Tag: M.W=200-300

Reference of 162744-59-4, Adding some certain compound to certain chemical reactions, such as: 162744-59-4, name is (4-Bromo-2,6-difluorophenyl)methanol,molecular formula is C7H5BrF2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 162744-59-4.

((4-bromo-2,6-difluorobenzyl)oxy)(tert-butyl)dimethylsilane A mixture of (4-bromo-2,6-difluorophenyl)methanol (7.5 g, 33.5 mmol), TBDMSCl (10.8 g, 67.0 mmol) and imidazole (3.0 g, 40.2 mmol) in DMF (70 mL) was stirred at 20C under N2 atmosphere for 2 hours, quenched with water (350 mL) and extracted with EtOAc (200 mL*3). The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated. The residue was purified by silica gel column chromatography to give Compound 17A (colorless oil, 10.2 g, 90% yield). LCMS (ESI) m/z: 338 (M+H+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 162744-59-4, (4-Bromo-2,6-difluorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Medshine Discovery Inc.; LONG, Chaofeng; CHEN, Shuhui; CHEN, Xiaoxin; LUO, Yunfu; LIU, Zhuowei; PAN, Jianfeng; (56 pag.)EP3287453; (2018); A1;,
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Adding a certain compound to certain chemical reactions, such as: 20605-01-0, Diethyl 2,2-bis(hydroxymethyl)malonate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: Diethyl 2,2-bis(hydroxymethyl)malonate, blongs to alcohols-buliding-blocks compound. name: Diethyl 2,2-bis(hydroxymethyl)malonate

Diethyl 2-(tert-butyldimethylsilyloxymethyl)-2-hydroxymethylmalonate (15). Diethyl 2,2-bis(hydroxymethyl)malonate (28.3 mmol; 6.23 g) was coevaporated twice from dry pyridine and dissolved in the same solvent (20 mL). tert-Butyldimethylsilyl chloride (25.5 mmol; 3.85 g) in dry pyridine (10 mL) was added portionwise. The reaction was allowed to proceed for 4 days. The mixture was evaporated to a solid foam, which was then equilibrated between water (200 mL) and DCM (4×100 mL). The organic phase was dried on Na2SO4. The product was purified by silica gel chromatography eluting with 10% ethyl acetate in DCM. The yield was 78%. 1H NMR (CDCl3) delta 4.18-4.25 (m, 4H, OCH2Me), 4.10 (s, 2H, CH2OSi), 4.06 (s, 2H, CH2OH), 2.63 (br s, 1H, OH), 1.26 (t, J=7.0 Hz, 6H, OCH2CH3), 0.85 (s, 9H, Si-SMe3), 0.05 (s, 6H, Me-Si). 13C NMR (CDCl3) delta 169.2 (CO), 63.3 (CH2OH), 62.8 (CH2OSi), 61.6 (spiro C), 61.4 (OCH2Me), 25.6 [C(CH3)3], 18.0 (Si-CMe3), 14.0 (OCH2CH3), -3.6 (Si-CH3). MS [M+H]+ obsd. 335.7, calcd. 335.2; [M+Na] obsd. 357.6, calcd. 357.2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,20605-01-0, Diethyl 2,2-bis(hydroxymethyl)malonate, and friends who are interested can also refer to it.

Reference:
Patent; Alios BioPharma Inc.; US2009/176732; (2009); A1;,
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Application of 60666-70-8, Adding some certain compound to certain chemical reactions, such as: 60666-70-8, name is (2-Bromo-5-chlorophenyl)methanol,molecular formula is C7H6BrClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 60666-70-8.

Add compound 3 (500 mg, 2.26 mmol) in DCM (40 mL) and DIPEA (1.12 mL, 6.77 mmol)DMAP (55.16 mg, 451.51 mumol) was added. Then, pivaloyl chloride (416.65 uL, 3.39 mmol) was added dropwise at 0 ° C to react.The mixture was stirred at 10 ° C for 0.1 hour and then at room temperature overnight. The reaction mixture was diluted with DCM and then usedWater, 10percent citric acid and brine were washed with MgSO4 and filtered. The filtrate was concentrated to give a crude product which was purified by CC.The compound 4 (605 mg, 87.69percent) was obtained as a pale yellow oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 60666-70-8, (2-Bromo-5-chlorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chinese Academy Of Sciences Tianjin Industry Bio-technology Institute; Lin Jianping; Liu Pi; Li Jinlong; Wang Zhonghua; Liu Cui; (15 pag.)CN108264467; (2018); A;,
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Adding a certain compound to certain chemical reactions, such as: 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, blongs to alcohols-buliding-blocks compound. name: 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol

General procedure: To a refluxing solution of 5-hydroxy-3-methoxy-7H-benzo[c]fluoren-7-one 12-4 (3.00 g, 10.9 mmol) in a mixture of toluene (123 mL) and 2-butanone (45 mL) were added 1,1-bis(4-methoxyphenyl)propyn-1-ol (5.23 g, 19.5 mmol) and catalytic amount of p-TsOH, and the resulting mixture was refluxed for 30 min. The solution was cooled down to room temperature, then 10% aq. sodium hydroxide (21 mL), tetrahydrofuran (120 mL) and10% aq. sodium chloride were added and the mixture was stirred well. The organic layer was separated, washed with water four times, and the solvent removed in vacuo. To the resulting residue was added acetone (100 mL) and the mixture was refluxed for 1 h. After the mixture was cooled down, the solid material precipitated was collected by filtration. After drying in vacuo, 6-methoxy-3,3-bis(4-methoxyphenyl)benzo[3,4]fluoreno[2,1-b]pyran-13(3H)-one 13-7 was obtained as a dark purple solid (2.47 g, 4.70 mmol) in 43% yield. 13-7: Mp 207-209 C. 1H NMR (CDCl3) delta/ppm 3.77 (3H, s), 3.96 (3H, s), 6.27 (1H, d, J = 10.0 Hz), 6.84 (4H, m), 7.20 (2H, m), 7.40 (5H, m), 7.57 (2H, m), 7.80 (1H, d, J = 8.0 Hz), 7.86 (1H, d, J = 10.0 Hz), 8.27 (1H, d, J = 9.2 Hz). LC-MS 527.2033 (M+1) (Calculated exact mass for C35H27O5 (M+1) 527.1853). FT-IR (KBr) nu/cm-1 3014, 2953, 2831, 1695, 1605, 1505, 1466, 1397, 1373, 1277, 1218.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, and friends who are interested can also refer to it.

Reference:
Article; Momoda, Junji; Izumi, Shinobu; Yokoyama, Yasushi; Dyes and Pigments; vol. 119; (2015); p. 95 – 107;,
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Related Products of 1208434-90-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1208434-90-5, name is (2,6-Difluoro-3,5-dimethoxyphenyl)methanol, molecular formula is C9H10F2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of (2,6-difluoro-3,5-dimethoxyphenyl)methanol (1.58 g, 7.74 mmol) in DCM(50 mL) at 0C was added MsC1 (1.76 g, 15.36 mmol,) and TEA (2 equiv). The resulting solutionwas stirred overnight at room temperature and then quenched with water (100 mL). The resulting solution was extracted with DCM and the organic layer was concentrated to afford 1.74 g (80%) of (2,6-difluoro-3 ,5 -dimethoxyphenyl)methyl methanesulfonate as a light yellow solid.

According to the analysis of related databases, 1208434-90-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PRINCIPIA BIOPHARMA, INC.; VERNER, Erik; BRAMELD, Kenneth Albert; WO2015/120049; (2015); A1;,
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Adding a certain compound to certain chemical reactions, such as: 4139-61-1, 6-Bromo-4-hydroxycoumarin, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C9H5BrO3, blongs to alcohols-buliding-blocks compound. COA of Formula: C9H5BrO3

EXAMPLE 27 6-Bromo-4-hydroxy-3-[4-(2-methoxyphenyl)butyl]-2H-1-benzopyran-2-one The title compound was prepared from 4-hydroxy-6-bromo-2H-1-benzopyran-2-one, and 4-(2-methoxyphenyl)butanoic acid using the procedure described in Example 13. A 55% yield of the title compound was obtained, m.p. 147.5-148.5 C.

The synthetic route of 4139-61-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Warner-Lambert Company; US5510375; (1996); A;,
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Reference of 722-92-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of 12a-e in DMSO (500 L) were added 4-(hexafluoro-2-hydroxyisopropyl)aniline (2 eq.)and N,N-diisopropylethylamine (2 eq.) at room temperature. The mixture was stirred for 15 min at 100 C,then poured into dilute hydrochloric acid and extracted with EtOAc. The organic layer washed with brine,dried over sodium sulfate and concentrated. The residue was purified by recrystallization from MeOH.

According to the analysis of related databases, 722-92-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kaitoh, Kazuma; Toyama, Hirozumi; Hashimoto, Yuichi; Fujii, Shinya; Heterocycles; vol. 95; 1; (2017); p. 547 – 556;,
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Electric Literature of 133803-81-3, Adding some certain compound to certain chemical reactions, such as: 133803-81-3, name is tert-Butyl 3-(2-(2-hydroxyethoxy)ethoxy)propanoate,molecular formula is C11H22O5, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 133803-81-3.

ferf-Butyl 3 (2 (2- hydroxyethoxy)ethoxy)propanoate (8.6 g, 37 mmol) was added to a suspension of Dess- Martin periodinane (DMP, 18.8 g, 44 mmol) and pyridine (7.0 g, 88 mmol) in DCM (150 mL) at 0C. The resulting mixture was stirred at room temperature for 16 hours, then filtered, washed with DCM (3 x 50 mL). The filtrate and washings were combined and washed with saturated NaHC03 solution and brine, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by silica chromatography (hexane:EtOAc = 10: 1 to 3: 1) to give the title compound (4.1 g, 48%) as a yellow oil. 1H NMR (400 MHz, CDC13): delta 9.76 (s, 1H), 4.16 (s, 2H), 3.50-3.80 (m, 6H), 2.53(t, 2H), 1.46 (s, 9H).

According to the analysis of related databases, 133803-81-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CORNELL UNIVERSITY; DANA-FARBER CANCER INSTITUTE, INC.; CHILDREN’S MEDICAL CENTER CORPORATION; MELNICK, Ari, M.; GABAS, Lorena, Fontan; US, Ilkay; CASALENA, Gabriella; GRAY, Nathanael, S.; SCOTT, David, A.; HATCHER, John; DU, Guangyan; WU, Hao; QIAO, Qi; (157 pag.)WO2018/85247; (2018); A1;,
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Electric Literature of 756520-66-8, Adding some certain compound to certain chemical reactions, such as: 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol,molecular formula is C8H7Cl2FO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 756520-66-8.

To a stirred mixture of D8 (65.5mg, 0.43mmol) and A5 (81mg, 0.39mmol) in THF (5mL), was added Ph3P (152mg, 0.58mmol) under the protection of nitrogen. After being stirred at r.t. for Ih, the mixture was added DIAD (1 17mg, 0.58mmol) at 00C. The resulting mixture was stirred at r.t. for two days and evaporated. The residue was purified by column chromatography (PE:EA=20: l) to afford D9 (1 13mg, 86%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; XCOVERY, INC.; WO2008/88881; (2008); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 23783-42-8, name is 2,5,8,11-Tetraoxatridecan-13-ol. A new synthetic method of this compound is introduced below., Safety of 2,5,8,11-Tetraoxatridecan-13-ol

Example 3. Allyl 2,2-bis(2,5,8,11,14-pentaoxadodecyl)-4,7,10,13,16-pentaoxatetradecyl ether (compound 5 of Scheme 1 wherein n=4) Tetraethyleneglycol monomethyl ether (1.91 ml, 9 mmol) dissolved in dry and degassed DMF (3.5 ml) was carefully added to sodium hydride (365 mg, 9 mmol) in dry and degassed DMF (15 ml) under nitrogen at 0 C using a syringe. The temperature was then raised to room temperature and the reaction mixture was stirred for another 30 min. Tribromide 4 (730 mg, 2.0 mmol, example 1) was then added and the temperature was raised to 100 C, After 14 h the reaction was completed and the temperature was decreased to room temperature whereupon the reaction mixture was slowly added to H2O (150 ml). The H2O-phase was washed with diethyl ether (2 x 50 ml). Sodium chloride was then added to the H2O-phase until saturation. The H2O-phase was extracted with EtOAc (4 x 50 ml) and the combined organic phases were washed with brine (2 x 30 ml). Sodium sulfate and charcoal was added to the organic phase. The clear organic phase was filtered and the volatile material was removed at reduced pressure. Column chromatography (EtOAc:MeOH 9:1) gave 1.05 g of the product. 1H-NMR (CDCl3); 5.90 (m, 1H), 5.20 (m, 2H), 3.94 (dt, 2H), 3.70-3.55 (m, 48H), 3.45 (s, 6H), 3.43 (s, 2H), 3.40 (s, 9H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 23783-42-8, 2,5,8,11-Tetraoxatridecan-13-ol.

Reference:
Patent; Spago Imaging AB; Axelsson, Oskar; Ek, Fredrik; EP2573089; (2013); A1;,
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