphospholane 1 or 2 or 2-chloro-1,3,2-dioxaphosphinane 6 or 7 in 10 mL of hexane was added dropwise with stirring over a period of 2 h to a solution of 0.05 mol of polyfluoroalkanol 3 or 4 and 6.1 g (0.06 mol) of triethylamine in 80 mL of hexane, maintaining the temperature at -10 to -5C. Triethylamine hydrochloride separated from the solution as a white solid. The cooling bath was removed, and the mixture was stirred for 3 h at room temperature and left overnight. The precipitate was filtered off and washed with hexane (3*20 mL). The filtrate was combined with the washings, the solvent was distilled off under reduced pressure, and the residue was distilled in a vacuum.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 355-80-6, 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol.

Reference:
Article; Gusarova; Verkhoturova; Arbuzova; Kazantseva; Albanov; Nalibaeva; Bishimbaeva; Apartsin; Kireeva; Trofimov; Russian Journal of General Chemistry; vol. 88; 4; (2018); p. 705 – 712; Zh. Obshch. Khim.; vol. 88; 4; (2018); p. 623 – 630,8;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.162744-59-4, name is (4-Bromo-2,6-difluorophenyl)methanol, molecular formula is C7H5BrF2O, molecular weight is 223.0148, as common compound, the synthetic route is as follows.Quality Control of (4-Bromo-2,6-difluorophenyl)methanol

Potassium hydroxide (0.377 g, 6.73 mmol) was added to a solution of 6-iodohexan-2-one(80% purity) (2.374 g, 8.40 mmol) in toluene (0.5 mL), followed by the addition of 4-bromo-2,6-difluorobenzylalcohol (1.25 g, 5.60 mmol). The solution mixture was stirred overnight atroom temperature. Water (20 mL) was added to the solution mixture. The mixture was extracted with ethyl acetate (3 x30 mL), and the organic layers were combined, washed with brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The crude was purified by column chromatography (dichloromethane/heptane 5:1 to dichloromethane/acetone 4:1) to give 774 mg (43%) of the product. MS (ESIj: m/z 321, 323[M+H]t

At the same time, in my other blogs, there are other synthetic methods of this type of compound,162744-59-4, (4-Bromo-2,6-difluorophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; F2G LIMITED; SIBLEY, Graham Edward Morris; MALMSTROeM, Lars Jonas; LARSSON, Johanna Maria; (212 pag.)WO2017/9651; (2017); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 27489-62-9, name is trans-4-Aminocyclohexanol. A new synthetic method of this compound is introduced below., Computed Properties of C6H13NO

To a round bottom flask with stir bar was added (S)-4-(1-(tert- butoxycarbonylamino)ethyl)-2-chlorobenzoic acid (450 mg, 1.20 mmol), (lr,4r)-4- aminocyclohexanol (415 mg, 3.60 mmol), EDO HCI (460 mg, 2.40 mmol), 1-hydroxy-7-aza- benzotriazole (229 mg, 1.68 mmol) and DMF (6 mL). To this mixture was then added DIEA (629 pL, 3.60 mmol). Reaction mixture was allowed to stir at room temperature for 18 hours. The reaction mixture was diluted with water and extracted with EtOAc. The organic phaseswere combined, washed with twice with water, brine, dried (Na2SO4), filtered and concentrated to a brown crystalline tert-butyl (S)- 1 -(3-chloro-4-((1 r,4S)-4- hydroxycyclohexylcarbamoyl)phenyl)ethylcarbamate (330 mg, 0.83 mmol, 69 % yield). LCMS m/z391.1 (M + H), RtO.71 mm.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 27489-62-9, trans-4-Aminocyclohexanol.

Reference:
Patent; NOVARTIS AG; CHO, Young Shin; LEVELL, Julian Roy; SHAFER, Cynthia; SHULTZ, Michael David; WO2014/147586; (2014); A1;,
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Adding a certain compound to certain chemical reactions, such as: 10160-24-4, 7-Bromo-1-heptanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 7-Bromo-1-heptanol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 7-Bromo-1-heptanol

A method for synthesizing cis-7-tetradecenol acetate, which is the main sex pheromone of the elm moth, comprises the following steps:(1) Preparation of (7-bromoheptyl-1 -) – 2-tetrahydropyranyl ether To a 500 ml four-necked flask equipped with an electromagnetic stirrer, a reflux condenser,Pressure dropping funnel in a 250 mL four-necked flask, 3,4-dihydropyran 8 g was added and 0.03 g of 37% hydrochloric acid was added as a catalyst with stirring. After 10 min, a solution of 7-bromo- Alcohol 17 g, control the dropping rate (the reaction is exothermic reaction, 7-bromo-1-heptanol dropping speed is accelerated, the reaction is accelerated, exothermic increase, to be ice bath cooling), keep the reaction temperature of 40 ~ 60 C, add room temperature after reaction 2 h, stop stirring, instead of distillation device, steamed unreacted 3,4-dihydropyran. After the residue was cooled, 85 g of petroleum ether was added, washed with saturated sodium hydrogencarbonate solution and saturated brine, dried over sodium sulfate for 10 to 15 hours, concentrated and evaporated to give (7-bromoheptyl-1- Tetrahydropyranyl ether 23.5 g, purity 99.2%, the yield was 96.7%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10160-24-4, 7-Bromo-1-heptanol, and friends who are interested can also refer to it.

Reference:
Patent; Shanxi Agricultural University; Yang, Meihong; Chen, Xupeng; Liu, Jinlong; Liu, Hongxia; Zhang, Jintong; Cao, Chuanjian; Jing, Xiaoyuan; Wang, Shifei; Fan, Lihua; (8 pag.)CN105418418; (2016); A;,
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