Author: tianli

Electric Literature of 4541-14-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4541-14-4, name is 4-(Benzyloxy)butan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

General Procedure P. A solution of the alcohol (1 equiv) in anhydrous CH2Cl2 (0.2 M) at 0 0C was treated with PCC (1.5 equiv) and the mixture was stirred for 45 min. The reaction mixture was allowed to warm at 25 C and stirred for 3 h. The suspension was filtered through Celite and concentrated. Column chromatography (SiO2) afforded the aldehyde.; 4-(Benzyloxy)butan-l-ol was oxidized to 4-(benzyloxy)butanal (7.35 g, 79%) following general procedure P

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4541-14-4, 4-(Benzyloxy)butan-1-ol.

Reference:
Patent; BOGER, Dale, L.; WO2008/150492; (2008); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5259-98-3, name is 5-Chloropentan-1-ol. A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Chloropentan-1-ol

A solution of 5-chloro-l-pentanol (10 g, 80 mmol) in DMF (100 mL) at 0 0C was treated with imidazole (19 g, 185 mmol) and TBDPS-Cl (26 g, 95 mmol), and the mixture was stirred and allowed to warm to room temperature over 2 hours before being quenched with the addition of water and extracted with EtOAc. The organic extract was washed with aqueous IN HCl, saturated aqueous NaHCOs, saturated aqueous NaCl, dried (Na2SO4), concentrated under reduced pressure, and subjected to flash chromatography to give 5 -(t-butyldimethylsilyloxy)-l -chloropentane as a colorless liquid (11 g, 38percent).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5259-98-3, 5-Chloropentan-1-ol.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; VITAE PHARMACEUTICALS, INC.; WO2008/124575; (2008); A1;,
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Synthetic Route of 24131-31-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.24131-31-5, name is (3,5-Bis(benzyloxy)phenyl)methanol, molecular formula is C21H20O3, molecular weight is 320.3817, as common compound, the synthetic route is as follows.

General procedure: 3-Hydroxybenzaldehyde (5.00 g, 0.041 mol) was dissolved in anhydrous acetonitrile (130 mL) under argon atmosphere. Cesium carbonate (20.01 g, 0.061 mol) was added and the suspension stirred for 5 min. Benzyl bromide (11.69 mL, 0.102 mol) was then added and the solution heated at reflux for 16 h. The solution was concentrated on rotary evaporator, water was added and the mixture was extracted with EtOAc. The organic phase was washed twice with water, once with brine, dried over MgSO4, filtered and concentrated. Water was added and the mixture was extracted with CH2Cl2. The crude product was purified by flash chromatography on silica gel with hexanes/EtOAc (80/20) to yield 3a as a white solid (8.59 g). 1H NMR delta (CDCl3) 5.13 (s, 2H, PhCH2O), 5.33 (s, 2H, COOCH2Ph), 7.35-7.50 (m, 9H, 2-CH, 4-CH, 5-CH, 6-CH and PhCH2O), 10.00 (s, 1H, PhCHO). The aldehyde 3a was dissolved in anhydrous THF (200 mL) under argon and cooled to 0 C. Lithium aluminum hydride (1.55 g, 0.041 mol) was added in small portions and the solution stirred at room temperature for 2 h. The reaction was then quenched using water (0.8 mL), a 10% wt aqueous NaOH solution (1.15 mL) and water again (1.9 mL) and left to settle. The suspension was then filtered and concentrated. Water was added and the mixture extracted with EtOAc, the organic phase dried over MgSO4, filtered and concentrated to yield 7.07 g crude alcohol 3b. 1H NMR delta (CDCl3) 4.68 (s, 2H, PhCH2OH), 5.08 (s, 2H, PhCH2O), 6.90-7.46 (m, 9H, 2-CH, 4-CH, 5-CH, 6-CH and PhCH2O). Crude alcohol 3b (7.06 g) was dissolved in anhydrous CH2Cl2 (330 mL) and the solution cooled to 0 C. Triphenylphosphine (17.28 g, 0.066 mol) and carbon tetrabromide (21.85 g, 0.066 mol) were then added and the solution stirred at room temperature for 2 h. The reaction mixture was quenched with water and extracted with CH2Cl2. The organic phase was dried over MgSO4, filtered and concentrated. The product was purified by flash chromatography on silica gel with hexanes/EtOAc (9/1) to yield 5.85 g (64%) of bromide 3c.

Statistics shows that 24131-31-5 is playing an increasingly important role. we look forward to future research findings about (3,5-Bis(benzyloxy)phenyl)methanol.

Reference:
Article; Fournier, Diane; Poirier, Donald; European Journal of Medicinal Chemistry; vol. 46; 9; (2011); p. 4227 – 4237;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 148043-73-6, name is 4,4,5,5,5-Pentafluoropentan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 4,4,5,5,5-Pentafluoropentan-1-ol

4,4,5,5,5-pentafluoropentanol (10 g) and methylene chloride (100 ml) is added to the reaction flask. Add triethylamine (11.3 g). Under ice bath, drop methanesulfonyl chloride (6.72 g). The completion of the dropping. Restoration to room temperature react for 2 hours. Water to wash the excess triethylamine and methyl chloride, dried with anhydrous sodium sulfate, turns on lathe does, get 14.14 g 4,4,5,5,5-pentafluoropentyl methanesulfonate.

With the rapid development of chemical substances, we look forward to future research findings about 148043-73-6.

Reference:
Patent; Tianjin Fuyin Biotechnology Development Co., Ltd.; Liu, Wenjuan; Mo, Lan; (9 pag.)CN104447447; (2017); B;,
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Electric Literature of 534-03-2, Adding some certain compound to certain chemical reactions, such as: 534-03-2, name is 2-Aminopropane-1,3-diol,molecular formula is C3H9NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 534-03-2.

General procedure: A stirred solution of 2-amino-1,3-propanediol (serinol) 4 (1 eq) and triethylamine (TEA) inMeOH (10 mL) was cooled at -20 C (carbon dioxide snow) and added dropwise a solutionof the corresponding acyl chloride (1.1 eq) in THF (5 mL). The reaction mixture was allowed towarm to room temperature and stirred overnight. Then it was poured into brine and extractedwith dichloromethane (3 10 mL). The combined organic phases were washed with brine, driedover MgSO4 and concentrated under reduced pressure. The residue was purified by flash columnchromatography on silica gel using as eluent EtOAc/MeOH (20:1 to 7:1) to provide the correspondingN-acyl serinol derivatives. 4.1.4. N-octanoyl Serinol (5)According to the general procedure serinol 4 (150 mg, 1.64 mmol) was treated with octyl chloride(1.81 mmol, 0.3 mL) and TEA (0.4 mL) to give 267 mg (75%) of 5 as an amorphous white solid. 1H NMR(400 MHz, DMSO-d6) 7.40 (d, J = 8.1 Hz, 1H, NHCO), 4.55 (t, J = 5.5 Hz, 2H, OH), 3.69 (m, 1H, CHNH),3.37 (t, J = 5.6 Hz, 4H, CH2OH), 2.06 (t, J = 7.4 Hz, 2H, CH2CO), 1.46 (m, 2H, CH2), 1.22 (m, 8H, CH2),0.86 (t, J = 6.8 Hz, 3H, CH3).

According to the analysis of related databases, 534-03-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Jimenez, Aranza; Garcia, Pablo; De La Puente, Sofia; Madrona, Andres; Camarasa, Maria Jose; Perez-Perez, Maria-Jesus; Quintela, Jose-Carlos; Garcia-del Portillo, Francisco; San-Felix, Ana; Molecules; vol. 23; 7; (2018);,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7541-49-3, name is 3,7,11,15-Tetramethylhexadec-2-en-1-ol, the common compound, a new synthetic route is introduced below. name: 3,7,11,15-Tetramethylhexadec-2-en-1-ol

Phytol (2.0 g, 6.7 mmol) was dissolved in ethanol, rhodium 5% on alumina was added and mixture was placed under H2 60 psi and shaken overnight. The reaction mixture was filtered and evaporated to give the desired compound as an oil (2.0 g, 100% yield).

The synthetic route of 7541-49-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CHIMERIX, INC.; UNIVERSITY OF CALIFORNIA, SAN DIEGO; WO2007/130783; (2007); A2;,
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Application of 13330-96-6 ,Some common heterocyclic compound, 13330-96-6, molecular formula is C6H15NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of 8 (1.00 mmol) in iPrOH (30 mL) was addedB2Pin2 (1.01 g, 4.00 mmol) and KOtBu (0.028 g, 2.50 mmol). Thereaction was stirred at 110 C. After 12 h, the mixture was cooled toroom temperature and was concentrated in vacuo. Then themixture was diluted with water and extracted with ethyl acetate.The combined organic layer was washed by saturated sodiumchloride solution for three times, dried over anhydrous Na2SO4 andconcentrated under reduced pressure. The residue was purified bysilica gel chromatography to give 9.To a stirred solution of 9 (0.29 mmol) and triphosgene (0.086 g,0.33 mmol) in anhydrous dichloromethane (5 mL) at 0 C wasadded triethylamine (0.12 mL, 0.87 mmol) under nitrogen atmosphere.Then a solution of 4-(dimethylamino)butan-1-ol(0.87 mmol) in dichloromethane (5 mL) was added. The mixturewas stirred at room temperature overnight, diluted withdichloromethane (15 mL) and washed with water (3 20 mL). Theorganic phases were separated, combined, dried over anhydrousNa2SO4 and concentrated in vacuo. The residue was purified byusing column chromatography to afford the corresponding product10a-10e.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13330-96-6, 4-(Dimethylamino)butan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Lu, Dong; Liu, Jianan; Zhang, Yunzhe; Liu, Feifei; Zeng, Limin; Peng, Runze; Yang, Li; Ying, Huazhou; Tang, Wei; Chen, Wuhong; Zuo, Jianping; Tong, Xiankun; Liu, Tao; Hu, Youhong; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 328 – 337;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 37585-25-4, name is (2-Amino-5-chlorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H8ClNO

General procedure: To an oven-dried 15 mL sealed tube were added 2-aminophenylmethanol 1 (0.425 mmol), benzonitrile 2(0.25 mmol), Ru cat. b (1.94 mg, 1 mol%), and KOtBu (14.02 mg, 0.5equiv) intamyl alcohol (1 mL) under an air atmosphere. The sealedtube was capped and heated at 130C for 2 h. The reaction mixturewas cooled down to room temperature and directly concentratedunder vacuum. The crude mixture was puried by preparative thin-layer-chromatography (petroleum ether/ethyl acetate 20/1) togive the desired product 3 or 4.

With the rapid development of chemical substances, we look forward to future research findings about 37585-25-4.

Reference:
Article; Wan, Xiao-Min; Liu, Zi-Lin; Liu, Wan-Qing; Cao, Xiao-Niu; Zhu, Xinju; Zhao, Xue-Mei; Song, Bing; Hao, Xin-Qi; Liu, Guoji; Tetrahedron; vol. 75; 18; (2019); p. 2697 – 2705;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 149965-40-2, name is (5-Bromo-2-chlorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 149965-40-2

(5-Bromo-2-chloro-benzyloxy)-tert-butyl-dimethyl-silane.TBDMS-Cl (10.6 g, 66.7 mmol) was added to a sol. of (5-bromo-2-chloro-phenyl)- methanol (12.8 g, 55.6 mmol) and imidazole (9.42 g, 138 mmol) in DMF (190 mL) at 0 0C. The mixture was stirred for 2 h at 0 0C, and aq. sat. NH4Cl was added. The mixture was extracted with heptane (2x). The combined org. extracts were dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Purification of the residue by FC (heptane ? EtOAc/heptane 1 :49) yielded the title compound (18.0 g, 96%). LC-MS: tR = 1.22 min.

With the rapid development of chemical substances, we look forward to future research findings about 149965-40-2.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2007/88514; (2007); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 927-74-2, name is 3-Butyn-1-ol, the common compound, a new synthetic route is introduced below. Quality Control of 3-Butyn-1-ol

Preparation 39 Methyl [4-(4-Hydroxybut-1-ynyl)phenyl]acetate To a stirred solution of the product of Preparation 38 (4.5 g, 16.3 mmol) in diethylamine (100 mL) was added but-3-yn-1-ol (1.9 mL, 32.6 mmol), Pd(PPh3)2Cl2 (500 mg, 1.63 mmol) and CuI (154 mg, 0.815 mmol) and resulting mixture was stirred for 17 h at room temperature. The solvent was then removed under reduced pressure and the residue was dissolved in diethyl ether (200 mL) and this solution was filtered to remove salts. The solvent was then removed under reduced pressure and the crude product was purified by silica gel chromatography (60% EtOAc/Hexane) to afford the title intermediate (3.03 g, 91% yield).

The synthetic route of 927-74-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Mammen, Mathai; Dunham, Sarah; US2005/113417; (2005); A1;,
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