Author: tianli

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The reduction of pyridine derivatives with lithium aluminum hydride》. Authors are Bohlmann, Ferdinand; Bohlmann, Magdalene.The article about the compound:Pyridine-3,5-dicarbonitrilecas:1195-58-0,SMILESS:N#CC1=CC(C#N)=CN=C1).COA of Formula: C7H3N3. Through the article, more information about this compound (cas:1195-58-0) is conveyed.

When pyridine derivatives (I) with CO2Et or CN groups at the 3- and 5-positions are treated with LiAlH4 (II) the ring system is attacked first; when the 2-, 4-, and 6-positions are substituted, the functional group are reduced. The reductions are carried out by adding a large excess of II in ether to the I in absolute ether with stirring and ice-cooling, treating the mixture with saturated NH4Cl solution, and evaporating the washed ether solution Reduction of 5 g. di-Et 2,6-lutidine-3,5-dicarboxylate in 50 cc. ether with 780 mg. II in 40 cc. ether gives 40% Et 3-hydroxymethyl-2,6-lutidine-5-carboxylate, m. 100-1°; when the mixture is refluxed 2 hrs. 65% 3,5-bis(hydroxymethyl)-2,6-lutidine, m. 141-2°, is obtained. Reduction of di-Me dinicotinate gives 50% di-Me 1,4-dihydrodinicotinate, m. 150-60°, λmaximum 220, 375 mμ (MeOH). Reduction of di-Me 2-methyl-dinicotinate also gives a dihydro derivative, b0.02 115-20°, yellow needles, m. 126°, λmaximum 220, 375 mμ (MeOH). Reduction of 10 g. 2-chloropyridine (III) with 1 g. II at 0° gives unchanged III. Reduction of 1 g. Et picolinate gives 2-pyridine methanol (picrate m. 159°). Reduction of Et 2-pyridyl-acetate gives 2-pyridineëthanol, b15 120° (picrate, m. 120°). Refluxing 50 g. dinicotinic acid with 150 cc. SOCl2 15 hrs. and treating the acid chloride with NH4OH give 26 g. diamide, m. 302°, which, warmed in 130 cc. C5H5N with 19 cc. POCl3 3 hrs at 60°, yields 15 g. dinitrile (IV), m. 113° after sublimation at 70°/1 mm. Reduction of 1 g. IV in 20 cc. ether with 300 mg. II in 10 cc. ether gives 1,4-dihydrodinicotinonitrile, yellow crystals, m. 197°, λmaximum 360 mμ (MeOH). Similar reduction of 0.43 g. 2,6-lutidine-3,5-dicarbonitrile gives the 1,4-dihydro derivative, yellow crystals, m. 225°, λmaximum 362.5 mμ (MeOH). Catalytic hydrogenation of 0.5 g. IV in 20 cc. MeOH 3 hrs. with 50 mg. PtO2, 0.5 g., gives a dihydro derivative with λmax. 360 mμ which reduces neutral AgNO3. Adding (0.5 hr.) 6.5 g. II in 300 cc. ether to 46 g. Me nicotinate in 300 cc. ether at 0°, decomposing the mixture with NH4Cl, and distilling the residue of the ether extract give 31.3 g. 3-pyridine methanol, b0.1 110° (picrate, m. 158-60°). The difference in the behavior of the pyridine esters and nitriles toward II is explained as resulting from the different polarization of the pyridine rings in these compounds

There is still a lot of research devoted to this compound(SMILES：N#CC1=CC(C#N)=CN=C1)COA of Formula: C7H3N3, and with the development of science, more effects of this compound(1195-58-0) can be discovered.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: tert-Butyl 5-bromo-1H-indazole-1-carboxylate(SMILESS: CC(C)(C)OC(=O)N1N=CC2=CC(Br)=CC=C12,cas:651780-02-8) is researched.HPLC of Formula: 3235-67-4. The article 《Scaffold oriented synthesis. Part 3: Design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing [2+3] cycloadditions》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:651780-02-8).

We report the synthesis and biol. evaluation of 5-substituted indazoles e. g., I and amino indazoles e. g., II as kinase inhibitors. The compounds were synthesized in a parallel synthesis fashion from readily available starting materials employing [2+3] cycloaddition reactions and were evaluated against a panel of kinase assays. Potent inhibitors were identified for numerous kinases such as Rock2, Gsk3β, Aurora2 and Jak2.

There is still a lot of research devoted to this compound(SMILES：CC(C)(C)OC(=O)N1N=CC2=CC(Br)=CC=C12)HPLC of Formula: 651780-02-8, and with the development of science, more effects of this compound(651780-02-8) can be discovered.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one( cas:7661-33-8 ) is researched.Formula: C10H10ClNO.Waly, Mohamed A.; Yossif, Shiam A.; Ibrahim, Ismail T.; Sofan, Mamdouh A. published the article 《Efficient Synthesis of N-Substituted 2,4-Azepandione Ring System as an Active Intermediate for Heterocyclic Syntheses》 about this compound( cas:7661-33-8 ) in Journal of Heterocyclic Chemistry. Keywords: azepandione preparation; butanoate acetylarylamino ethyl cyclization. Let’s learn more about this compound (cas:7661-33-8).

An improved efficient synthesis for 2,4-azepandiones I [R = H, CH3, Cl; R1 = H, CO2CH3] could be achieved by a careful control of the reaction conditions to cyclize Et 4-(N-acetylarylamino)butanoates 4-R-2-R1C6H3N[(CH2)3CO2CH2CH3]C(O)CH3, resp. Et 4-arylamino butanoates 4-R-2-R1C6H3NH(CH2)3C(O)2CH2CH3 was prepared by stirring the Et 4-bromobutanoate and substituted anilines 4-R-2-R1C6H3NH2 at room temperature Then, they were acetylated with acetyl chloride and triethylamine under the conditions that avoid the formation of 2-pyrrolidinone derivatives II. Due to the rapid decomposition of Et 4-(N-acetylarylamino)butanoates to Et 4-arylaminobutanoates, the reaction mixture was directly transferred without workup to the next cyclization step. The azepandione synthesis was favored by using a weak base at low temperature, where it was in a competition with the other modes of ring closure. The structures of the new compounds were supported by correct anal. and spectral data.

There is still a lot of research devoted to this compound(SMILES：O=C1N(C2=CC=C(Cl)C=C2)CCC1)Formula: C10H10ClNO, and with the development of science, more effects of this compound(7661-33-8) can be discovered.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Quality Control of Dichloro(1,5-cyclooctadiene)platinum(II). The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about Confined Spaces in [n]Cyclo-2,7-pyrenylenes. Author is Grabicki, Niklas; Nguyen, Khoa T. D.; Weidner, Steffen; Dumele, Oliver.

A set of strained aromatic macrocycles based on [n]cyclo-2,7-(4,5,9,10-tetrahydro)pyrenylenes is presented with size-dependent photophys. properties. The K-region of pyrene was functionalized with ethylene glycol groups to decorate the outer rim and thereby confine the space inside the macrocycle. This confined space is especially pronounced for n=5, which leads to an internal binding of up to 8.0×104 M-1 between the ether-decorated [5]cyclo-2,7-pyrenylene and shape-complementary crown ether-cation complexes. Both the ether-decorated [n]cyclo-pyrenylenes as well as one of their host-guest complexes have been structurally characterized by single-crystal X-ray anal. In combination with computational methods the structural and thermodn. reasons for the exceptionally strong binding have been elucidated. The presented rim confinement strategy makes cycloparaphenylenes an attractive supramol. host family with a favorable, size-independent read-out signature and binding capabilities extending beyond fullerene guests.

There is still a lot of research devoted to this compound(SMILES：C1=CCC/C=CCC/1.[Pt+2].[Cl-].[Cl-])Quality Control of Dichloro(1,5-cyclooctadiene)platinum(II), and with the development of science, more effects of this compound(12080-32-9) can be discovered.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

COA of Formula: C8H12Cl2Pt. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about Dynamics of the efficient cyclometalation of the undercoordinated organoplatinum complex [Pt(COD)(neoPh)]+ (neoPh = 2-methyl-2-phenylpropyl). Author is Neugebauer, Michael; Schmitz, Simon; Bruenink, Dana; Doltsinis, Nikos L.; Klein, Axel.

Reaction of the organoplatinum complex [Pt(COD)(neoPh)Cl] (neoPh = (2-methyl-2-phenylpropyl)) with Ag(PF6) leads to the undercoordinated cationic complex [Pt(COD)(neoPh)]+ which rapidly and quant. rearranges to the complex [Pt(COD)(κ2-neoPh)] through intramol. cyclometalation. Detailed NMR spectroscopy and single crystal XRD reveal a doubly metalated neoPh ligand. In line with exptl. observations, ab initio mol. dynamics simulations confirm that the cyclometalation reaction is exothermic and has a relatively low free energy barrier. In addition, the simulations provide detailed insight into the reaction mechanism, showing that an intermediate species exists in which the newly formed Pt-C bond coexists with a covalent Pt-H bond involving the leaving proton. The latter is found to eventually transfer onto an acetone solvent mol.

There is still a lot of research devoted to this compound(SMILES：C1=CCC/C=CCC/1.[Pt+2].[Cl-].[Cl-])COA of Formula: C8H12Cl2Pt, and with the development of science, more effects of this compound(12080-32-9) can be discovered.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 23002-78-0, is researched, SMILESS is CC(C1=CSC(C)=N1)=O, Molecular C6H7NOSJournal, Article, Synlett called An efficient protocol for the oxidative hydrolysis of ketone SAMP hydrazones employing SeO2 and H2O2 under buffered (pH 7) conditions, Author is Smith, Amos B. III; Liu, Zhuqing; Simov, Vladimir, the main research direction is SAMP hydrazone ketone oxidative hydrolysis selenium oxide hydrogen peroxide.Electric Literature of C6H7NOS.

An effective oxidative protocol for the liberation of ketones from SAMP hydrazones employing peroxyselenous acid under aqueous buffered conditions (pH 7) has been developed. The procedure proceeds without epimerization of adjacent stereocenters or dehydration, in representative SAMP alkylation and aldol reaction adducts, resp.

There is still a lot of research devoted to this compound(SMILES：CC(C1=CSC(C)=N1)=O)Electric Literature of C6H7NOS, and with the development of science, more effects of this compound(23002-78-0) can be discovered.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Chemical Communications (Cambridge, United Kingdom) called Transition metal decorated soft nanomaterials through modular self-assembly of an asymmetric hybrid polyoxometalate, Author is Hampson, Elizabeth; Cameron, Jamie M.; Watts, Julie A.; Newton, Graham N., which mentions a compound: 12080-32-9, SMILESS is C1=CCC/C=CCC/1.[Pt+2].[Cl-].[Cl-], Molecular C8H12Cl2Pt, Reference of Dichloro(1,5-cyclooctadiene)platinum(II).

An asym. functionalised Wells-Dawson organic-inorganic hybrid polyoxometalate has been post-functionalised by Pt2+ coordination, and demonstrates self-assembly into surface-decorated micellar nanostructures. This multifunctional hybrid material is found to be a redox-active soft nanomaterial and demonstrates a new mol. design strategy with potential for applications in photo- or electro-catalysis.

There is still a lot of research devoted to this compound(SMILES：C1=CCC/C=CCC/1.[Pt+2].[Cl-].[Cl-])Reference of Dichloro(1,5-cyclooctadiene)platinum(II), and with the development of science, more effects of this compound(12080-32-9) can be discovered.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Quality Control of 1-(4-Chlorophenyl)pyrrolidin-2-one. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Cyclization of ω-halo amides to lactams. Author is Manhas, Maghar S.; Jeng, Stella J..

N-Aryl-β-bromopropionamides and -γ-bromobutyramides, where the aryl group is Ph or 3 α-cholestanyl, are treated with Na in liquid NH3 to give 1 aryl-2-azetidionones (I) (Ar = Ph, o- and p-BrC6H4, etc.) and 1-aryl-2-pyrrolidinones. Lactams are also prepared from bromo amides and NaH in Me2SO and KOBu-tert in Me2SO.

There is still a lot of research devoted to this compound(SMILES：O=C1N(C2=CC=C(Cl)C=C2)CCC1)Quality Control of 1-(4-Chlorophenyl)pyrrolidin-2-one, and with the development of science, more effects of this compound(7661-33-8) can be discovered.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Safety of 1-(4-Chlorophenyl)pyrrolidin-2-one. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Iridium(III)-catalyzed regioselective direct arylation of sp2 C-H bonds with diaryliodonium salts. Author is Gao, Pan; Liu, Li; Shi, Zhuangzhi; Yuan, Yu.

A regioselective direct arylation of arenes and olefins with aryliodonium salts at the ortho position to provide biaryl compounds, e.g., I was reported. The key to the high selectivity was the appropriate choice of aryliodonium salts as the arylating reagent in presence of a cationic iridium(III) catalyst. The coordination of the metal with an oxygen atom or a nitrogen atom and subsequent C-H activation allowed for direct arylation with coupling partners. This reaction proceeded under mild reaction conditions and with a high tolerance of various functional groups including many halide functional groups.

There is still a lot of research devoted to this compound(SMILES：O=C1N(C2=CC=C(Cl)C=C2)CCC1)Safety of 1-(4-Chlorophenyl)pyrrolidin-2-one, and with the development of science, more effects of this compound(7661-33-8) can be discovered.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Organic Chemistry called Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF, Author is Petersen, Trine P.; Larsen, Anders F.; Ritzen, Andreas; Ulven, Trond, which mentions a compound: 16588-26-4, SMILESS is BrC1=C(C=CC(=C1)[N+](=O)[O-])Cl, Molecular C6H3BrClNO2, Formula: C6H3BrClNO2.

A safe, practical, and scalable continuous flow protocol for the in situ generation of dimethylamine from DMF followed by nucleophilic aromatic substitution of a broad range of aromatic and heteroaromatic halides is reported.

There is still a lot of research devoted to this compound(SMILES：BrC1=C(C=CC(=C1)[N+](=O)[O-])Cl)Formula: C6H3BrClNO2, and with the development of science, more effects of this compound(16588-26-4) can be discovered.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts