Author: tianli

Electric Literature of 100751-63-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 100751-63-1, name is 6-Bromo-2-naphthylmethanol. This compound has unique chemical properties. The synthetic route is as follows.

3.47a (6-iodo-naphthalen-2-yl)-methanol Prepared according to general working method II from (6-bromo-naphthalen-2-yl)-methanol (500 mg, 2.11 mmol). Yield: 450 mg (75.1% of theory). C11H9IO (M=284.10).

According to the analysis of related databases, 100751-63-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Boehringer Ingelheim Pharma GmbH & Co. KG; US2004/209865; (2004); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 616-29-5, name is 1,3-Diaminopropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 1,3-Diaminopropan-2-ol

Example 7 Preparation of 1,3-di(oleylamino)propan-2-ol Oleic acid (5.698 g, 0.020 mol) and 1,3-diaminopropan-2-ol (1 g, 0.011 mol) were placed in a flask and heated at 190 C. for 2 hours. The reaction mixture was cooled to room temperature, then taken up in chloroform and washed with water. The aqueous phase was extracted with chloroform and the organic phases were combined, dried on magnesium sulfate, filtered and evaporated to dryness to yield an oily black residue (6.64 g) which was purified by chromatography on silica gel (eluent:dichloromethane/methanol 99:1). The resulting product was then washed with ether and filtered. Yield: 23% Rf (dichloromethane/methanol 95:5): 0.43 IR: nuNH 3306 cm-1; nuCO amide 1646 and 1630 cm-1

With the rapid development of chemical substances, we look forward to future research findings about 616-29-5.

Reference:
Patent; Gentif; US2006/35977; (2006); A1;,
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Reference of 675580-49-1, Adding some certain compound to certain chemical reactions, such as: 675580-49-1, name is (6-Chloroimidazo[1,2-b]pyridazin-3-yl)methanol,molecular formula is C7H6ClN3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 675580-49-1.

6-Chloro-imidazo[1 ,2-b]pyridazine-3-carbaldehyde (intermediate C) To a solution of (6-chloro-imidazo[1 ,2-b]pyridazin-3-yl)-methanol (1.3 g, 7.1 mmol) in DCM (50 ml.) was added active MnO2 (3 g, 34.5 mmol). The mixture was stirred at rt overnight and then filtered. The filtrate was concentrated under vacuum and the residue was washed with EtOAc to afford 6-chloro-imidazo[1 ,2-b]pyridazine-3-carbaldehyde (0.7 g) in 54% yield. 1H- NMR (400MHz, CDCI3) delta 10.36 (s, 1 H), 8.42 (s, 1 H), 8.08 (d, 1 H), 7.38 (d, 1 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 675580-49-1, (6-Chloroimidazo[1,2-b]pyridazin-3-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; FU, Xingnian; HE, Feng; LI, Yue; LIU, Lei; MI, Yuan; XU, Yao-chang; XUN, Guoliang; YU, Zhengtian; ZHANG, Ji Yue (Jeff); DAI, Miao; WO2011/18454; (2011); A1;,
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Synthetic Route of 23147-58-2, Adding some certain compound to certain chemical reactions, such as: 23147-58-2, name is Glycerol aldehyde dimer,molecular formula is C4H8O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 23147-58-2.

tbcadpnHCOOH (200 mg, 0.3 mmol) was dissolved in methanol (25 mL). Acetic acid (75 pL), glycolaldehyde dimer (50 mg, 0.4 mmol) and 5-ethyl-2-methylpyridine borane (80 pL, 0.5 mmol) were successively added. The clear solution was stirred for 3 days at ambient temperature. The solvent was removed and the residue purified via preparative HPLC (018 column, solvent: water + 0.1 wt% formic acid (A) I acetonitrile (B); gradient:from 15 % B to 55 % B in 15 minutes; UV detection at 232 nm). The combined product fractions were lyophilized. The residue (50 mg) was suspended in 6 M hydrochloric acid (100 mL), heated to reflux for 3 hours and stirred for 12 hours at rt afterwards. The solution was evaporated to dryness. The remaining solid was dissolved in 0.5 M hydrochloric acid (5 mL) and sorbed on DOWEX 50. The column was washed with water(0.5 L) and 0.5 M hydrochloric acid (1 L) and the product was eluted with 3 M hydrochloric acid (1.5 L). The eluant was removed and the solid dried in vacuo to yield 40 mg H2tacidphe3H ClxH2O.1H-NMR (300 MHz, D20, pH* = 0): 6 = 2.99 (t, 4H), 3.44 (m, 2H), 3.57 (t, 4H), 3.78 (m,3H), 3.97 (m, 2H), 4.76 (m, 3H) ppm.

