Author: tianli

Application of 16308-92-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 16308-92-2 as follows.

General procedure: In a 5 ml glass flask, catalyst (10 mg, containing 0.2 mol% Pd), alcohol(0.5 mmol), K2CO3 (104 mg, 0.75 mmol) and H2O or toluene(2 mL) were added and reaction mixture was stirred continuously at90 C for the desired time under O2 atmosphere (from a balloon). Then,in the case of water as solvent, products were extracted with ethylacetate and the catalyst was recovered by an external magnet. Yields ofdesired products were determined by gas chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16308-92-2, its application will become more common.

Reference:
Article; Gholinejad, Mohammad; Afrasi, Mahmoud; Nikfarjam, Nasser; Najera, Carmen; Applied Catalysis A: General; vol. 563; (2018); p. 185 – 195;,
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Related Products of 35106-82-2 ,Some common heterocyclic compound, 35106-82-2, molecular formula is C9H10O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of the corresponding alkene (0.75 mmol) and (R)-1-phenylpent-4-en-3-ol (363 mg,2.2 mmol, 3.0 equiv) in CH2Cl2 (4 mL) was added Grubbs catalyst 2nd generation (6 mg, 7.5 mumol,0.01 equiv). The mixture was refluxed for 6 hours under an Ar atmosphere. After cooling, the reactionmixture was condensed its volume to 1 mL under the reduced pressure and the mixture wascharged directly on silica gel column chromatography to purify the corresponding cross-metathesisproduct.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,35106-82-2, its application will become more common.

Reference:
Article; Ida, Akiko; Kitao, Kazuyuki; Hoshiya, Naoyuki; Uenishi, Jun’ichi; Tetrahedron Letters; vol. 56; 15; (2015); p. 1956 – 1959;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 495-76-1, name is Benzo[d][1,3]dioxol-5-ylmethanol, molecular formula is C8H8O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: alcohols-buliding-blocks

(2S,3R)-3-(2-(benzo[d] [l,3]dioxol-5-yl)ethyl)-4-oxo-l- (phenylcarbamoyl)azetidine-2-carboxylic acid (35): Compound 35 was synthesized by general method A (step 1) using 5-(2-bromoethyl)benzo[d][l,3] dioxole as the electrophile instead of 4-bromomethyl-2-bis-Boc-aminopyridine. The starting 5- (bromomethyl)benzo[Patent; DAIAMED, INC.; WO2006/108039; (2006); A2;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 68327-04-8, name is (1S,2S)-2-Aminocyclopentanol hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 68327-04-8

H) 6- (2-fluoro-4- ( lH-pyrazol-l-yl ) benzyl ) -2- ( (1S,2S) -2- hydroxycyclopentyl ) -4 , 5-dimethylisoindolin-l-on.e A solution of methyl 5- (2-fluoro-4- ( lH-pyrazol-1- yl) benzyl) -2-formyl-3, 4-dimethylbenzoate (0.17 g) , (lS,2S)-2- aminocyclopentanol hydrochloride (0,06 g) , triethylamine (0.06 mL) and anhydrous magnesium sulfate (0.10 g) in THF (3.40 mL) was stirred at room temperature for 10 hr. The insoluble substance was removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was diluted with methanol (3.40 mL) and THF (3.40 mL) , sodium triacetoxyborohydride (0.19 g) was added thereto, and the mixture was stirred overnight at room temperature. The reaction mixture was diluted with ethyl acetate, and the mixture was washed with water and saturated brine. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (0.07 g) . XH NMR (300 MHz, DMSO-d6) delta 1.45-1.60 (1H, m) , 1.62-1.79 (3H, m) , 1.80-1.98 (2H, m) , 2.24 (3H, ‘s), 2.25 (3H, s), 4.08-4.29 (4H, m),.4.39 (2H, s) , 4.88 (1H, d, J = 4.9 Hz), 6.52-6.58 (1H, m) , 7.15 (1H, t, J = 8.4 Hz), 7.23 (1H, s) , 7.63 (1H, dd, J = 8.3, 2.1 Hz), 7.68-7.77 (2H, m) , 8.52 (1H, d, J = 2.5 Hz).

