Author: tianli

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 599-67-7, name is 1,1-Diphenylethanol. This compound has unique chemical properties. The synthetic route is as follows. name: 1,1-Diphenylethanol

General procedure: In a vacuum dried 100 mL Schlenk flask, benzyl alcohol I (10.0 mmol) and triethylamine(20.0 mmol) were dissolved in THF (50 mL) under Ar atmosphere. Then, HClSiMe2 (12 mmol)was added at room temperature and the resulting mixture was stirred overnight. After the reactionwas complete, the solvent was removed via rotary evaporation. Then, petroleum ether (40 mL)was added. Simple filteration to remove Et3N?HCl and concentration in vacuo could give the pure(hydrido)silyl ether product as a colorless liquid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 599-67-7, 1,1-Diphenylethanol.

Reference:
Article; Fang, Huaquan; He, Qiaoxing; Liu, Guixia; Huang, Zheng; Synlett; vol. 28; 18; (2017); p. 2468 – 2472;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 402-63-1, name is 1-(3-Fluorophenyl)ethanol, molecular formula is C8H9FO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 402-63-1

Example 98 1-(3-Fluorophenyl)ethyl N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylaniline (86 mg) was added to toluene/triethylamine = 10/1 (9 ml), and the mixture was heated under reflux to prepare a solution. A solution of triphosgene (150 mg) in methylene chloride was then added to the solution, and the mixture was heated under reflux for 15 min. Subsequently, 3-fluoro-alpha-methylbenzyl alcohol (70 mg) was added thereto, and the mixture was further stirred with heating under reflux for 2 hr. After the completion of the reaction, the reaction solution was allowed to cool to room temperature before distilled water was added thereto. The mixture was subjected to separatory extraction with chloroform, followed by washing with a 1 N aqueous hydrochloric acid solution and saturated brine. The washed solution was dried over sodium sulfate andwas concentrated. The residue was purified on a column using chloroform/methanol to give the title compound (89 mg, yield 64%). 1H-NMR (CDCl3, 400 MHz): 8.38 – 8.44 (1H, m), 8.13 (1H, s), 7.66 – 7.75 (1H, m), 7.64 (1H, s), 6.95 – 7.36 (6H, m), 6.51 (1H, d, J = 6.4 Hz), 5.87 (1H, q, J = 6.6 Hz), 4.15 (3H, s), 4.09 (3H, s), 2.25 (3H, s), 2.07 (3H, s) Mass spectrometry value (ESI-MS, m/z): 492 (M++1)

With the rapid development of chemical substances, we look forward to future research findings about 402-63-1.

Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1243582; (2002); A1;,
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Synthetic Route of 1124-63-6, Adding some certain compound to certain chemical reactions, such as: 1124-63-6, name is 3-Cyclohexylpropan-1-ol,molecular formula is C9H18O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1124-63-6.

The crude mixture was reacted with phthalimide (15.0 mmol) in THF (20 mL) under reflux for 2 h to get a the phthalimide intermediate as white powder. It was filtered and further reacted with hydrazine (98%, 63 mmol) in absolute ethanol (15 mL) at 60 C for 30 min. The reaction mixture was diluted with water and extracted using ethyl acetate to get the 3-cyclohexylpropan-1-amine 47. The amine 47 was reacted with phenethylisocyanate according to the general procedure to get 23. Yield 87%; White solid; mp 84-86 C; Rf 0.40 (1: 2 Ethylacetate: Hexane), IR (neat): 3359, 3307, 2911, 2849, 1625, 1560, 1496 cm-1; 1H NMR (CDCl3) delta 0.81-0.89 (m, 2H), 1.11-1.26 (m, 6H), 1.41-1.49 (m, 2H), 1.62-1.69 (m, 5H), 2.81 (t, J = 8.00 Hz, 2H), 3.05-3.10 (m, 2H), 3.41-3.46 (m, 2H), 4.26-4.33 (m, 2H), 7.19-7.24 (m, 3H), 7.28-7.33 (m, 2H). 13C NMR (CDCl3) delta 26.24, 26.53, 27.45, 33.24, 34.51, 36.37, 37.33, 40.82, 41.57, 126.40, 128.59, 128.86, 139.30, 158.31. HRMS Calcd for C18H28N2O2 m/z [M+H] 289.2281, found 289.2308.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1124-63-6, 3-Cyclohexylpropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Manickam, Manoj; Jalani, Hitesh B.; Pillaiyar, Thanigaimalai; Sharma, Niti; Boggu, Pulla Reddy; Venkateswararao, Eeda; Lee, You-Jung; Jeon, Eun-Seok; Jung, Sang-Hun; European Journal of Medicinal Chemistry; vol. 134; (2017); p. 379 – 391;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 57772-50-6, name is (2-Amino-3-methylphenyl)methanol, the common compound, a new synthetic route is introduced below. Recommanded Product: 57772-50-6

Acetophenone (144 mg, 1.2 mmol),[Cp * Ir (6,6 ‘- (OH) 2bpy) (H2O)] [OTf] 2 (8.3 mg,0.01 mmol, 1 mol%), potassium hydroxide (56 mg, 1.0 mmol, 1.0 equiv.),2-Amino-3-methylbenzyl alcohol(137 mg, 1.0 mmol) and water (1 mL) were sequentially added to a 5 mL round bottom flask.The reaction mixture was refluxed in air for 12 hours and then cooled to room temperature.Extraction with ethyl acetate, removal of the solvent by rotary evaporation and purification of the target compound by column chromatography (developing solvent: petroleum ether / ethyl acetate) yielded 83%

The synthetic route of 57772-50-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing University of Science and Technology; Li Feng; Wang Rongzhou; (15 pag.)CN107400084; (2017); A;,
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Reference of 6995-79-5, Adding some certain compound to certain chemical reactions, such as: 6995-79-5, name is trans-Cyclohexane-1,4-diol,molecular formula is C6H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6995-79-5.

A 5 mL microwave vial was charged with 60percent sodium hydride (70 mg, 1.750 mmol) and trans-1,4- cyclohexanediol (180 mg, 1.550 mmol), purged with nitrogen, added DMF (2 mL), and stirred the mixture for 10 min at ambient temperature. A solution of 7-(2-fluoropyridin-4-yl)-4-(2-methoxyphenyl)- 3,4-dihydro-2H-pyrano[2′,3′:4,5]imidazo[l,2-a]pyridine (151 mg, 0.402 mmol, Preparation 93) in DMF (2 mL) was added, and heated at 120 °C for 105 min. Quenched with water (50 mL), extracted twice with EtOAc, washed with 10 mL brine, and dried over NaaSOzi. Chromatographed on a Grace Reveleris 24g column, eluted with 0-100percent 3: 1 EtOAc:EtOH in 1 : 1 DCM:Heptane (30 mL/min), affording the title compound (83.4 mg, 44.0percent); lH NMR (400 MHz, DMSO- 6) delta 8.09 (dd, J = 5.4, 0.6 Hz, 1H), 7.93 (dd, J= 1.9, 1.0 Hz, 1H), 7.54 (dd, J= 9.3, 1.8 Hz, 1H), 7.50 (dd, J= 9.3, 1.0 Hz, 1H), 7.21 (ddd, J= 8.2, 7.4, 1.7 Hz, 1H), 7.09 – 7.02 (m, 2H), 6.90 (dd, J = 1.6, 0.8 Hz, 1H), 6.73 (td, J = 7.5, 1.1 Hz, 1H), 6.44 (dd, J = 7.6, 1.7 Hz, 1H), 4.95 – 4.85 (m, 1H), 4.82 (dd, J= 6.2, 3.5 Hz, 1H), 4.54 (d, J= 4.2 Hz, 1H), 4.25 (ddd, J = 11.2, 4.8, 3.2 Hz, 1H), 3.95 (td, J = 11.0, 2.1 Hz, 1H), 3.87 (s, 3H), 3.52 – 3.42 (m, 1H), 2.42 – 2.31 (m, 1H), 2.09 – 2.02 (m, 1H), 2.02 – 1.93 (m, 2H), 1.84 – 1.75 (m, 2H), 1.46 – 1.32 (m, 2H), 1.32 – 1.18 (m, 2H). MS (ESI+) m/z 472 (M+H). LC/MS (Table 1, ab) Rt = 0.86 min; MS m/z: 472 (M+H)+ (TNF ICso = A).

According to the analysis of related databases, 6995-79-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ABBVIE INC.; BREINLINGER, Eric, C.; COX, Phil, B.; DAANEN, Jerome; DIETRICH, Justin; DJURIC, Stevan; DOMBROWSKI, Amanda, W.; FRANK, Kristine, E.; FRIEDMAN, Michael, M.; GOMTSYAN, Arthur; LI, Huan-Qui; LONGENECKER, Kenton; OSUMA, Augustine; ROWLEY, Ann, Marie; SCHMIDT, Robert; VASUDEVAN, Anil; WILSON, Noel; (378 pag.)WO2016/168641; (2016); A1;,
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Reference of 27489-62-9, Adding some certain compound to certain chemical reactions, such as: 27489-62-9, name is trans-4-Aminocyclohexanol,molecular formula is C6H13NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 27489-62-9.

