Month: October 2022

Zong, Shuai; Ye, Hongling; Ye, Ziyang; He, Yaling; Zhang, Xinmiao; Ye, Ming published the artcile< Polysaccharides from Lachnum sp. Inhibited colitis-associated colon tumorigenesis in mice by modulating fecal microbiota and metabolites>, Category: alcohols-buliding-blocks, the main research area is Lachnum polysaccharide mice colitis colon tumorigenesis fecal microbiota metabolite; AOM/DSS; Colorectal cancer; Gut microbiota; Lachnum sp. polysaccharides.

It is still uncertain whether the consumption of Lachnum sp. polysaccharides (LEP) alleviates colorectal cancer (CRC) through the gut microbiota. In this study, our efforts are focused on the influence of LEP on CRC, intestinal barrier and inflammation, and fecal microbiota and the metabolites, in azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced CRC mice. Results showed that LEP inhibited CRC mouse colon shortening and weight loss, decreased tumor incidence, restored intestinal barrier integrity, and reduced excessive inflammation. LEP consumption significantly altered microbiota overall structure and community, with reduced pernicious bacteria (such as Parabacteroides, Escherichia_Shigella, Desulfovibrio and Helicobacter), and increased beneficial bacterium (such as Alistipes, Alloprevotella and Ruminiclostridium). Fecal-metabolome profile indicated that a total of 43 metabolites were clearly changed, with 10 down-regulated and 33 up-regulated metabolites. In addition, short-chain fatty acids (SCFAs), including acetic acid, propionic acid and n-butyric acid, were significantly increased after LEP administration. Moreover, a strong correlation between the fluctuant gut microbiota and metabolites was found. These findings provided not only deeper insights into the responsibility of LEP for CRC alleviation, and but also the potential of LEP as a promising candidate for CRC prevention and treatment.

International Immunopharmacology published new progress about Acidobacteria. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Duan, Xiaohui; Zhang, Mina; Du, Huan; Gu, Xiu; Bai, Caihong; Zhang, Liuqiang; Chen, Kaixian; Hu, Kaifeng; Li, Yiming published the artcile< Effect of Different Processing Methods on the Chemical Constituents of Scrophulariae Radix as Revealed by 2D NMR-Based Metabolomics>, Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol, the main research area is Scrophularia metabolomics steaming chem markers; 2D NMR; Scrophulariae Radix; chemical markers; processing methods; “sweating” processing.

Scrophulariae Radix (SR) is one of the oldest and most frequently used Chinese herbs for oriental medicine in China. Before clin. use, the SR should be processed using different methods after harvest, such as steaming, “”sweating””, and traditional fire-drying. In order to investigate the difference in chem. constituents using different processing methods, the two-dimensional (2D) 1H-13C heteronuclear single quantum correlation (1H-13C HSQC)-based metabolomics approach was applied to extensively characterize the difference in the chem. components in the extracts of SR processed using different processing methods. In total, 20 compounds were identified as potential chem. markers that changed significantly with different steaming durations. Seven compounds can be used as potential chem. markers to differentiate processing by sweating, hot-air drying, and steaming for 4 h. These findings could elucidate the change of chem. constituents of the processed SR and provide a guide for the processing. In addition, our protocol may represent a general approach to characterizing chem. compounds of traditional Chinese medicine (TCM) and therefore might be considered as a promising approach to exploring the scientific basis of traditional processing of TCM.

Molecules published new progress about Amino acids Role: ANT (Analyte), BSU (Biological Study, Unclassified), PUR (Purification or Recovery), THU (Therapeutic Use), ANST (Analytical Study), BIOL (Biological Study), PREP (Preparation), USES (Uses). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Maohua; He, Jie; Xie, Songzhi; Wang, Tao; Ran, Pan; Zhang, Zhanlin; Li, Xiaohong published the artcile< Intracellular bacteria destruction via traceable enzymes-responsive release and deferoxamine-mediated ingestion of antibiotics>, Reference of 5505-63-5, the main research area is deferoxamine ciprofloxacin mPET nanoparticle intracellular enzyme antibiotic; Antibiotic-siderophore complex; Enzyme-responsive release; Intracellular bacteria; Self-indicating nanoparticle; Traceable release.

