Author: tianli

Reference of 57772-50-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.57772-50-6, name is (2-Amino-3-methylphenyl)methanol, molecular formula is C8H11NO, molecular weight is 137.18, as common compound, the synthetic route is as follows.

EXAMPLE 13 2-Amino-3-methylbenzyl alcohol (1.7 g.) and anhydrous chloral (2.4 ml.) were mixed for 10 minutes with external ice-cooling, and the mixture was left to stand for 1/2 hour. The mixture was then chromatographed on silica, and elution with diethyl ether/petroleum ether (b.p. 60-80 C.), 7:3 by volume, gave 1,2-dihydro-8-methyl-2-trichloromethyl-4H-benzo[d]-[1,3]-oxazine, which was crystallized from aqueous ethanol, m.p. 69-70 C. The process described above was repeated, using the appropriate o-aminobenzyl alcohol as starting material, to give the following analogous products:

The chemical industry reduces the impact on the environment during synthesis 57772-50-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Imperial Chemical Industries Limited; US4268510; (1981); A;,
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Adding a certain compound to certain chemical reactions, such as: 55414-72-7, (2-Amino-5-methoxyphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 55414-72-7, blongs to alcohols-buliding-blocks compound. Recommanded Product: 55414-72-7

In a 50 mL round bottom flask, 2 mmol of 2-amino-5-methoxybenzyl alcohol (Formula (1-3)), 2 mmol of benzaldehyde (Formula (2-1)), 0.2 mmol of ABNO, 0.6 was added. The KOH of mmol and the toluene of 4mL replace the air in the bottle with oxygen, seal the bottle mouth with a rubber stopper and insert an oxygen balloon.The reaction flask was placed in a pre-heated oil bath and heated to 80C for 5 hours.The solvent was distilled off under reduced pressure and then subjected to column chromatography. The mixture of ethyl acetate/petroleum ether having a volume ratio of 1:50 was used as an eluent to collect the eluent containing the target compound, and the solvent was distilled off to obtain the product 6- Methoxy-2-phenyl-4H-3,1-benzoxazine with isolated yield of 94%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,55414-72-7, its application will become more common.

Reference:
Patent; Zhejiang University of Technology; Shen Zhenlu; Li Meichao; Ma Jiaqi; Hu Xinquan; Hu Baoxiang; (13 pag.)CN106831632; (2017); A;,
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Related Products of 7735-42-4, Adding some certain compound to certain chemical reactions, such as: 7735-42-4, name is 1,16-Hexadecanediol,molecular formula is C16H34O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7735-42-4.

4.2 1 6-Bromohexadecan- 1 -ol10215] The diol 14 (1.047 g, 4.05 mmol) was dissolved in cyclohexane (30 mE) and vigorously stirred with 48% HBr (0.5 mE, 4.46 mmol, 1.1 eq.). The mixture was refluxed for 6 h, diluted with water (50 mE) and the phases were separated. The aqueous phase was extracted with a mixture of dichloromethane and methanol (v/v, 4:1 3×20 mE). The combined organic layer was dried over Mg504. The product was purified by column chromatography with silica gel (6×6 cm, cyclohexane/ethyl acetate, 8:1) and isolated as a white solid. Yield: 4.598 g (96%). Traces of i,i6-dibromohexadecane were also found.1515 13 11 9 7 5 3 1j0216] M.p.: 65 C. (lit. 53-54 C.)j0217] ?H-NMR (300 MHz, CDC13) oe [ppm]: 1.26-1.47 (m, 23H, 4-CH2 to i4-CH2, i-OH), 1.51-1.62 (m, 4H, 2-CH2, 3-CH2), 1.85 (m, 2H, i5-CH2), 3.41 (t, 3JH,H=6.9 Hz, 2H, i6-CH2), 3.64 (t, 3J,y=6.6 Hz, 2H, i-CH2).10218] ?3C-NMR (75 MHz, CDC13) oe [ppm]: 25.9 (t, C-3),28.3, 28.9, 29.6, 29.7, 29.8 (t, C-4 to C-i4), 33.0 (t, C-2, C-iS), 34.3 (t, C-i6), 63.3 (t, C-i).10219] Refs.: M.p. P. Chuit, J. Hausser, Helv. Chim. Acta1929, 12, 850-859.10220] ?H-NMR spectroscopic data agree with those given by: S. Takanashi, M. Takagi, H. Takikawa; K. Mori, I Chem. Soc., Perkin Trans. 11998, 1603-1606.

According to the analysis of related databases, 7735-42-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER; Haufe, Guenter; Levkau, Bodo; Schaefers, Michael; Schilson, Stefani Silke; Keul, Petra; US2014/170067; (2014); A1;,
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Related Products of 37585-25-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 37585-25-4, name is (2-Amino-5-chlorophenyl)methanol, molecular formula is C7H8ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Benzyl alcohol derivative 11 (1 eq.) was dissolved in CH2Cl2 (0.4 M). Manganese (IV) oxide (2.1 eq.)was added under argon and the solution was left to stir at room temperature for 48 h. The progress ofthe reaction was monitored by TLC analysis. After completion, manganese oxide was filtered off andthe resulting filtrate was concentrated under reduced pressure. The crude product was purified by silicacolumn chromatography employing mixtures of n-hexane and ethyl acetate as eluents to obtain thedesired product 10.

According to the analysis of related databases, 37585-25-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Jarrige, Lucie; Merad, Jeremy; Zaied, Siwar; Blanchard, Florent; Masson, Geraldine; Synlett; vol. 28; 14; (2017); p. 1724 – 1728;,
Alcohol – Wikipedia,
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Reference of 22348-44-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.22348-44-3, name is trans-4-(Methylamino)cyclohexanol, molecular formula is C7H15NO, molecular weight is 129.2, as common compound, the synthetic route is as follows.

EXAMPLE 161 2-Acetamino-5-bromo-4-tert.butyl-N-(trans-4′-hydroxy-cyclohexyl)-N-methyl-benzylamine, m.p. 174-176 C, was prepared from 2-acetamino-5-bromo-4-tert.butyl-benzyl bromide and trans-4-methylamino-cyclohexanol analogous to Example 4.

Statistics shows that 22348-44-3 is playing an increasingly important role. we look forward to future research findings about trans-4-(Methylamino)cyclohexanol.

Reference:
Patent; Boehringer Ingelheim GmbH; US4101671; (1978); A;,
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Related Products of 7218-43-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 7218-43-1 as follows.

Weigh 200mg of 1-adamantanacetic acid, dissolve it in 3mL of dichloromethane, add DCC, DMAP successively under ice bath, stir for 30min under ice bath, add 156mg of intermediate 6, The reaction was performed at room temperature for 5 hours. After the reaction was detected to be complete by LC-MS, the insoluble matter was removed by filtration, and dichloromethane (20 mL x 3) was added. Extracted twice with 20 mL of saturated sodium bicarbonate, dried by adding anhydrous MgSO4 for 5 h, filtered with suction, and purified by column chromatography under reduced pressure to obtain 180 mg of intermediate H-1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7218-43-1, its application will become more common.

Reference:
Patent; Zhengzhou University; Ke Yu; Xie Hang; Liu Hongmin; Xu Xia; Liang Jianjia; (25 pag.)CN110759897; (2020); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 172023-97-1, name is (3-Bromo-5-(trifluoromethyl)phenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 172023-97-1

3-(Hydroxymethyl)-5-(trifluoromethyl)benzonitrile. (3-Bromo-5-(trifluoromethyl)phenyl)methanol (1.4 g, 5.5 mmol), tetrakis(triphenylphosphine) palladium(0) (0.64, 0.55 mmol) and zinc cyanide (388 mg, 3.31 mmol) were combined in dimethylformamide (6 mL). The reaction mixture degassed repeatedly using the freeze-thaw method. After warming to room temperature, the reaction was heated at 90 C. for 1 h, cooled to room temperature and concentrated. The crude product was dissolved in ethyl acetate, washed with water (2×), 1 N hydrochloric acid (2×), brine (2×), dried over sodium sulfate, and concentrated. Flash chromatography on silica gel gave 0.37 g (33%). LC/MS (HPLC method 3): tR=2.06 min, 202.02(MH)+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 172023-97-1, (3-Bromo-5-(trifluoromethyl)phenyl)methanol.

Reference:
Patent; Bristol-Myers Squibb Company; US2007/249607; (2007); A1;,
Alcohol – Wikipedia,
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Reference of 4728-12-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 4728-12-5 as follows.

Example 492-Nitro-6-f4-(4-trifluoromethoxy-phenyl)-piperazin-1-ylmethyl1-6,7-dihvdro-5H-imidazof2,1- b1H .31oxazine (53)Pyridinium chlorochromate (10.54 g, 48.9 mmol) is dissolved in dichloromethane (100 ml) and celite (10 g) is added and the suspension is stirred for 30 minutes. A solution of (2,2- dimethyl-1 ,3-dioxan-5-y.)rpiethanol (5 g, 34.2 mmol) in dry dichloromethane is added drop wise to the reaction mixture and stirred for 2h at room temperature. The reaction mixture is diluted with diethyl ether (80 ml), stirred for 10 minutes, filtered through celite, washed several times with ether and the solvent is removed in vacuo to give crude 2,2-dimethyl- [1,3]dioxane-5-carbaldehyde, which is used in the next step without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4728-12-5, its application will become more common.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GmbH; US DEPARTMENT OF HEALTH & HUMAN SERVICES; WO2007/75872; (2007); A2;,
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Related Products of 30379-58-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 30379-58-9, name is Benzyl 2-hydroxyacetate, molecular formula is C9H10O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: The benzyl glycolate or thiobenzyl glycolate (1.5 equivalent) was added to the stirred suspension of peracetobromo-alpha-D-glucose, mannose, galactose (1 equivalent) and indium tribromide (10-15 mol%) in anhydrous dichloromethane (2 mL) at room temperature for an hour. The progress of reaction was monitored with thin layer chromatography. After the completion of the reaction, the reaction mixture was diluted with water and quenched with 10% aqueous acidic acid solution (1 mL). The organic layer washed with water and brine, the solvent was evaporated under reduced pressure and the crude product was purified by flash column chromatography on silica gel (90% ethyl acetate/hexanes). The corresponding beta-carboxymethyl glucosides (beta-CMGL) were afforded in good yield with high anomeric selectivity.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 30379-58-9, Benzyl 2-hydroxyacetate.

Reference:
Article; Chandra, Sunena; Yadav, Ram N.; Paniagua, Armando; Banik, Bimal K.; Tetrahedron Letters; vol. 57; 13; (2016); p. 1425 – 1429;,
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Adding a certain compound to certain chemical reactions, such as: 26021-57-8, 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 26021-57-8, blongs to alcohols-buliding-blocks compound. name: 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol

Compound 54 (36 mg, 0.24 mmol) was dissolved in a solution of z-PrOFl/FhO (9/1, 1 mL) at 80 C for 30 min. A suspended solution of 35 (52 mg, 0.25 mmol) and HCIO4 (70%, 25 pL) in 90% z-PrOH (2 mL) was added in 4 portions over 1 h. The resulting solution was stirred overnight. After which, the dark blue solution was evaporated under reduced pressure, and the residue was purified on a Biotage Isolera Flash System using SNAP Ultra cartridge with a mobile phase of CHCh and MeOH containing 0.5% formic acid (gradient, 2-15% of MeOH in CHCh). The fractions containing product were pooled and evaporated, affording LGW-03-37 (27 mg, 32%) as a dark blue solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,26021-57-8, its application will become more common.

Reference:
Patent; OREGON HEALTH & SCIENCE UNIVERSITY; GIBBS, Summer L.; WANG, Lei G.; BARTH, Connor W.; (159 pag.)WO2020/23911; (2020); A2;,
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