Author: tianli

Application In Synthesis of (4-Methoxyphenyl)methanol. Authors Yang, SN; Liu, XY; Lu, SJ; Li, Z; Zhang, YM; Yu, SN; Song, J; Ding, CF; Yang, HY in WILEY-V C H VERLAG GMBH published article about in [Yang, Shouning; Yu, Shaoning; Yang, Huayan] Ningbo Univ, Sch Mat Sci & Chem Engn, Inst Mass Spectrometry, Zhejiang Prov Key Lab Adv Mass Spectrometry & Mol, Ningbo 315211, Zhejiang, Peoples R China; [Zhang, Yanmin; Song, Jian] Henan Normal Univ, Sch Phys, Xinxiang 453007, Henan, Peoples R China; [Yang, Shouning; Liu, Xiaoyang; Lu, Sijia; Li, Zhuo; Yang, Huayan] Henan Normal Univ, Collaborat Innovat Ctr Henan Prov Green Mfg Fine, Key Lab Green Chem Media & React, Minist Educ,Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China in 2021, Cited 65. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5

The development of eco-friendly and low cost catalysts is challenging. Here, heterostructures of Bi2S3 quantum dots (QDs) doped onto ultrathin BiOCl nanosheets were synthesized by a facile hydrothermal method to exploit efficient photosensitizers with appropriate electronic states to enhance the transfer of electrons. The obtained Bi2S3-BiOCl showed highly efficient photocatalytic ability for selective oxidation of aromatic alcohols to aldehydes. More oxygen vacancies are formed on the exposed 001 facet of the ultrathin BiOCl, which can effectively trap electrons and form O-.(2)- radicals. The cooperation between the BiOCl and the Bi2S3 QDs effectively separates photogenerated electron-hole pairs at the heterointerface and facilitates the cooperative actions of O-.(2)- radicals and holes, which brings about a desirable photocatalytic eciency for the selective oxidation of aromatic alcohols. This work highlights the synergistic effect of semiconductor QDs and two-dimensional materials on selective conversion processes and provides a new design paradigm using noble metal-free heteromaterials with high photocatalytic activity. This opens new possibilities for photocatalyst design using heteromaterials with high photocatalytic activity.

Application In Synthesis of (4-Methoxyphenyl)methanol. About (4-Methoxyphenyl)methanol, If you have any questions, you can contact Yang, SN; Liu, XY; Lu, SJ; Li, Z; Zhang, YM; Yu, SN; Song, J; Ding, CF; Yang, HY or concate me.

Reference:
Alcohol – Wikipedia,
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Recently I am researching about CARBON-DIOXIDE EXTRACTION; FLUID EXTRACTION; ANTIOXIDANT ACTIVITY; CHEMICAL-COMPOSITION; FRACTIONATION; PERFORMANCE; VOLATILES; KINETICS; LUPEOL; LINK, Saw an article supported by the Ministry of Science and Innovation of SpainSpanish Government [CTM2015-68503-R]; Xunta de Galicia (Centro singular de investigacion de Galicia accreditation 2019-2022); European Union (European Regional Development Fund -ERDF) [ED431G2019/06]. Published in ELSEVIER in AMSTERDAM ,Authors: Casas, MP; Lopez-Hortas, L; Diaz-Reinoso, B; Moure, A; Dominguez, H. The CAS is 105-13-5. Through research, I have a further understanding and discovery of (4-Methoxyphenyl)methanol. Category: alcohols-buliding-blocks

Supercritical CO2 was used for the production of extracts from Acacia dealbata flowers. Pressures from 10 to 35 MPa and temperatures from 35? to 55?C were studied to assess their influence on the yield, antiradical properties and composition of the volatiles. The use of ethanol as modifier was also evaluated. Operating at 30 MPa and 45 ?C with 10% ethanol, up to 15% of the ethanol extractables were obtained in 3 h. The selectivity towards alcohol type compounds decreased with time and was enhanced in a sequence of static extraction with pure and ethanol modified CO2 followed by a dynamic stage. The most active fractions showed ABTS radical scavenging activity of 0.22 g Trolox/g extract. Different mathematical models were used to describe the kinetic data. The most abundant compounds in the supercritical extracts were oxygenated triterpenes whereas in conventional ethanolic extracts the main constituents were aliphatic compounds.

About (4-Methoxyphenyl)methanol, If you have any questions, you can contact Casas, MP; Lopez-Hortas, L; Diaz-Reinoso, B; Moure, A; Dominguez, H or concate me.. Category: alcohols-buliding-blocks

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An article Indium-Catalyzed Deoxygenation of Sulfoxides with Hydrosilanes WOS:000621808900001 published article about CHEMOSELECTIVE DEOXYGENATION; SULFIDES; SELENOXIDES; EFFICIENT; SELENIDES; SULFONES; SELENOLS; THIOLS; MILD in [Sakai, Norio; Shimada, Retsu; Ogiwara, Yohei] Tokyo Univ Sci RIKADAI, Fac Sci & Technol, Dept Pure & Appl Chem, Noda, Chiba 2788510, Japan in 2021, Cited 75. Name: (4-Methoxyphenyl)methanol. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5

Described herein is that a novel InBr3/PhSiH3 reducing system in a 1,4-dioxane solution smoothly and effectively undertook deoxygenation of a variety of sulfoxides leading to the facile preparation of sulfide derivatives. Also, it was demonstrated that the reducing system shows a higher reactivity towards sulfoxides than that towards commonly reducible functional groups, such as carboxylic acids, esters, amides, and sulfones.

Name: (4-Methoxyphenyl)methanol. About (4-Methoxyphenyl)methanol, If you have any questions, you can contact Sakai, N; Shimada, R; Ogiwara, Y or concate me.

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Safety of (4-Methoxyphenyl)methanol. Authors Xiao, WL; Mo, YH; Guo, J; Su, ZS; Dong, SX; Feng, XM in ROYAL SOC CHEMISTRY published article about in [Xiao, Wanlong; Mo, Yuhao; Guo, Jing; Su, Zhishan; Dong, Shunxi; Feng, Xiaoming] Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Peoples R China in 2021, Cited 64. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5

New types of C-2-symmetric chiral macrodiolides are readily obtained via chiral N,N ‘-dioxide-scandium(iii) complex-promoted asymmetric tandem Friedel-Crafts alkylation/intermolecular macrolactonization of ortho-quinone methides with C3-substituted indoles. This protocol provides an array of enantioenriched macrodiolides with 16, 18 or 20-membered rings in moderate to good yields with high diastereoselectivities and excellent enantioselectivities through adjusting the length of the tether at the C3 position of indoles. Density functional theory calculations indicate that the formation of macrocycles is more favorable than that of 9-membered-ring lactones in terms of kinetics and thermodynamics. The potential utility of these intriguing chiral macrodiolide molecules is demonstrated in the enantiomeric recognition of aminols and chemical recognition of metal ions.

Safety of (4-Methoxyphenyl)methanol. About (4-Methoxyphenyl)methanol, If you have any questions, you can contact Xiao, WL; Mo, YH; Guo, J; Su, ZS; Dong, SX; Feng, XM or concate me.

Reference:
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Synthetic Route of 20017-67-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 20017-67-8, name is 3,3-Diphenyl-1-propanol. A new synthetic method of this compound is introduced below.

A solution (5 ML) of 1-(2-hydroxy-5-nitrophenyl)propan-1-one (500 mg, 2.56 mmol), 3,3-diphenylpropanol (765 mg, 3.84 mmol), 1,1-(azodicarbonyl)dipiperidine (969 mg, 3.84 mmol) and triphenylphosphine (1.01 g, 3.84 mmol) in toluene was stirred for 4 hours at 80C, and to the reaction solution were added 3,3-diphenylpropanol (765 mg, 3.84 mmol), 1,1-(azodicarbonyl)dipiperidine (969 mg, 3.84 mmol), triphenylphosphine (1.01 g, 3.84 mmol) and toluene (5 ML).. The mixture was stirred for 4 hours at 80C. To the reaction solution were further added 3,3-diphenylpropanol (765 mg, 3.84 mmol), 1,1-(azodicarbonyl)dipiperidine (967 mg, 3.84 mmol), triphenylphosphine (1.01 g, 3.84 mmol) and toluene (5 ML), and the mixture was stirred for 12 hours at 80C. The reaction solution was poured into water, and was extracted with ethyl acetate.. The extracted solution was washed with water, was dried with anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure.. The residue was purified by silicagel column chromatography (hexane:ethyl acetate = 20:1), to obtain the titled compound as oil. 600 mg (60.2%) 1H-NMR (CDCl3) delta; 1.23 (3H, t, J = 7.2 Hz), 2.58 – 2.69 (2H, m), 3.04 (2H, q, J = 7.2 Hz), 4.07 to 4.25 (3H, m), 6.87 (1 H, d, J = 9.0 Hz), 7.15 to 7.36 (10H, m), 8.24 (1H, dd, J = 9.0, 2.8 Hz), 8.55 (1H, d, J = 2.8Hz)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,20017-67-8, 3,3-Diphenyl-1-propanol, and friends who are interested can also refer to it.

Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1437344; (2004); A1;,
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Related Products of 127-66-2, Adding some certain compound to certain chemical reactions, such as: 127-66-2, name is 2-Phenylbut-3-yn-2-ol,molecular formula is C10H10O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127-66-2.

General procedure: A 50-mL stainless steel autoclave equipped with a magnetic stir bar was charged with ZnCl2 (27.2 mg, 20 molpercent), DBU (76 mg, 50 molpercent), 2b (154.1 mg, 1 mmol), H2O (27 mg, 1.5 mmol) and CH3CN (2.0 mL) successively and sealed at r.t. Then, the pressure was adjusted to 1 MPa with CO2 at the preset temperature (80 °C) and the autoclave was heated at this temperature for 48 h. After the reaction was complete, the reactor was cooled in ice-water bath, and then excess CO2 was carefully vented. Then, the residue was obtained by removing the solvent under vacuum and further purified by column chromatography (petroleum ether/EtOAc 100:1-5:1) to obtain 6b.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 127-66-2, 2-Phenylbut-3-yn-2-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Song, Qing-Wen; Zhao, Qing-Ning; Li, Jing-Yuan; Zhang, Kan; Liu, Ping; Synthesis; vol. 51; 3; (2019); p. 739 – 746;,
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Electric Literature of 5333-42-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 5333-42-6 as follows.

Example 13 Preparation of 2-octyldodecyl 2-(2-(2-methoxyethoxy)ethoxy)acetate To a 3-neck 1000 ml round-bottomed flask was added 2-octyl-1-dodecanol (220.00 g, 736.89 mmol, 1.0 equiv.), 2-(2-(2-methoxyethoxy)ethoxy)acetic acid (170.693 g, 957.95 mmol, 1.30 equiv.), toluene (200 ml) and p-toluenesulfonic acid monohydrate (1.4017 g, 7.3688 mmol, 0.010 equiv.) at room temperature. The resulting mixture was heated at reflux with stirring in an oil bath at 134 C. under a nitrogen atmosphere for 6 hours. The water produced in the reaction was collected in a Dean-Stark trap. The cooled mixture was diluted with diethyl ether, washed with dilute aqueous Na2CO3 solution, water, brine, dried (MgSO4), filtered, and concentrated in vacuo to afford a crude product. Excess solvent was further removed by heating the crude product with stirring in an oil bath under high vacuum for 2 hours to afford a clear light yellow liquid (319.67 g, 94%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5333-42-6, its application will become more common.

Reference:
Patent; ExxonMobil Research and Engineering Company; Ng, Man Kit; Oumar-Mahamat, Halou; Cheng, Hong; Blain, David A.; Cooper, Kathleen K.; Carey, James T.; Douglass, Michael R.; Kanga, Percy R.; Patil, Abhimanyu O.; Bodige, Satish; Lewis, Kyle G.; Hagemeister, Mark P.; (40 pag.)US2017/183595; (2017); A1;,
Alcohol – Wikipedia,
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Reference of 24034-73-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 24034-73-9, name is (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol. A new synthetic method of this compound is introduced below.

[0364] Methyl 2E,6E,10E-geranylgeranyl thiocarbamate (10a) (R= Methyl-): A dry reaction flask equipped with a stir bar, N2 inlet was charged with alcohol 1 (0.087 g, 0.3 mmol), pyridine (0.48 mL, 0.6 mmol) and DCM (1 mL). After cooling it to 0 C, methyl thioisocyanate (0.051 mL, 1.0 mmol) was added dropwise and the resulting reaction mixture was allowed to stir for 24 h. The reaction was monitored by TLC. After completion of the reaction, it was quenched with H20 (5 mL), acidified, extracted with n-hexanes (3 x 15 m L) and the combined n-hexanes were washed with H20 (10 mL). After drying the organic solution over anhydrous Na2S04, the solvent was evaporated and the resulting residue was purified by silica gel column chromatography using 1-2% EtOAc in n-hexanes to afford the desired thiocarbamate 10a. Yield: 0.030g (28%); LCMS: MS (m/z): 386.4 (M+Na).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,24034-73-9, its application will become more common.

Reference:
Patent; COYOTE PHARMACEUTICALS, INC.; SERIZAWA, Hiroaki; ARGADE, Ankush B.; DATWANI, Akash; SPENCER, Natalie; PAN, Yonghua; ERMINI, Florian; WO2013/130654; (2013); A1;,
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Adding a certain compound to certain chemical reactions, such as: 1202577-61-4, trans-(4-(Trifluoromethyl)cyclohexyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1202577-61-4, blongs to alcohols-buliding-blocks compound. Computed Properties of C8H13F3O

To a solution of 489 trans-4-(trifluoromethyl)cyclohexyl)methanol (209 mg, 1.15 mmol) in 12 DMF (4 mL) was added 490 sodium bis(trimethylsilyl)amide (1.15 mL, 1.0 M, 1.15 mmol) at rt and after stirring at rt for 5 min., 154 6-bromo-3-isopropyl-7-methylimidazo[1,5-a]pyrazin-8(7H)-one (238 mg, 0.88 mmol) was added as a solid. After stirring at rt for 2 h, the mixture was diluted with a 1 M solution of 195 NH4Cl, 18 water and 68 DCM, partitioned and the aqueous layer was extracted with DCM (2×15 mL). The combined organic extracts were dried (MgSO4) and evaporated. The residue was purified (FCC, SiO2, 10-100% EtOAc/heptanes) to provide the 491 title compound (131 mg, 40%) as a white solid. 1H NMR (400 MHz, CDCl3) delta 7.86 (s, 1H), 6.34 (s, 1H), 3.81 (d, J=6.0 Hz, 2H), 3.42 (s, 3H), 3.14 (td, J=6.8, 13.7 Hz, 1H), 2.14-2.02 (m, 5H), 1.92 (dtt, J=3.2, 6.0, 12.0 Hz, 1H), 1.47-1.40 (m, 8H), 1.28-1.12 (m, 2H). [M+H]=372.3.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1202577-61-4, its application will become more common.

Reference:
Patent; Dart NeuroScience, LLC; Bookser, Brett; Botrous, Iriny; Branstetter, Bryan; Dyck, Brian; Weinhouse, Michael; US2019/177327; (2019); A1;,
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Application of 637031-88-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 637031-88-0 as follows.

To a mixture of 3-methyl-4-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazin-6-yl]phenol (80 mg, 0.27 mmol), 3,3-difluorocyclobutanol (88.17 mg, 0.82 mmol) and Ph3P (142.64 mg, 0.54 mmol) in THF (2 mL) was added DEAD (94.7 mg, 0.54 mmol) at 0 C under N2. Then the mixture was stirred at 70 C for 16 hours. The mixture was concentrated to give the crude product. The crude product was purified by Prep-HPLC (Waters Xbridge (150 mm x 25 mm, 5 _) A = H20 (10 mM NH4HCO3) and B = CH3CN; 43-73% B over 6 minutes) to give the product (4.22 mg, 11.0 mmol) as a solid. 1H NMR (400MHz, CDC13) _ = 9.57 (d, 1H), 8.13 (s, 1H), 7.38 (d, 1H), 6.84 – 6.80 (m, 1H), 6.77 (dd, 1H), 4.78 -4.66 (m, 1H), 3.20 – 3.09 (m, 2H), 2.86 -2.74 (m, 2H), 2.41 (s, 3H). LCMS R, = 1.16 min in 2.0 min chromatography, 10-80AB, purity 100%, MS ESI calcd. for Ci7H14F5N40 [M+H]+ 385.1, found 385.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,637031-88-0, its application will become more common.

Reference:
Patent; PRAXIS PRECISION MEDICINES, INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; (364 pag.)WO2018/98499; (2018); A1;,
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