Intracellular bacteria (ICBs) are among the most life-threatening causes of drug resistance. Challenges remains in the intracellular drug release specific to ICB-infected cells and efficient uptake into ICBs. In this study, mannose-grafted polymers containing enzymes-responsive and tetraphenylethylene segments (mPET) are assembled into nanoparticles with loading complexes of deferoxamine-ciprofloxacin conjugates with Fe3+ (DFeC). The aggregation-induced emission (AIE) of tetraphenylethylene segments is overlapped with DFeC absorptions, leading to fluorescence resonance energy transfer (FRET)-caused quenching of mPET@DFeC nanoparticles. Nanoparticles are efficiently acquired by infected macrophages via mannose mediation, and the DFeC release is triggered by intracellular lipase and alk. phosphatase specific to ICB-engulfed macrophages, followed by deferoxamine-mediated ingestion of ciprofloxacin into ICBs. The gradual alleviation of FRET effect and the concurrent restoration of AIE activity demonstrate capabilities of dynamically tracking the drug release and ICB treatment outcome. The mPET@DFeC treatment inhibits the hematol., hepatic and nephric toxicities caused by ICB infections, and all the infected mice survive with dramatic reductions of bacterial levels in livers (over 430 folds), spleens (over 240 folds) and kidneys (5.6 × 104 folds). Thus, this study has provided a feasible strategy to achieve intracellular enzymes-responsive and traceable release of antibiotics and then deferoxamine-mediated bacterial ingestion for ICB destruction.

Journal of Controlled Release published new progress about Antibacterial agents. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Reference of 5505-63-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Traeger, Hanna; Ghielmetti, Alyssa; Sagara, Yoshimitsu; Schrettl, Stephen; Weder, Christoph published the artcile< Supramolecular Rings as Building Blocks for Stimuli-Responsive Materials>, Computed Properties of 10602-04-7, the main research area is stimuli responsive material supramol ring; benzothiadiazole; chromogenic; fluorescence; luminescence; naphthalene diimide; quenching; stimuli-responsive polymers.

Stimuli-responsive polymers are of great interest due to their ability to translate changing environmental conditions into responses in defined materials. One possibility to impart such behavior is the incorporation of optically active mols. into a polymer host. Here, we describe how sensor mols. that consist of a π-extended benzothiadiazole emitter and a naphthalene diimide quencher can be exploited in this context. The two optically active entities were connected via different spacers and, thanks to attractive intramol. interactions between them, the new sensor mols. assembled into cyclic structures in which the fluorescence was quenched by up to 43% when compared to solutions of the individual dyes. Detailed spectroscopic investigations of the sensor mols. in solution show that the extent of donor/acceptor interactions is influenced by various factors, including solvent polarity and ion concentration The new sensor mol. was covalently incorporated into a polyurethane; the investigation of the optical characteristics in both the solid and solvent-swollen states indicates that a stimulus-induced formation of associated dye pairs is possible in polymeric materials. Indeed, a solvatochromic quenching effect similar to the behavior in solution was observed for solvent-swollen polymer samples, leading to an effective change of the green emission color of the dye to a yellow color.

Gels published new progress about Differential scanning calorimetry. 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Computed Properties of 10602-04-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nallagangula, Madhu; Sujatha, Chandragiri; Bhat, Venugopal T.; Namitharan, Kayambu published the artcile< A nanoscale iron catalyst for heterogeneous direct N- and C-alkylations of anilines and ketones using alcohols under hydrogen autotransfer conditions>, Synthetic Route of 5344-90-1, the main research area is aryl amine preparation; alc amine alkylation iron catalyst; preparation aryl ketone; acetophenone alc alkylation iron catalyst; quinoline preparation; amino benzyl alc Friedlander iron catalyst.

An efficient synthesis of amine and ketone derivatives RCH2NHR1 [R = n-pentyl, Ph, 4-OMe, etc.; R1 = Ph, 2-MeOC6H4, 2-pyridyl etc.] and R2CH2CH2C(O)R3 [R2 = Ph, 2-MeC6H4, 4-MeSC6H4, etc.; R3 = Ph, 4-MeC6H4, 4-EtOC6H4, etc.] was described via heterogeneous iron catalyzed direct N- and C-alkylation reactions of amines and acetophenones with alcs. under hydrogen autotransfer conditions. In addition, modified Friedlander synthesis of quinolines I [R4 = H, Me; R5 = Ph, 4-EtC6H4, 4-FC6H4, etc.] was demonstrated from 2-amino benzyl alcs. and acetophenones. A hydrogen autotransfer mechanism was found to operate in these reactions by deuterium labeling studies.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkylation. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Synthetic Route of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kang, Suyoung; Yan, Han; Zhu, Yin; Liu, Xu; Lv, Hai-Peng; Zhang, Yue; Dai, Wei-Dong; Guo, Li; Tan, Jun-Feng; Peng, Qun-Hua; Lin, Zhi published the artcile< Identification and quantification of key odorants in the world's four most famous black teas>, Application In Synthesis of 78-70-6, the main research area is odorant black tea gas chromatog mass spectrometry; Black teas; GC-O; GC × GC-TOFMS; Key odorants; OAV.

Keemun, Assam, Darjeeling and Ceylon black teas are honored as the world’s four most famous black teas, and their excellent aroma qualities are well received by people around the world. In this study, aroma components in these four types of teas were analyzed by comprehensive two-dimensional gas chromatog. time-of-flight mass spectrometry (GC × GC-TOFMS) and gas chromatog.-olfactometry (GC-O) technologies. A total of 42 aroma-active compounds were ultimately identified, especially benzeneacetaldehyde, geraniol, (Z)-3-hexen-1-yl hexanoate, trans-β-ionone, cis-linalool oxide (pyranoid), hotrienol, and Me salicylate presented the strongest aroma strengths with pleasant scents in all tested teas. The quantification results indicated that 19 compounds including (Z)-3-hexenol, 1-octen-3-ol, linalool, phenylethyl alc., hexanal, benzeneacetaldehyde, limonene, heptanoic acid, (Z)-3-hexen-1-ol, acetate, benzyl alc., trans-linalool oxide (furanoid), hotrienol, 1-octen-3-one, 2-nonanone, (E)-2-octenal, nonanal, β-myrcene, 2-pentylfuran, and methylpyrazine were identified as the key compounds with odor activity values (OAVs) higher than 1.0 in the world’s four most famous black teas. Notably, the comparison of GC-O and OAV calculation results showed that Me salicylate (Ceylon), (E)-2-octenal (Assam), benzeneacetaldehyde (Keemun) and linalool and trans-linalool oxide (furanoid) (Darjeeling) might be the most definitive odorants in the corresponding tea categories.

Food Research International published new progress about Black tea beverages. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Application In Synthesis of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fakhfakh, Jawhar; Athmouni, Khaled; Mallek-Fakhfakh, Hanen; Ayedi, Habib; Allouche, Noureddine published the artcile< Polysaccharide from Lycium arabicum: Structural Features, in Vitro Antioxidant Activities and Protective Effect against Oxidative Damage in Human Erythrocytes>, Product Details of C6H12O6, the main research area is Lycium polysaccharide antioxidant erythrocyte; Lycium arabicum; antioxidant potential; human erythrocytes; polysaccharide.

In this research work, a water-soluble polysaccharide (LAP) isolated from the fruits of Lycium arabicum was investigated. LAP contains carbohydrates (82.45±1.23%), protein (1.56±0.21%), and uronic acids (3.56±0.34%). The anal. of the monosaccharide composition revealed the presence of rhamnose, arabinose, galactose, glucose and mannose in a molar ratio of 4.7 : 1.5 : 1 : 8.7 : 16.4 : 5.6. The extracted polysaccharide (PS) was considered as heterogeneous and highly branched by interpreting its GC/MS, FT-IR and NMR data. Crystallinity of LAP was inferred from its X-ray diffractometry (XRD) and SEM (SEM) anal. LAP exhibited an interesting stability at high temperatures (∼254°C) and in a wide range of pH (3-9) deduced, resp., from its DSC and zeta potential anal. LAP displayed a strong antioxidant activity at low concentrations evaluated by the 2,2-diphenyl-1-picrylhydrazyl (DPPH)-radical scavenging, ferric reducing activity power (FRAP), free radical scavenging ability, superoxide radical-scavenging and hydroxyl radical-scavenging abilities. Inhibition of erythrocyte hemolysis and lipid peroxidation was also assessed. In 5 h, LAP treatment allowed the protection of the damaged erythrocytes caused by AAPH (2,2-azobis(2-amidinopropane) dihydrochloride), to reduce the level of malondialdehyde (MDA) as well as to increase the reduced glutathione (GSH) level.

Chemistry & Biodiversity published new progress about Antioxidants. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mondal, Prasenjit; Lovisari, Marta; Twamley, Brendan; McDonald, Aidan R. published the artcile< Fast Hydrocarbon Oxidation by a High-Valent Nickel-Fluoride Complex>, Category: alcohols-buliding-blocks, the main research area is hydrocarbon oxidation kinetics bond dissociation enthalpy activation entropy; fluorination; high-valent oxidants; metal-oxo species; oxidation catalysis; reactive intermediates.

In the search for highly reactive oxidants we have identified high-valent metal-fluorides as a potential potent oxidant. The high-valent Ni-F complex [NiIII(F)(L)] (2, L=N,N’-(2,6-dimethylphenyl)-2,6-pyridinedicarboxamidate) was prepared from [NiII(F)(L)]- (1) by oxidation with selectfluor. Complexes 1 and 2 were characterized by using 1H/19F NMR, UV-vis, and EPR spectroscopies, mass spectrometry, and X-ray crystallog. Complex 2 was found to be a highly reactive oxidant in the oxidation of hydrocarbons. Kinetic data and products anal. demonstrate a hydrogen atom transfer mechanism of oxidation The rate constant determined for the oxidation of 9,10-dihydroanthracene (k2=29 M-1 s-1) compared favorably with the most reactive high-valent metallo-oxidants. Complex 2 displayed reaction rates 2000-4500-fold enhanced with respect to [NiIII(Cl)(L)] and also displayed high kinetic isotope effect values. Oxidative hydrocarbon and phosphine fluorination was achieved. Our results provide an interesting direction in designing catalysts for hydrocarbon oxidation and fluorination.

Angewandte Chemie, International Edition published new progress about Activation enthalpy. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Otsuka, Yuji; Yamamoto, Toshihiro; Fukase, Koichi published the artcile< β-Selective Glycosylation by Using O-Aryl-Protected Glycosyl Donors>, Recommanded Product: ((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methanol, the main research area is aryl thioglycoside preparation stereoselective glycosylation aryliodonium triflate; glycosylation; protecting groups; stereoselectivity; synthetic methods; thioglycosides.

New glycosyl donors have been developed that contained several para-substituted O-aryl protecting groups and their stereoselectivity for the glycosylation reaction was evaluated. A highly β-selective glycosylation reaction was achieved by using thioglycosides that were protected by 4-nitrophenyl (NP) groups, which were introduced by using the corresponding diaryliodonium triflate. Anal. of the stereoselectivities of several glycosyl donors indicated that the β-glycosides were obtained through an SN2-type displacement from the corresponding α-glycosyl triflate. The NP group could be removed by reduction of the nitro group and acylation, followed by oxidation with ceric ammonium nitrate (CAN).

Chemistry – An Asian Journal published new progress about Acylation. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Recommanded Product: ((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Meng, Shan-Shui; Lin, Li-Rong; Luo, Xiang; Lv, Hao-Jun; Zhao, Jun-Ling; Chan, Albert S. C. published the artcile< Aerobic oxidation of alcohols with air catalyzed by decacarbonyldimanganese>, Reference of 403-41-8, the main research area is manganese catalyzed aerobic oxidation functionalized alc.

The oxidation of alcs. to carbonyl compounds using air as the terminal oxidant is highly desirable. As described in previous reports, the abstraction of α-H of the alc. is the most important step, and it typically requires not only a metal catalyst but also complex ligands, co-catalysts and bases. Herein, we report a practical and efficient method for the oxidation of primary alcs., secondary alcs., 1,2-diols, 1,2-amino alcs., and other α-functionalized alcs. using a com. available catalyst, Mn2(CO)10, and no additives. Preliminary mechanistic studies indicated that an alkoxyl radical intermediate existed in our system, and a plausible mechanism consistent with the exptl. results and literature was proposed.

Green Chemistry published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Reference of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts