Month: October 2022

Mukherji, Ananya; Addanki, Rupa Bai; Halder, Suvendu; Kancharla, Pavan K. published their research in Journal of Organic Chemistry on December 3 ,2021. The article was titled 《Sterically Strained Bronsted Pair Catalysis by Bulky Pyridinium Salts: Direct Stereoselective Synthesis of 2-Deoxy and 2,6-Dideoxy-β-thioglycosides from Glycals》.Application of 20880-92-6 The article contains the following contents:

A sterically strained ionic Bronsted pair complex obtained from a sterically bulky base 2,4,6-tri-tert-butylpyridine and hydrochloric acid unusual reactivity to the anionic chloride. The complete shielding of the cationic [N-H]+ by the bulky ortho-tert-Bu groups weakens the possible hydrogen-bonding interactions with the chloride anion, and the [N-H]+···Cl- distance is unusually longer (3.10 Å). This results in strained/frustrated electrostatic interactions between the ion-pair, thus infusing an increased reactivity in both of the ions, which results in the activation of a third mol. like thiol via hydrogen-bonding. This intriguing weak interaction-based reactivity has been utilized to develop an organocatalytic synthesis of 2-deoxy-β-thioglycosides from glycals. While the 1H NMR studies showcase the diamagnetic activation of thiols in the presence of the catalyst, the ESR (EPR) studies reveal the generation of a radical species that suggests a possible frustrated radical pair catalysis. Besides, IR spectroscopic studies explain the intriguing influence of size/charge d. of the anion on the solvation-insusceptible, cationic [TTBPyH]+ and on the observed reactivity. In the experiment, the researchers used many compounds, for example, ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Application of 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Application of 20880-92-6

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Stavber, Stojan; Planinsek, Zdenka; Kosir, Iztok; Zupan, Marko published their research in Journal of Fluorine Chemistry on December 31 ,1992. The article was titled 《Substituent modulation of mild fluorination of aromatic molecules with cesium fluoroxysulfate》.Formula: C13H11ClO The article contains the following contents:

Functionalization of mono- and disubstituted benzene derivative with CsSO4F has been modulated by substituents on the benzene ring. α-Hydroxyalkylbenzenes, with a deactivated ring, were oxidized to phenones, while fluorodealkylation was achieved in high yield when electron-donating groups were present in a para position. Electron-withdrawing substituents favored chain fluorofunctionalization in alkylbenzenes, while ring fluorination was found exclusively in acylamino-derivatized alkylbenzenes; fluoro-addition products were formed in the case of p-alkoxy-substituted alkylbenzene derivatives In the experiment, the researchers used (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Formula: C13H11ClO)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Formula: C13H11ClO

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The author of 《2-[(Phenylthio)methyl]pyridine derivatives: new antiinflammatory agents》 were Haviv, Fortuna; DeNet, Robert W.; Michaels, Raymond J.; Ratajczyk, James D.; Carter, George W.; Young, Patrick R.. And the article was published in Journal of Medicinal Chemistry in 1983. Application of 55218-73-0 The author mentioned the following in the article:

The title compounds I (R = H, Br, Cl, F, Me, NH2, OMe, etc., R1 = H, Cl, OH, Me, OMe, Ph, etc.) and related compounds as the HCl salts, prepared mostly by the reaction of 2-picolyl chloride [4377-33-7] or 2-(hydroxymethyl)pyridine  [586-98-1] with the appropriate mercaptol either in 48% HBr under reflux or in the presence of NaOEt in EtOH at room temperature, were investigated as inflammation inhibitors in rat. I (R = H, Br, Cl, F, or NO2 and R1 = H) were effective inhibitors of immune complex induced inflammation as represented by the rat reverse passive Arthus reaction. 2-[[(4-bromophenyl)thio]methyl]pyridine (I; R = Br, R1 = H) [83782-10-9] also inhibited both exudate formation and cellular accumulation in the more conventional carrageenin pleural test, whereas indomethacin inhibited only exudate volume in this model. Structure-activity relations are discussed. The results came from multiple reactions, including the reaction of (4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0Application of 55218-73-0)

(4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.Application of 55218-73-0

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The author of 《Paper-Based Colorimetric Sensor System for High-Throughput Screening of C-H Borylation》 were Kim, Han-Sung; Eom, Min Sik; Han, Min Su; Lee, Sunwoo. And the article was published in Chemistry – A European Journal in 2017. SDS of cas: 401797-00-0 The author mentioned the following in the article:

A paper-based colorimetric sensor system (PBCSS) was developed to detect the amount of bis(pinacolato)diboron (B2Pin2) and applied as a high-throughput screening protocol in Ir-catalyzed C-H borylation. First, 96 ligands were screened for the borylation of benzene, and then 12 of them were selected and tested for five substrates. These reaction mixtures were spotted in the PBCSS, showing a blue-violet color. The value of the gray scale of each reaction was obtained from these colored spots and converted to the extent of conversion of B2Pin2. The extents of conversion of B2Pin2 obtained from the PBCSS showed good correlation with those obtained from gas chromatog. anal. The modified conversion using blank data showed good correlation with the yield of products. In the part of experimental materials, we found many familiar compounds, such as 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0SDS of cas: 401797-00-0)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.SDS of cas: 401797-00-0

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In 1996,Dave, Paritosh R. published 《Acylative Dealkylation of N-tert-Butyl-3-substituted Azetidines: Facile Access to [1.1.0]Azabicyclobutane, 3-Hydroxyazetidinium Hydrochloride, and 3-Azetidinones》.Journal of Organic Chemistry published the findings.Safety of Azetidin-3-ol hydrochloride The information in the text is summarized as follows:

A novel acylative dealkylation of N-tert-butylazetidines and its application to the facile high-yield syntheses of [1.1.0]azabicyclobutane, 3-hydroxyazetidinium hydrochloride, and 3-azetidinones is described. In the experiment, the researchers used many compounds, for example, Azetidin-3-ol hydrochloride(cas: 18621-18-6Safety of Azetidin-3-ol hydrochloride)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Safety of Azetidin-3-ol hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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In 2018,Nitha, P. R.; Joseph, Manu M.; Gopalan, Greeshma; Maiti, Kaustabh Kumar; Radhakrishnan, K. V.; Das, Parthasarathi published 《Chloroform as a carbon monoxide source in palladium-catalyzed synthesis of 2-amidoimidazo[1,2-a]pyridines》.Organic & Biomolecular Chemistry published the findings.Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The information in the text is summarized as follows:

A palladium-catalyzed aminocarbonylation strategy exploiting chloroform as a CO source has been developed for the synthesis of biol. potent 2-amidoimidazopyridine I (R1, R2 = -(CH2)4-, -(CH2)5-, cyclohexyl, etc.) scaffolds. The aminocarbonylation reaction was found to be general with a range of amines and substituted imidazopyridines. Preliminary biol. evaluation of cytotoxicity on selected examples provides scope for future investigations. In the part of experimental materials, we found many familiar compounds, such as (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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In 2019,ACS Applied Materials & Interfaces included an article by Ding, Jiheng; Zhao, Hongran; Shao, Zhenzong; Yu, Haibin. Recommanded Product: 6-Aminohexan-1-ol. The article was titled 《Bioinspired Smart Anticorrosive Coatings with an Emergency-Response Closing Function》. The information in the text is summarized as follows:

Emergency-response closing (ERC) of diffusion pathways for aggressive species in graphene/epoxy (G/EP) coatings was achieved via terpyridine derivative (TDD)-functionalized graphene oxide (tGO). Under stimulation from corrosion produced ferrous (Fe2+) ions, tGO sheets urgently aggregated through complexation reminiscent of leaves closing on a mimosa. Consequently, the coating showed significantly decreased oxygen (ORT) and water vapor transmittance rate (WVTR) changes after immersion in ferrous solution According to the simulation and electrochem. results, tGO sheets could self-assemble into 3D architectures with Fe2+ ions and efficiently protect metals from aggressive species attack. This tGO/EP coating provided an ERC function via self-adaptability with the Fe2+ ions to achieve long-term anticorrosion. The application of tGO/EP to the protection of metal components is therefore validated as a fascinating route for the enhancement of anticorrosion efficiency on graphene anticorrosive coatings, with great potential in durable anticorrosive coatings application. The results came from multiple reactions, including the reaction of 6-Aminohexan-1-ol(cas: 4048-33-3Recommanded Product: 6-Aminohexan-1-ol)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Recommanded Product: 6-Aminohexan-1-ol

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《Organophotoredox-Mediated Amide Synthesis by Coupling Alcohol and Amine through Aerobic Oxidation of Alcohol》 was published in Chemistry – A European Journal in 2020. These research results belong to Shah, Sk. Sheriff; Shee, Maniklal; Venkatesh, Yarra; Singh, Amit Kumar; Samanta, Samya; Singh, N. D. Pradeep. COA of Formula: C7H7BrO The article mentions the following:

The combination of an organic photocatalyst [4CzIPN (1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene) or 5MeOCzBN (2,3,4,5,6-pentakis(3,6-dimethoxy-9 H-carbazol-9-yl)benzonitrile)], quinuclidine, and tetra-n-butylammonium phosphate (hydrogen-bonding catalyst) was employed for amide bond formations. The hydrogen-bonded OH group activated the adjacent C-H bond of alcs. towards hydrogen atom transfer (HAT) by a radical species. The quinuclidinium radical cation, generated through single-electron oxidation of quinuclidine by the photocatalyst, employed to abstract a hydrogen atom from the α-C-H bond of alcs. selectively due to a polarity effect-produced α-hydroxyalkyl radical, which subsequently converted to the corresponding aldehyde under aerobic conditions. Then the coupling of the aldehyde and an amine formed a hemiaminal intermediate that upon photocatalytic oxidation produced the amide. In the part of experimental materials, we found many familiar compounds, such as (4-Bromophenyl)methanol(cas: 873-75-6COA of Formula: C7H7BrO)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.COA of Formula: C7H7BrO It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

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《An nπ* gated decay mediates excited-state lifetimes of isolated azaindoles》 was published in Physical Chemistry Chemical Physics in 2020. These research results belong to Lamas, Iker; Montero, Raul; Martinez-Martinez, Virginia; Longarte, Asier; Blancafort, Lluis. Recommanded Product: 7748-36-9 The article mentions the following:

Aiming to serve as a guide to understand the relaxation mechanisms of more complex aza-aromatic compounds, such as purine bases, we have studied the non-radiative channels of a set of azaindole structural isomers: 4-, 5-, 6- and 7-azaindole (AI). The relaxation of the isolated mols., after excitation at the low energy portion of their spectra, has been tracked by femtosecond time-resolved ionization, and the decay paths have been obtained with MS-CASPT2//TD-DFT calculations Although the ultrashort measured lifetimes for 5- and 6-Al are in contrast to the long-living excited state found in 7-Al, the calculations describe a common relaxation pathway. Along it, the initially excited ππ* states decay to the ground state through a conical intersection accessed through an nπ* state that functions as a gate state. The work reveals that the position of the nitrogen atoms in the purine ring determines the barrier to access the gate state and therefore, the rate of the non-radiative relaxation. In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9Recommanded Product: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: 7748-36-9

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《Synthesis, biological evaluation and molecular docking study of dihydropyrimidine derivatives as potential anticancer agents》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Safari, Sahand; Ghavimi, Reza; Razzaghi-Asl, Nima; Sepehri, Saghi. Application of 100-83-4 The article mentions the following:

A series of dihydropyrimidine analogs I (R = H, 3-Cl, 2-OH, 4-NO2, etc.; R1 = Et, Ph; X = O, S) was prepared via one-pot Biginelli three-component condensation reaction. Subsequently, they were screened for in vitro anticancer effect. These analogs revealed good cytotoxic activity against three human cancer cell lines including MCF-7, HepG-2, and A549. Among these analogs, compounds I (R = H, R1 = Ph, X = S (A); R = 4-NO2, R1 = Ph, X = S (B)) were the most potent against three cell lines. Cell viability assays indicated that I (R = H, R1 = Ph, X = O; R = 2-OH, R1 = Ph, X = O) had lower cytotoxicity. In vitro cytotoxicity study on all synthesized compounds demonstrated that introduction of electron withdrawing substituents on C4 position of Ph ring of dihydropyrimidine contributed to the antiproliferative potency. Moreover, in silico mol. docking results stipulated a sign of good correlation between exptl. activity and calculated binding affinity. It proved (A) and (B) as the strongest compounds Binding modes of analogs proposed the involvement of hydrophobic interactions and hydrogen bonds with Eg5 active site. Structure activity relationship studies indicated that incorporating electron withdrawing substituents on C4 position of Ph ring of dihydropyrimidine are important for this biol. activity. After reading the article, we found that the author used 3-Hydroxybenzaldehyde(cas: 100-83-4Application of 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Application of 100-83-4

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