Author: tianli

Tan, Bryan Yong-Hao; Teo, Yong-Chua published the article 《Mild and Efficient Cobalt-Catalyzed Cross-Coupling of Aliphatic Amides and Aryl Iodides in Water》. Keywords: aryl iodide aliphatic amide cross coupling cobalt catalyst water; arylamide flutamide preparation.They researched the compound: 1-(4-Chlorophenyl)pyrrolidin-2-one( cas:7661-33-8 ).Related Products of 7661-33-8. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:7661-33-8) here.

A convenient protocol for the C-N cross-coupling of aliphatic amides and iodobenzene is demonstrated using a simple and inexpensive Co(C2O4)·2H2O/N,N’-dimethylethylenediamine (DMEDA) catalytic system in water. Good yields of N-arylated products I [R1 = Pr, i-Pr, Bu, etc; R2 = Ph, 2-F-C6H4, 4-Me-C6H4, etc.] were isolated (up to 85%) and the protocol has been successfully applied to the synthesis of the anticancer drug, flutamide.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Shook, Brian C.; Chakravarty, Devraj; Barbay, J. Kent; Wang, Aihua; Leonard, Kristi; Alford, Vernon; Powell, Mark T.; Rassnick, Stefanie; Scannevin, Robert H.; Carroll, Karen; Wallace, Nathaniel; Crooke, Jeffrey; Ault, Mark; Lampron, Lisa; Westover, Lori; Rhodes, Kenneth; Jackson, Paul F. researched the compound: Pyridine-3,5-dicarbonitrile( cas:1195-58-0 ).Recommanded Product: 1195-58-0.They published the article 《Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists》 about this compound( cas:1195-58-0 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: thienopyrimidine preparation adenosine A2A antagonist. We’ll tell you more about this compound (cas:1195-58-0).

A novel series of benzyl substituted thieno[2,3-d]pyrimidines, e.g. I, were identified as potent A2A receptor antagonists. Several five- and six-membered heterocyclic replacements for the optimized methylfuran were explored. Select compounds effectively reverse catalepsy in mice when dosed orally.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Dihydropyridines. V. Formation of the isomeric 1,2- and 1,4-dihydro derivatives in the reaction of methylmagnesinm iodide with 3,5-dicyanopyridine and 3,5-dicyano-2-methylpyridine》. Authors are Kuthan, J.; Janeckova, E.; Havel, M..The article about the compound:Pyridine-3,5-dicarbonitrilecas:1195-58-0,SMILESS:N#CC1=CC(C#N)=CN=C1).Quality Control of Pyridine-3,5-dicarbonitrile. Through the article, more information about this compound (cas:1195-58-0) is conveyed.

cf. CA 58, 5626a. MeMgI adds to 3,5-dicyanopyridine (I) to give 3,5-dicyano-2-methyl-1,2-dihydropyridine (II) and 3,5-dicyano-4-methyl-1,4-dihydropyridine (III). Similarly, 3,5-dicyano-2-methylpyridine (IV) forms 3,5-dicyano-2,6-dimethyl-1,2-dihydropyridine (V) and 3,5-dicyano-2,4-dimethyl-1,4-dihydropyridine (VI), resp. Nicotinoyl chloride-HCl (from 500 g. nicotinoic acid and 1400 ml. SOCl2) refluxed 35 hrs. with 500 ml. Br, the mixture evaporated on a steam bath, the residue dissolved in 1 l. absolute EtOH, and the solution heated 30 min. on a steam bath gave 81% HBr salt of Et 5-bromonicotinate, m. 147-7.5° (EtOH), from which 80% Et 5-bromonicotinate (VII), b0.5 86-92°, m. 42°, was obtained by treatment with Na2CO3. VII (50 g.) stirred with 30 g. CuCN in 50 ml. HCONMe2 2 hrs. at 160-75°, the mixt evaporated in vacuo, and the residue shaken with 500 ml. concentrated NH4OH and extracted successively with 800 ml. C6H6 and 200 ml. Et2O gave after evaporation 45% Et 5-cyanonicotinate (VIII), b16 143-5°, m. 89-90° (petr. ether). VIII (50 g.) in 1 l. absolute EtOH saturated with NH3 kept 7 days at room temperature gave 72% 5-cyanonicotinamide (IX), m. 220-1° (H2O, EtOH). A mixture of 14 g. IX and 40 ml. anhydrous C5H5N treated over 15 min. with 9 ml. POCl3, stirred 8 hrs., decomposed with ice, alkalized with NH4OH, and extracted with CHCl3 gave 64% I, m. 113-13.5° (dilute EtOH), sublimed 80-90°/10 mm. K salt of 2-hydroxy-3,5-dicyano-6-methylpyridine (6.07 g.) and 7 g. PCl5 treated with 10 ml. POCl3, and the mixture refluxed 30 min., evaporated in vacuo, decomposed with ice, and extracted with C6H6 gave 35% 3,5-dicyano-2-chloro-6-methylpyridine, m. 143-3.5°, which gave IV, m. 76-7°, on catalytic hydrogenation. Reaction of 1.04 g. I in 70 ml. Et2O with MeMgI (from 0.8 g. Mg, 2 ml. MeI, and 30 ml. Et2O) followed by chromatography on Al2O3 (activity II) gave 512 mg. yellow II, m. 114-15° (C6H6, dilute EtOH), and 240 mg. yellowish III, m. 180.5-81° (dilute EtOH). Similarly, 670 mg. IV with MeMgI (from 0.72 g. Mg, 1.9 ml. MeI, and 25 ml. Et2O) afforded 405 mg. yellow V, m. 152-3° (dilute MeOH), and 138 mg. yellowish VI, m. 129.5-30.5°. Dehydrogenation of II, III, V, and VI by heating with equal amounts 30% Pd-C 20 min. at 200-5° gave IV, 3,5-dicyano-4-methylpyridine, m. 84.5-85°, 3,5-dicyano-2,6-dimethylpyridine, m. 118-18.5°, and 3,5-dicyano-2,4-dimethylpyridine, m. 115-15.5°, resp. Ultraviolet and infrared data for II, III, V, and VI, and of some of the intermediates, are given.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 12080-32-9, is researched, Molecular C8H12Cl2Pt, about Manipulations of Chiroptical Properties in Belt-Persistent Cycloarylenes via Desymmetrization with Heteroatom Doping, the main research direction is cycloarylene preparation dipole moment fluorescence UV spectrum CD; chirality; circular dichroism; cylinders; macrocycles; nanotubes.Formula: C8H12Cl2Pt.

A desymmetrization strategy has been devised in the design of mol. cylinders to maximize the dissymmetry factor relevant to circularly polarized light. Although the highest dissymmetry factor of organic mols. was previously achieved with a chiral belt-persistent cycloarylene having magnetic and elec. transition dipole moments in parallel, we noticed that an unbalanced magnitude of two moments was detrimental for higher dissymmetry factors. In this study, a mol. cylinder was desymmetrized by arraying doped and undoped panels via stereoselective cross-coupling macrocyclization. The desymmetrization succeeded in balancing two moments by reducing the elec. transition moment at the global min. but failed to maximize the dissymmetry factor. Structural studies revealed that the dissymmetry factor is sensitive to subtle structural fluctuations, while the rotatory strength is not affected. This study is important for the development of chiroptical materials.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(2-Methylthiazol-4-yl)ethanone(SMILESS: CC(C1=CSC(C)=N1)=O,cas:23002-78-0) is researched.Product Details of 438630-64-9. The article 《Selenium heterocycles. XXXVII. Synthesis of 4-(thiazol-4-yl)-1,2,3-selenadiazoles and 4-(selenazol-4-yl)-1,2,3-selenadiazoles》 in relation to this compound, is published in Journal of Heterocyclic Chemistry. Let’s take a look at the latest research on this compound (cas:23002-78-0).

Starting from readily available 2-substituted-4-formylthiazoles and selenazoles, a series of selenazolylselenadiazoles I (R = e.g. Ph, 4-MeOC6H4, 4-BrC6H4; X = Se) and thiazolylselenadiazoles I (X = S) were prepared Pyrolysis of compound I (X = S) afforded thiazolylacetylenes II. Addition of KOH pellets to an alc. solution of I (X = S) gave diselenafulvenes III. Decomposition of compound I (X = S) with base followed by the addition of CS2 gave thiazolylthioxothiaselenoles IV.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 438630-64-9, is researched, SMILESS is ClS(=O)(=O)C1=CNN=C1, Molecular C3H3ClN2O2SJournal, Organic Chemistry Frontiers called A robust and facile method for desulfonation to amines, Author is Li, Chen; Huang, Yilei; Cao, Sheng; Luo, Yunhao; Zhang, Ying; Yang, Guang, the main research direction is amine preparation; aromatic aliphatic sulfonamide desulfonation.Product Details of 438630-64-9.

In this study, a robust and facile method for desulfonation to achieve secondary amines is demonstrated. Diphenylphosphine (Ph2PH) was shown to significantly expedite the cleavage of sulfonamides under basic conditions. Aromatic and aliphatic sulfonamides were cleanly converted, with a rapid reaction time, into the required amines with good to excellent chem. yields. Moreover, the functional groups tested were generally well tolerated.

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Computed Properties of C10H10ClNO. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Ozonation of tertiary aromatic amines. II. Reactions of N,N-dialkylanilines with diethyl azodicarboxylate and with ozone.

Thermolysis of the adduct I from N-phenylpyrrolidine and EtO2CN:NCO2Et gave the isomeric dimers II, which were also formed by ozonation of N-phenylpyrrolidine. The ozonation of 11 other N,N-dialkylanilines and 22-pyrrolylpyridines was also studied.

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Angel-Jijon, Carlos; Rendon-Nava, David; Vazques-Perez, Jose M.; Alvarez-Hernandez, Alejandro; Mendoza-Espinosa, Daniel; Salazar-Pereda, Veronica published an article about the compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9,SMILESS:C1=CCC/C=CCC/1.[Pt+2].[Cl-].[Cl-] ).Related Products of 12080-32-9. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:12080-32-9) through the article.

Treatment of NHC-AuCl (NHC = IPr and IMes) complexes with equimolar amounts of KTpR2 (R = Me, H) salts in THF produces in high yields the heteroleptic complexes 3-6 with the general formula NHC-Au-TpR2. As the TpR ligand in complexes 3-6 features a k1-N type coordination toward the gold(I) center, the subsequent addition of group 10 and 11 metal precursors (NiII, PtII, CuII) results in the isolation of heterobimetallic Au/M complexes supported by TpR platforms. All new metal complexes have been fully characterized by elemental anal. and NMR spectroscopy, and in the case of 3, 4 and 6 by X-ray crystallog.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Hartman, Tomas; Sturala, Jiri; Cibulka, Radek researched the compound: Pyridine-3,5-dicarbonitrile( cas:1195-58-0 ).Synthetic Route of C7H3N3.They published the article 《Two-Phase Oxidations with Aqueous Hydrogen Peroxide Catalyzed by Amphiphilic Pyridinium and Diazinium Salts》 about this compound( cas:1195-58-0 ) in Advanced Synthesis & Catalysis. Keywords: green chem oxidation amphiphilic pyridinium diazinium salt catalyst; oxidation aqueous hydrogen peroxide amphiphilic pyridinium diazinium salt catalyst. We’ll tell you more about this compound (cas:1195-58-0).

Amphiphilic pyridinium and diazinium salts were shown to be effective catalysts in two-phase (water/chloroform or water/dichloromethane) sulfoxidations and N-oxidations with hydrogen peroxide under mild conditions. This unprecedented oxidation method utilizes covalent bonding of hydrogen peroxide to a simple pyridinium or diazinium nucleus to increase the lipophilicity of the hydroperoxide species and to subsequently activate it for oxidations in a non-polar medium. The catalytic efficiency was found to depend on the type of heteroarenium core and on the lipophilicity of the catalyst. Five series of heteroarenium catalysts were prepared and investigated: 1-Alkyl-3,5-dicyanopyridinium, 1-alkyl-3,5-dinitropyridinium, 1-alkyl-3-cyanopyrazinium, 1-alkyl-4-cyanopyrimidinium and 1-alkyl-4-(trifluoromethyl)pyrimidinium triflates (alkyl=butyl, hexyl, octyl, decyl, dodecyl and hexadecyl). Among them, the 1-octyl-3,5-dinitropyridinium and 1-decyl-4-(trifluoromethyl)pyrimidinium triflates were found to be superior catalysts, showing the best stability and the highest catalytic activity, achieving acceleration by a factor of 350 relative to the non-catalyzed reaction. In contrast to other organocatalytic two-phase oxidations that use hydrogen peroxide, the presented method is characterized by high chemoselectivity and low catalyst loading (5 mol%) and with the reactions being performed under mild conditions, i.e., at 25° using diluted hydrogen peroxide and a non-basic aqueous phase. The catalysts have simple structures and are readily available from com. materials. Practical applications are demonstrated via the oxidation of several types of sulfides and amines.

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Category: alcohols-buliding-blocks. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 3-Bromo-4-chloronitrobenzene, is researched, Molecular C6H3BrClNO2, CAS is 16588-26-4, about Ligand-free Suzuki-Miyaura cross-coupling with low Pd content: rapid development by a fluorescence-based high-throughput screening method. Author is Lim, Taeho; Ryoo, Jeong Yup; Jang, Mingyeong; Han, Min Su.

In this study, a highly efficient Suzuki-Miyaura (SM) cross-coupling was developed using metal oxide catalysts: 0.02 mol% Pd, aqueous solvent, no ligand, and room temperature Metal oxides containing low Pd content (ppm scale) were prepared by a simple co-precipitation method and used as a catalyst for the SM reaction. A fluorescence-based high-throughput screening (HTS) method was developed for the rapid evaluation of catalytic activity and reaction conditions. Among the various metal oxides, Pd/Fe2O3 showed the highest activity for the SM reaction. After further optimization by HTS, various biaryl compounds RR1 (R = 2-formylphenyl, 4-fluorophenyl, 2-chloro-5-nitrophenyl, etc.; R1 = Ph, 6-methoxynaphthalen-2-yl, pyren-1-yl, 4-fluoro-2-methylphenyl) were obtained under optimal conditions: Pd/Fe2O3 (0.02 mol% Pd) in aqueous ethanol at mild temperature without any ligands.

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