Month: November 2022

Chen, Cheng; Wang, Zhi-Qin; Gong, Yan-Yan; Wang, Ji-Chao; Yuan, Ye; Cheng, Hua; Sang, Wei; Chaemchuen, Somboon; Verpoort, Francis published their research in Carbon in 2021. The article was titled 《Cobalt embedded in nitrogen-doped porous carbon as a robust heterogeneous catalyst for the atom-economic alcohol dehydrogenation to carboxylic acids》.Computed Properties of C6H15NO The article contains the following contents:

Herein, cobalt embedded in nitrogen-doped porous carbon (Co@NC) was developed as a robust heterogeneous catalyst for the dehydrogenative coupling of primary alcs. and hydroxides. With Co@NC as the first earth-abundant metal/carbon composite material for this transformation, numerous aromatic and aliphatic carboxylic acids were efficiently afforded. Notably, the newly prepared Co@NC was fabricated in a facile and straightforward manner and reused up to 15 recycle rounds without activity decay. It is also worth emphasizing that the catalyst recycling was realized via magnetic separation with no special treatment or activation. Addnl., further experiments elucidated the pivotal role of the cobalt and nitrogen elements dispersed in the carbon matrix as well as the hierarchical porosity (micro-/meso-pores) in the catalytic activity and recyclability. Considering the active sites of Co@NC, we envisioned that the Co-N species was the most active site, while other active sites such as Co-O, Co0 species and free N-doped carbon were also present, but demonstrating lower activity or stability in comparison with the Co-N species. Addnl. mechanistic investigations were carried out to gain more insights into the possible reaction pathways. We found that the aldehyde was identified as a crucial intermediate, and two possible pathways were proposed for this catalytic process. In the part of experimental materials, we found many familiar compounds, such as 6-Aminohexan-1-ol(cas: 4048-33-3Computed Properties of C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Computed Properties of C6H15NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 627-18-9In 2020 ,《Metathesis cyclopolymerization triggered self-assembly of azobenzene-containing nanostructure》 appeared in Molecules. The author of the article were Song, Wei; Shen, Jiamin; Li, Xiang; Huang, Jinhui; Ding, Liang; Wu, Jianhua. The article conveys some information:

Azobenzene (AB) units were successfully introduced into poly(1,6-heptadiyne)s in order to ensure smooth synthesis of double- and single-stranded poly(1,6-heptadiyne)s (P1 and P2) and simultaneously realize the self-assembly by Grubbs-III catalyst-mediated metathesis cyclopolymn. (CP) of AB-functionalized bis(1,6-heptadiyne) and 1,6-heptadiyne monomers (M1 and M2). Monomers and polymers were characterized by 1H NMR, mass spectroscopy, and GPC techniques. The double-stranded poly(1,6-heptadiyne)s exhibited a large scale of ordered ladder nanostructure. This result was attributed to the π-π attractions between end groups along the longitudinal axis of the polymers and van der Waals interactions between the neighboring polymeric backbones. While the azo chromophore connected in the side chain of P2 induced conformation of micelles nanostructure during the CP process without any post-treatment. Furthermore, the photoisomerization of azo units had an obviously different regulatory effect on the conjugated degree of the polymer backbone, especially for the single-stranded P2, which was attributed to the structural differences and the interaction between AB chromophores in the polymers. After reading the article, we found that the author used 3-Bromopropan-1-ol(cas: 627-18-9Application of 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Application of 627-18-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In ,Organic Letters included an article by Pan, Ting; Shi, Pan; Chen, Bo; Zhou, Da-Gang; Zeng, Ya-Li; Chu, Wen-Dao; He, Long; Liu, Quan-Zhong; Fan, Chun-An. COA of Formula: C13H11ClO. The article was titled 《CuH-Catalyzed Asymmetric 1,6-Conjugate Reduction of p-Quinone Methides: Enantioselective Synthesis of Triarylmethanes and 1,1,2-Triarylethanes》. The information in the text is summarized as follows:

The first copper hydride (CuH)-catalyzed asym. 1,6-conjugate reduction of p-quinone methides is reported. This protocol provides a new method to access a variety of triarylmethanes and 1,1,2-triarylethanes in good yields with excellent enantioselectivities and broad functional group tolerance. The results came from multiple reactions, including the reaction of (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3COA of Formula: C13H11ClO)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.COA of Formula: C13H11ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Efficient approach to carbinol derivatives through palladium-catalyzed base-free addition of aryltriolborates to aldehydes》 were Hu, Kun; Ye, Pengqing; Zhen, Qianqian; Yao, Xinrong; Xu, Tong; Shao, Yinlin; Chen, Jiuxi. And the article was published in Molecules in 2017. Reference of (3-Chlorophenyl)(phenyl)methanol The author mentioned the following in the article:

