Author: tianli

Reference of 756520-66-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol, molecular formula is C8H7Cl2FO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To the solution of compound 6 (17 mg, 0.13 mmol), 3-morpholinopropan-1-ol (19 mg, 0.13 mmol) and PPh3 (51 mg, 0.19 mmol) in anhydrous THF (5 mL) was added 33 uL DEAD (0.19 mmol) dropwise. The reaction mixture was stirred at room temperature for 3h. After completion of reaction, the reaction mixture was concentrated and the residue was purified by silica gel column chromatography using DCM: MeOH=60:1 as eluents.

According to the analysis of related databases, 756520-66-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; An, Xiao-De; Liu, Hongyan; Xu, Zhong-Liang; Jin, Yi; Peng, Xia; Yao, Ying-Ming; Geng, Meiyu; Long, Ya-Qiu; Bioorganic and Medicinal Chemistry Letters; vol. 25; 3; (2015); p. 708 – 716;,
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Electric Literature of 770-71-8 , The common heterocyclic compound, 770-71-8, name is Adamantan-1-ylmethanol, molecular formula is C11H18O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The adamantane 4-methylbenzenesulfonate was synthesized by reacting adamantyl alcohol (20.5 g, 123 mmol) with p-toluenesulfonic chloride (23.6 g, 123 mmol) in 75 mL of regular DCM, in the presence of 25 mL of triethylamine for 48 hours at room temperature. More DCM was added (100 mL) and the organic layer was washed with water (3×100 mL). Drying, (MgSO4), and evaporation of the solvent gave 34.5 g of tea color oil which under trituration with hexane afforded white solid adamantane 4-methylbenzenesulfonate (30.5 g, 76%).

The synthetic route of 770-71-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NITTO DENKO CORPORATION; RACHWAL, MILA; YAMAMOTO, MICHIHARU; (134 pag.)JP2016/509621; (2016); A;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol, molecular formula is C3H6F3NO, molecular weight is 129.0811, as common compound, the synthetic route is as follows.Recommanded Product: 3-Amino-1,1,1-trifluoropropan-2-ol

General procedure: Sodium triacetoxyhydroborate (900 mg, 4.2 mmol) was added to a solution of 1-naphthaldehyde (2.8 mmol) and the amine (2.8 mmol) in 1,2-dichloroethane (80 mL) at r.t. under nitrogen atmosphere. The reaction mixture was stirred for 6 h at r.t. and was quenched with sat. aq. NaHCO3 (20 mL) and extracted with DCM (3 x 50 mL). The combined organic layer was washed with brine (50 mL), dried and evaporated. The compound was purified by preparative HPLC on a XBridge C18 column (10 m 250×19 ID mm) using a gradient of 30-80% Acetonitrile in H2O/ACN/NH3 95/5/0.2 buffer over 20 minutes with a flow of 19 mL/min. The compounds were detected by UV at 220 nm to provide the product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol, and friends who are interested can also refer to it.

Reference:
Article; Giordanetto, Fabrizio; Wallberg, Andreas; Ghosal, Saswati; Iliefski, Tommy; Cassel, Johan; Yuan, Zhong-Qing; Von Wachenfeldt, Henrik; Andersen, Soren M.; Inghardt, Tord; Tunek, Anders; Nylander, Sven; Bioorganic and medicinal chemistry letters; vol. 22; 21; (2012); p. 6671 – 6676,6;,
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Adding a certain compound to certain chemical reactions, such as: 186020-66-6, tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate, blongs to alcohols-buliding-blocks compound. name: tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate

tert-Butyl 3-(2-(2-(2-hydroxyethoxy)- ethoxy)ethoxy)propanoate [Broadpharm, 9380 Waples St., Suite 101, San Diego, CA 92121] (50 mg, 0.180 mmol, 1.00 equiv), N-(((9H-fluoren-9-yl)methoxy)- carbonyl)-O-(tert-butyl)-L-serine (69 mg, 0.180 minol, 1.00 equiv) and DMAP (22 mg, 0.180 rnrnol, 1.00 equiv) were dissolved in CH2C12 (0.9 mL) . Upon dissolution of the reagents (about 5 minutes), EDCIoHC1 (52 mg, 0.270 nirnol, 1.50 equiv) was added in one portion at room temperature, and the reaction mixture was stirred for 17.5 hours, after which it was poured into aqueous 1 N HC1 (3 mL) and EtOAc (15 niL) . The aqueous phase was extracted twice with EtOAc (5 mL), and the combined organic phases were washed with aqueous 1 N HC1 (2 mL), saturated aqueous NaHCO3 (2 mL), and saturated aqueous NaC1 (2 mL), sequentially. The organic phase was dried over Na2504, filtered and concentrated. Flash column chromatography (5i02, 5% MeOH/CH2C12) provided 95.7 mg (83%) of the title compound as a colorless oil. ?H NMR (500 MHz, DMSOd 6) 6 7.76 (d, J = 7.5 Hz, 2H), 7.63 (d, J = 7.5 Hz, 1H), 7.62 (d, J = 7.5 Hz, 1H), 7.40 (t, J = 7.5 Hz, 2H), 7.32 (t, J = 7.5 Hz, 2H), 5.68 (d, J = 8.5 Hz, lH), 4.54 – 4.49 (m, 1H), 4.43 – 4.21 (m, SM), 3.85 (br, iN), 3.74 – 3.57 (m, 13H) , 2.49 (t, J = 6.5 Hz, 2H), 1.44 (s, 9H), 1.16 (s, 9H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,186020-66-6, tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate, and friends who are interested can also refer to it.

Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; BEUTLER, Bruce; BOGER, Dale, L.; (334 pag.)WO2018/5812; (2018); A1;,
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Related Products of 455-01-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 455-01-6 as follows.

Example 82 3-(Trifluoromethyl)phenethyl N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate 4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline (72 mg) was added to toluene/triethylamine = 10/1 (7 ml), and the mixture was heated under reflux to prepare a solution. A solution of triphosgene (125 mg) in methylene chloride was then added to the solution, and the mixture was heated under reflux for 15 min. Subsequently, 3-trifluoromethylphenethyl alcohol (70 mg) was added thereto, and the mixture was further stirred with heating under reflux for 2 hr. After the completion of the reaction, the reaction solution was allowed to cool to room temperature before distilled water was added thereto. The mixture was subjected to separatory extraction with chloroform, followed by washing with a 1 N aqueous hydrochloric acid solution and saturated brine. The washed solution was dried over sodium sulfate and was concentrated. The residue was purified on a column using chloroform/methanol to give the title compound (101 mg, yield 76%). 1H-NMR (CDCl3, 400 MHz): 8.42 – 8.49 (1H, m), 8.12 (1H, s), 7.61 (1H, s), 7.42 – 7.59 (6H, m), 7.13 – 7.18 (2H, m), 6.76 (1H, s), 6.66 (1H, d, J = 6.6 Hz), 4.44 (2H, t, J = 6.7 Hz), 4.15 (3H, s), 4.08 (3H, s), 3.07 (2H, t, J = 6.7 Hz) Mass spectrometry value (ESI-MS, m/z): 513 (M++1)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,455-01-6, its application will become more common.

Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1243582; (2002); A1;,
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Synthetic Route of 27489-62-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 27489-62-9, name is trans-4-Aminocyclohexanol, molecular formula is C6H13NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

5-Fluoro-2-nitrobenzotrifluoride (400 mg, 1.91 mmol) and trans-4- aminocyclohexanol (220 mg, 1.91 mmol) are dissolved in dimethylsulfoxide (10 mL) and the reaction is then heated at 95C for 3.5 hours. After cooling to room temperature, the mixture is diluted with dichloromethane (15 mL) and washed with water (3 x 10 mL). The organic phase is collected and dried over sodium sulphate, filtered and concentrated under reduced pressure. The crude product is recrystallised from petrol ether. The desired product is finally isolated as a yellow solid (84% yield).

According to the analysis of related databases, 27489-62-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; INTERVET INTERNATIONAL B.V.; CHASSAING, Christophe Pierre Alain; MEYER, Thorsten; WO2010/146083; (2010); A1;,
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Adding a certain compound to certain chemical reactions, such as: 349-95-1, (4-(Trifluoromethyl)phenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C8H7F3O, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C8H7F3O

General procedure: Under an N2 atmosphere, a mixture of secondary alcohol (0.5 mmol), primary alcohol (0.6 mmol), 1a (5 mol %), NaOH (0.1 mmol), 4 A molecular sieve (0.6 g), and toluene (1.5 mL) was added into a 25 mL Schlenk tube equipped with a stirring bar. The mixture was heated to 120 C under a slow and steady N2 flow for 24 h. After cooling to ambient temperature, 6 mL water was added and the aqueous solution extracted with ethyl acetate (3 x 5 mL). The combined extracts were dried over anhydrous Na2SO4, and concentrated under reduced pressure. The crude product purified on a short flash chromatography column.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,349-95-1, (4-(Trifluoromethyl)phenyl)methanol, and friends who are interested can also refer to it.

Reference:
Article; Zhang, Shi-Qi; Guo, Bin; Xu, Ze; Li, Hong-Xi; Li, Hai-Yan; Lang, Jian-Ping; Tetrahedron; vol. 75; 47; (2019);,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16545-68-9, name is Cyclopropanol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 16545-68-9

KO’Bu (938 mg, 8.36 mmol) was added to a stirred solution of 5-chloro-l-methyl-4- nitro-lH-pyrazole (900 mg, 5.57 mmol) and cyclopropanol (970.713 mg, 16.713 mmol) in MeCN (7.27 mL) at rt. Addition was done portionwise. The mixture was stirred at rt for 3hours. Water was added and the mixture acidified with 3N HCl(aq). The reaction mixture was extracted with DCM, dried over MgS04, filtered and evaporated. A purification was performed via preparative LC (Stationary phase: irregular SiOH 15- 40muiotaeta 80g GraceResolv, Mobile phase: gradient from 100% DCM to 98% DCM, 2% MeOH, 0, 1% NH4OH) to afford intermediate 620 (470 mg, yield 46 %).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 16545-68-9, Cyclopropanol.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; STANSFIELD, Ian; QUEROLLE, Olivier, Alexis, Georges; LIGNY, Yannick, Aime, Eddy; GROSS, Gerhard, Max; JACOBY, Edgar; MEERPOEL, Lieven; GREEN, Simon, Richard; HYND, George; KULAGOWSKI, Janusz, Jozef; MACLEOD, Calum; MANN, Samuel, Edward; (472 pag.)WO2018/2217; (2018); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4654-39-1, name is 2-(4-Bromophenyl)ethanol, the common compound, a new synthetic route is introduced below. Formula: C8H9BrO

Production Example 4 Synthesis of 4-bromophenethyl bromide 4-Bromophenethyl alcohol (1.3 ml) was treated as in Production Example 1 to give the title compound (2.345 g) as a pale yellow oil (yield: 88.8%). 1H-NMR (400 MHz, CDCl3): delta(ppm) 3.12(2H, t, J=7.4Hz), 3.54(2H, t, J=7.4Hz), 7.09(2H, d, J=8.4Hz), 7.45(2H, d, J=8.4Hz).

The synthetic route of 4654-39-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Eisai Co., Ltd.; US2002/19531; (2002); A1;,
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Electric Literature of 13674-16-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 13674-16-3 as follows.

2-{4′-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-biphenyl-4-yloxy}-3-phenyl-propionic Acid Diisopropyl azodicarboxylate (0.42 mL, 2.52 mmol) in benzene (10 mL) was added dropwise into a cold (0 C.) mixture of 4′-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-biphenyl-4-ol (0.5 g, 1.26 mmol), 3-phenyllactic acid methyl ester (0.45 g, 2.52 mmol), triphenylphosphine (0.66 g, 2.52 mmol), and benzene (20 mL). The reaction mixture was stirred at room temperature for 30 minutes, poured into water, and extracted with ethyl ether. The organic extracts were dried over MgSO4. Evaporation gave a yellow oil (0.6 g). This residue was taken in methyl alcohol (15 mL) and tetrahydrofuran (15 mL) and treated with sodium hydroxide (2 N, 3.0 mL). The reaction mixture was stirred for 30 minutes, poured into water, acidified with HCl (2 N), and extracted with ethyl ether. The organic extracts were dried over MgSO4. Evaporation and crystallization from ethyl ether/hexanes gave a white solid (0.38 g, 55% yield): mp 183-184; MS m/e 544 (M+H)+; Analysis for: C32H24F3NO4Calc’d: C, 70.71; H, 4.45; N, 2.58 Found: C, 70.50; H, 4.32; N, 2.53.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13674-16-3, its application will become more common.

Reference:
Patent; Wyeth; US6699896; (2004); B1;,
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