Month: October 2022

《New Aqueous Solutions with Lower Viscosities than Water》 was published in Bulletin of the Chemical Society of Japan in 2021. These research results belong to Haraguchi, Kazutoshi; Kimura, Yuji. Computed Properties of C3H5F3O The article mentions the following:

Liquid water exhibits many anomalous phys. properties because of its unique structure and hydrogen bonding networks, which were mostly uncovered at the beginning of the 20th century. Because of its interesting properties and microstructures under various conditions and in aqueous solutions, understanding the behavior of water is important, but remains scientifically challenging. Regarding the viscosity of aqueous solutions, despite the discovery 147 years ago that very small amounts of certain salts decrease the viscosity of water slightly, there has been no significant progress to date. Herein, we report new aqueous solutions, with low additive fractions and much lower viscosities than pure water, which exhibit unique viscosity-composition curves. The findings should spark renewed interest in scientific research on water, which may greatly impact numerous industries. The experimental part of the paper was very detailed, including the reaction process of 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Computed Properties of C3H5F3O)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Computed Properties of C3H5F3O

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《Stereoselective Tandem Bis-Electrophile Couplings of Diborylmethane》 was written by Murray, Stephanie A.; Liang, Michael Z.; Meek, Simon J.. Product Details of 78782-17-9This research focused onthree component coupling diborylmethane epoxide allyl bromide preparation hydroxyboronate; diol hydroxyboronate chiral preparation stereoselective borylation ring opening epoxide. The article conveys some information:

A copper-catalyzed three-component linchpin coupling method for the stereoselective union of readily available epoxides R1R2C(O)CHR3 with diborylmethyl lithium (pinB)2CHLi and allyl electrophiles is disclosed; the reaction afforded borylated alc. derivatives R1R2C(OX)CH2CHBpinCH2CH:CH2 (X = TBSO, H) or the corresponding 1,3-diols R1R2C(OH)CH2CH(OH)CH2CH:CH2 after oxidation Transformations employ [B(pin)]2-methane as a conjunctive reagent, resulting in the formation of two C-C bonds at a single carbon center bearing a C(sp3) organoboron functional group. Products are obtained in 42-99% yield, and up to >20:1 dr. The utility of the approach is highlighted by stereospecific transformations entailing allylation, tandem cross coupling, and application to the synthesis 1,3-polyol motifs. In the experiment, the researchers used Bis[(pinacolato)boryl]methane(cas: 78782-17-9Product Details of 78782-17-9)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Product Details of 78782-17-9 Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.

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Recommanded Product: 4,4-Diethoxybutan-1-amineOn September 27, 2021 ,《Direct Amidation of Esters by Ball Milling》 was published in Angewandte Chemie, International Edition. The article was written by Nicholson, William I.; Barreteau, Fabien; Leitch, Jamie A.; Payne, Riley; Priestley, Ian; Godineau, Edouard; Battilocchio, Claudio; Browne, Duncan L.. The article contains the following contents:

The direct mechanochem. amidation of esters RC(O)OR1 (R = Cy, Ph, pyridin-2-yl, etc.; R1 = Me, Et) by ball milling is described. The operationally simple procedure requires an ester, amines R2NHR3 (R2 = H, Me, Et; R3 = i-Pr, Ph, 2,4,6-trimethylphenyl, etc.; R2R3 = -(CH2)2O(CH2)2-, -(CH2)5-, -(CH2)6-, etc.) and 1,2,3,4-tetrahydroquinoline, and substoichiometric KOtBu, and was used to prepare a large and diverse library of 78 amide structures RC(O)N(R2)R3 and (3,4-dihydroquinolin-1(2H)-yl)(phenyl)methanone with modest to excellent efficiency. Heteroaromatic and heterocyclic components are specifically shown to be amenable to this mechanochem. protocol. This direct synthesis platform has been applied to the synthesis of active pharmaceutical ingredients (APIs) and agrochems. as well as the gram-scale synthesis of an active pharmaceutical, all in the absence of a reaction solvent. In the experimental materials used by the author, we found 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Recommanded Product: 4,4-Diethoxybutan-1-amine)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Recommanded Product: 4,4-Diethoxybutan-1-amine

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In 2019,International Research Journal of Pharmacy included an article by Wadher, Sailesh J.; Supekar, Bhagwan B.; Shivpuje, Shivraj S.. Synthetic Route of C13H19Br2ClN2O. The article was titled 《Development and validation of new FT-IR spectrophotometric method for simultaneous estimation of ambroxol hydrochloride and cetirizine hydrochloride in combined pharmaceutical solid tablet dosage form》. The information in the text is summarized as follows:

IR spectroscopy is also known as vibrational spectroscopy. FTIR is a non-destructive, highly sensitive, highly specific and robust anal. technique by which almost any solid, liquid or gas samples can be analyzed. The given research work is related with successful development and validation of newer, accurate, precise and sensitive FT-IR anal. method for estimation of cetirizine hydrochloride and ambroxol hydrochloride in their combined tablet dosage form. Literature survey reveals that, there is no FT-IR spectrophotometric method was developed and validated until now for this combination. KBr (Ar) grade was used as diluent. The functional groups were selected as AR-NH (1631 cm-1) for ambroxol HCl and C=O (1741 cm-1) for cetirizine HCl. The method was validated as per ICH guidelines. The linearity was developed at 6.0-36.0% weight/weight for AMB HCl and 0.5-3.0% weight/weight for CET HCl resp. The correlation coefficients were found to be 0.9993 and 0.9995 resp. The precision was found to be within acceptable limit. The developed method was found to be accurate and repeatable the % RSD was found to be within 2%. The results came from multiple reactions, including the reaction of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Synthetic Route of C13H19Br2ClN2O)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a medication indicated to alleviate chest congestion associated with conditions that include bronchitis, pneumonia, bronchospasm asthma, cough, and allergy.Synthetic Route of C13H19Br2ClN2O Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion.

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Shaghafi, Michael B.; Barrett, David G.; Willard, Francis S.; Overman, Larry E. published an article on February 15 ,2014. The article was titled 《The insulin secretory action of novel polycyclic guanidines: Discovery through open innovation phenotypic screening, and exploration of structure-activity relationships》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.SDS of cas: 93524-95-9 The information in the text is summarized as follows:

We report the discovery of the glucose-dependent insulin secretogogue activity of a novel class of polycyclic guanidines through phenotypic screening as part of the Lilly Open Innovation Drug Discovery platform. Three compounds from the University of California, Irvine, I.HCl, II.HCl and III.HCl, having the 3-arylhexahydropyrrolo[1,2-c]pyrimidin-1-amine scaffold acted as insulin secretagogues under high, but not low, glucose conditions. Exploration of the structure-activity relationship around the scaffold demonstrated the key role of the guanidine moiety, as well as the importance of two lipophilic regions, and led to the identification of IV.HCl, which stimulated insulin secretion in isolated rat pancreatic islets in a glucose-dependent manner. In the experimental materials used by the author, we found 3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9SDS of cas: 93524-95-9)

3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.SDS of cas: 93524-95-9

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Singh, Pallavi; Peddinti, Rama Krishna published an article in Journal of Chemical Sciences (Berlin, Germany). The title of the article was 《In situ generated superacid BF3-H2O catalyzed alkylation of p-quinols with diaryl carbinols leading to triarylmethanes》.Product Details of 63012-03-3 The author mentioned the following in the article:

In this paper, a highly efficient and sustainable synthesis of triarylmethanes 4-R-3,6-(OH)2C6H2CH(4-R2C6H4)(4-R1C6H4) (R = Me, Et, i-Pr, Ph; R1 = H, F, Cl, Me; R2 = H, F, Cl, Me, Br) through the dehydrative coupling of p-quinols I with diaryl carbinols 4-R1C6H4CH(OH)(4-R2C6H4) is presented. The catalyst involved in this protocol is in situ generated superacid BF3-H2O from BF3-OEt2. Therefore, moisture has been used as an efficient initiator in this reaction system. A variety of diaryl carbinols and p-quinols have been investigated and found to be compatible to give the triarylmethanes in yields up to 96%.(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Product Details of 63012-03-3) was used in this study.

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.Product Details of 63012-03-3

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Suvarna, Vasanti; Gujar, Parul; Murahari, Manikanta; Sharma, Dhvani; Chamariya, Rinkal published an article on January 31 ,2022. The article was titled 《Supramolecular ternary inclusion complexes of Irbesartan with hydroxypropyl-beta-cyclodextrin》, and you may find the article in Journal of Drug Delivery Science and Technology.Computed Properties of C6H12O6 The information in the text is summarized as follows:

Current study investigated the formation of binary and ternary inclusion complexes of Irbesartan (IRB) with Hydroxypropyl-β-Cyclodextrin (HP-βCD) as host and L-Arginine (L-Arg) as ternary agent. Inclusion complexes were characterized using solubility, invitro release, DSC and XRD studies. Host-guest interactions were explored by FTIR, 1H NMR and mol. docking studies. Significant enhancement in stability constant and complexation efficiency of HP-βCD was observed in ternary complexes due to the presence of L-Arg. Ternary complexes exhibited greater solubility and dissolution of IRB than binary complexes. Thus, ternary complexation of IRB could offer an innovative strategy for improvement of solubility and dissolution of IRB. In the part of experimental materials, we found many familiar compounds, such as rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Computed Properties of C6H12O6)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is the monohydrate form of the alpha isoform of D-glucopyranose, a synthetic simple monosaccharide that is used as an energy source.Computed Properties of C6H12O6

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In 2016,De Leon-Gonzalez, Grecia; Gonzalez-Valdez, Jose; Mayolo-Deloisa, Karla; Rito-Palomares, Marco published 《Intensified fractionation of brewery yeast waste for the recovery of invertase using aqueous two-phase systems》.Biotechnology and Applied Biochemistry published the findings.Safety of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate The information in the text is summarized as follows:

The potential recovery of high-value products from brewery yeast waste confers value to this industrial residue. Aqueous two-phase systems (ATPS) have demonstrated to be an attractive alternative for the primary recovery of biol. products and are therefore suitable for the recovery of invertase from this residue. Sixteen different polyethylene glycol (PEG)-potassium phosphate ATPS were tested to evaluate the effects of PEG mol. weight (MW) and tie-line length (TLL) upon the partition behavior of invertase. Concentrations of crude extract from brewery yeast waste were then varied in the systems that presented the best behaviors to intensify the potential recovery of the enzyme. Results show that the use of a PEG MW 400 g mol-1 system with a TLL of 45.0% (weight/weight) resulted in an invertase bottom phase recovery with a purification factor of 29.5 and a recovery yield of up to 66.2% after scaling the system to a total weight of 15.0 g. This represents 15.1 mg of invertase per mL of processed bottom phase. With these results, a single-stage ATPS process for the recovery of invertase is proposed. In the part of experimental materials, we found many familiar compounds, such as Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Safety of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Safety of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate As a Biuret reagent, it is used to measure the protein concentration. Furthermore, it is used as laxative and is also used in food industry.

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In 2016,Farzaneh, Amir; Hosseini, Mir Ghasem; Asl, Shahin Khameneh; Mermer, Omer published 《Electrochemical, structural and nano tribological behavior of Ni-W-PTFE nanocomposite coatings prepared by tartrate bath》.International Journal of Electrochemical Science published the findings.SDS of cas: 6381-59-5 The information in the text is summarized as follows:

A tartrate nickel plating bath has been used to prepare nickel- tungsten (Ni-W) dispersed PTFE composite coatings with four different PTFE contents (0, 4, 8 and 20 gl-1). The coatings are characterized using of Field-Emission SEM (SEM), Energy Dispersive Xray Anal. (EDAX) and X-ray Diffractrometry (XRD). XRD results indicate that the PTFE particle changed the surface texture significantly. The nano tribol. behavior of the nano composite coating was estimated by contact mode of AFM. Electrochem. performance of the nanocomposite depositions was evaluated using potentiodynamic polarization and electrochem. impedance spectroscopy (EIS). The results show that the Ni-W/PTFE nanocomposite films exhibit better electrochem. and tribol. performance than the Ni-W coating. The corrosion rate and surface roughness decreased about 50 and 5 times less than bare coating in optimum condition 8 gl-1 PTFE. After reading the article, we found that the author used Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5SDS of cas: 6381-59-5)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. SDS of cas: 6381-59-5 It may be used as a constituent to prepare DNS (3,5- dinitrosalicylic acid) reagent and Fehling′s solution B, which are used in the determination of reducing sugar.

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In 2017,Pilicer, Samantha L.; Bakhshi, Pegah R.; Bentley, Keith W.; Wolf, Christian published 《Biomimetic Chirality Sensing with Pyridoxal-5′-phosphate》.Journal of the American Chemical Society published the findings.Product Details of 126456-43-7 The information in the text is summarized as follows:

Pyridoxal-5′-phosphate (PLP) is introduced to a biomimetic indicator displacement assay for simultaneous determination of the absolute configuration, enantiomeric composition and concentration of unprotected amino acids, amino alcs. and amines. The chiroptical assay is based on fast imine metathesis with a PLP aryl imine probe to capture the target compound for CD and fluorescence sensing anal. The substrate binding yields characteristic Cotton effects that provide information about the target compound ee and the synchronous release of the indicator results in a nonenantioselective off-on fluorescence response that is independent of the enantiomeric sample composition and readily correlated to the total analyte concentration The experimental process involved the reaction of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Product Details of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Product Details of 126456-43-7

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