Palladium-catalyzed base-free addition of aryltriolborates to aldehydes was developed, led to a wide range of carbinol derivatives in good to excellent yields. The efficiency of this transformation was demonstrated by compatibility with a wide range of functional groups. The present synthetic route to carbinol derivatives was readily scaled up to gram quantity without difficulty. Thus, this method represented a simple and practical procedure to access carbinol derivatives The experimental process involved the reaction of (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Reference of (3-Chlorophenyl)(phenyl)methanol)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.Reference of (3-Chlorophenyl)(phenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Synthesis of new polyesters by acyclic diene metathesis polymerization of bio-based α,ω-dienes prepared from eugenol and castor oil (undecenoate)》 were Le, Duy; Samart, Chanatip; Kongparakul, Suwadee; Nomura, Kotohiro. And the article was published in RSC Advances in 2019. Computed Properties of C6H12O The author mentioned the following in the article:

Synthesis of new polyesters by acyclic diene metathesis (ADMET) polymerization of α,ω-diene, 4-allyl-2-methoxyphenyl 10-undecenoate (M1), prepared from bio-renewable eugenol and castor oil (undecenoate), have been demonstrated. Ruthenium-carbene (called second generation Grubbs) catalyst afforded polymers with unimodal mol. weight distributions (Mn = 12 700, Mw/Mn = 1.85). The polymerization in the presence of a triarm crosslinker, 5-formylbenzene-1,2,3-triyl tris(undec-10-enoate), also afforded polymers with certain uniform network structures. After reading the article, we found that the author used 5-Hexen-1-ol(cas: 821-41-0Computed Properties of C6H12O)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Computed Properties of C6H12O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Lvting; Zhang, Lili; Lin, Bizhou; Zheng, Yanzhen; Chen, Jingling; Zheng, Yun; Gao, Bifen; Long, Jinlin; Chen, Yilin published an article in 2021. The article was titled 《Activation of Carbonyl Oxygen Sites in β-Ketoenamine-Linked Covalent Organic Frameworks via Cyano Conjugation for Efficient Photocatalytic Hydrogen Evolution》, and you may find the article in Small.Recommanded Product: 34374-88-4 The information in the text is summarized as follows:

2D covalent organic frameworks (COFs) are drawing intense attention in heterogenous photocatalysis due to their porous, crystalline, and tailor-made structures. For highly efficient solar-to-chem. energy conversion, revealing and modulating active centers in the skeletons of COFs are of great importance but encounter severe challenges. Herein, it is demonstrated that cyano conjugation on a typical β-ketoenamine-linked COF via aldehyde-imine Schiff-base condensation contributes to an enhanced stable photocatalytic H2-evolution rate of 1.8 mmol h-1 g-1 (λ > 420 nm) with a superior apparent quantum yield of 2.12% at 420 nm, compared to pristine COFs. Both exptl. results and d. functional theory calculations disclose that the cyano conjugation can efficiently improve photoinduced charge separation and effectively decrease the energy barrier for H-intermediate generation on the carbonyl oxygen sites of the functionalized COFs. These findings present a precise organic functionalization strategy to optimize active centers on COF-based photocatalysts for the practical applications.2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Recommanded Product: 34374-88-4) was used in this study.

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Regarding monomeric phloroglucinols, this group encompasses acryl phloroglucinols, phloroglucinol-terpene adducts, phloroglucinol glycosides, halogenated phloroglucinols, prenylated phloroglucinols, and cyclicroup polyketides.Recommanded Product: 34374-88-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Category: alcohols-buliding-blocksIn 2022 ,《One-pot synthesis of hydroxyl terminated hyperbranched semi-aromatic Poly(ester-imide)s》 appeared in Polymer. The author of the article were Zhou, Jiajun; Li, Mao; Wu, Jiadong; Zhang, Chongyin; He, Zidong; Xiao, Yan; Tong, Gangsheng; Zhu, Xinyuan. The article conveys some information:

A new kind of hyperbranched semi-aromatic poly(ester-imide)s with hydroxyl terminated groups has been prepared from com. available 1,2,4-benzenetricarboxylic anhydride (TMA) as the AA’-type aromatic monomer and 3-amino-1,2-propanediol (3APPD), 2-amino-1,3-propanediol (2APPD), N,N-bis(2-hydroxyethyl)ethylenediamine (BHED) as CB2-type aliphatic monomers via a simple one-pot melting polymerization method. The effects of synthesis conditions on the structures and properties of the products were investigated in detail. The combination of FTIR, 1H NMR, 2D NMR, MALDI-FTICR-MS and model reactions have been used to characterize the structures of the obtained polymers. As assessed using thermal measurements, the obtained hyperbranched semi-aromatic poly(ester-imide)s possess low glass transition temperature (≤120°C) and high thermostability with an onset decomposition temperature ranging from 355 to 420°C in nitrogen. The products possess abundant terminal hydroxyl functional groups. Hydroxyl values vary between 198 and 248 mg KOH/g depending on the particular precursors used to generate the polymers. The experimental part of the paper was very detailed, including the reaction process of 2-Aminopropane-1,3-diol(cas: 534-03-2Category: alcohols-buliding-blocks)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of C7H7BrOIn 2019 ,《Efficient Synthesis of Quinazolinones by Transition-Metal-Free Direct Aerobic Oxidative Cascade Annulation of Alcohols with o-Aminoarylnitriles》 appeared in ChemSusChem. The author of the article were Wang, Qi; Lv, Miao; Liu, Jianping; Li, Yang; Xu, Qing; Zhang, Xu; Cao, Hongen. The article conveys some information:

A mild and atom-economic method was developed for direct and efficient synthesis of quinazolinones I (R1 = H, 5-Cl, 6-Br, 7-CH3, etc.; R2 = C6H5, naphthalen-2-yl, thiophen-2-yl, etc.) through a transition-metal-free aerobic oxidative cascade annulation reaction of widely available o-aminoarylnitriles R32-H2NC6H3CN (R3 = H, 4-CH3, 5-Br, 6-Cl, etc.) and alcs. R2CH2OH. Air could be employed as an effective oxidant under mild conditions, generating water as the only byproduct. Possibly owing to the ”cesium effect”, the water-soluble base CsOH was found to be crucial in all key steps of the reaction mechanism. Because a wide range of substrates can be used to prepare substituted quinazolinones without contamination by transition-metal residues, this method may be of interest for application in pharmaceutical synthesis. Possible reaction paths were also proposed according to control reactions. In the experiment, the researchers used many compounds, for example, (4-Bromophenyl)methanol(cas: 873-75-6Electric Literature of C7H7BrO)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Electric Literature of C7H7BrO It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

HPLC of Formula: 7748-36-9In 2020 ,《Cu(II)-catalyzed sulfonylation of 7-azaindoles using DABSO as SO2-Source and its mechanistic study》 was published in Tetrahedron. The article was written by Urvashi; Dar, Mohammad Ovais; Bharatam, Prasad V.; Das, Parthasarathi; Kukreti, Shrikant; Tandon, Vibha. The article contains the following contents:

DABSO mediated sulfonylation of iodinated 7-azaindoles I [R = H, Cl; R1 = H, Br, 4-methoxyphenyl, 2-(4-methylphenyl)ethynyl; R2 = H, Cl, OMe, ; R3 = H, 4-methoxyphenyl] was achieved for the first time through sulfonylative Suzuki-Miyaura cross coupling (SMC) reaction under mild conditions giving good yields of sulfonylated 7-azaindole derivatives II (R4 = 3,4,5-trimethoxyphenyl, pyridin-4-yl, naphthalen-1-yl, etc.). Interestingly, control experiments suggest that present method involves in-situ generation of ArSO2 free radical followed by the key steps of SMC reaction. Scope of the reaction was explored with both electronically different and bulky group carrying boronic acids ArB(OH)2 as coupling partner. The sulfonylation is scalable and occurred selectively at iodo group, irresp. of its position on azaindole. Moreover, the proposed mechanism has been supported by ESR (EPR) and d. functional theory (DFT) calculations In the experimental materials used by the author, we found Oxetan-3-ol(cas: 7748-36-9HPLC of Formula: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.HPLC of Formula: 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-olIn 2019 ,《Preparation of 1,3-Thiazolidine-2-thiones by Using Potassium Ethylxanthate as a Carbon Disulfide Surrogate》 was published in Synlett. The article was written by Lu, Zheng; Yang, Yong-Qing; Xiong, Weixiang. The article contains the following contents:

A simple procedure is presented for preparing 1,3-thiazolidine-2-thiones, e.g., I by using potassium ethylxanthate and the corresponding β-amino alcs. as the starting materials in the presence of ethanol. The experimental part of the paper was very detailed, including the reaction process of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts