Author: tianli

Electric Literature of 7589-27-7 ,Some common heterocyclic compound, 7589-27-7, molecular formula is C8H9FO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 2-(2,4-dichlorophenoxy)propanoicacid (100 mg, 0.43 mmol) in DMF (2 mL) were added 2-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyl uronium hexafluorophosphate(HATU; 200 mg, 0.53 mmol), 2-(4-fluorophenyl)ethanol(64 lL, 0.50 mmol), and diisopropylethylamine (100 lL,0.57 mmol). The resulting mixture was stirred at room temperaturefor 2 days, then poured into water (20 mL). The aqueous mixturewas then extracted with EtOAc (20 mL 3), and the combinedorganic extracts were dried over MgSO4, filtered, and evaporated toprovide a yellow oil. The oil was subjected to flash chromatographyon silica gel with 0?30percent EtOAc/hexane. Product-containing fractionswere pooled and evaporated to provide 120 mg (75percent) ofproduct as a clear, colorless oil: Rf 0.79 (1:1 EtOAc/hexane); 1HNMR (CDCl3) d 7.37 (d, 1H), 7.12?7.05 (m, 3H), 6.95 (t, 2H), 6.64(d, 1H), 4.67 (q, 1H), 4.37?4.31 (m, 2H), 2.89 (t, 2H), 1.61 (d, 3H);m/z expected 356.0 found 356.1 (GC?MS).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7589-27-7, its application will become more common.

Reference:
Article; Williams, John D.; Torhan, Matthew C.; Neelagiri, Venugopal R.; Brown, Carson; Bowlin, Nicholas O.; Di, Ming; McCarthy, Courtney T.; Aiello, Daniel; Peet, Norton P.; Bowlin, Terry L.; Moir, Donald T.; Bioorganic and Medicinal Chemistry; vol. 23; 5; (2015); p. 1027 – 1043;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13826-35-2, name is (3-Phenoxyphenyl)methanol, the common compound, a new synthetic route is introduced below. Recommanded Product: (3-Phenoxyphenyl)methanol

(a) 3-Phenoxybenzaldehyde Chromium trioxide (3.00 g.) was added to a stirred solution of pyridine (4.75 g.) in dry methylene chloride (75 ml.), and stirring was continued for a further 15 minutes. 3-Phenoxybenzyl alcohol (1 g.) in methylene chloride (5 ml.) was added, the mixture stirred for a further 15 minutes, decanted and the residue washed with diethyl ether (100 ml.). The filtrate was washed with 5% sodium hydroxide solution (3*50 ml), 2.5 NHCl (50 ml.) and 5% sodium carbonate solution (50 ml.) and dried over Na2 SO4 to give 3-phenoxy-benzaldehyde. Alternatively the alcohol can be oxidized using Jones’ reagent, a similar yield of aldehyde being obtained.

The synthetic route of 13826-35-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; National Research Development Corporation; US4464391; (1984); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 101-98-4, name is 2-(Benzyl(methyl)amino)ethanol. A new synthetic method of this compound is introduced below., HPLC of Formula: C10H15NO

EXAMPLE 3 N-Benzyl-N-methyl-ethanolamine (20.73 g), 61.94 g of toluene and 83.41 g of a 30% aqueous solution of NaOH were respectively weighed and placed in a 300-mL four-necked flask. While the mixture was stirred, the flask inside temperature was lowered to 6.8 C. Then, 31.68 g of methanesulfonyl chloride was added dropwise over 3 hours and 17 minutes at a flask inside temperature of 5 to 10 C. Water (33 mL) was added to dissolve the NaCl which had precipitated out in the aqueous phase, and the mixture was separated into the toluene phase and aqueous phase. A toluene solution of N-benzyl-N-methyl-ethanolamine methanesulfonate was thus obtained in a yield of 68.8 mole percent.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 101-98-4, 2-(Benzyl(methyl)amino)ethanol.

Reference:
Patent; Kano, Fumihiko; Kunihiro, Shigeki; Yoshida, Noritaka; Mori, Natsuki; US2003/162966; (2003); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3637-61-4, name is Cyclopentanemethanol, molecular formula is C6H12O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: alcohols-buliding-blocks

1 ,3-Dibromo-5-cyclopentylmethoxy-benzene. [00479] 3,5-Dibromophenol (5.0 g; 19.8 mmol), cyclopentane-methanol (2.0 g; 19.9 mmol) and tributylphosphine (8.8 mL; 35.7 mmol) were dissolved in dry THF (250 mL) in a dried reaction flask under an atmosphere of nitrogen. l,l’-(Azodicarbonyl)dipiperidine (9.01 g; 35.7 mmol) dissolved in dry THF (150 mL) was added to the reaction mixture, which was EPO stirred at room temperature for 16 hours. The reaction mixture was filtered, evaporated to dryness and purified by flash chromatography (heptane – > ethyl acetate: heptane 2:3). Yield: 5.68 g; 86 %.

With the rapid development of chemical substances, we look forward to future research findings about 3637-61-4.

Reference:
Patent; NOVO NORDISK A/S; WO2007/3581; (2007); A1;,
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Reference of 7541-49-3 ,Some common heterocyclic compound, 7541-49-3, molecular formula is C20H40O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Platinum oxide (PtO2, 1.15 g, 6.61 mmol) is added to a solution of phytol (30.00 g, 101.20 mmol) in THF (450 mL) under argon and the medium is placed under 1 bar of dihydrogen, then stirred for 4 hours at room temperature. After filtration through celite rinsed with THF, a black oil of molecule A27 is obtained after concentration under reduced pressure. Yield: 29.00 g (96%)1H-NMR (CDCl3, ppm): 0.84 (6H); 0.86 (6H); 0.89 (3H); 1.00-1.46 (22H); 1.46-1.68 (3H); 3.61-3.73 (2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7541-49-3, 3,7,11,15-Tetramethylhexadec-2-en-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ADOCIA; GEISSLER, Alexandre; (119 pag.)US2019/275108; (2019); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4845-50-5, name is 1,4-Dioxane-2,3-diol, the common compound, a new synthetic route is introduced below. HPLC of Formula: C4H8O4

To a solution of the corresponding compound 39G (0.9 mmol) in ethanol/water (30 mL/4 mL) was added l,4-dioxane-2,3-diol (130 mg, 1.08 mmol) and the resulting suspension was stirred at 30C overnight. The solvent was removed in vacuo and the residue was partitioned between water and EtOAc. The organic layer was separated and washed with water and brine, dried over Na2S04 and concentrated, and then purified by a standard method to give title product 39H.

The synthetic route of 4845-50-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; CIANCHETTA, Giovanni; POPOVICI-MULLER, Janeta; ZAHLER, Robert; CAO, Sheldon; WANG, Xiaolei; YE, Zhixiong; WO2014/139325; (2014); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 575-03-1

General procedure: The appropriate bromoketone (6a-o) (1.7 mmol) and triethylamine (1.6 mmol) were added to as olution of either7-hydroxy-4-methyl-2H-chromen-2-one 4 (1.4 mmol)or 7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one 5 (1.4 mmol) in THF (20 mL). The mixture was stirred at room temperature for 24h, filtered and the solvent was evaporated under reduced pressure.The solid residue was purified by column chromatography eluting with DCM/MeOH 9:1 to afford (7a-n) and (8a-o).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin.

Reference:
Article; Kandil, Sahar; Westwell, Andrew D.; Mcguigan, Christopher; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 2000 – 2004;,
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Synthetic Route of 15258-73-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15258-73-8, name is (2,6-Dichlorophenyl)methanol, molecular formula is C7H6Cl2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To solution of 6-chloro-1,2,3,4-tetrahydro-2,7-naphthyridine hydrochloride (500 mg;2.44 mmol; 1 eq) in 30 mL toluene were added (2,6-dichlorophenyl)methanol (518 mg; 2.93 mmol; 1.2 eq), 1,4,7,1O,13,16-hexaoxacyclooctadecane (18-Crown-6; 64.4 mg; 0.244 mmol; 1.1 eq) and KOH (547 mg; 9.75 mmol; 4 eq). The mixture was stirred for 3h at RT. The mixture was evaporated and the residue was purified byflash chromatography (silica gel, DCM:MeOH 9:1) giving the product with a yield of 710 mg (1.378 mmol; 47%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 15258-73-8, (2,6-Dichlorophenyl)methanol.

Reference:
Patent; ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG; LANGE, Udo; OCHSE, Michael; VAN DER KAM, Elizabeth; VAN BERGEIJK, Jeroen; TURNER, Sean; OELLIEN, Frank; WALLESER, Patrick; AMBERG, Wilhelm; HORNBERGER, Wilfried; GENESTE, Herve; MEZLER, Mario; HUTCHINS, Charles; (301 pag.)WO2017/36978; (2017); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1205037-95-1, name is trans-3-Aminocyclobutanol hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of trans-3-Aminocyclobutanol hydrochloride

In an ice bath, 44.5 mg (1 .12 mmol) sodium hydride (60% dispersion in mineral oil) were dispensed in 5 mL of anhydrous THF. 91 .6 mg (0.742 mmol) trans-3- aminocyclobutan-1 -ol (hydrochloride salt) were slowly added. Stirring at 0 C was continued for 15 min. 100 mg (0.371 mmol) of intermediate 2 were added, the ice bath was removed and the resulting mixture was stirred for 5 days at 40 C. The reaction mixture was carefully poured into water. The aqueous layer was extracted with ethyl acetate. The combined organic layers were dried over magnesium sulfate, and concentrated. The crude product was purified by HPLC to give 32 mg of the title compound as a solid material. 1H-NMR (300 MHz ,DMSO-d6), delta [ppm]= 2.49-2.57 (2H), 3.72 (2H), 5.53 (1 H), 7.01 (1 H), 7.31 (2H), 7.58-7.67 (2H), 7.71 -7.77 (1 H), 8.1 1 -8.19 (2H). LC-MS (Method 3): Rt = 0.73 min; MS (ESIpos) m/z = 321 [M+H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1205037-95-1, trans-3-Aminocyclobutanol hydrochloride.

Reference:
Patent; Bayer Intellectual Property GmbH; EIS, Knut; PUeHLER, Florian; ZORN, Ludwig; SCHOLZ, Arne; LIENAU, Philip; GNOTH, Mark, Jean; BOeMER, Ulf; GUeNTHER, Judith; HITCHCOCK, Marion; WO2013/34570; (2013); A1;,
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Electric Literature of 7073-69-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol, molecular formula is C9H11BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To the crude alcohol was added conc. HCl (3 drops) and 3,4-dihydro-2H-pyran (S3) (4.07 g, 48.5 mmol, 1.20 equiv) and stirred neat at room temperature for 24 h. The mixture was diluted with Et20 (50 mL), and washed with a sat. aq. NaHCO3 (25 mL). The aqueous layer was extracted with Et20 (2 x 50 mL) and the combined organic layers were washed with brine, dried (MgSO4), filtered and concentrated under reduced pressure to afford 2-((2-(2-bromophenyl)propan-2-yl)oxy)tetrahydro-2H-pyran (S4) (8.30 g, ca. 38.8 mmol, 1.00 equiv) which was used without further purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7073-69-0, 2-(2-Bromophenyl)propan-2-ol.

Reference:
Patent; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; HOYE, Adam, T.; KIM, Won-suk; MARTINEZ-SOLORIO, Dionicio; SMITH, Amos, B.; SANCHEZ, Luis; TONG, Rongbiao; NGUYEN, Minh, Huu; WO2013/185021; (2013); A2;,
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