According to the analysis of related databases, 23147-58-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BERGER, Markus; SUeLZLE, Detlev; FRENZEL, Thomas; GRAHAM, Keith; JOST, Gregor; NEIS, Christian; HEGETSCHWEILER, Kaspar; PIETSCH, Hubertus; WO2014/173857; (2014); A1;,
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Application of 7250-55-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7250-55-7, name is Dimethyl 3-hydroxypentanedioate, molecular formula is C7H12O5, molecular weight is 176.17, as common compound, the synthetic route is as follows.

Example 1 (Synthesis of dimethyl 3-benzyloxycarbonyloxyglutarate) In 10 ml of 1,2-dichloromethane was dissolved 1.01 g (5.78 mmol) of dimethyl 3-hydroxyglutarate, 847 mg (6.93 mmol) of 4,4-dimethylaminopyridine and 990 mul (6.93 mmol) of benzyloxycarbonyl chloride were added to the solution at room temperature, and the mixture was reacted at 0C for 30 minutes, and at room temperature for 1 hour under stirring. After completion of the reaction, the obtained reaction mixture was concentrated under reduced pressure, and the organic layer was extracted by adding 20 ml of ethyl acetate and 10 ml of water. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to obtain an oily substance.

Statistics shows that 7250-55-7 is playing an increasingly important role. we look forward to future research findings about Dimethyl 3-hydroxypentanedioate.

Reference:
Patent; Ube Industries, Ltd.; EP1500642; (2005); A1;,
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Reference of 3360-41-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3360-41-6, name is 4-Phenylbutan-1-ol. A new synthetic method of this compound is introduced below.

A CH2Cl2 solution (25 mL) of PPh3 (1.97 g,7.50 mmol) and I2 (1.90 g, 7.50 mmol) was stirred for 10 min at room temperature.Imidazole (851 mg, 12.5 mmol) was added to the resulting mixture. After a 10 min,4-phenylbutan-1-ol (751 mg, 5.00 mmol) was added to the mixture, and the resultingmixture was further stirred for 2 h. The mixture was quenched by the addition of satd.Na2S2O5 (25 mL). The aqueous and organic layers were separated, followed byextraction of the aqueous phase with CH2Cl2 (25 mL x 3). The combined organic phases were dried over anhydrous MgSO4, and the solvent was evaporated under reducedpressure. The crude product was purified by silica gel chromatography (eluent:hexane/AcOEt = 95/5) to give 4-iodobutylbenzene (1.14 g, 88%) as colorless oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3360-41-6, 4-Phenylbutan-1-ol, and friends who are interested can also refer to it.

Reference:
Article; Sakai, Norio; Kobayashi, Taichi; Ogiwara, Yohei; Chemistry Letters; vol. 44; 11; (2015); p. 1503 – 1505;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 73978-41-3, name is (2,4-Diaminopteridin-6-yl)methanol hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 73978-41-3

2,4-diamino-6-(hydroxymethyl)pteridine hydrochloride (4.40 g; 19.19 mmol) was dissolved in hot water (150 mL) and the solution was neutralized by addition of 1 M NaOH (ca. 20 mL). The precipitate was filtered, washed with water, and dried in vacuo over P2O5. Subsequently, this was suspended in DMAc (25 mL), and triphenylphosphine dibromide (18.12 g; 42.92 mmol) was added. The turbid reaction mixture was stirred for 20 hr at 200C. 4-(Methylamino)benzoic acid (2.95 g; 19.50 mmol) and DIPEA (5.04 g; 39.00 mmol) were added, and the turbid reaction mixture was stirred for 3 days at 200C. Then, it was poured in 0.33 M NaOH-solution (250 mL), the precipitate was filtered off, and the filtrate was neutralized by addition of 10% acetic acid in water (ca. 20 mL). The precipitate was filtered, washed with water, triturated with methanol (30 mL), and dried in vacuo over P2O5, to yield the product as a beige/orange powder (3.48 g; 56%).1H-NMR (DMSO): delta 8.59 (s, IH), 7.53 (d, 2H, 8.8 Hz), 7.7 (br. s, IH), 7.5 (br. s, IH), 6.83 (d, 2H, 8.8 Hz), 4.79 (s, 2H), 3.23 (s, 3H) ppm. FT-IR (ATR): V 3335, 3194, 2964, 1651, 1597, 1292, 1187 cm”1.

With the rapid development of chemical substances, we look forward to future research findings about 73978-41-3.

Reference:
Patent; KONINKLIJKE PHILIPS ELECTRONICS N.V.; WO2007/110811; (2007); A2;,
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Adding a certain compound to certain chemical reactions, such as: 111-90-0, Diethylene Glycol Monoethyl Ether, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H14O3, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C6H14O3

[00150] Copper (I) iodide (FW 190.45, 0.90 grams, 4.72 mmol), 1,10-phenanthroline (FW 180.21, 0.83 grams, 4.62 mmol), cesium carbonate (FW 325.82, 19.00 grams, 58.30 mmol), 1 ,2-diiodobenzene (FW 329.90, 7.50 grams, 22.70 mol), di(ethylene glycol) ethyl ether (FW 134.17, 9.18 grams, 68.40 mol) and 100 milliliters of dry xylene were charged in a 350 milliliter three necked round bottom flask. The reaction mixture was heated with stirring at reflux temperature for 20 hours under nitrogen. The resulting suspension was cooled to room temperature by adding 50 milliliters of toluene. Then reaction mixture was filtered through celite and alumina. The low boiling (xylene and toluene) component was removed by a rotary evaporator and high boiling component di(ethylene glycol) ethyl ether by air bath oven at 200C under high vacuum for 2 hours. The residue was purified by flask chromatography on silica gel. The final dark yellow product yielded 7.00 grams (90%). The product I and C NMR analysis shows the formation of aryl ether product. IR: neat (cm” FontWeight=”Bold” FontSize=”10″ ): 745, 843, 931, 1052, 1 1 16, 1219, 1256, 1325, 1350, 1373, 1453, 1501, 1593, 2869, 2929, 2973. 1H NMR (CDC13): delta 6.76 (m, 4H, Ph), 4.02 (t, 4H, -OCH2-), 3.71 (m, 4H, -CH2O-) 3.57 (m, 4H, -OCH2), 3.45(m, 4H, -OCH2-), 3.37(t, 4H, -OCH2-), 1.06 (t, 6H, -CH3). 13C NMR (CDC13): 149.42, 121.61, 1 15.04, 70.89, 69.89, 69.76, 68.93, 66.59, 15.14.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,111-90-0, Diethylene Glycol Monoethyl Ether, and friends who are interested can also refer to it.

Reference:
Patent; EXXONMOBIL RESEARCH AND ENGINEERING COMPANY; PATIL, Abhimanyu, Onkar; BODIGE, Satish; WO2015/60985; (2015); A1;,
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Application of 50411-26-2 ,Some common heterocyclic compound, 50411-26-2, molecular formula is C9H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The object product (160 mg, 73%) was obtained in the same manner as in Example 36(3) and using 6-(1’H-spiro[indene-1,4′-piperidin]-1′-yl)pyridazine-3-carboxylic acid (150 mg) obtained in Example 36(2), 1-amino-3-phenylpropan-2-ol (91 mg), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (150 mg) and hydroxybenzotriazole hydrate (120 mg).1H NMR (300 MHz, DMSO-d6) delta ppm 1.33 (d, J=13.37 Hz, 2H) 2.01-2.20 (m, 2H) 2.59-2.81 (m, 2H) 3.17-3.29 (m, 1H) 3.37-3.54 (m, 3H) 3.79-3.96 (m, 1H) 4.60 (d, J=13.56 Hz, 2H) 5.05 (d, J=5.65 Hz, 1H) 6.87 (d, J=5.65 Hz, 1H) 7.11-7.48 (m, 11H) 7.87 (d, J=9.42 Hz, 1H) 8.67 (t, J=5.75 Hz, 1H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,50411-26-2, its application will become more common.

Reference:
Patent; Taniguchi, Takahiko; Miyata, Kenichi; Kubo, Osamu; US2010/69351; (2010); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 768-95-6, name is Adamantan-1-ol, the common compound, a new synthetic route is introduced below. category: alcohols-buliding-blocks

Adamantane acetic acid (1.6 g, 8.2 mmol) was dissolved in 20 mL dichloromethane and treated with dimethylformamide (2 drops) and oxalyl chloride (2.1 mL, 24.7 mmol) dropwise. The reaction was stirred at ambient temperature for 18 hours, concentrated in vacuo, and placed under hard vacuum overnight to yield the product as an oil (quant.).

The synthetic route of 768-95-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SPG THERAPEUTICS, INC.; SHAPOSHNIK, Zory; (120 pag.)WO2018/204422; (2018); A1;,
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