Month: November 2022

In 2019,Green Chemistry included an article by Li, Xing; Qi, Yue; Yue, Guozong; Wu, Qianxun; Li, Yang; Zhang, Meicheng; Guo, Xinghua; Li, Xiaofeng; Ma, Lijian; Li, Shoujian. Related Products of 34374-88-4. The article was titled 《Solvent- and catalyst-free synthesis of an azine-linked covalent organic framework and the induced tautomerization in the adsorption of U(VI) and Hg(II)》. The information in the text is summarized as follows:

A green and facile solvent- and catalyst-free method, without inert gas protection and/or mech. grinding to synthesize an azine-linked covalent organic framework (ACOF) with high efficiency, was proposed for the first time. Characterization techniques and experimentations show that the as-synthesized ACOF has high crystallinity and superior phys. and chem. stability and exhibits good adsorption performance for both radioactive heavy metal U(VI) and ordinary heavy metal Hg(II), with adsorption capacities of 169 mg g-1 for U(VI) and 175 mg g-1 for Hg(II), which makes the ACOF a potential adsorbent material for heavy metal removal and uranium recycling. Tautomerization between the enol-form and keto-form was verified in the structure of the ACOF which can be induced by the adsorption of metal ions and also affect the adsorption properties simultaneously. It was found that tautomerization from the enol-form to keto-form was promoted in the adsorption, which can be ascribed to the better coordination ability of C=O in the keto-form towards the target metal ion, while the selectivity of the ACOF towards U(VI) increases with the decreasing solution pH and reaches 96.2% when the pH is 1.5, which is due to the tautomerization from the keto-form to enol-form under acidic conditions and the consequent size-matching effect. The study on tautomerization in solid materials is rarely reported and is of great importance for deep understanding of the relationship between material structures and properties. The synthesis strategy proposed in this paper provides references for the convenient, efficient and green synthesis of COFs. The results came from multiple reactions, including the reaction of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Related Products of 34374-88-4)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.Related Products of 34374-88-4Phloroglucinols are known for their broad-spectrum antiviral, antibacterial, antifungal, antihelminthic, and phytotoxic activities.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Molecules included an article by Nakamae, Ikuko; Morimoto, Tsumoru; Shima, Hiroki; Shionyu, Masafumi; Fujiki, Hisayo; Yoneda-Kato, Noriko; Yokoyama, Takashi; Kanaya, Shigehiko; Kakiuchi, Kiyomi; Shirai, Tsuyoshi; Meiyanto, Edy; Kato, Jun-ya. Synthetic Route of C7H6O3. The article was titled 《Curcumin derivatives verify the essentiality of ROS upregulation in tumor suppression》. The information in the text is summarized as follows:

Curcumin has been shown to exert pleiotropic biol. effects, including anti-tumorigenic activity. We previously showed that curcumin controls reactive oxygen species (ROS) levels through the ROS metabolic enzymes, to prevent tumor cell growth. In this study, we synthesized 39 novel curcumin derivatives and examined their anti-proliferative and anti-tumorigenic properties. Thirty-nine derivatives exhibited anti-proliferative activity toward human cancer cell lines, including CML-derived K562 leukemic cells, in a manner sensitive to an antioxidant, N-acetyl-cysteine (NAC). Some compounds exhibited lower GI50 values than curcumin, some efficiently induced cell senescence, and others markedly increased ROS levels, efficiently induced cell death and suppressed tumor formation in a xenograft mouse model, without any detectable side effects. A clustering anal. of the selected compounds and their measurement variables revealed that anti-tumorigenic activity was most well-correlated with an increase in ROS levels. Pulldown assays and a mol. docking anal. showed that curcumin derivatives competed with co-enzymes to bind to the resp. ROS metabolic enzymes and inhibited their enzymic activities. The anal. of novel curcumin derivatives established the importance of ROS upregulation in suppression of tumorigenesis, and these compounds are potentially useful for the development of an anti-cancer drug with few side effects. In the experiment, the researchers used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Synthetic Route of C7H6O3)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Synthetic Route of C7H6O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Heterocyclic iodoniums as versatile synthons to approach diversified polycyclic heteroarenes》 were Zhu, Daqian; Wu, Zhouming; Liang, Liyun; Sun, Yameng; Luo, Bingling; Huang, Peng; Wen, Shijun. And the article was published in RSC Advances in 2019. Application In Synthesis of 4-Aminobutan-1-ol The author mentioned the following in the article:

In current work, unique iodoniums were employed to construct various complex polycyclic heteroarenes, e.g., I with structural diversity via tandem dual arylations. As a result, indole, thiophene and triphenylene motifs were fused into these heterocycles with high mol. quality, which might provide promising fragments in drug discovery. Moreover, these heterocycles could be diversified at a late stage.4-Aminobutan-1-ol(cas: 13325-10-5Application In Synthesis of 4-Aminobutan-1-ol) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Application In Synthesis of 4-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Dendron-functionalized surface: Efficient strategy for enhancing the capture of microvesicles》 were Jiang, Jian-Qiao; Chanseau, Christel; Alves, Isabel D.; Nlate, Sylvain; Durrieu, Marie-Christine. And the article was published in iScience in 2019. Product Details of 4048-33-3 The author mentioned the following in the article:

Microvesicles (MVs) are used by various types of cells in the human body for intercellular communication, making them biomarkers of great potential for the early and non-evasive diagnosis of a spectrum of diseases. An integrated anal. including morphol., quant., and compositional studies is most desirable for the clin. application of MV detection; however, such integration is limited by the currently available anal. techniques. In this context, exploiting the phosphatidylserine (PS) exposure of MVs, we synthesized a series of dendritic mols. with PS-binding sites at the periphery. PS-dendron binding was studied at the mol. level using NMR approaches, whereas PS-containing membrane-dendron interaction was investigated in an aqueous environment using plasmon waveguide resonance spectroscopy. As a proof of concept, polyethylene terephthalate surface was functionalized with the synthetic dendrons, forming devices that can capture MVs to facilitate their subsequent analyses. The experimental part of the paper was very detailed, including the reaction process of 6-Aminohexan-1-ol(cas: 4048-33-3Product Details of 4048-33-3)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Product Details of 4048-33-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Tailoring the degradation and mechanical properties of poly(e-caprolactone) incorporating functional e-caprolactone-based copolymers》 were Xu, Mi; Guo, Cuili; Dou, Haozhen; Zuo, Yi; Sun, Yawei; Zhang, Jinli; Li, Wei. And the article was published in Polymer Chemistry in 2019. Recommanded Product: 27489-62-9 The author mentioned the following in the article:

A series of functional block copolymers (COPs) was synthesized through the ring-opening polymerization of ε-caprolactone (CL) and γ-(carbamic acid benzyl ester)-ε-caprolactone (CABCL) monomers at different ratios, and then the effects of the COP additives on the hydrolytic and oxidative degradation and mech. properties of PCL/COP samples were studied. From characterization using DSC, POM, AFM, WAXD, SAXS, etc., it was demonstrated that the content and distribution of pendant side chains in the COPs can alter the nucleation of macromol. chains, and then modulate the lamellar thickness and crystallinity of the PCL/COP samples. Such variations of the macromol. structures result in distinct changes in the mech. properties during degradation These results provide useful guidance for the development of ideal materials for biodegradable polymer stents with tunable degradation rates and the desirable evolution of the mech. properties. In the part of experimental materials, we found many familiar compounds, such as trans-4-Aminocyclohexanol(cas: 27489-62-9Recommanded Product: 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Recommanded Product: 27489-62-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《SO3H-dendrimer functionalized magnetic nanoparticles (Fe3O4@D-NH-(CH2)4-SO3H): Synthesis, characterization and its application as a novel and heterogeneous catalyst for the one-pot synthesis of polyfunctionalized pyrans and polyhydroquinolines》 were Maleki, Behrooz; Reiser, Oliver; Esmaeilnezhad, Ehsan; Choi, Hyoung Jin. And the article was published in Polyhedron in 2019. Category: alcohols-buliding-blocks The author mentioned the following in the article:

In this study, novel SO3H-dendrimer functionalized magnetic nanoparticles (Fe3O4@D-NH-(CH2)4-SO3H) were prepared and characterized by using FT-IR, X-ray diffraction patterns, SEM, transmission electron microscopy, thermogravimetry anal., and energy-dispersive X-ray spectroscopy. The synthesized nanosized catalyst was successfully applied to the synthesis of highly substituted pyrans and polyhydroquinolines via a straightforward one-pot multicomponent condensation reaction. The key advantages are the short reaction time, high yields, simple workup, and purification of products by simple recrystallization from ethanol. The experimental process involved the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Category: alcohols-buliding-blocks)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Highly efficient oxidation of alcohols to carboxylic acids using a polyoxometalate-supported chromium(III) catalyst and CO2》 was published in Green Chemistry in 2020. These research results belong to Wang, Ying; Wu, ZhiKang; Yu, Han; Han, Sheng; Wei, Yongge. Recommanded Product: (4-Bromophenyl)methanol The article mentions the following:

Direct catalytic oxidation of alcs. to carboxylic acids is very attractive, but economical catalysis systems have not yet been well established. Here, we show that a pure inorganic ligand-supported chromium compound, (NH4)3[CrMo6O18(OH)6] (simplified as CrMo6), could be used to effectively promote this type of reaction in the presence of CO2. In almost all cases, oxidation of various alcs. (aromatic and aliphatic) could be achieved under mild conditions, and the corresponding carboxylic acids can be achieved in high yield. The chromium catalyst 1 can be reused several times with little loss of activity. Mechanism study and control reactions demonstrate that the acidification proceeds via the key oxidative immediate of aldehydes. In the part of experimental materials, we found many familiar compounds, such as (4-Bromophenyl)methanol(cas: 873-75-6Recommanded Product: (4-Bromophenyl)methanol)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Recommanded Product: (4-Bromophenyl)methanol It undergoes efficient trimethylsilylation reaction with 1,1,1,3,3,3-hexamethyldisilazane in the presence of catalytic amount of aspartic acid in acetonitrile.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Reactions of Criegee Intermediates are Enhanced by Hydrogen-Atom Relay Through Molecular Design》 was published in ChemPhysChem in 2020. These research results belong to Kuo, Mei-Tsan; Takahashi, Kaito; Lin, Jim Jr-Min. Formula: C3H9NO The article mentions the following:

We report a type of highly efficient double hydrogen atom transfer (DHAT) reaction. The reactivities of 3-aminopropanol and 2-aminoethanol towards Criegee intermediates (syn- and anti-CH3CHOO) were found to be much higher than those of n-propanol and propylamine. Quantum chem. calculation has confirmed that the main mechanism of these very rapid reactions is DHAT, in which the nucleophilic attack of the NH2 group is catalyzed by the OH group which acts as a bridge of HAT. Typical gas-phase DHAT reactions are termol. reactions involving two hydrogen bonding mols.; these reactions are typically slow due to the substantial entropy reduction of bringing three mols. together. Putting the reactive and catalytic groups in one mol. circumvents the problem of entropy reduction and allows us to observe the DHAT reactions even at low reactant concentrations This idea can be applied to improve theor. predictions for atmospherically relevant DHAT reactions. In the part of experimental materials, we found many familiar compounds, such as 3-Aminopropan-1-ol(cas: 156-87-6Formula: C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Formula: C3H9NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《CaCl2-Promoted Dehydroxytrifluoromethylselenolation of Alcohols with [Me4N][SeCF3]》 was published in Organic Letters in 2020. These research results belong to Wu, Shuai; Jiang, Tian-Hao; Zhang, Cheng-Pan. Formula: C7H9NO2 The article mentions the following:

A direct trifluoromethylselenolation of alcs. with the readily accessible [Me4N][SeCF3] salt has been reported. The reaction is significantly promoted by CaCl2 and proceeds smoothly through unprecedented carbonoselenoate intermediates to form the corresponding alkyl trifluoromethyl selenoethers in good yields. This protocol is also applicable to the late-stage dehydroxytrifluoromethylselenolation of complex alcs. owing to its mildness, good compatibility, high efficiency, and broad functional group tolerance. The experimental part of the paper was very detailed, including the reaction process of 2,6-Pyridinedimethanol(cas: 1195-59-1Formula: C7H9NO2)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Formula: C7H9NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Synthesis and Biological Screening of New Lawson Derivatives as Selective Substrate-Based Inhibitors of Cytochrome bo3 Ubiquinol Oxidase from Escherichia coli》 was published in ChemMedChem in 2020. These research results belong to Elamri, Isam; Radloff, Melanie; Hohmann, Katharina F.; Nimbarte, Vijaykumar D.; Nasiri, Hamid R.; Bolte, Michael; Safarian, Schara; Michel, Hartmut; Schwalbe, Harald. Electric Literature of C7H6O3 The article mentions the following:

The respiratory chain of Escherichia coli contains two different types of terminal oxidase that are differentially regulated as a response to changing environmental conditions. These oxidoreductases catalyze the reduction of mol. oxygen to water and contribute to the proton motive force. The cytochrome bo3 oxidase (cyt bo3) acts as the primary terminal oxidase under atm. oxygen levels, whereas the bd-type oxidase is most abundant under microaerobic conditions. In E. coli, both types of respiratory terminal oxidase (HCO and bd-type) use ubiquinol-8 as electron donor. Here, we assess the inhibitory potential of newly designed and synthesized 3-alkylated Lawson derivatives through L-proline-catalyzed three-component reductive alkylation (TCRA). The inhibitory effects of these Lawson derivatives on the terminal oxidases of E. coli (cyt bo3 and cyt bd-I) were tested potentiometrically. Four compounds were able to reduce the oxidoreductase activity of cyt bo3 by more than 50 % without affecting the cyt bd-I activity. Moreover, two inhibitors for both cyt bo3 and cyt bd-I oxidase could be identified. Based on mol.-docking simulations, we propose binding modes of the new Lawson inhibitors. The mol. fragment benzyl enhances the inhibitory potential and selectivity for cyt bo3, whereas heterocycles reduce this effect. This work extends the library of 3-alkylated Lawson derivatives as selective inhibitors for respiratory oxidases and provides mol. probes for detailed investigations of the mechanisms of respiratory-chain enzymes of E. coli. The results came from multiple reactions, including the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Electric Literature of C7H6O3)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Electric Literature of C7H6O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts