Month: October 2022

《Synthesis and application of a novel 5-hydroxymethyl resorcinol diglycidyl ether-terminated polyurethane》 was published in Journal of Macromolecular Science, Part A: Pure and Applied Chemistry in 2020. These research results belong to Li, Shuan; Sun, Mingming; Liu, Caizhao; Zhang, Xugang; Li, Jianhui; Wang, Weiping; Zhang, Bin. Name: 3,5-Dihydroxybenzaldehyde The article mentions the following:

Epoxy resin containing active hydroxymethyl group, 5-hydroxymethyl resorcinol diglycidyl ether, was synthesized to produce 5-hydroxymethyl resorcinol diglycidyl ether-terminated polyurethane (ETPU1000). The synthesized epoxy resin is a small monomer mol., and no polymer is produced during the synthesis process. A monomer contains one hydroxyl group, and more flexible polyurethane segments can be introduced into the main chain when synthesizing the epoxy-terminated polyurethane. The synthesis process of ETPU1000 was investigated by FT-IR spectroscopy. The disappearance of NCO peak in the FT-IR spectrum showed that diisocyanate has completely reacted to form ETPU1000. Then, a series of epoxy cured systems were prepared by changing the mass ratio of ETPU1000 and the diglycidyl ether of bisphenol A (DGEBA), and cured with 4,4′-diaminodiphenyl methane (DDM). The effect of the content of ETPU1000 on the thermal properties, mech. properties and fracture morphol. of epoxy cured systems were investigated. The results showed that when the DGEBA/ETPU1000 blends with 75 wt% ETPU1000, impact strength of the cured systems reached 29.6 kJ·m-2, which significantly increased by 176.6% compared to that of neat epoxy. SEM was used to observe the fracture surfaces of cured DGEBA/ETPU1000 blends, which showed obvious ductile fracture characteristics. In the experimental materials used by the author, we found 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Name: 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Name: 3,5-Dihydroxybenzaldehyde

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《Ethylene glycol-rich thermosensitive poly(ss-hydroxyl amine)s》 was written by Oh, Junki; Hong, Jeonghui; Khan, Anzar. Quality Control of 4-Aminobutan-1-ol And the article was included in Journal of Macromolecular Science, Part A: Pure and Applied Chemistry in 2020. The article conveys some information:

This work illustrates a new mol. design for preparing amphiphilic ethylene glycol-rich poly(ss-hydroxyl amine) polymers. In this design, the backbone and the termini of the side-chain represents hydrophilic parts of the polymer chain. Incorporation of a short hydrophobic alkyl segment between the hydrophilic parts endows an amphiphilic character to the material. Due to this amphiphilic nature, the polymer chains show alkyl-length-dependent thermoresponsive aggregation behavior in aqueous solutions In the experimental materials used by the author, we found 4-Aminobutan-1-ol(cas: 13325-10-5Quality Control of 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Quality Control of 4-Aminobutan-1-ol

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The author of 《New perylenebisimide decorated cyclotriphosphazene heavy atom free conjugate as singlet oxygen generator》 were Okutan, Elif; Eserci, Hande; Senkuytu, Elif. And the article was published in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2019. Recommanded Product: 6-Aminohexan-1-ol The author mentioned the following in the article:

Perylenebisimide-cyclotriphosphazene based inorganic-organic system was synthesized by a multistep procedure. The substitution reaction of asym. perylenebisimide (PBI) derivative with the hexachloroyclotriphosphazene (trimer) resulted in the formation of fully PBI decorated cyclotriphosphazene (5). The identity of newly synthesized compound (5) was confirmed by using 31P, 1H and 13C NMR spectroscopies and mass spectrometry. The photophys. (UV- Vis absorption, fluorescence emission, fluorescence lifetime and fluorescence quantum yield) and photochem. (the singlet oxygen generation, and photostability) properties of this conjugate were investigated as novel heavy atom free triplet photosensitizer. The singlet oxygen quantum yield of the PBI-cyclotriphosphazene (5) was calculated to be 0.86 which is good for a heavy atom free triplet photosensitizer. These results will add to the development of cyclotriphosphazene based heavy atom free singlet oxygen triplet photosensitizer systems for applications in organic oxygenation reactions.6-Aminohexan-1-ol(cas: 4048-33-3Recommanded Product: 6-Aminohexan-1-ol) was used in this study.

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Recommanded Product: 6-Aminohexan-1-ol

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The author of 《Crystal structures of (E)-3-(4-hydroxybenzylidene)chroman-4-one and (E)-3-(3-hydroxybenzylidene)-2-phenylchroman-4-one》 were Suchojad, Kamil; Dolega, Anna; Adamus-Grabicka, Angelika; Budzisz, Elzbieta; Malecka, Magdalena. And the article was published in Acta Crystallographica, Section E: Crystallographic Communications in 2019. Safety of 3-Hydroxybenzaldehyde The author mentioned the following in the article:

The synthesis and crystal structures of (E)-3-(4-hydroxybenzylidene)chroman-4-one, C16H12O3, I, and (E)-3-(3-hydroxybenzylidene)-2-phenylchroman-4-one, C22H16O3, II, are reported. These compounds are of interest with respect to biol. activity. Both structures display intermol. C-H···O and O-H···O hydrogen bonding, forming layers in the crystal lattice. The crystal structure of compound I is consolidated by π-π interactions. The lipophilicity (logP) was determined as it is one of the parameters qualifying compounds as potential drugs. The logP value for compound I is associated with a larger contribution of C···H interaction in the Hirshfeld surface.3-Hydroxybenzaldehyde(cas: 100-83-4Safety of 3-Hydroxybenzaldehyde) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Safety of 3-Hydroxybenzaldehyde

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In 2021,Journal of Materials Chemistry B: Materials for Biology and Medicine included an article by Jiang, Bowen; Hao, Dengyuan; Li, Chaonan; Lu, Shaojin; Pei, Qing; Xie, Zhigang. Quality Control of 3,3,3-Trifluoropropan-1-ol. The article was titled 《Fluorinated paclitaxel prodrugs for potentiated stability and chemotherapy》. The information in the text is summarized as follows:

Robust colloidal stability is an essential prerequisite for effective drug delivery. Herein, a series of fluorinated paclitaxel prodrugs bridged with redox-responsive linkages were synthesized, and the effect of fluorination on the assembly behavior and physiol. stability was investigated. The 17-fluorinated ethanol-modified paclitaxel prodrug could self-assemble into stable nanoparticles without the addition of any surfactants. Fluorinated paclitaxel prodrug nanoparticles possessed potent cytotoxicity toward cancer cells and superior antitumor activity. This study offers a universal fluorination approach to improve drug delivery efficacy by enhancing the self-assembly capability and improving the colloidal stability of prodrugs for potentiating chemotherapy. The experimental part of the paper was very detailed, including the reaction process of 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Quality Control of 3,3,3-Trifluoropropan-1-ol)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Quality Control of 3,3,3-Trifluoropropan-1-ol

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The author of 《Analytical method development and validation for the simultaneous estimation of salbutamol sulphate, guaifenesin, and ambroxol hydrochloride by RP-HPLC method in commercial oral liquid dosage form》 were Thangavelu, Prabha; Grace, Arul Caroline; Murugesan, Jagadeeswaran. And the article was published in International Journal of Pharmaceutical Sciences and Research in 2019. SDS of cas: 23828-92-4 The author mentioned the following in the article:

Salbutamol is a bronchodilator, Guaifenesin is an expectorant and Ambroxol is a mucolytic. Combination of these drugs is used in the formulation of cough syrups. In the literature, there is no method reported for the simultaneous estimation of the drugs in oral liquid dosage form. Hence, the present work is aimed to develop reverse phase HPLC method for the simultaneous determination of Salbutamol sulfate (SAL), Guaifenesin (GUA) and Ambroxol hydrochloride (AMB) in oral liquid dosage form and validation of the developed method. The chromatog. separation of the drugs was achieved with the mobile phase system sodium dihydrogen phosphate buffer pH 3.0: acetonitrile: methanol in the ratio of 65:10:25 with the flow rate of 1 mL/min and injection volume 10μL. An Inertsil C8-3 (250 × 4.6 mm, 5μm) column was used, and the detection wavelength was 276 nm. This system produced sharp peaks with good resolution, min. tailing and satisfactory retention times of SAL, GUA and AMB were found to be 3.157, 9.949 and 11.883 min resp. indicating the suitability of the system. The developed method was validated for various parameters accuracy, precision, linearity, robustness, and specificity as per ICH guidelines. After reading the article, we found that the author used trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4SDS of cas: 23828-92-4)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a mucolytic expectorant and a metabolite of bromhexine.SDS of cas: 23828-92-4 It is used in the treatment of respiratory disorders characterized by viscous or excessive mucus.

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In 2019,International Journal of Pharmaceutics (Amsterdam, Netherlands) included an article by Chaudhari, Kapil S.; Akamanchi, Krishnacharya G.. Recommanded Product: 156-87-6. The article was titled 《Novel bicephalous heterolipid based self-microemulsifying drug delivery system for solubility and bioavailability enhancement of efavirenz》. The information in the text is summarized as follows:

There is an increasing demand for new lipidic biocompatible and safe materials for self-microemulsifying drug delivery system (SMEDDS). The present work reports the synthesis, characterization, oral mucosal irritation study, and application of novel erucic acid ester of G0-PETIM dendron based bicephalous heterolipid (BHL) as an oil phase in SMEDDS using Efavirenz (EFA), a BCS class II drug with poor water solubility and poor bioavailability. Studies were conducted to optimize EFA SMEDDS using different ratios of the BHL as oil phase and surfactant: co-surfactant weight ratios (Km). At Km (1.5), the microemulsion was spontaneously formed in water with mean globule size of 22.78 ± 0.25 nm and polydispersity index (PDI) of 0.23 ± 0.031 with high drug loading efficiency of 80.35 ± 3.1%. Standard stability tests were performed on EFA SMEDDS and the results indicated it to be highly stable. The in vitro dissolution profile of EFA SMEDDS showed >95% of the drug release within an hour and expectedly substantial enhancement in in vivo bioavailability was observed; almost 6-fold increase in bioavailability with parameters Cmax 5.2 μg/mL, Tmax 3 h, and AUC(0-∞) 23.48 μg/h/mL resp. as compared the plain suspension of the drug. In conclusion, the BHL can be used effectively as an oil phase in SMEDDS to enhance solubility and bioavailability of BCS Class II drugs. Further, it holds, in general, a great promise as a new excipient for solubility and bioavailability enhancements. The experimental part of the paper was very detailed, including the reaction process of 3-Aminopropan-1-ol(cas: 156-87-6Recommanded Product: 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Recommanded Product: 156-87-6

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《Nanocomposites of ionic copolymer integrating Gd-containing polyoxometalate as a multiple platform for enhanced MRI and pH-response chemotherapy》 was written by Zhou, Tingting; Wan, Guofeng; Li, Bao; Wu, Lixin. Synthetic Route of C3H7BrO And the article was included in Journal of Materials Chemistry B: Materials for Biology and Medicine in 2020. The article conveys some information:

This article describes the fabrication of nanosized paramagnetic drug carriers via the assembly of a pH-responsive hydrophilic block copolymer poly(polyethylene glycol Me ether methacrylate)-b-poly(methacrylic acid-co-trimethyl ammonium bromide Pr methacrylate) (PPMT) and polyoxometalate K13[Gd(β2-SiW11O39)2] (GdSiW11) through electrostatic interaction. Owing to the hydrophilicity, large mol. weight, and high content of the GdSiW11 cluster bearing in the nanocomposites, the organic-inorganic nanocomposite exhibited an impressive longitudinal relaxivity as a contrast agent for magnetic resonance imaging (MRI). The surplus neg. charges from the polyoxometalate cluster in the polymer nanocomposites facilitated the capture of the anti-tumor drug doxorubicin (DOX). The DOX-loaded nanocomposites were stable under the physiol. environment, whereas a responsive release of DOX was achieved at pH values similar to the tumor microenvironment due to the regulation of the polyoxometalate and carboxyl groups. The DOX-loaded PPMT2-GdSiW11 nanocomposites were observed to enrich effectively at tumor sites through MRI after i.v. injection. Furthermore, the DOX-loaded composites manifested enhanced in vivo anti-tumor therapeutic efficacy and sustainable circulation time of more than 5 h, which were favorable for imaging measurement. With the advantages of the designed composite system, the present experiments propose a strategy for developing a new multiple imaging-drug delivery-local therapy platform for synergistic diagnosis and therapy. After reading the article, we found that the author used 3-Bromopropan-1-ol(cas: 627-18-9Synthetic Route of C3H7BrO)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Synthetic Route of C3H7BrO

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《Exploring AIE luminogens as stickers to construct self-healing ionomers and as probes to detect the microscopic healing dynamics》 was written by Gu, Shiyu; Wang, Hao; Zhang, Hao; Peng, Yan; Zhang, Linjun; Zhang, Junqi; Zheng, Jing; Wu, Jinrong. Application In Synthesis of 3-Bromopropan-1-ol And the article was included in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2021. The article conveys some information:

In spite of considerable progress in self-healing polymers, detecting the healing kinetics and its underlying mol. mechanism is still in the early development stage. Herein, we design a self-healing ionomer by grafting AIEgens (PyTPE) as sticky groups onto a bromo-matrix (PBMB). The ionomer shows good mech. properties (15 MPa, 300%) and crack healing efficiency at room temperature Interestingly, the grafted AIEgen stickers enable us to quantify the healing kinetics and its underlying microscopic structural change through the evolution of fluorescence intensity induced by the AIE effect. In addition, a 2D correlation anal. indicates that the decoupled ionic moieties move first to recombine again during the healing process, finally leading to the reconstruction of a transient network and macro-healing. Therefore, this work offers a fluorescence-based method to study the microscopic self-healing mechanism of ionomers during damage and healing processes. In the experimental materials used by the author, we found 3-Bromopropan-1-ol(cas: 627-18-9Application In Synthesis of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Application In Synthesis of 3-Bromopropan-1-ol

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Formula: C4H12KNaO10In 2013 ,《Studies on solution-grown pure and doped sodium potassium tartrate crystals》 appeared in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy. The author of the article were Mathivanan, V.; Haris, M.. The article conveys some information:

A systematic anal. of the FTIR spectroscopy and Raman spectra of pure and Cu(NO3)2.3H2O doped Rochelle salt (NaKC4H4O6.4H2O) in terms of the standard frequency correlations, deuteration shift and typical nature (with respect to intensity and width) of bands due to different modes is reported. The bands due to the internal modes (excluding some skeletal modes) of the C4H4O62- ion appear as doublets. For certain modes (e.g. βCH, γC(OH) and δCOO) doublets arise owing to interaction between 2 identical oscillations of 2 identical groups in COO(HO)HCCH(OH)COO2-, while for other modes (e.g. γCH, γCOa, γCOa, γCOs, δCOH and τCOO) they arise owing to crystallog. distinguishable sites for 2 identical oscillators. The effect of dopant in the pure Rochelle salt crystals is found out by using Elemental anal. The unit cell volume of pure and Cu(NO3)2.3H2O doped Rochelle salt crystals is found out from powder x-ray diffraction studies. The experimental process involved the reaction of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Formula: C4H12KNaO10)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Formula: C4H12KNaO10 It is utilized to break up emulsion in organic synthesis as well as a common precipitant in protein crystallography.

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