Month: November 2022

Category: alcohols-buliding-blocksIn 2022 ,《δ-C-H Halogenation Reactions Enabled by a Nitrogen-Centered Radical Precursor》 was published in Organic Letters. The article was written by Herron, Alastair N.; Hsu, Ching-Pei; Yu, Jin-Quan. The article contains the following contents:

Herein, new hydrazonyl carboxylic acids RN(S(O)2R1)N=C(Me)C(O)OH (R = octyl, 2-(adamantan-1-yl)ethyl, 4-methylpentyl, etc.; R1 = 4-methylphenyl, 4-methoxyphenyl, 4-bromophenyl, 4-(trifluoromethyl)phenyl) precursor to nitrogen-centered radicals and its application toward remote C-H fluorination and chlorination reactions of sulfonyl-protected alkyl amines R1S(O)2NHR2 (R2 = 4-fluorooctyl, 2-(2-fluorocyclobutyl)ethyl, 4-fluoro-4-methylpentyl, etc.) via 1,5-HAT were disclosed.6-Aminohexan-1-ol(cas: 4048-33-3Category: alcohols-buliding-blocks) was used in this study.

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Category: alcohols-buliding-blocks

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Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrateIn 2021 ,《Selectivity between an Alder-ene reaction and a [2+2] cycloaddition in the intramolecular reactions of allene-tethered arynes》 was published in Organic Chemistry Frontiers. The article was written by Le, Anh; Lee, Daesung. The article contains the following contents:

Substituent-dependent reactivity and selectivity in the intramol. reactions of arynes tethered with an allene were described. With a 1,3-disubstituted allene moiety, an Alder-ene reaction of an allenic C-H bond was preferred over a [2+2] cycloaddition, whereas a [2+2] cycloaddition of the terminal π-bond of the allene was preferred with a 1,1-disubstituted allene. With a 1,1,3-trisubstituted allene-tethered aryne, an Alder-ene reaction with an allylic C-H bond was preferred over a [2+2] cycloaddition After reading the article, we found that the author used Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate As a Biuret reagent, it is used to measure the protein concentration. Furthermore, it is used as laxative and is also used in food industry.

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Application In Synthesis of 2-Hydroxyphenylboronic acidIn 2020 ,《Tandem Suzuki Coupling/Intramolecular Oxetane Ring Opening to Form Polycyclic Ring Systems》 was published in Organic Letters. The article was written by DeRatt, Lindsey G.; Lawson, Edward C.; Kumar, Kiran; Hwang, Soyon S.; DesJarlais, Renee L.; Kuduk, Scott D.. The article contains the following contents:

A tandem one-pot reaction featuring a cross-coupling followed by an intramol. oxetane ring opening by mild nucleophiles is reported. The overall transformation comprises a carbon-carbon bond formation along with a carbon-heteroatom bond construction providing diverse multicyclic ring systems with a pendant hydroxymethyl handle for further elaboration. This approach constitutes a convergent method for rapid access to various scaffolds. Furthermore, a comparison of computed low-energy conformers is presented to rationalize instances in which cyclization was not observed In the experiment, the researchers used many compounds, for example, 2-Hydroxyphenylboronic acid(cas: 89466-08-0Application In Synthesis of 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA), a synthetic molecule applied in RNA affinity chromatography, is able to form reversible covalent ester bonds with 1,2- or 1,3-cis-doils on the ribose ringApplication In Synthesis of 2-Hydroxyphenylboronic acid

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Product Details of 1195-59-1In 2021 ,《Azine-N-oxides as effective controlling groups for Rh-catalyzed intermolecular alkyne hydroacylation》 was published in Chemical Science. The article was written by Moseley, Daniel F.; Kalepu, Jagadeesh; Willis, Michael C.. The article contains the following contents:

Azine N-oxide substituted aldehydes are used as highly effective substrates with good reactivity for intermol. hydroacylation of alkynes. Employing a Rh(I)-catalyst, a mild and scalable aldehyde C-H activation, that permits the coupling with unactivated terminal alkynes was achieved in good yields and with high regioselectivities (up to >20 : 1 l:b). Both substrates can tolerate a broad variety of functional groups. The reaction can also be applied to diazine aldehydes that contain a free N-lone pair. Conversion of the hydroacylation products to the corresponding azine, through a one-pot hydroacylation/deoxygenation sequence was also demonstrated. A one-pot hydroacylation/cyclization, using N-Boc propargylamine, addnl. leads to the synthesis of a bidentate pyrrolyl ligand. In the part of experimental materials, we found many familiar compounds, such as 2,6-Pyridinedimethanol(cas: 1195-59-1Product Details of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Product Details of 1195-59-1

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Related Products of 100-83-4In 2019 ,《[AcMIM]FeCl4: A Magnetically Separable Organocatalyst for the Clean Synthesis of Tetrahydrobenzo[b]pyran Derivatives》 was published in Current Organocatalysis. The article was written by Saha, Arijit; Payra, Soumen; Asatkar, Archana; Patel, Ashok Raj; Banerjee, Subhash. The article contains the following contents:

A facile and convenient methodol. has been developed for the synthesis of bio-active tetrahydrobenzo[b]pyran derivatives I (R = H, 3-Cl, 4-NO2, 3,4-(OCH3)2, etc.) using [AcMIm]FeCl4 ionic liquid as an sufficient and reusable magnetically separable oganocatalyst under environment-benign conditions. In the experiment, the researchers used 3-Hydroxybenzaldehyde(cas: 100-83-4Related Products of 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Related Products of 100-83-4

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Alcohol – Wikipedia,
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《A new catalytic approach for aerobic oxidation of primary alcohols based on a Copper(I)-thiophene carbaldimines》 was written by Lagerspets, Emi; Valbonetti, Evelyn; Eronen, Aleksi; Repo, Timo. Application of 1195-59-1This research focused onthiophenyl methanimine preparation; primary alc copper thiophenyl methanimine catalyst oxidation; diol copper thiophenyl methanimine catalyst oxidation. The article conveys some information:

Novel Cu(I) thiophene carbaldimine catalysts for the selective aerobic oxidation of primary alcs. to their corresponding aldehydes and various diols to lactones or lactols was reported. In the presence of the in-situ generated Cu(I) species, a persistent radical (2,2,6,6-tetramethylpiperdine-N-oxyl (TEMPO)) and N-methylimidazole (NMI) as an auxiliary ligand, the reaction proceeds under aerobic conditions and at ambient temperature Especially the catalytic system of 1-(thiophen-2-yl)-N-(4-(trifluoromethoxy)phenyl)methanimine with copper(I)-iodide showed high reactivity for all kind of alcs. (benzylic, allylic and aliphatic). In the case of benzyl alc. even 2.5 mol% of copper loading gave quant. yield. Beside high activity under aerobic conditions, the catalysts ability to oxidize 1,5-pentadiol to the corresponding lactol (86% in 4 h) and N-phenyldiethanolamine to the corresponding morpholine derivate lactol (86% in 24 h) is particularly noteworthy. In the experimental materials used by the author, we found 2,6-Pyridinedimethanol(cas: 1195-59-1Application of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Application of 1195-59-1

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Alcohol – Wikipedia,
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《A new preparative method for optically active diarylcarbinols》 was published in Tetrahedron: Asymmetry in 1991. These research results belong to Toda, Fumio; Tanaka, Koichis; Koshiro, Kenzo. Related Products of 63012-03-3 The article mentions the following:

Diarylcarbinols RC6H4CHPhOH (I; R = 3-Me, 4-Me, 3-Cl, 4-Cl, 3-Br, 4-Br, 3-MeO, 3-NO2, 4-NO2) were resolved by complexation with brucine. Me3CCHPhOH and Cl3CCHPhOH were resolved similarly, but ortho isomers of I were not resolved, although they also formed complexes with brucine. The experimental part of the paper was very detailed, including the reaction process of (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Related Products of 63012-03-3)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.Related Products of 63012-03-3 The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

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Alcohol – Wikipedia,
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《Prediction of biological activity of compounds containing a 1,3,5-triazinyl sulfonamide scaffold by artificial neural networks using simple molecular descriptors》 was written by Havrankova, Eva; Pena-Mendez, E. M.; Csollei, Jozef; Havel, Josef. Reference of 3-Aminopropan-1-olThis research focused ontriazinyl sulfonamide carbonic anhydrase inhibition neural network structure activity; 1,3,5-triazinyl sulfonamide derivatives; ANN; Carbonic anhydrase; Structural descriptors. The article conveys some information:

Simple mol. descriptors of extensive series of 1,3,5-triazinyl sulfonamide derivatives, based on the structure of sulfonamides and their physicochem. properties, were designed and calculated These descriptors were successfully applied as inputs for artificial neural network (ANN) modeling of the relationship between the structure and biol. activity. The optimized ANN architecture was applied to the prediction of the inhibition activity of 1,3,5-triazinyl sulfonamides against human carbonic anhydrase (hCA) II, tumor-associated hCA IX, and their selectivity (hCA II/hCA IX). In the experiment, the researchers used many compounds, for example, 3-Aminopropan-1-ol(cas: 156-87-6Reference of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Reference of 3-Aminopropan-1-ol

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《Vicinal difunctionalization of carbon-carbon double bond for the platform synthesis of trifluoroalkyl amines》 was written by Beke, Ferenc; Meszaros, Adam; Toth, Agnes; Botlik, Bence Bela; Novak, Zoltan. Application In Synthesis of Azetidin-3-ol hydrochlorideThis research focused ontrifluoroalkyl amine preparation regioselective; amine trifluoroalkenyl iodonium salt three component diamination. The article conveys some information:

Herein, the controllable double nucleophilic functionalization of an activated alkene synthon I, originated from a trifluoropropenyliodonium salt with two distinct nucleophiles, enables the selective synthesis of trifluoromethylated ethylene amines and diamines RCH(CF3)CH2R1 (R = methyl(naphthalen-1-ylmethyl)aminyl, methyl(prop-2-yn-1-yl)aminyl, 3-azabicyclo[3.2.2]nonan-3-yl, etc.; R1 = {1-[(tert-butoxy)carbonyl]azetidin-3-yl}(2-phenylethyl)aminyl, 2-sulfanylidene-1,2-dihydropyridin-1-yl, etc.) on broad scale with high efficiency under mild reaction conditions. Considering the chem. nature of the reactants, this synthetic approach brings forth an efficient methodol. and provides versatile access to highly fluorinated amines. The results came from multiple reactions, including the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6Application In Synthesis of Azetidin-3-ol hydrochloride)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Application In Synthesis of Azetidin-3-ol hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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Alcohol – Wikipedia,
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《Zinc oxide catalyzed, environmentally benign protocol for the synthesis of substituted carboxylic acid》 was written by Shaikh, Majid; Shaikh, Mujahed; Wagare, Devendra; Kasim, Sayyad Sultan. Application of 26153-38-8This research focused onzinc oxide substituted carboxylic acid benign protocol synthesis. The article conveys some information:

Carboxylic acid act as a versatile precursor to synthesized biol. valuable mol. like amide, acid chloride and many more. Hence, we have developed convenient method to synthesized substituted carboxylic acid. The previous synthetic method found limitations regarding the use of hazardous solvent, tedious work-up, slow and moderate product yields. To over come, these lacunas herein we have developed a facial and highly efficient synthetic protocol for the synthesis of carboxylic acids from the reaction of substituted aldehydes and hydrogen peroxide (70%) with zinc oxide (10% mol) as a catalyst and in onion extract Reported method is better substitute for the existing previous methods because it has many advantages such as easy work-up, reduces the reaction time in just 1-2 h with excellent yield and most important the Zinc oxide easily removed with filtration. The results came from multiple reactions, including the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Application of 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Application of 26153-38-8

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Alcohol – Wikipedia,
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