Author: tianli

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Bromidge, Steven M.; Dabbs, Steven; Davies, David T.; Davies, Susannah; Duckworth, D. Malcolm; Forbes, Ian T.; Gaster, Laramie M.; Ham, Peter; Jones, Graham E.; King, Frank D.; Mulholland, Keith R.; Saunders, Damian V.; Wyman, Paul A.; Blaney, Frank E.; Clarke, Stephen E.; Blackburn, Thomas P.; Holland, Vicky; Kennett, Guy A.; Lightowler, Sean; Middlemiss, Derek N.; Trail, Brenda; Riley, Graham J.; Wood, Martyn D. researched the compound: 3-Bromo-4-chloronitrobenzene( cas:16588-26-4 ).Formula: C6H3BrClNO2.They published the article 《Biarylcarbamoylindolines Are Novel and Selective 5-HT2C Receptor Inverse Agonists: Identification of 5-Methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a Potential Antidepressant/Anxiolytic Agent》 about this compound( cas:16588-26-4 ) in Journal of Medicinal Chemistry. Keywords: biarylcarbamoyl indoline preparation structure 5HT2C agonist; antidepressant anxiolytic biarylcarbamoylindoline serotoninergic agonist. We’ll tell you more about this compound (cas:16588-26-4).

The evolution, synthesis, and biol. activity of a novel series of 5-HT2C receptor inverse agonists are reported. Biarylcarbamoylindolines have been identified with excellent 5-HT2C affinity and selectivity over 5-HT2A receptors. In addition, (pyridyloxypyridyl)carbamoylindolines have been discovered with addnl. selectivity over the closely related 5-HT2B receptor. Compounds from this series are inverse agonists at the human cloned 5-HT2C receptor, completely abolishing basal activity in a functional assay. The new series have reduced P 450 inhibitory liability compared to a previously described series of 1-(3-pyridylcarbamoyl)indolines (Bromidge et al. J. Med. Chem. 1998, 41, 1598) from which they evolved. Compounds from this series showed excellent oral activity in a rat mCPP hypolocomotion model and in animal models of anxiety. On the basis of their favorable biol. profile, SB-228357 and SB-243213 have been selected for further evaluation to determine their therapeutic potential for the treatment of CNS disorders such as depression and anxiety.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Copper-catalyzed C-N coupling of amides and nitrogen-containing heterocycles in the presence of cesium fluoride, published in 2009-12-30, which mentions a compound: 7661-33-8, Name is 1-(4-Chlorophenyl)pyrrolidin-2-one, Molecular C10H10ClNO, Reference of 1-(4-Chlorophenyl)pyrrolidin-2-one.

The copper-catalyzed C-N coupling of amides to aryl halides usually requires the use of strong alkali metal bases, such as K2CO3, K3PO4, and Cs2CO3, at high temperature We discovered that CsF is sufficiently basic to promote the cross-coupling of amides and carbamates with aryl halides. Most aryl iodides coupled in high yield at room temperature This alternative base may be a suitable replacement for substrates that are incompatible with high temperature and strongly basic conditions and can further enhance the chemoselectivity of this reaction.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Hunt, Hazel J.; Belanoff, Joseph K.; Walters, Iain; Gourdet, Benoit; Thomas, Jennifer; Barton, Naomi; Unitt, John; Phillips, Timothy; Swift, Denise; Eaton, Emily researched the compound: 1H-Pyrazole-4-sulfonyl chloride( cas:438630-64-9 ).Product Details of 438630-64-9.They published the article 《Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist》 about this compound( cas:438630-64-9 ) in Journal of Medicinal Chemistry. Keywords: glucocorticoid receptor antagonist CORT125134 preparation Cushing’s. We’ll tell you more about this compound (cas:438630-64-9).

The nonselective glucocorticoid receptor (GR) antagonist mifepristone has been approved in the U.S. for the treatment of selected patients with Cushing’s syndrome. While this drug is highly effective, lack of selectivity for GR leads to unwanted side effects in some patients. Optimization of the previously described fused azadecalin series of selective GR antagonists led to the identification of CORT125134, which is currently being evaluated in a phase 2 clin. study in patients with Cushing’s syndrome.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A Predictive Substrate Model for Rat Glutathione S-Transferase 4-4, published in 1995-08-31, which mentions a compound: 16588-26-4, Name is 3-Bromo-4-chloronitrobenzene, Molecular C6H3BrClNO2, Recommanded Product: 3-Bromo-4-chloronitrobenzene.

Mol. modeling techniques have been used to derive a substrate model for class mu rat glutathione S-transferase 4-4 (GST 4-4). Information on regio- and stereoselective product formation of 20 substrates covering three chem. and structurally different classes was used to construct a substrate model containing three interaction sites responsible for Lewis acid-Lewis base interactions (IS1, IS2, and IS3), as well as a region responsible for aromatic interactions (IS4). Exptl. data suggest that the first protein interaction site (pIS1, interacting with IS1) corresponds with Tyr115, while the other protein interaction sites (pIS2 and pIS3) probably correspond with other Lewis acidic amino acids. All substrates exhibited pos. mol. electrostatic potentials (MEPs) near the site of conjugation with glutathione (GSH), as well as neg. MEP values near the position of groups with Lewis base properties (IS1, IS2, or IS3), which interact with pIS1, pIS2, or pIS3, resp. Obviously, complementarity between the MEPs of substrates and protein in specific regions is important. The substrate specificity and stereoselectivity of GST 4-4 are most likely determined by pIS1 and the distance between the site of GSH attack and Lewis base atoms in the substrates which interact with either pIS2, pIS3, or a combination of these sites. Interaction between aromatic regions in the substrate with aromatic amino acids in the protein further stabilizes the substrate in the active site. The predictive value of the model has been evaluated by rationalizing the conjugation to GSH of 11 substrates of GST 4-4 (representing 3 classes of compounds) which were not used to construct the model. All known metabolites of these substrates are explained with the model. As the computer-aided predictions appear to correlate well with exptl. results, the presented substrate model may be useful to identify new potential GST 4-4 substrates.

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Formula: C10H10ClNO. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Ozonation of tertiary aromatic amines. II. Reactions of N,N-dialkylanilines with diethyl azodicarboxylate and with ozone. Author is Kerr, Geoffrey H.; Meth-Cohen, Otto; Mullock, Ernest B.; Suschitzky, Hans.

Thermolysis of the adduct I from N-phenylpyrrolidine and EtO2CN:NCO2Et gave the isomeric dimers II, which were also formed by ozonation of N-phenylpyrrolidine. The ozonation of 11 other N,N-dialkylanilines and 22-pyrrolylpyridines was also studied.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Mild and Efficient Cobalt-Catalyzed Cross-Coupling of Aliphatic Amides and Aryl Iodides in Water.Safety of 1-(4-Chlorophenyl)pyrrolidin-2-one.

A convenient protocol for the C-N cross-coupling of aliphatic amides and iodobenzene is demonstrated using a simple and inexpensive Co(C2O4)·2H2O/N,N’-dimethylethylenediamine (DMEDA) catalytic system in water. Good yields of N-arylated products I [R1 = Pr, i-Pr, Bu, etc; R2 = Ph, 2-F-C6H4, 4-Me-C6H4, etc.] were isolated (up to 85%) and the protocol has been successfully applied to the synthesis of the anticancer drug, flutamide.

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Zhang, Pengfei; Behl, Marc; Peng, Xingzhou; Balk, Maria; Lendlein, Andreas published the article 《Chemoresponsive Shape-Memory Effect of Rhodium-Phosphine Coordination Polymer Networks》. Keywords: chemoresponsive shape memory rhodium phosphine coordination polymer network.They researched the compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9 ).Safety of Dichloro(1,5-cyclooctadiene)platinum(II). Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:12080-32-9) here.

Chemoresponsive polymers are of technol. significance for smart sensors or systems capable of mol. recognition. An important key requirement for these applications is the material’s structural integrity after stimulation. We explored whether covalently crosslinked metal ion-phosphine coordination polymers (MPN) can be shaped into any temporary shape and are capable of recovering from this upon chemoresponsive exposure to triphenylphosphine (Ph3P) ligands, whereas the MPN provide structural integrity. Depending on the metal-ion concentration used during synthesis of the MPN, the degree of swelling of the coordination polymer networks could be adjusted. Once the MPN was immersed into Ph3P solution, the reversible ligand-exchange reaction between the metal ions and the free Ph3P in solution causes a decrease of the coordination crosslink d. in MPN again. The Ph3P-treated MPN was able to maintain its original shape, indicating a certain stability of shape even after stimulation. In this way, chemoresponsive control of the elastic properties (increase in volume and decrease of mech. strength) of the MPN was demonstrated. This remarkable behavior motivated us to explore whether the MPN are capable of a chemoresponsive shape-memory effect. In initial experiments, shape fixity of around 60% and shape recovery of almost 90% were achieved when the MPN was exposed to Ph3P in case of rhodium. Potential applications for chemoresponsive shape-memory systems could be shapable semiconductors, e.g., for lighting or catalysts, which provide catalytic activity on demand.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Bright Luminescent Platinum(II)-Biaryl Emitters Synthesized Without Air-Sensitive Reagents, published in 2020-04-28, which mentions a compound: 12080-32-9, mainly applied to platinum biaryl emitter synthesis photoluminescence photophys property; ligand design; ligand effects; luminescence; metallacycles; photophysics; platinum, Recommanded Product: Dichloro(1,5-cyclooctadiene)platinum(II).

Transition-metal complexes bearing biaryl-2,2′-diyl ligands tend to show intense luminescence. However, difficulties in synthesis have prevented their further functionalization and practical applications. Herein, a series of platinum(II) complexes bearing biaryl-2,2′-diyl ligands, which have never been prepared in air, were synthesized through transmetalation and successive cyclometalation of biarylboronic acids. This approach does not require any air- or moisture-sensitive reagents and features a simple synthesis even in air. The resulting (Et4N)2[Pt(m,n-F2bph)(CN)2] (m,n-F2bph=m,n-difluorobiphenyl-2,2′-diyl) complexes exhibit intense green emissions with high quantum efficiencies of up to 0.80 at 298 K. The emission spectral fitting and variable-temperature emission lifetime measurements indicate that the high quantum efficiency was achieved because of the tight packing structure and strong σ-donating ability of bph.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Mastrocinque, Francesco; Anderson, Craig M.; Elkafas, Adel M.; Ballard, Isabel V.; Tanski, Joseph M. researched the compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9 ).Safety of Dichloro(1,5-cyclooctadiene)platinum(II).They published the article 《Synthesis, characterization, and photophysical properties of cyclometalated N-Heterocyclic carbene Platinum(II) complexes》 about this compound( cas:12080-32-9 ) in Journal of Organometallic Chemistry. Keywords: platinum cyclometalated thienyl benzothienyl imidazolylidene benzimidazolylidene complex preparation photoluminescence; crystal structure platinum cyclometalated thienyl benzothienyl imidazolylidene benzimidazolylidene complex; mol structure platinum cyclometalated thienyl benzothienyl imidazolylidene benzimidazolylidene complex. We’ll tell you more about this compound (cas:12080-32-9).

Cyclometalated platinum complexes I (R = Me, 3-thienylmethyl; X1, X2 = H, benzo) were prepared by a two-step, one-pot procedure and characterized; the complexes showed photoluminescence at 450-550 nm. Thiophene and benzothiophene ligands containing N-heterocyclic carbene (NHC) moieties were used to synthesize five and six-membered Pt(II) metallacycles. Ligand scaffolding was synthesized using two methods. The ligands were synthesized using a coupling reaction, utilizing Cu2O as the catalyst or were synthesized using a nucleophilic substitution reaction. The ligands were then metalated by chelate-assisted C-H activation. The synthesis, characterization, reactivity, and photophys. properties of these NHC-functionalized, cyclometalated products are reported.

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Category: alcohols-buliding-blocks. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-(2-Methylthiazol-4-yl)ethanone, is researched, Molecular C6H7NOS, CAS is 23002-78-0, about An efficient protocol for the oxidative hydrolysis of ketone SAMP hydrazones employing SeO2 and H2O2 under buffered (pH 7) conditions. Author is Smith, Amos B. III; Liu, Zhuqing; Simov, Vladimir.

An effective oxidative protocol for the liberation of ketones from SAMP hydrazones employing peroxyselenous acid under aqueous buffered conditions (pH 7) has been developed. The procedure proceeds without epimerization of adjacent stereocenters or dehydration, in representative SAMP alkylation and aldol reaction adducts, resp.

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