Author: tianli

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4654-39-1, name is 2-(4-Bromophenyl)ethanol. A new synthetic method of this compound is introduced below., SDS of cas: 4654-39-1

To a mixture of 2-(4- bromophenyl)ethanol (10.0 g, 49.7 mmol) in DCM (100 mL) were added imidazole (10.0 g, 149.2 mmol) and TBSC1 (8.2 g, 54.7 mmol) at 0 C. After stirring at room temperature for 3 h, the reaction mixture was quenched with water, extracted with DCM. The organic layer was washed with brine, dried over Na2S04, filtered and concentrated. The crude was purified by silica gel column (PE: EA = 50: 1) to get (4-bromophenethoxy)(tert-butyl)dimethylsilane (16.2 g, 99%) as a colorless oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4654-39-1, 2-(4-Bromophenyl)ethanol.

Reference:
Patent; NIKANG THERAPEUTICS, INC.; LOU, Yan; FU, Jiping; HE, Yigang; (0 pag.)WO2020/14332; (2020); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4654-39-1, name is 2-(4-Bromophenyl)ethanol, molecular formula is C8H9BrO, molecular weight is 201.06, as common compound, the synthetic route is as follows.Computed Properties of C8H9BrO

The reaction kettle was charged with 4-bromophenethyl alcohol (1.0 kg, 5.0 mol) 10 times the volume of methylene chloride dissolved, Triethylamine (1.01 kg, 10.0 mol) And catalytic amount of DMAP, TBSCl (0.9 kg, 6.0 mol) was added in batches. Reaction to the disappearance of raw materials at room temperature, Washed, Saturated brine, After drying with anhydrous sodium sulfate, the liquid compound VA (1.5 kg, 95.5%) was obtained as a colorless oil. Directly into the next reaction.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4654-39-1, 2-(4-Bromophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Hangzhou Lide Biological Technology Co., Ltd.; Ren Guobao; Wu Yan; Li Chuanbin; (6 pag.)CN106565467; (2017); A;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3068-00-6, name is 1,2,4-Butanetriol, molecular formula is C4H10O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 1,2,4-Butanetriol

Example 1; Instead of PEG-400 and the para-toluenesulfonic acid catalyst used in ComparativeExample 1, dioxane and a strong acid ion exchange resin (Amberlyst 15, H+ form) containing a sulfonic acid group were used in equal amounts. Then, the reaction was conducted using a batch type reactor under conditions of atmospheric pressure and 1000C for 20 hours. The reaction yield was 96 mol%.

With the rapid development of chemical substances, we look forward to future research findings about 3068-00-6.

Reference:
Patent; SK CORPORATION; WO2007/81065; (2007); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 616-29-5, name is 1,3-Diaminopropan-2-ol, the common compound, a new synthetic route is introduced below. COA of Formula: C3H10N2O

First a 30mL methanol solution of salicyldehyde (30 mmol,3.66 g) was added to a 15mL methanol solution of 1,3-diamino-2-propanol (15 mmol, 1.35 g). The resulting orange solution wasthen refluxed for 1 h, and after cooling down, the solvent wasremoved under reduced pressure to afford an orange crystallinesolid which was collected as the ligand. Yield: 69%. Anal. Calc. forC17H18N2O3: C, 68.42; H, 6.09; N, 9.39. Found: C, 68.77; H, 5.73; N,9.71%.

The synthetic route of 616-29-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Das, Kuheli; Massera, Chiara; Garribba, Eugenio; Frontera, Antonio; Datta, Amitabha; Journal of Molecular Structure; vol. 1199; (2020);,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4170-90-5, name is Mesitylmethanol. A new synthetic method of this compound is introduced below., Quality Control of Mesitylmethanol

(1) 2,4,6-trimethylbenzyl alcohol (0.150 g, 1.0 mmol) was added to the reaction flask,Diphenylphosphine oxide (0.304 g, 1.5 mmol),Potassium persulfate (0.540 g, 2.0 mmol) and acetone (5 mL)Room temperature reaction; (2) TLC tracking reaction until complete; (3) The crude product obtained after the completion of the reaction was separated by column chromatography (dichloromethane: methanol = 40: 1) to give the desired product30-2 (yield 79%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4170-90-5, Mesitylmethanol.

Reference:
Patent; Soochow University (Suzhou); Zou Jianping; Li Chengkun; Zhou Zhihao; Zhang Peizhi; Zhang Ling; (14 pag.)CN106496268; (2017); A;,
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Synthetic Route of 180205-28-1, Adding some certain compound to certain chemical reactions, such as: 180205-28-1, name is 1-(Aminomethyl)cyclobutanol,molecular formula is C5H11NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 180205-28-1.

EXAMPLE 8 SYNTHESIS AND CHARACTERIZATION 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-((1-hydroxycyclobutyl)methyl)acetamide A solution of sodium 2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetate (Intermediate 4, 300 mg, 0.835 mmol), 1-(aminomethyl)cyclobutanol (84.4 mg, 0.835 mmol), DIPEA (216 mg, 1.67 mmol), and DMF (5 mL) was stirred at 0 C. for 1 h. Next, PyBrOP (467 mg, 1.00 mmol) was added and was stirred at room temperature overnight, then quenched with 10 mL water. The reaction was purified by preparative basic HPLC using a Kromasil 150 mm*25 mm, 10 mum column (eluent: water (0.05% ammonia hydroxide v/v)-ACN from 9% to 39%, v/v) to provide the title compound (90 mg, 26% yield) as a white solid. MS (ESI): mass calcd. for C23H28N6O2, 420.23; m/z found, 421.2 [M+H]-. 1H NMR (400 MHz, DMSO-d6): delta 11.58 (br s, 1H), 8.50 (s, 1H), 7.94-7.85 (m, 1H), 7.46-7.40 (m, 1H), 6.75-6.70 (m, 1H), 4.89 (br s, 1H), 4.57-4.47 (m, 1H), 4.04 (s, 2H), 3.27 (d, J=6.0 Hz, 2H), 2.55 (d, J=6.0 Hz, 2H), 2.45-2.31 (m, 2H), 2.10-1.88 (m, 9H), 1.71-1.60 (m, 1H), 1.54-1.35 (m, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 180205-28-1, 1-(Aminomethyl)cyclobutanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Janssen Pharmaceutica NV; Koudriakova, Tatiana; Kreutter, Kevin D.; Leonard, Kristi; Rizzolio, Michele C.; Smith, Russell C.; Tichenor, Mark S.; Wang, Aihua; (40 pag.)US2018/170931; (2018); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3637-61-4, name is Cyclopentanemethanol, molecular formula is C6H12O, molecular weight is 100.16, as common compound, the synthetic route is as follows.category: alcohols-buliding-blocks

General procedure: The PBr3 (1.5 equiv) was added to a solution of alkyl alcohol (1.0equiv) in anhydrous tetrahydrofuran (5.0 mL) at 0 C and then theice bath was removed and the reaction mixture was further stirredat room temperature for 5 h. Water (30.0 mL) was added and thenextracted with EtOAc, the combined organic extracts were driedwith Na2SO4, and the solvent was evaporated in vacuo to get titlecompound, suitable for the next step without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3637-61-4, Cyclopentanemethanol, and friends who are interested can also refer to it.

Reference:
Article; Chen, Ying; Wu, Bolin; Hao, Yameng; Liu, Yunqi; Zhang, Zhili; Tian, Chao; Ning, Xianling; Guo, Ying; Liu, Junyi; Wang, Xiaowei; European Journal of Medicinal Chemistry; vol. 171; (2019); p. 420 – 433;,
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Synthetic Route of 56-81-5, Adding some certain compound to certain chemical reactions, such as: 56-81-5, name is Propane-1,2,3-triol,molecular formula is C3H8O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56-81-5.

General procedure: In(OTf)3 (5.6 mg, 10 mumol, 1 mol %) was added to a mixture of cyclohexanone dimethylacetal (144 mg, 1.00 mmol) and finely ground 2,2-dimethyl-1,3-propanediol (111 mg, 1.10 mmol) and the reaction mixture stirred at room temperature for 30 min. At this time, residual MeOH was removed under reduced pressure and the crude residue passed through a short plug of basic alumina, which was washed with hexane (2×2 mL). The solvent was removed under reduced pressure to give the product, as a colourless oil (170 mg, 92%).

According to the analysis of related databases, 56-81-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Smith, Brendan M.; Kubczyk, Tomasz M.; Graham, Andrew E.; Tetrahedron; vol. 68; 38; (2012); p. 7775 – 7781;,
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Electric Literature of 575-03-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin. A new synthetic method of this compound is introduced below.

General procedure: The appropriate bromoketone (6a-o) (1.7 mmol) and triethylamine (1.6 mmol) were added to as olution of either7-hydroxy-4-methyl-2H-chromen-2-one 4 (1.4 mmol)or 7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one 5 (1.4 mmol) in THF (20 mL). The mixture was stirred at room temperature for 24h, filtered and the solvent was evaporated under reduced pressure.The solid residue was purified by column chromatography eluting with DCM/MeOH 9:1 to afford (7a-n) and (8a-o).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin, and friends who are interested can also refer to it.

Reference:
Article; Kandil, Sahar; Westwell, Andrew D.; Mcguigan, Christopher; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 2000 – 2004;,
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Electric Literature of 101597-25-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, molecular formula is C17H16O3, molecular weight is 268.31, as common compound, the synthetic route is as follows.

Comparative Example 1 3,3-Dianisyl-3H-naphtho[2,1-b]pyran. A mixture of 2-naphthol (3.23 g;0.0224 mol), 1,1-dianisylprop-2-yn-1-ol (6.00 g;0.0224 mol), acidic alumina Brockmann 1(6 g) and toluene (250 ml) was heated and stirred for 1.5 h, cooled, filtered and the solid washed with toluene. The filtrate was evaporated to give a pale purple tacky solid which was washed with pet. ether (40-60)/diethyl ether to yield crude product (7.07 g). Purification of the solid by crystallisation from ethylacetate gave 3,3-dianisyl-3H-naphtho[2,1-b]pyran as a white solid (5.52 g;66% yield), m.pt 176-177 C. STR10

The chemical industry reduces the impact on the environment during synthesis 101597-25-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Pilkington PLC; US5520853; (1996); A;,
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