Author: tianli

Application of 28539-02-8, Adding some certain compound to certain chemical reactions, such as: 28539-02-8, name is 1-(Hydroxymethyl)benzotriazole,molecular formula is C7H7N3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 28539-02-8.

Step A: To a mixture of 5a (0.44 g, 2.0 mmol) and EtOH (9.0 mL)was added 1H-benzotriazole-1-methanol (0.30 g, 2.0 mmol). After stirring at room temperature overnight, the reaction mixture was concentrated in vacuo and the obtained residue was triturated with hexane. The resulting precipitate was collected by filtration to give N-(1H-Benzotriazol-1-ylmethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (0.59 g, 84%) as a brown solid. 1HNMR (CDCl3) d: 8.03 (1H, d, J = 8.2 Hz), 7.67 (1H, d, J = 8.2 Hz),7.62 (1H, dd, J = 7.4, 1.6 Hz), 7.44-7.40 (1H, m), 7.33-7.28 (2H,m), 7.09 (1H, t, J = 7.2 Hz), 7.02 (1H, d, J = 8.2 Hz), 6.73 (1H, td,J = 7.4, 0.8 Hz), 6.16 (2H, d, J = 7.4 Hz), 1.37 (12H, s). MS (ESI-) m/z:349 (MH).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 28539-02-8, 1-(Hydroxymethyl)benzotriazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ogiyama, Tomoko; Yamaguchi, Mitsuhiro; Kurikawa, Nobuya; Honzumi, Shoko; Yamamoto, Yuka; Sugiyama, Daisuke; Takakusa, Hideo; Inoue, Shin-ichi; Bioorganic and Medicinal Chemistry; vol. 25; 7; (2017); p. 2234 – 2243;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 15852-73-0, (3-Bromophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 15852-73-0, blongs to alcohols-buliding-blocks compound. Formula: C7H7BrO

To a solution of 3-bromobenzyl alcohol (3.00 g, 16.0 mmol) and triethylamine (2.91 mL, 20.9 mmol) indichloromethane (50 mL) at 0 °C was added methanesulfonyl chloride drop-wise. After 2 h, the reaction mixture was washed with saturated aqueous sodium bicarbonate solution and water. The organic layer was dried over magnesium sulfate, filtered, and concentrated under reduced pressure to afford the title compound as a light yellow oil.Yield: 4.3 g, 16 mmol, 100percent. 1H NMR (400 MHz, CDCI3) oe 2.99 (5, 3H), 5.21 (5, 2H),7.30 (dd, J=7.8, 7.7 Hz, 1 H), 7.34-7.38 (m, 1 H), 7.52-7.56 (m, 1 H), 7.57-7.59 (m, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,15852-73-0, its application will become more common.

Reference:
Patent; PFIZER INC.; PETTERSSON, Martin Youngjin; JOHNSON, Douglas Scott; SUBRAMANYAM, Chakrapani; O’DONNELL, Christopher John; AM ENDE, Christopher William; GREEN, Michael Eric; PATEL, Nandini Chaturbhai; STIFF, Cory Michael; TRAN, Tuan Phong; KAUFFMAN, Gregory Wayne; STEPAN, Antonia Friederike; VERHOEST, Patrick Robert; WO2015/49616; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 55362-80-6, name is 9-Bromononan-1-ol, molecular formula is C9H19BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 55362-80-6

A mixture of 9-bromo-1-nonanol (1.1 kg) N, N-dimethylformamide (2.86 L), Imidazole (363 g) Was added to 10 L of the reaction flask, To the ice bath was added dimethyl tert-butylchlorosilane (772 g) Temperature below 20 C, reaction for 1 hour, Add water (5 L), Toluene (1 L), Stir, Dispensing, The aqueous phase was extracted with toluene (1 L) Mixed organic phase, The organic phase was washed with water (1 L) Dried over anhydrous sodium sulfate, At 80 C, Get 1.56 kg product, Directly for the next step reaction

With the rapid development of chemical substances, we look forward to future research findings about 55362-80-6.

Reference:
Patent; Tianjin Pharmaceutical Innovation Co., Ltd.; LIU, WENJUAN; MO, LAN; (14 pag.)CN103965280; (2016); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 764-48-7, name is Ethylene Glycol Vinyl Ether. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

In to a reactor, 3.79 parts of the compound represented by formula (I-2-a), 10 parts of tetrahydrofuran and 4.79 parts of triethylamine were charged and stirred at 23 C. for 30 minutes. The obtained mixture was cooled into 0 C. Then, 4.50 parts of the compound represented by formula (I-1-b) was dropped thereto over 30 minutes at 0 C., and the obtained mixture was stirred for 1 hour at 0 C. 100 parts of ethyl acetate, 50 parts of ion exchanged water and 50 parts of a saturated aqueous ammonium chloride solution were added to the resulting reactant, the obtained mixture was stirred at 23 C. for 30 minutes, and left still to separate an organic layer. To the obtained organic layer, 100 parts of ion exchanged water was added, stirred at 23 C. for 30 minutes, and left still, followed by separating an organic layer to wash with water. The washing step was conducted five times. The obtained organic layer was concentrated and purified with column chromatography [silica gel 60N spherical shape, neutral, 100-210 mum, solvent: mixture of n-heptane/ethyl acetate=5/I, manufactured by Kanto Chem. Ltd.], to provide 3.12 parts of the compound represented by formula (I-2-c).

With the rapid development of chemical substances, we look forward to future research findings about 764-48-7.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; NISHIMURA, Takashi; ICHIKAWA, Koji; (98 pag.)US2016/334702; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 575-03-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin, molecular formula is C10H5F3O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Commercially available 7-hydroxy-4-trifluoromethyl coumarin (0.069g, 0.30mmol) was dissolved in dry DMF (2.0mL) and then 60percent NaH in mineral oil (0.012g, 0.30mmol) was added while cooling at 0°C. The mixture was slowly warmed at room temperature, then 3-chlorobenzyl bromide (0.040mL, 0.30mmol) was added dropwise via syringe after 1h and stirring was continued for 24h at room temperature. After addition of crushed ice, the suspension was treated with 2.0N aq. solution of NaOH (5mL). The mixture was stirred for 1h and the resulting precipitate was filtered and washed with water, yielding compound 24. White crystals; yield: 84percent, mp: 118.8?120.3°C (ethanol). 1H NMR (300MHz, DMSO-d6) delta: 5.27 (s, 2H), 6.85 (s, 1H), 7.13 (dd, J1=2.4Hz, J2=8.9Hz, 1H), 7.23 (d, J=2.4Hz, 1H), 7.40?7.45 (m, 3H), 7.54 (s, 1H), 7.61?7.64 (m, 1H). Anal. (C17H10ClF3O3) C, H.

According to the analysis of related databases, 575-03-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Pisani, Leonardo; Catto, Marco; Nicolotti, Orazio; Grossi, Giancarlo; Di Braccio, Mario; Soto-Otero, Ramon; Mendez-Alvarez, Estefania; Stefanachi, Angela; Gadaleta, Domenico; Carotti, Angelo; European Journal of Medicinal Chemistry; vol. 70; (2013); p. 723 – 739;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 20605-01-0 ,Some common heterocyclic compound, 20605-01-0, molecular formula is C9H16O6, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 1 (comparative example) Diethyl 1,5-dioxaspiro[5.5]undecane-3,3-dicarboxylate A stirred mixture of 165.0 g of diethyl bis(hydroxymethyl)malonate (98%, 0.75 mol), 75.3 g of cyclohexanone and 500 g of cyclohexane as a solvent and entrainer was admixed with 1.0 g of sulfuric acid. The mixture was then heated to reflux temperature (70-80 C.), the reaction water formed being continuously removed over a period of 5 hours. After the reaction was complete, the reaction mixture was cooled to room temperature and introduced into dilute, excess aqueous sodium hydrogen carbonate solution. The aqueous phase was re-extracted with methyl t-butyl ether, and the combined organic phases were washed once with water. After drying over sodium sulfate the solvents were distilled off on a rotary evaporator, and the product was isolated by distillation in an oil pump vacuum. This gave 168.4 g of target product (75% of the theoretical yield, based on the diethyl bis(hydroxymethyl)malonate used) with a boiling point of 140 C./0.2 mm. The purity, determined by gas chromatography, was 97 to 98 FID percent by area.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,20605-01-0, its application will become more common.

Reference:
Patent; Huels Aktiengesellschaft; US5932747; (1999); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 56456-49-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56456-49-6, name is 4-Chloro-2-fluorobenzyl alcohol, molecular formula is C7H6ClFO, molecular weight is 160.5733, as common compound, the synthetic route is as follows.

To a solution of (4-chloro-2-fluorophenyl)methanol (222 mg) in MeCN (20 mL) was added MnC>2 (480 mg). The mixture was stirred for 24h. The mixture was filtered over celite, the org. layer was dried over MgS04 and evaporated in vacuo. The crude aldehyde was used without purification in the next step. LC-MS (A): tR = 0.76 min; [M+H]+: not visible.

Statistics shows that 56456-49-6 is playing an increasingly important role. we look forward to future research findings about 4-Chloro-2-fluorobenzyl alcohol.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; BUR, Daniel; GRISOSTOMI, Corinna; NAYLER, Oliver; REMEN, Lubos; VERCAUTEREN, Magali; WELFORD, Richard; WO2015/75023; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol, the common compound, a new synthetic route is introduced below. COA of Formula: C3H5F3O

Tert-butyl [(lr,4r)-6′-bromo-4-methoxy-5″-methyl-3’H-dispiro[cyclohexane-l,2′-indene- ,2″- imidazol]-4″-yl]carbamate (Intermediate 12, 715 mg, 1.50 mmol), allylpalladium(II) chloride (21.95 mg, 0.06 mmol), di-tert-butyl(2′,4′,6′-triisopropyl-3-methoxy-6-methylbiphenyl-2- yl)phosphine (70.3 mg, 0.15 mmol) and CS2CO3 (733 mg, 2.25 mmol) were placed in a MW- vial. Toluene (8 mL) was added and the head space was evacuated and refilled with argon. 3,3,3- Trifluoropropan-l-ol (684 mg, 6.00 mmol) was added and the mixture was heated to 100 C in a MW apparatus for 2 h. 2 M methanolic ammonia (8.57 mL, 60.0 mmol) and water (1.08 mL, 60.0 mmol) was added and the mixture was heated to 80 C for 12 h. The reaction mixture was cooled to r.t. The organic solvents were evaporated and the aqueous residue was extracted with DCM. The combined extracts were concentrated and the residue was purified by reverse phase preparative chromatography providing the title compound (410 mg, 67% yield). 1H MR (500 MHz, DMSO-de) delta 0.90 (td, 1 H), 1.08 – 1.27 (m, 2 H), 1.34 – 1.49 (m, 3 H), 1.80 (d, 2 H), 2.15 (s, 3 H), 2.69 (tt, 2 H), 2.82 – 2.99 (m, 3 H), 3.15 – 3.22 (m, 3 H), 4.00 – 4.10 (m, 2 H), 6.08 (d, 1 H), 6.51 (br. s., 2 H), 6.75 (dd, 1 H), 7.18 (d, 1 H); MS (APCI+) m/z 410 [M+H]+.

The synthetic route of 2240-88-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; KARLSTROeM, Sofia; CSJERNYIK, Gabor; SWAHN, Britt-Marie; SANDBERG, Lars; KOLMODIN, Karin; SOeDERMAN, Peter; OeHBERG, Liselotte; WO2013/190298; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 4415-82-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4415-82-1, name is Cyclobutylmethanol. This compound has unique chemical properties. The synthetic route is as follows.

A 50-L jacket vessel was charged with DCM (20 L) (KF 34 ppm), and cyclobutylmethyl alcohol (5.0 kg, 58.0 mol) followed by TEA (8850 mL, 63.5 mol). The reaction mixture was cooled to approximately -10C, and MsCl (4735 mL, 60.8 mol) was added via an addition funnel dropwise over approximately 3 hours, while the temperature was maintained below -5C. The reaction resulted in a yellow slurry after 70 minutes of aging. H20 (8 L) was added to give a clear solution, which was agitated for 15 minutes. Then, the organic layer was separated. H20 (8 L) was charged to the organic layer. The mixture was agitated for 20 minutes, and then the organic layer was separated. Brine (10% solution, 4 L) was charged to the organic layer. The mixture was agitated for 20 minutes, and then the organic layer was separated. The organic phase was concentrated by vacuum distillation at approximately 30C to 40C and 28 inches Hg, resulting in a light brown residue (10.0 kg crude, approximately 9.5 kg product assumed, 58.0 mol, approximately 100% yield). A portion of the material was purified by distillation for characterization.1H NMR (CDC13, 400 MHz): ? 4.18 (d, J = 6.8 Hz, 2H), 3.00 (s, 3H), 2.71 (m, 1H), 2.11 (m, 2H), 2.00-1.80 (m, 4H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4415-82-1, Cyclobutylmethanol.

Reference:
Patent; MERCK SHARP & DOHME CORP.; WU, George, G.; ITOH, Tetsuji; MCLAUGHLIN, Mark; LIU, Zhijian; QIAN, Gang; WO2013/66734; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 100-37-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

34.9 g (0.1 mol) of 4-[l-(5,6,7,8 -tetrahydro- 3,5,5,8,8-pentamethyl -2-naphthalenyl) ethenyl] benzoic acid (bexarotene, Targretin ) was dissolved in 300 ml of chloroform. 20.6 g of N, N’-Dicyclohexylcarbodiimide was added into the reaction mixture. 11.6 g of dimethylaminoethanol was added into the reaction mixture. The mixture was stirred for 3 hours at RT. The solid was removed by filtration. The chloroform solution was washed with 5% NaHCO (2 x 100 ml) and water (3 x 100 ml). The organic solution was dried over anhydrous sodium sulfate. Sodium sulfate was removed by filtration. 3.6 g of HCl gas in ether (100 ml) was added into the reaction mixture with stirring. The solid product was collected by filtration. After drying, it yielded 40 g of the desired product (85.8%). Hygroscopic product; Elementary analysis: C H ClNO ; MW: 484.11. Calculated % C: 74.43; H: 8.74; Cl:30 42 27.32; N: 2.89; O: 6.61; Found % C: 74.39; H: 8.76; Cl: 7.29; N: 2.91, O: 6.65.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100-37-8, 2-(Diethylamino)ethanol.

Reference:
Patent; YU, Chongxi; WO2008/87493; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts