Month: December 2022

Ono, Masako et al. published their research in Eisei Shikensho Hokoku in 1973 | CAS: 52010-89-6

2,5-Dihydroxy-4-methylbenzaldehyde (cas: 52010-89-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Related Products of 52010-89-6

Hallucinogens. IV. Synthesis of 2,5-dimethoxy-4-methylamphetamine was written by Ono, Masako;Shimamine, Mochihiko;Takahashi, Kazunori. And the article was included in Eisei Shikensho Hokoku in 1973.Related Products of 52010-89-6 The following contents are mentioned in the article:

2,5-Dimethoxy-4-methylamphetamine (I) was prepared The J. C. Duff method was improved to give 2-hydroxy-4-methylbenzaldehyde from m-cresol and hexamine; the reaction temperature was 140°. 2,5-Dihydroxy-4-methylbenzaldehyde (II) was obtained by the J. Renz method and methylation of II with Me2SO4 in alk. solution afforded 2,5-dimethoxy-4-methylbenzaldehyde (III). Reaction of III with EtNO2 in the presence of AcONH4 gave 1-(2,5-dimethoxy-4-methylphenyl)-2-nitropropene (IV). Reduction of IV with LiAlH4 afforded I and its hydrochloride. This study involved multiple reactions and reactants, such as 2,5-Dihydroxy-4-methylbenzaldehyde (cas: 52010-89-6Related Products of 52010-89-6).

2,5-Dihydroxy-4-methylbenzaldehyde (cas: 52010-89-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Related Products of 52010-89-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Wei-lu et al. published their research in Changchun Gongye Daxue Xuebao, Ziran Kexueban in 2006 | CAS: 115-84-4

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C9H20O2

Kinetics in the AA/TMPD and AA/BEPD reaction system was written by Zhang, Wei-lu;Zhang, Dong;Zhao, Ya-juan. And the article was included in Changchun Gongye Daxue Xuebao, Ziran Kexueban in 2006.Formula: C9H20O2 The following contents are mentioned in the article:

The removal of the byproduct, water, during polyesterification process between diacids and diols may have some effects on the kinetics parameters. Concerning the effects, kinetics parameters in AA/BEPD and AA/TMPD systems, such as rate constant-k’, activation energy-E’ and re-exponential factor-A’ are calculated Then they are compared with the one which neglects the effects. Results show that the relative errors between the two will increase when the temperature raise. Especially in the high temperature, the error may increase to 12%. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Formula: C9H20O2).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C9H20O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Blake, James F. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2014 | CAS: 496856-52-1

(S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol (cas: 496856-52-1) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Synthetic Route of C8H9ClFNO

Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2 was written by Blake, James F.;Gaudino, John J.;De Meese, Jason;Mohr, Peter;Chicarelli, Mark;Tian, Hongqi;Garrey, Rustam;Thomas, Allen;Siedem, Christopher S.;Welch, Michael B.;Kolakowski, Gabrielle;Kaus, Robert;Burkard, Michael;Martinson, Matthew;Chen, Huifen;Dean, Brian;Dudley, Danette A.;Gould, Stephen E.;Pacheco, Patricia;Shahidi-Latham, Sheerin;Wang, Weiru;West, Kristina;Yin, Jianping;Moffat, John;Schwarz, Jacob B.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.Synthetic Route of C8H9ClFNO The following contents are mentioned in the article:

The discovery and optimization of a series of tetrahydropyridopyrimidine based extracellular signal-regulated kinase (Erks) inhibitors discovered via HTS and structure based drug design is reported. The compounds demonstrate potent and selective inhibition of Erk2 and knockdown of phospho-RSK levels in HepG2 cells and tumor xenografts. Proliferation of HCT116 (K-RasG12D) and A375 (BRafV600E) cell lines was inhibited by compound (I) with EC50s of 0.74 and 0.39 μM, resp. Pharmacokinetic parameters of I are given. This study involved multiple reactions and reactants, such as (S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol (cas: 496856-52-1Synthetic Route of C8H9ClFNO).

(S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol (cas: 496856-52-1) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Synthetic Route of C8H9ClFNO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Herron, Alastair N. et al. published their research in Organic Letters in 2022 | CAS: 106-21-8

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Name: 3,7-Dimethyloctan-1-ol

δ-C-H Halogenation Reactions Enabled by a Nitrogen-Centered Radical Precursor was written by Herron, Alastair N.;Hsu, Ching-Pei;Yu, Jin-Quan. And the article was included in Organic Letters in 2022.Name: 3,7-Dimethyloctan-1-ol The following contents are mentioned in the article:

Herein, new hydrazonyl carboxylic acids RN(S(O)2R1)N=C(Me)C(O)OH (R = octyl, 2-(adamantan-1-yl)ethyl, 4-methylpentyl, etc.; R1 = 4-methylphenyl, 4-methoxyphenyl, 4-bromophenyl, 4-(trifluoromethyl)phenyl) precursor to nitrogen-centered radicals and its application toward remote C-H fluorination and chlorination reactions of sulfonyl-protected alkyl amines R1S(O)2NHR2 (R2 = 4-fluorooctyl, 2-(2-fluorocyclobutyl)ethyl, 4-fluoro-4-methylpentyl, etc.) via 1,5-HAT were disclosed. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Name: 3,7-Dimethyloctan-1-ol).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Name: 3,7-Dimethyloctan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shi, Bin et al. published their research in Angewandte Chemie, International Edition in 2022 | CAS: 923-61-5

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate

Synthesis of Chiral Endocyclic Allenes by Palladium-Catalyzed Asymmetric Annulation Followed by Cope Rearrangement was written by Shi, Bin;Liu, Jia-Bin;Wang, Ze-Tian;Wang, Liang;Lan, Yu;Lu, Liang-Qiu;Xiao, Wen-Jing. And the article was included in Angewandte Chemie, International Edition in 2022.Recommanded Product: (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate The following contents are mentioned in the article:

Catalytic asym. synthesis of chiral endocyclic allenes remains a challenge in allene chem. owing to unfavored tension and complex chirality. Here,a new relay strategy merging Pd-catalyzed asym. [3+2] annulation with enyne-Cope rearrangement, providing a facile route to chiral 9-membered endocyclic allenes with high efficiency and enantioselectivity was presented. Moreover, theor. calculations and exptl. studies were performed to illustrate the critical, but unusual Cope rearrangement that allows for the complete central-to-axial chirality transfer. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Recommanded Product: (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate).

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vaahtio, Marja et al. published their research in European Coatings Journal in 1998 | CAS: 115-84-4

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Safety of 2-Butyl-2-ethylpropane-1,3-diol

Use of 2-butyl-2-ethyl-1,3-propanediol in polyester resins for coil coatings was written by Vaahtio, Marja. And the article was included in European Coatings Journal in 1998.Safety of 2-Butyl-2-ethylpropane-1,3-diol The following contents are mentioned in the article:

A report on the phys. properties of polyester resins and coatings containing different amounts of 2-butyl-2-ethyl-1,3-propanediol and 1,6-hexanediol is given. Topics include the synthesis of the resins, phys. properties of the resins (e.g. glass transition temperature, hydroxyl values) and the coatings (e.g. viscosity, flexibility vs. hardness, weathering, stain and MEK-rub resistance), and a brief discussion of the exptl. obtained results. Moreover, the effect of addnl. adipic acid, for enhanced flexibility, on the coating properties was determined This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Safety of 2-Butyl-2-ethylpropane-1,3-diol).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Safety of 2-Butyl-2-ethylpropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cao, Jingsong’s team published research in Molecular Therapy in 2019-07-03 | CAS: 97-67-6

Molecular Therapy published new progress about Body weight. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, COA of Formula: C4H6O5.

Cao, Jingsong published the artcilemRNA Therapy Improves Metabolic and Behavioral Abnormalities in a Murine Model of Citrin Deficiency, COA of Formula: C4H6O5, the main research area is metabolic behavioral abnormality citrin deficiency mRNA lipid nanoparticle.

Citrin deficiency is an autosomal recessive disorder caused by loss-of-function mutations in SLC25A13, encoding the liver-specific mitochondrial aspartate/glutamate transporter. It has a broad spectrum of clin. phenotypes, including life-threatening neurol. complications. Conventional protein replacement therapy is not an option for these patients because of drug delivery hurdles, and current gene therapy approaches (e.g., AAV) have been hampered by immunogenicity and genotoxicity. Although dietary approaches have shown some benefits in managing citrin deficiency, the only curative treatment option for these patients is liver transplantation, which is high-risk and associated with long-term complications because of chronic immunosuppression. To develop a new class of therapy for citrin deficiency, codon-optimized mRNA encoding human citrin (hCitrin) was encapsulated in lipid nanoparticles (LNPs). We demonstrate the efficacy of hCitrin-mRNA-LNP therapy in cultured human cells and in a murine model of citrin deficiency that resembles the human condition. Of note, i.v. (i.v.) administration of the hCitrin-mRNA resulted in a significant reduction in (1) hepatic citrulline and blood ammonia levels following oral sucrose challenge and (2) sucrose aversion, hallmarks of hCitrin deficiency. In conclusion, mRNA-LNP therapy could have a significant therapeutic effect on the treatment of citrin deficiency and other mitochondrial enzymopathies with limited treatment options.

Molecular Therapy published new progress about Body weight. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, COA of Formula: C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Kai’s team published research in Journal of Computer-Aided Molecular Design in 2019-03-31 | CAS: 111-87-5

Journal of Computer-Aided Molecular Design published new progress about Dipole. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Liu, Kai published the artcileUncovering abnormal changes in logP after fluorination using molecular dynamics simulations, Recommanded Product: n-Octanol, the main research area is mol dynamics simulations; Fluorination; Molecular dynamics; Solvation free energy calculation; logP.

The fluorination-induced changes in the logP (1-octanol/water partition coefficient) of ligands were examined by mol. dynamics simulations. The protocol and force field parameters were first evaluated by calculating the logP values for n-alkanes, and their monofluorinated and monochlorinated analogs. Then, the logP values of several test sets (1-butanol, 3-propyl-1H-indole, and analogs fluorinated at the terminal Me group) were calculated The calculated results agree well with experiment, and the root mean square error values are 0.61 and 0.68 log units for the GAFF and GAFF2 force fields, resp. Finally, the logP estimation was extended to a drug mol., TAK-438, for which fluorination-induced abnormal logP reduction has been observed exptl. This abnormal change was qual. reproduced by the mol. dynamics simulations. We found that the abnormal logP reduction can be mainly attributed to the effect of fluorination-induced dipole change. Our results suggest that mol. simulation is a useful strategy to predict the fluorination-induced change in logP for drug discovery applications.

Journal of Computer-Aided Molecular Design published new progress about Dipole. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Jing’s team published research in Bioresource Technology in 2016-07-31 | CAS: 58783-82-7

Bioresource Technology published new progress about Aromatic hydrocarbons Role: PRP (Properties), TEM (Technical or Engineered Material Use), USES (Uses). 58783-82-7 belongs to class alcohols-buliding-blocks, name is 5-Tridecanol, and the molecular formula is C13H28O, SDS of cas: 58783-82-7.

Yang, Jing published the artcileHigh-quality bio-oil from one-pot catalytic hydrocracking of kraft lignin over supported noble metal catalysts in isopropanol system, SDS of cas: 58783-82-7, the main research area is kraft lignin isopropanol metal catalyst bio oil catalytic hydrocracking; Hydrocracking; Isopropanol; Kraft lignin; Nobel metal catalysts; Orthogonal array design.

Catalytic hydrocracking of kraft lignin was carried out in isopropanol system and an orthogonal array design (OAD) was employed to optimize the exptl. conditions. GC-MS/FID, elemental anal., GPC and 1H-13C HSQC NMR were carried out for entire investigation of the liquid products. The results indicated that the hydrocracking process was thermally controlled and catalysts showed significant influences on the product distributions. Comparing with Pd/C, Pt/C and Ru/C, Rh/C inhibited the self-condensation of isopropanol and reduced the formation of oxygenic-chain compounds The excellent catalytic activity for phenols conversion was obtained over Rh/C. The routes of oxygenic-chain compounds formation and phenol conversion were proposed in detail. The least oxygenic-chain compounds formation, the highest phenols conversion (93.4%), the lowest O/C ratio (0.094) and the highest HHV (37.969 MJ/kg) provided the possibility of the high quality bio-oil obtained over Rh/C in isopropanol medium.

Bioresource Technology published new progress about Aromatic hydrocarbons Role: PRP (Properties), TEM (Technical or Engineered Material Use), USES (Uses). 58783-82-7 belongs to class alcohols-buliding-blocks, name is 5-Tridecanol, and the molecular formula is C13H28O, SDS of cas: 58783-82-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Panikashvili, David’s team published research in Plant Physiology in 2007-12-31 | CAS: 13099-34-8

Plant Physiology published new progress about Alkanes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (in wax monomers). 13099-34-8 belongs to class alcohols-buliding-blocks, name is 17-Hydroxyheptadecanoic acid, and the molecular formula is C17H34O3, COA of Formula: C17H34O3.

Panikashvili, David published the artcileThe Arabidopsis DESPERADO/AtWBC11 transporter is required for cutin and wax secretion, COA of Formula: C17H34O3, the main research area is Arabidopsis DSO transport protein cutin wax secretion.

The cuticle fulfills multiple roles in the plant life cycle, including protection from environmental stresses and the regulation of organ fusion. It is largely composed of cutin, which consists of C16-18 fatty acids. While cutin composition and biosynthesis have been studied, the export of cutin monomers out of the epidermis has remained elusive. Here, we show that DESPERADO (AtWBC11) (abbreviated DSO), encoding a plasma membrane-localized ATP-binding cassette transporter, is required for cutin transport to the extracellular matrix. The dso mutant exhibits an array of surface defects suggesting an abnormally functioning cuticle. This was accompanied by dramatic alterations in the levels of cutin monomers. Moreover, electron microscopy revealed unusual lipidic cytoplasmatic inclusions in epidermal cells, disappearance of the cuticle in postgenital fusion areas, and altered morphol. of trichomes and pavement cells. We also found that DSO is induced by salt, abscisic acid, and wounding stresses and its loss of function results in plants that are highly susceptible to salt and display reduced root branching. Thus, DSO is not only essential for developmental plasticity but also plays a vital role in stress responses.

Plant Physiology published new progress about Alkanes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (in wax monomers). 13099-34-8 belongs to class alcohols-buliding-blocks, name is 17-Hydroxyheptadecanoic acid, and the molecular formula is C17H34O3, COA of Formula: C17H34O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts