Month: June 2021

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 41175-50-2, name is 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 41175-50-2

Compound 26 (50 mg, 0.26 mmol) was dissolved in a solution of z-Pr0H/H20 (9/1, 1 mL) at 80 C for 30 min. A suspended solution of 35 (58 mg, 0.28 mmol) and HCIO4 (70%, 30 pL) in 90% z-PrOH (2 mL) was added in 4 portions over 1 h. The resulting solution was stirred overnight. After which, the dark blue solution was evaporated under reduced pressure, and the residue was purified on a Biotage Isolera Flash System using SNAP Ultra cartridge with a mobile phase of CHCh and MeOH containing 0.5% formic acid (gradient, 2-15% of MeOH in CHCh). The fractions containing product were pooled and evaporated, affording LGW-02-86 (36 mg, 34%) as a dark blue solid.

With the rapid development of chemical substances, we look forward to future research findings about 41175-50-2.

Reference:
Patent; OREGON HEALTH & SCIENCE UNIVERSITY; GIBBS, Summer L.; WANG, Lei G.; BARTH, Connor W.; (159 pag.)WO2020/23911; (2020); A2;,
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Synthetic Route of 7314-44-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7314-44-5, name is (2,4-Dimethoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

TMS protected treprostinil was dissolved in DCM (2.5 mE) and H20 (60 pL). DMAP (76 mg, 0.624 mmol),EDC.HC1 (119 mg, 0.624 mmol) and Dmob-alcohol (105 mg, 0.624 mmol) dissolved in DCM (1 ml) were added. Thereaction mixture was stirred at RT until reaction was com25 plete (EC/MS). The solution was diluted with DCM andquenched by addition of 0.1 N HC1 solution saturated withNaC1. The aqueous phase was extracted several times withDCM. Combined organic layers were dried with Mg504 andthe solvent was removed in vacuo obtaining crude product8. Crude product was purified using RP-HPEC (solvent A:H20 with 0.05% TFA, solvent B: MeCN with 0.05% TFA, gradient: 35-85% B over 16 mm, flow: 40 ml/min). Combined HPEC fractions were adjusted to a pH of approx. 7 by adding sat. NaHCO3 soln. MeCN was removed in vacuo. The remaining H20 layer was extracted several times with DCM and the combined organic phases were dried with Mg504, filtered and the solvent was removed in vacuo obtaining product 8 as colorless solid.Yield: 69 mg (82%).MS: mlz 563.20 g/mol=[M+Na] (MW+Na calculated=563.67 g/mol).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7314-44-5, (2,4-Dimethoxyphenyl)methanol.

Reference:
Patent; Ascendis Pharma A/S; Hersel, Ulrich; Rau, Harald; Lessmann, Torben; Bisek, Nicola; Maitro, Guillaume; Sprog°e, Kennett; Wegge, Thomas; Keil, Oliver; Zettler, Joachim; (89 pag.)US9561287; (2017); B2;,
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Electric Literature of 112-47-0 ,Some common heterocyclic compound, 112-47-0, molecular formula is C10H22O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 1 To a mixture of 1,10-decanediol (35.73g, 0.205 mol) and toluene (700 mL) was added concentrated HBr (29 mL of 47% aqueous solution, 0.24 mol). The heterogeneous mixture was stirred and heated at reflux for 36 hours. TLC analysis indicated substantial amounts of 1,10-decanediol still remained. Thus a further quantity of HBr (15 mL, 0.12 mol) was added and the mixture was heated at reflux for further 36 h, at which time TLC analysis showed no diol remaining. The reaction mixture was allowed to cool to room temperature and the phases were separated. The organic layer was concentrated by evaporating the toluene and diluted with ethyl acetate and washed with water, sodium bicarbonate and brine. Then the organic layer was dried over Na2SO4 and concentrated to yellow liquid and purification of this crude reaction mixture by column chromatography provided pure 10-bromodecanol (43.0 g) in 90% yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 112-47-0, 1,10-Decanediol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Council of Scientific and Industrial Research; EP1818336; (2007); A1;,
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Adding a certain compound to certain chemical reactions, such as: 504-63-2, 1,3-Propanediol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 504-63-2, blongs to alcohols-buliding-blocks compound. Recommanded Product: 504-63-2

Propane-1,3-diol (5.0 g, 65.78 mmol) was taken in 50 mL of dry THF. Next, NaH (60% dispersion in mineral oil, 2.49 g, 65.78 mmol) was added in portions at 0 C. The reaction mixture was stirred at 0 C for 30 min. Tetrabutylammonium iodide (TBAI) (1.6 g, 0.66 mmol) was added to it followed by the addition of 4-methoxybenzylbromide (13.2 g, 65.78 mmol) in THF (50 mL). The reaction mixture was stirred for a further 2 h at room temperature. Ice water (15 mL) was added carefully to the reaction mixture to quench any excess of NaH. The reaction mixture was extracted with EtOAc (50 mL). The organic layer was washed with water (15 mL) and brine (20 mL). Evaporation and purification by means of silica gel chromatography (EtOAc/hexane = 20:80) afforded compound 8 (11.6 g, 90%) as a colorless liquid. IR: nu 3393, 1613, 1513, 1462, 1248 cm-1; 1H NMR (200 MHz, CDCl3): 7.22 (2H, d, J = 8.0 Hz), 6.83 (2H, d, J = 8.0 Hz), 4.41 (2H, s), 3.79 (3H, s), 3.70 (2H, d, J = 7.0 Hz), 3.56 (2H, d, J = 7.0 Hz), 2.52 (1H, br s), 1.86-1.74 (2H, m); 13C NMR (50 MHz): delta; ESIMS: m/z 197 [M+H]+, Anal. Calcd for C11H16O3: C, 67.35; H, 8.16. Found: C, 67.46; H, 8.11.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,504-63-2, its application will become more common.

Reference:
Article; Das, Biswanath; Nagendra, Siddavatam; Reddy, Cheruku Ravindra; Tetrahedron Asymmetry; vol. 22; 11; (2011); p. 1249 – 1254;,
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Synthetic Route of 62285-58-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.62285-58-9, name is (2,6-Dimethylphenyl)methanol, molecular formula is C9H12O, molecular weight is 136.19, as common compound, the synthetic route is as follows.

To a solution of 2,6-dimethylbenzyl alcohol (456 mg, 3.35 mmol) and triethylamine (0.560 mL, 4.02 mmol) in dichloromethane (CH2Cl2, 15 mL) was added methanesulfonyl chloride (0.258 mL, 3.68 mmol) under ice-cooling and the mixture was stirred for one hour. Thereto was subsequently added lithium bromide (LiBr, 582 mg, 6.70 mmol) under ice-cooling, and the mixture was warmed to room temperature and the mixture was stirred for 2 hours. Thereto was added water to quench the reaction and the reactant was extracted with ethyl acetate and the organic layer was washed twice with water. The organic layer was dried over anhydrous magnesium sulfate and filtered, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography to give the title compound 364 mg as colorless oils. 1H-NMR delta (DMSO-d6); 2.37 (6H, s), 4.71 (2H, s), 7.04-7.16 (3H, m).

Statistics shows that 62285-58-9 is playing an increasingly important role. we look forward to future research findings about (2,6-Dimethylphenyl)methanol.

Reference:
Patent; Dainippon Sumitomo Pharma Co., Ltd.; EP1736467; (2006); A1;,
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Adding a certain compound to certain chemical reactions, such as: 140373-17-7, 2-Amino-2-(4-fluorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 140373-17-7, blongs to alcohols-buliding-blocks compound. name: 2-Amino-2-(4-fluorophenyl)ethanol

step 1 4- (4-fluorophenyl) oxazolidin-2-one2-amino-2- (4-fluorophenyl) ethan-1-ol 600mg and diethyl carbonate 914mg potassium carbonate 80mg It was suspended in, and stirred for 2.5 hours at 130 , further stirred for 2.5 hours at 100 , except for the ethanol to produce.The reaction mixture was diluted with ethyl acetate, washed successively with water and saturated brine, and dried with magnesium sulfate.Under reduced pressure, the solvent was distilled off, to give the title compound 610mg as a pale yellow oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,140373-17-7, its application will become more common.

Reference:
Patent; NIPPON SHINYAKU COMPANY LIMITED; FUJIHARA, HIDETAKA; ASAKI, TETSUO; HORI, KATSUTOSHI; NAITO, HARUNA; (146 pag.)JP5668756; (2015); B2;,
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Reference of 7589-27-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 7589-27-7 as follows.

To a stirring solution of 4-fluorophenylethyl alcohol (110 g, 184.8 mmol) in dry DMSO (800 mL) triethylamine (220 mL, 1589.2 mmol) was added dropwise. The temperature was maintained at 15 C. stirring under N2. A solution of pyridine sulfur trioxide (253 g, 1589.2 mmol) in dry DMSO (900 mL) was added dropwise to the reaction keeping the temperature below 25 C. The subsequent mixture was stirred at 15 C. for 1.5 h. After this time, 1N HCl (aqueous) was added carefully until the mixture reached pH 4.3. The reaction mixture was extracted with MTBE, the organic layer dried and evaporated to give 4-fluorophenylacetaldehyde (110.8 g) as yellow oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7589-27-7, its application will become more common.

Reference:
Patent; Callahan, James Frances; Li, Yue Hu; US2006/116419; (2006); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 217479-60-2, name is 2,4,6-Trichlorobenzyl alcohol, molecular formula is C7H5Cl3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 2,4,6-Trichlorobenzyl alcohol

Tert-butyl 4-{6-[(2,4,6-trichlorophenyl)methoxy]-2H-spiro[l- benzofuran-3,4′-piperidine]-l’-yl}butanoate. To a solution of (2,4,6- trichlorophenyl)methanol (164.5 mg; 0.78 mmol) and tert-butyl 4-{6-hydroxy- 2H-spiro[l-benzofuran-3,4′-piperidine]- l’-yl}butanoate (250 mg; 0.62 mmol) in dichloromethane (20 mL) was added triphenylphosphine (204 mg; 0.78 mmol), followed, after 30 minutes by DIAD (0.15 mL; 0.78 mmol). Subsequently, the resulting mixture was stirred at RT overnight, and concentrated in vacuo. Subsequently, the reaction mixture was partitioned between 5% aqueous NaHC03 solution and EtOAc. The layers were separated and the organic layer was dried (Na2S04), filtered, and concentrated. The residue was purified by column chromatography (S1O2, Et20: hexanes 1:2) to afford the product (174 mg, 52%). Rt 1.59 min (System B), [M+H]+ 542.0.

With the rapid development of chemical substances, we look forward to future research findings about 217479-60-2.

Reference:
Patent; ABBOTT HEALTHCARE PRODUCTS B.V.; STOIT, Axel; IWEMA BAKKER, Wouter, I.; COOLEN, Hein K.A.C.; VAN DONGEN, Maria J.P.; LEFLEMME, Nicolas J.-L.D.; WO2012/4378; (2012); A1;,
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Adding a certain compound to certain chemical reactions, such as: 16369-21-4, 2-(Propylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 16369-21-4, blongs to alcohols-buliding-blocks compound. Formula: C5H13NO

A mixture of 2-(propylamino)ethanol (41 mg, 0.397 mmol) and (R)-1-(3-((3′-(3- bromopropoxy)-2,2′-dimethyl-[1,1′-biphenyl]-3-yl)oxy)propyl)pyrrolidin-3-ol (20 mg, 0.043 mmol) in methanol (1.0 mL) and N,N-diisopropylethylamine (40 muL, 0.229 mmol) was heated at 65-70 C for 72 h. The crude material was purified via preparative LC/MS with the following conditions: Column: XBridge C18, 19 x 200 mm, 5-mum (0379) particles;Mobile Phase A: 5:95 acetonitrile: water with 10-mM ammonium acetate; Mobile Phase B: 95:5 acetonitrile: water with 10-mM ammonium acetate; Gradient: 20- 60% B over 15 minutes, then a 5-minute hold at 100% B; Flow: 20 mL/min to give the pure title compound: (12.5 mg, 59%). LC/MS Condition E: ret time 1.27 min; m/e = 485 (M+H)+; LC/MS Condition F: ret time 1.22 min; m/e = 485 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16369-21-4, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; YEUNG, Kap-Sun; GRANT-YOUNG, Katharine A.; ZHU, Juliang; SAULNIER, Mark G.; FRENNESSON, David B.; LANGLEY, David R.; HEWAWASAM, Piyasena; WANG, Tao; ZHANG, Zhongxing; MENG, Zhaoxing; SUN, Li-Qiang; MULL, Eric; SCOLA, Paul Michael; (370 pag.)WO2018/44963; (2018); A1;,
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Reference of 599-67-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 599-67-7, name is 1,1-Diphenylethanol. This compound has unique chemical properties. The synthetic route is as follows.

Into a 1-liter reaction flask were introduced 200.23 g of the crude 1,1-diphenylethanol obtained above, 400 ml of toluene, and 1 g of p-toluenesulfonic acid (PTSA). Azeotropic dehydration was conducted for 2 hours with toluene refluxing (94-116 C.). The resulting reaction mixture was cooled, washed with water and then with 2% soda ash solution, dried with magnesium sulfate, and concentrated to obtain 190.09 g of crude 1,1-diphenylethylene (4a; R1,R2 =H). This crude 1,1-diphenylethylene (4a) was distilled with a Claisen flask equipped with a vigreux (b.p., 103 C./1 mmHg), giving 174.06 g of 1,1-diphenylethylene (4a). The theoretical yield based on the benzophenone was 96.5%.

According to the analysis of related databases, 599-67-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Takasago International Corporation; US5573878; (1996); A;,
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