Author: tianli

Related Products of 78573-45-2, Adding some certain compound to certain chemical reactions, such as: 78573-45-2, name is 3-(3-(Trifluoromethyl)phenyl)propan-1-ol,molecular formula is C10H11F3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 78573-45-2.

A solution of (R) -N- [1- (1-naphthyl) ethyl] -2-nitrobenzenesulfonamide in toluene (83 g pure)92 g of triphenylphosphine,72 g of 3- (3-trifluoromethylphenyl) propanol and 125 mL of toluene were added and stirred. Adjust the solution temperature to 50 ° C,DiisopropylazodicarboxylateA diluted solution obtained by adding 330 mL of toluene to 71 g was dropped. After the dripping end50 mL of toluene was added and stirred at 50 ° C. for 1 hour.After completion of the reaction, 133 g of anhydrous magnesium chloride and 42 mL of toluene were added. After stirring at 50 ° C. for 2 hours, the liquid temperature was cooled to 0 ° C.The reaction solution was filtered to remove insolubles, and then washed with 415 mL of toluene cooled to 0° 415 mL of tap water was added to the filtrate and stirred, and the aqueous layer was removed by liquid separation operation. The same operation was repeated twice, and the obtained organic layer was concentrated under reduced pressure at 55 ° C. to 1165 mL,(R) -N- [1- (1-naphthyl) ethyl] -3- [3- (trifluoromethyl) phenyl]Propane-2-nitrobenzenesulfonamide tolueneA solution was obtained (pure yield 127 g, pure yield 100percent, chemical purity 92percent).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 78573-45-2, 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Iwaki Pharmaceutical Co Ltd; Nagasaki, Atsushi; Fukushima, Koichi; (8 pag.)JP2019/14687; (2019); A;,
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Application of 599-67-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 599-67-7, name is 1,1-Diphenylethanol, molecular formula is C14H14O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A solvent (5 mL) was placed in a 10 mL round bottom-flask equipped with a magnetic stirrerunder reflux, NXS (1.1 mmol) was then added and, after being dissolved, the substrate (1 mmol) wasadded and the solution was stirred for 4-24 h. The progress of the reaction mixture was monitoredby TLC, whilst the consumption of NXS was tested by KI (0.1 M). Upon completion of the reaction,the crude reaction mixture was cooled down at room temperature, diluted with EtOAc (15 mL),washed with aqueous Na2S2O3 (6 mL), NaHCO3 (6 mL), and water (10 mL), and dried over anhydrousNa2SO4. The solvent was evaporated under reduced pressure and the crude product obtained wasanalyzed by 1H-NMR. The pure final products were obtained after flash chromatography, columnchromatography or preparative thin layer chromatography.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 599-67-7, 1,1-Diphenylethanol.

Reference:
Article; Ajvazi, Njomza; Stavber, Stojan; Molecules; vol. 21; 10; (2016);,
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Application of 3391-86-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3391-86-4, name is Oct-1-en-3-ol, molecular formula is C8H16O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: In a sealed tube, under nitrogen atmosphere, the ruthenium complex [RuCl2( 6-C6H6)(PTA-Me)] (3a) (0.02-0.1 mmol; 0.5-2.5 mol% of Ru) and K2CO3 (0.05-0.25 mmol; 1.25-6.25 mol%) were added to a solution of the corresponding allylic alcohol 4a-o (4 mmol) in tetrahydrofuran (4 mL), and the resulting mixture stirred at 75 C for the indicated time (see Table 4 and Scheme 3). The course of the reaction was monitored by taking regularly samples of ca. 10 L which after dilution with dichloromethane (3 mL) were analyzed by GC. After the reaction was finished, the mixture was cooled to room temperature leading to the partial precipitation of 3a. The solid was separated by filtration and the reaction product isolated by solvent removal and chromatographic workup of the residue on silica-gel using a mixture of EtOAc-hexane (1:10) as eluent. The identity of the resulting carbonyl compounds 5a-o was assessed by comparison of their retention times with those of commercially available pure samples (Sigma-Aldrich or Acros Organics), by their fragmentation in GC/MS, and/or NMR spectroscopy.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3391-86-4, Oct-1-en-3-ol.

Reference:
Article; Menendez-Rodriguez, Lucia; Crochet, Pascale; Cadierno, Victorio; Journal of Molecular Catalysis A: Chemical; vol. 366; (2013); p. 390 – 399;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 55414-72-7, name is (2-Amino-5-methoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 55414-72-7

A mixture of compound 6 (0.081 g, 0.35 mmol) and thionyl chloride (1.12 mL, 15.4 mmol) was stirred at reflux for 5 h. The excess thionyl chloride was removed and the residue was cooled to 0 C. Aqueous saturated sodium bicarbonate solution (10 mL) and a solution of compound 4 (0.046 g, 0.30 mmol) in methanol (2 mL) were added slowly with rapid stirring. The mixture was stirred at room temperature overnight and the resultant pink-orange solid was collected and washed with aqueous HCl (1 M, 5 mL), water (5 mL), diethyl ether (5 mL) and hexane (5 mL). The solid was dried to obtain the title compound as a sticky orange powder (0.063 g, 58%); 1H NMR (300 MHz, CDCl3): delta 3.81 (s, 3H), 3.82 (s, 3H), 4.71 (s, 2H), 6.82-6.93 (m, 3H), 7.17 (d, J = 3.1 Hz, 1H), 7.49 (d, J = 8.8 Hz, 1H), 7.91 (d, J = 8.8 Hz, 1H), 8.57 (br s, 1H); this material was carried forward to the next step without further purification.

With the rapid development of chemical substances, we look forward to future research findings about 55414-72-7.

Reference:
Article; Lizarme, Yuvixza; Wangsahardja, Jonatan; Marcolin, Gabriella M.; Morris, Jonathan C.; Jones, Nicole M.; Hunter, Luke; Bioorganic and Medicinal Chemistry; vol. 24; 7; (2016); p. 1480 – 1487;,
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Reference of 702-23-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.702-23-8, name is 2-(4-Methoxyphenyl)ethanol, molecular formula is C9H12O2, molecular weight is 152.19, as common compound, the synthetic route is as follows.

Reactant: 6. To a stirred solution of compound 6 (1.0 g, 6.57 mmol) in toluene (40 mL) triethylamine(2.0 mL, 19.71 mmol) was added at 0 C. TsCl (1.5 g, 7.88 mmol) was added slowly and the reaction mixture stirred 48 h at RT. The solution was diluted with diethyl ether and washed with saturatedaqueous NaHCO3 (20 mL). The residue of unreacted precipitated TsCl was filtered out and organiclayer was dried, filtered and concentrated to give light yellow crystals: 29 (2.0 g, 99 %).

The chemical industry reduces the impact on the environment during synthesis 702-23-8, I believe this compound will play a more active role in future production and life.

Reference:
Article; Blaess, Markus; Bibak, Nelly; Claus, Ralf A.; Kohl, Matthias; Bonaterra, Gabriel A.; Kinscherf, Ralf; Laufer, Stefan; Deigner, Hans-Peter; European Journal of Medicinal Chemistry; vol. 153; (2018); p. 73 – 104;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111-90-0, name is Diethylene Glycol Monoethyl Ether. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 111-90-0

General procedure: To a solution of 4 (50 mg, 0.08 mmol, 1 equiv) in DMF (2 mL), N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) (39.6 mg, 0.16 mmol, 2 equiv) was added and the mixture was stirred for 10 minutes at room temperature. N,N-Diisopropylethylamine (DIEA) (20.7 mg, 0.16 mmol, 2 equiv) was added to the reaction at room temperature. In a separate flask, alkyl amine or alcohol (0.12 mmol, 1.5 equiv) was dissolved in DMF (2 mL) and added to the reaction mixture. The reaction was then heated to 60 C and continued for 12 hours. The reaction progress was monitored by TLC until completion. The productwas extracted in DCM (10 mL) and washed with H2O (3 x 10 mL) and brine (10 mL). The organic layer was dried with Na2SO4, filtered and concentrated in vacuo prior to purification by silica gel column chromatography.

With the rapid development of chemical substances, we look forward to future research findings about 111-90-0.

Reference:
Article; Patel, Pradeepkumar; Hanawa, Emi; Yadav, Reeta; Samuni, Uri; Marzabadi, Cecilia; Sabatino, David; Bioorganic and Medicinal Chemistry Letters; vol. 23; 18; (2013); p. 5086 – 5090;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14320-38-8, name is Cyclopent-3-enol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C5H8O

AddN-pyrimidinylpurine 1a (0.2 mmol), RhCl3?3H2O (0.004 mmol), Cu(OAc)2(0.4 mmol) andcyclopent-3-enol 2k (1.0 mmol) to 2.0 mL of DMF. , three times with carbon monoxide in the Young’s replacement tubeafter filling with carbon monoxide (1 atm), the reaction and after 90 deg.] C oil bath for 10 hours, the reaction was stopped until the reaction was cooled to roomtemperature, add ethyl acetate and saturated brine plurality Wash and extract.The organic phase was dried over anhydrous sodium sulfate and filtered.The solvent was evaporated to dryness, and ethyl acetate / petroleum ether (1:10 to 1:1) was purified by chromatography.The product was a whitesolid with a yield of 80%.

With the rapid development of chemical substances, we look forward to future research findings about 14320-38-8.

Reference:
Patent; Chinese Academy Of Sciences Lanzhou Chemical Physics Institute; Yang Lei; Zhao Kang; Liu Jianhua; Xia Chungu; Du Rongrong; (35 pag.)CN109851608; (2019); A;,
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Application of 15852-73-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15852-73-0, name is (3-Bromophenyl)methanol, molecular formula is C7H7BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of compound 8a (1.08 g, 10 mmol) and Et3N (1.52g, 15 mmol) in anhydrous DCM (100 mL) was added dropwisemethanesulfonyl chloride (1.36 g, 12 mmol) in anhydrous DCM(20 mL). The mixture was stirred for 12 h while being cooled withan ice-water bath. DCM was evaporated under vacuum. The residuewas dissolved in EtOAc (100 mL) and washed with 10percent HCl(3 100 mL), saturated NaHCO3 (3 100 mL) and brine (3 100mL), and then dried over MgSO4 overnight. EtOAc was evaporatedto give 11a as yellow oil (1.77 g, yield: 95percent). ESI-MS m/z 187.4 [M+H]+. The crude product was used directly in the next reactionwithout further purification.Compounds 11b?11w, 11aa?11ff and 23a?23h were preparedusing the same procedure described above.

According to the analysis of related databases, 15852-73-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Cao, Jiangying; Ma, Chunhua; Zang, Jie; Gao, Shuai; Gao, Qianwen; Kong, Xiujie; Yan, Yugang; Liang, Xuewu; Ding, Qin’ge; Zhao, Chunlong; Wang, Binghe; Xu, Wenfang; Zhang, Yingjie; Bioorganic and Medicinal Chemistry; vol. 26; 12; (2018); p. 3145 – 3157;,
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Adding a certain compound to certain chemical reactions, such as: 171011-37-3, (4-Bromo-1,2-phenylene)dimethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 171011-37-3, blongs to alcohols-buliding-blocks compound. Recommanded Product: 171011-37-3

(1) In 380 ml of diethyl ether was dissolved 19.0 g of 1-bromo-3,4-di(hydroxymethyl)benezene and to the solution was added 112 g of phosphorus tribromide under ice-cooling, after which the resulting mixture was allowed to stand for 3 days. The reaction mixture was added to 1,000 ml of ice water and the pH was adjusted to 7 with sodium hydrogencarbonate, followed by extraction with 1,000 ml of ethyl acetate. The organic layer thus obtained was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then distilled under reduced pressure to remove the solvent, whereby 28.5 g of 1-bromo-3,4-di(bromomethyl)benzene were obtained as colorless crystals.

The synthetic route of 171011-37-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Toyama Chemical Co., Ltd.; US6025370; (2000); A;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 702-23-8, name is 2-(4-Methoxyphenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-(4-Methoxyphenyl)ethanol

6 (2.0 g, 13.1 mmol) was dissolved in dry toluene (50mL), dry CaCO3 (3.94 g, 39.4 mmol), PCl5 (5.47 g, 26.3 mmol) were added slowly over a period of 40 min under argon atmosphere at 0 C; temperature in the mixture was allowed to reach RT and stirred for another 3 h. The mixture was poured into ice-cold saturated NaHCO3 solution (20 mL) and extracted twice with diethyl ether (100 mL). The organic layer was dried with Na2SO4 and evaporated. Purification by silica gel column chromatography (n-hexane-ethyl acetate 9:1 (v/v)) yielded a yellow oil:7 (1.95 g, 87 %).

With the rapid development of chemical substances, we look forward to future research findings about 702-23-8.

Reference:
Article; Blaess, Markus; Bibak, Nelly; Claus, Ralf A.; Kohl, Matthias; Bonaterra, Gabriel A.; Kinscherf, Ralf; Laufer, Stefan; Deigner, Hans-Peter; European Journal of Medicinal Chemistry; vol. 153; (2018); p. 73 – 104;,
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