With the rapid development of chemical substances, we look forward to future research findings about 68327-04-8.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; YAMADA, Masami; SUZUKI, Shinkichi; SUGIMOTO, Takahiro; NAKAMURA, Minoru; SAKAMOTO, Hiroki; KAMATA, Makoto; WO2015/163485; (2015); A1;,
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Application of 355-80-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 355-80-6, name is 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of 64.7 mmol of organyl dichlorophosphite 3 in 150 mL of an organic solvent [diethyl ether (3a), dichloromethane(60 mL) (3b), hexane (3c, 3d)] was added dropwise with stirring a solution of 155 mmol of polyfluoroalkanol 4 or 5 and 155 mmol ( 15.7 g) of triethylamine in 30 mL of the corresponding solvent for 1-2 h at low temperature [-10-8C (3a, 3b), -30-25C (3c, 3d), dry ice-acetone]. The formation of a white precipitate of triethylamine hydrochloride was observed. The reaction mixture was stirred for 1-2 h at room temperature, argon was passed to remove HCl, and the mixture was kept overnight in the case of obtaining compounds 6a and 6b. The precipitate (triethylamine hydrochloride) was filtered off, washed (3 × 30 mL) with diethyl ether (3a) or hexane (3b-3d). Washings and the filtrate were combined, the solvents were distilled off under reduced pressure, and the residue was distilled in vacuum. To prevent symmetrization of the aryl bis(polyfluoroalkyl) phosphites 6c and 6d, the distillation flask was placed into a heated glycerin bath (100-120) and distillation was carried out rapidly.

According to the analysis of related databases, 355-80-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Arbuzova, S. N.; Belogorlova, N. A.; Bishimbayeva, G. K.; Chernysheva, N. A.; Gusarova, N. K.; Malysheva, S. F.; Nalibayeva, A. M.; Oparina, L. A.; Trofimov, B. A.; Verkhoturova, S. I.; Yas?ko, S. V.; Russian Journal of General Chemistry; vol. 90; 5; (2020); p. 839 – 844; Zh. Obshch. Khim.; vol. 90; 5; (2020); p. 744 – 750;,
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Synthetic Route of 5343-92-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5343-92-0, name is 1,2-Pentanediol, molecular formula is C5H12O2, molecular weight is 104.1476, as common compound, the synthetic route is as follows.

A generic experiment was as follows. In a two-neck roundbottomflask of 10 mL, 1,2-phenylenediamine (1a, 0.5 mmol),1,2-propyleneglycol (2a, 0.6 mmol), 1.5 mL of diethylene glycol dimethylether (diglyme), and an amount of catalyst were added.Subsequently, the reaction mixture was heated at 140 C in a siliconebath that contains a magnetic stirrer and a temperature controller.

The chemical industry reduces the impact on the environment during synthesis 5343-92-0, I believe this compound will play a more active role in future production and life.

Reference:
Article; Climent; Corma; Hernandez; Hungria; Iborra; Martinez-Silvestre; Journal of Catalysis; vol. 292; (2012); p. 118 – 129;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 42514-50-1, name is 3-Amino-3-methylbutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. name: 3-Amino-3-methylbutan-1-ol

To the primary amine 36 (3 g, 29 mmol) was added formic acid (2.86 mL, 73 mmol) and formalin (5.43 mL, 73 mmol) slowly. The resulting reaction mixture was heated up to reflux for 5h, then cooled to room temperature and basified by excess KOH. The mixture was extracted with ether (100 mL x 2). The ether layer was dried over Na2SO4 and concentrated to give a colorless oil. The oil (Ig, 7.63 mmol) was dissolved in chloroform(15 mL) and thionyl chloride (2.78 mL, 38.2 mmol) was added. The reaction mixture was heated to reflux for 2 hours, evaporated to dryness, and then triturated by ether. The resulting off-white solid (1.35 g, 95% yield) was dried in vacuum over night. 1H NMR (CDCl3) delta 1.41 (s, 6H), 2.20 (t, 2H, J= 8.0), 2.65 (s, 3H), 2.68 (s, 3H), 3.62 (t, 2H, J= 8.0); 13C NMR (CDCl3) delta 21.9, 37.6, 38.8, 39.6, 63.7

With the rapid development of chemical substances, we look forward to future research findings about 42514-50-1.

Reference:
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY; LAVOIE, Edmond, J.; FENG, Wei; LIU, Leroy, F.; WO2010/102219; (2010); A1;,
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Application of 575-03-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin, molecular formula is C10H5F3O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To around bottomed flask equipped with a magnetic stir bar were added, the7-hydroxycoumarin substrate (1 equiv.), acetone (25 mL/mmol of substrate), and K2CO3 (3 equiv.). The solution wasstirred for 5 minutes at room temperature followed by addition of R3-X (1 equiv.; R3 = alkyl, X = Br or OTs.). The reaction mixture was placed under anArgon atmosphere (balloon) and stirred at reflux temperature for 16 hours atwhich point complete consumption of substrate was observed by TLC in all cases. The reaction was cooled to r.t., poured intowater, and extracted with EtOAc (x 3). The combined extracts were dried over MgSO4. The solvent was removed in vacuo and theremaining residue purified via flash chromatography over silica gel using gradient elution with EtOAc and Hexanes to yield Compounds 18-28. 

According to the analysis of related databases, 575-03-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Farley, Conner M.; Dibwe, Dya Fita; Ueda, Jun-Ya; Hall, Eric A.; Awale, Suresh; Magolan, Jakob; Bioorganic and Medicinal Chemistry Letters; vol. 26; 5; (2016); p. 1471 – 1474;,
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Reference of 86770-74-3 , The common heterocyclic compound, 86770-74-3, name is 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol, molecular formula is C8H19NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethan-1-ol (25) (61.4 g, 318 mmol) was stirred in H2O (500 ml) with Na2CO3 (50.51 g, 476 mmol) at 5C. Benzyl chloroformate (26) (65.0 g, 381 mmol) in THF (480 ml) was added dropwise and the reaction stirred for 16 h allowing to warm to RT. THF was removed in-vacuo and the aqueous layer extracted with EtOAc (× 3). The combined organics were dried (Na2SO4), concentrated in-vacuo and the residue purified by automated flash chromatography (5% MeOH/DCM) to give benzyl (2-(2-(2-(2- hydroxyethoxy)ethoxy)ethoxy) ethyl)carbamate (27) (23.6 g, 22.7%). Product confirmed by MS (ESI +ve).

The synthetic route of 86770-74-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ARBUTUS BIOPHARMA CORPORATION; HEYES, James; HOLLAND, Richard J.; PALMER, Lorne Ralph; WOOD, Mark; (0 pag.)WO2020/93053; (2020); A1;,
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Electric Literature of 928-51-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 928-51-8, name is 4-Chlorobutan-1-ol, molecular formula is C4H9ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 21 Synthesis of 3-(4-((4-(4-ethynyl- lH-pyrazol- l-yl)butyl)amino)- l-oxoisoindolin-2- -2,6-dione Step 1 : To a solution of 4-iodo-lH-pyrazole (3.88 g, 20 mmol) in CH3CN (140 mL) was added 4-chlorobutan- l-ol (3.3 g, 1.3eq), Cs2C03 (16.4 g, 60 mmol), and Nal (600 mg). The reaction mixture was heated at 50 C for 12 hour. The reaction mixture was filtered and the filtrate was evaporated. The residue was purified by chromatography (EtOAc/Hexanes: 1: 1 to EtOAc) to afford 4-(4-iodo-lH-pyrazol-l- yl)butan-l-ol (4 g, 75%).

According to the analysis of related databases, 928-51-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; WANG, Shaomeng; LI, Yangbing; AGUILAR, Angelo; ZHOU, Bing; HU, Jiantao; XU, Fuming; QIN, Chong; HU, Yang; XIANG, Weiguo; REJ, Rohan; YANG, Jiuling; HAN, Xin; BAI, Longchuan; YANG, Chao-Yie; (252 pag.)WO2017/176958; (2017); A1;,
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