Preparation of Intermediate 21) di-tert-butyl dicarbon .at?e 2) 1,1′-carbonyl trans-4-aminocyclohexanol diimidazole Intermediate 2To a 250ml flask under nitrogen atmosphere was charged DMF (98 mL) and di-t-butyl dicarbonate (63.6g, 0.291 mole). The mixture was stirred at ambient temperature to give a solution. To a second IL flask was charged tfralphakappas-4-aminocyclohexanoI (commercially available) (32.5 g, 0.285 mole) and DMF (160 mL). The mixture was heated to 55-600C to give a solution. Approximately 33% of the di-t-butyl dicarbonate in DMF solution was slowly added to the *r°/s-4-aminocyclohexanol over approximately 30 minutes, keeping the process temperature below 75C during the charge. The mixture was stirred for ~30min- 1 hour at 55-600C. The slow addition of ~33% of the di-t-butyl dicarbonate DMF solution was repeated twice more and the mixture was stirred for ~30min – 1 hour at 55-600C after each addition. After the last addition the reaction mixture was stirred at 70-750C over 1-2 hours. When GC analysis indicated that the ratio between intermediate N-Boc-frflHs-4-aminocyclohexanol and fralpha«s-4-aminocyclohexanol was greater than 33:1, the reaction mixture was cooled to 15-20C. DMF (250 mL) was charged to the reaction and stirred to give a solution. 1, 1′ -Carbonyldiimidazole (59.2g, 1.3 eq) was charged to the reaction in one portion. The reaction was stirred at ~19C for 15 hours and reaction progress was monitored by HPLC. When the HPLC analysis indicated that the ratio between Intermediate 2 and N-Boc~’««,s~4-aminocyclohexanol was greater than 49:1, the reaction mixture was cooled to ~0C. Water (600 mL) was charged slowly to the reaction mixture while keeping the process temperature below ~20C. The white solid product precipitated out of solution. The mixture was cooled to ~ 00C and stirred for 1 hour. The product was filtered and the wet cake was washed with water (100 mL) twice. The product was dried at 60-65C under vacuum to a constant weight. Yield: 82.1 g, 94%.

According to the analysis of related databases, 27489-62-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXO GROUP LIMITED; WO2007/62334; (2007); A2;,
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Adding a certain compound to certain chemical reactions, such as: 64431-96-5, 2,2′-(Propane-1,3-diylbis(azanediyl))bis(2-(hydroxymethyl)propane-1,3-diol), can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2,2′-(Propane-1,3-diylbis(azanediyl))bis(2-(hydroxymethyl)propane-1,3-diol), blongs to alcohols-buliding-blocks compound. Safety of 2,2′-(Propane-1,3-diylbis(azanediyl))bis(2-(hydroxymethyl)propane-1,3-diol)

[0052]To a solution of bis-ths propane (56.5 g, 0.2 mol) in 200 ml of dry THF in a three-necked round bottom flask with mechanical stir was added trimethylamine (40.52 g, 0.4 mol) at room temperature. The resulting solution was cooled down to 0 C under N2, then a solution of acryloyl chloride (36.2 g, 0.4 mol) in 100 ml of dry THF was added dropwise at 0 C. After the addition was complete, the mixture was allowed to warm to room temperature and continued to stir at room temperature for overnight. The white solid was collected by filtration and washed with THF (3X50 ml). The combined THF filtrate and THF washing solutions were evaporated off to give a residue. The residue was dissolved into 500 ml of chloroform and washed with saturated sodium (0121) bicarbonate aqueous solution (3X100 ml) until no gas generated. The chloroform layer was then dried with sodium sulfate. Sodium sulfate was removed by filtration and the filtrate was evaporated off to give the desired BIS TRIS Propane diacrylamide (BTPDA, Photo Active Co-solvent-1 ) (50.7 g, 65%).

The synthetic route of 64431-96-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.; ZHOU, Zhang-Lin; BAR, Mazi; LANE, Gregg A.; (29 pag.)WO2018/143916; (2018); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 62058-03-1, name is trans-4-Aminoadamantan-1-ol, molecular formula is C10H17NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C10H17NO

General procedure: To a solution of ethyl 1-phenyl-5-(2-methyl-4-oxobutan-2-yl)-1H-pyrazole-4-carboxylate 14b (45 mg, 0.15 mmol) in CHCl3 (9 mL) was added trans-5-hydroxy-2-adamantylamine (25 mg, 0.15 mmol), acetic acid (0.025 mL, 0.45 mmol) and sodium triacetoxyborohydride (85 mg, 0.45 mmol) at room temperature. After stirring at ambient temperature for 16 hours, the reaction mixture was quenched with aq. NaHCO3, extracted with CHCl3, and washed with aq. NaCl. The combined organic layer was dried over Na2SO4 and concentrated in vacuo. The residue was dissolved in methanol (0.30 mL), and added 1.0 N NaOH (0.22 mL, 0.22 mmol) at room temperature. After stirring at ambient temperature for 16 hours, the solvent was removed under vacuum. The mixture of the residue in CHCl3 (1.5 mL) and DIPEA (0.078 mL, 0.45 mmol) and HBTU (35 mg, 0.15 mmol) was stirred at room temperature. After 16 hours, the reaction mixture was quenched with aq. NaHCO3, extracted with CHCl3, and washed with aq. NaCl., then purified with column chromatography (silica gel, eluting with CHCl3/methanol) to give the title compound as a white solid (0.025 g, 42 percent yield).

With the rapid development of chemical substances, we look forward to future research findings about 62058-03-1.

Reference:
Article; Udagawa, Shuji; Sakami, Satoshi; Takemura, Takahiro; Sato, Mikiya; Arai, Takahiro; Nitta, Aiko; Aoki, Takumi; Kawai, Koji; Iwamura, Tomokatsu; Okazaki, Seiji; Takahashi, Takehiro; Kaino, Mie; Bioorganic and Medicinal Chemistry Letters; vol. 23; 6; (2013); p. 1617 – 1621;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 34598-50-0, name is 5-Bromo-2,3-dihydro-1H-inden-1-ol, molecular formula is C9H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 5-Bromo-2,3-dihydro-1H-inden-1-ol

[001036] Part B. Preparation of l-azido-5-bromo-2,3-dihydro-lH-indene.; [001037] A solution of the product from Part A (l.Olg, 4.73mmol) in toluene (8.ImL) was treated with the diphenyl phosphoroyl azide (1.23mL, 1.56g, 5.67mmol) followed by cooling to O0C. The solution was treated dropwise with DBU (855muL, 863mg, 5.67mmol) followed by stirring at O0C for 2h, and then warming to room temperature for 48h. The mixture was diluted with ethyl acetate and extracted with water and 1 M citric acid solution, and then with saturated sodium chloride solution. Drying (Na2SO4) and concentration in vacuo afforded a brown oil, which was purified by flash chromatography, eluting with 5-50 % ethyl acetate in hexanes. These procedures afforded the title compound (889mg, 79%) as a light yellow oil.

With the rapid development of chemical substances, we look forward to future research findings about 34598-50-0.

Reference:
Patent; ABBOTT LABORATORIES; WO2009/39134; (2009); A1;,
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Adding a certain compound to certain chemical reactions, such as: 223251-16-9, (4-(2-(Azepan-1-yl)ethoxy)phenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C15H23NO2, blongs to alcohols-buliding-blocks compound. COA of Formula: C15H23NO2

4-Hydroxybenzyl alcohol (10 g) is added to a solution of sodium hydroxide (7.73 g) in water (150 mL). The mixture is stirred to obtain a clear solution, and then toluene (100 mL), 2-chloroethylazepan hydrochloride (20.74 g), and tetrabutylammonium bromide (0.519 g) are added. The mixture is refluxed for completion of the reaction (1 -1.5 hours), as verified using TLC. The mixture is cooled to 25-35C and the organic layer is separated and washed with 10% NaCI solution (100 mL) at 500C. The organic layer is distilled completely under vacuum, and then dichloromethane (200 mL) is added to the residue. The mixture is stirred for dissolution under a nitrogen atmosphere. Dry HCI gas is passed through the solution for 30-60 minutes at 25-35C and the mixture is stirred for 1 -1.5 hours at the same temperature. About 85-90% of the solvent is distilled from the mixture, then acetone (60 mL) is added, and 85-90% of the solvent is distilled. This addition and distillation step is repeated twice with acetone (60 mL). To the residue, acetone (60 mL) is added and mixture is cooled to 0-50C and further stirred at same temperature for 4-4.5 hours. The solid obtained is filtered under a nitrogen atmosphere, washed with chilled acetone (40 mL) under a nitrogen atmosphere, and dried under vacuum at 50-550C for 4-5 hours to afford the title compound in 61.2% yield.

The synthetic route of 223251-16-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; DR. REDDY’S LABORATORIES, INC.; BANDICHHOR, Rakeshwar; LEKKALA, Amarnath Reddy; HALDAR, Pranab; MYLAVARAPU, Ravi Kumar; GOLLA, China Malakondaiah; VAGWALA, Raghunath; KARRI, Vijaya Kumar; AKULA, Swapna; WO2011/22596; (2011); A2;,
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