Tag: M.W=150-200

Kucinski, Krzysztof published the artcileA Highly Effective Route to Si-O-Si Moieties through O-Silylation of Silanols and Polyhedral Oligomeric Silsesquioxane Silanols with Disilazanes, Quality Control of 17877-23-5, the publication is ChemSusChem (2019), 12(5), 1043-1048, database is CAplus and MEDLINE.

A simple and highly practical catalyst-free O-silylation of silanols with com. available disilazanes has been developed under mild conditions. In the case of polyhedral oligomeric silsesquioxane (POSS) silanols and some other silanols, it was necessary to use catalytic amounts of inexpensive Bi(OTf)₃ as addnl. catalyst. This efficient chlorine-free protocol involves the synthesis of a wide range of important organosilicon derivatives such as unsym. disiloxanes and functionalized silsesquioxanes.

ChemSusChem published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Quality Control of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kucinski, Krzysztof published the artcileO-Metalation of silanols and POSS silanols over Amberlyst-15 catalyst: A facile route to unsymmetrical siloxanes, borasiloxanes and germasiloxanes, Name: Triisopropylsilanol, the publication is Inorganica Chimica Acta (2019), 261-266, database is CAplus.

A simple and highly practical Amberlyst-catalyzed direct O-metalation of silanols, POSS silanols and alkoxysilanes under mild conditions is proposed. This protocol can be applied to the synthesis of a wide range of important organosilicon derivatives such as siloxanes, germasiloxanes, borasiloxanes and functionalized silsesquioxanes. It is worth noting that Amberlyst-15 can be reused for further experiments and its catalytic activity in this process is well-preserved for several recycling steps.

Inorganica Chimica Acta published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Name: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sedlacko, Erin M. published the artcileMetabolomics reveals primary response of wheat (Triticum aestivum) to irrigation with oilfield produced water, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Environmental Research, database is CAplus and MEDLINE.

The reuse of oilfield produced water (PW) for agricultural irrigation has received increased attention for utility in drought-stricken regions. It was recently demonstrated that PW irrigation can affect physiol. processes in food crops. However, metabolomic evaluations are important to further discern specific mechanisms of how PW may contribute as a plant-environmental stressor. Herein, the primary metabolic responses of wheat irrigated with PW and matching salinity controls were investigated. Non-targeted gas chromatog. mass spectrometry (GC-MS) metabolomics was combined with multivariate anal. and revealed that PW irrigation altered the primary metabolic profiles of both wheat leaf and grain. Over 600 compounds (183 annotated metabolites) were detected that varied between controls (salinity control and tap water) and PW irrigated plants. While some of these changed metabolites are related to salinity stress, over half were found to be unique to PW. The primary metabolites exhibiting changes in abundance in leaf and grain tissues were amines/amino acids, organic acids, and saccharides. Metabolite pathway anal. revealed that amino acid metabolism, sugar metabolism, and nitrogen remobilization are all impacted by PW irrigation, independent of regular plant responses to salinity stress. These data, when combined with prior physiol. studies, support a multi-faceted, physio-metabolic response of wheat to the unique stressor imposed by irrigation with PW.

Environmental Research published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C11H22N2O4, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huber, Verena published the artcileUncovering the curcumin solubilization ability of selected natural deep eutectic solvents based on quaternary ammonium compounds, Recommanded Product: 2-Hydroxy-2-phenylacetic acid, the publication is Journal of Molecular Liquids (2022), 119661, database is CAplus.

The solubility of curcumin in ethanolic solutions can be increased twentyfold through the addition of natural deep eutectic solvents (NADES). Instead of only screening nine different NADES based on choline chloride, betaine, and carnitine mixed with lactic, levulinic, and pyruvic acid in terms of their solving ability, they were investigated regarding the mechanism of solvation as well. The curcumin solubility enhancement was assessed via UV/Vis measurements, while the investigation of the intermol. effects was performed theor. by COSMO-RS predictions of the chem. potential and exptl. via 1H and NOESY NMR measurements. The addition of the quaternary ammonium compounds to ethanol resulted in a solubility increase regardless of addnl. functionalities, which was not the case for the acids, where functionalities showed a significant influence. A solubility synergy in the levulinic acid NADES was reached, which could be explained through the combination of COSMO-RS and NMR experiments, yielding indications that an interplay of non-specific and directed intermol. interactions was the responsible driving force for an efficient solubility enhancement of curcumin. Thus, the NADES based on levulinic acid achieved the best results.

Journal of Molecular Liquids published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Recommanded Product: 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fuwa, Haruhiko published the artcileSynthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors, Synthetic Route of 120103-18-6, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(16), 4184-4189, database is CAplus and MEDLINE.

Synthesis and biol. evaluation of arylsulfonamide inhibitors of γ-secretase are described. Design, synthesis, and biol. evaluation of multifunctional mol. probes harboring a benzophenone photophore as a crosslinking group and a biotin tag are also reported.

Bioorganic & Medicinal Chemistry Letters published new progress about 120103-18-6. 120103-18-6 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Nitro Compound,Benzene,Phenol, name is 2,5-Difluoro-4-nitrophenol, and the molecular formula is C6H3F2NO3, Synthetic Route of 120103-18-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

De Mesmaeker, Alain published the artcileStereoselective carbon-carbon bond formation in carbohydrates by radical cyclization reactions. I, Formula: C4H7BrO, the publication is Tetrahedron Letters (1988), 29(50), 6585-8, database is CAplus.

A 3 step synthesis of α-C(2) branched pyranosides from the glycal I is described. Thus, I was treated with HOCH₂CH₂Cl and BF₃.Et₂O in C₆H₆ to give 92% a mixture of α- and β-glycosides II in the ratio of 89:11 resp. On treatment with Bu₃SnH and AIBN in C₆H₆ II cyclized stereoselectively to give predominately the α-C(2) branched pyranoside III.

Tetrahedron Letters published new progress about 50915-29-2. 50915-29-2 belongs to alcohols-buliding-blocks, auxiliary class Cyclopropanes, name is (1-Bromocyclopropyl)methanol, and the molecular formula is C4H7BrO, Formula: C4H7BrO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Klein, Jan J. published the artcileSynthesis of a New Class of Bis(thiourea)hydrazide Pseudopeptides as Potential Inhibitors of β-Sheet Aggregation, Formula: C10H15NO, the publication is Organic Letters (2012), 14(1), 330-333, database is CAplus and MEDLINE.

The modular synthesis of a novel pseudopeptide scaffold based on a bis(thiourea)hydrazide motif is reported. This compound class is designed to display “amphifinity”, i.e. association with a peptide strand on one but not the other face of the scaffold, and hence could potentially inhibit β-sheet aggregation.

Organic Letters published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Formula: C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shafiee, A. published the artcileSynthesis and pharmacological activity of benzo[b]thiophene-3-carboxylic acid derivatives, Name: 2-(Benzyl(methyl)amino)ethanol, the publication is Journal of Pharmaceutical Sciences (1983), 72(2), 198-202, database is CAplus and MEDLINE.

Benzothiophenes I (R = amino, aminoalkyl) and II (R¹ = aminoalkoxy, amino) were prepared from I (R = Cl, N₃) resp. I (R = Me₂NCH₂CH₂) showed significant anticholinergic and antihistamine activity at 1 μg/mL whereas I (R = Me₂NCMe₂CH₂, morpholinoethyl) showed local anesthetic activity comparable to that of lidocaine HCl.

Journal of Pharmaceutical Sciences published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C12H23N3S, Name: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sams, Anette G. published the artcileDiscovery of N-{1-[3-(3-Oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): An Allosteric Muscarinic M₁ Receptor Agonist with Unprecedented Selectivity and Procognitive Potential, Related Products of alcohols-buliding-blocks, the publication is Journal of Medicinal Chemistry (2010), 53(17), 6386-6397, database is CAplus and MEDLINE.

The discovery and structure-activity relationship (SAR) of a series of allosteric muscarinic M₁ receptor agonists are described. Compound 17 (Lu AE51090) was identified as a representative compound from the series, based on its high selectivity as an agonist at the muscarinic M₁ receptor across a panel of muscarinic receptor subtypes. Furthermore, 17 displayed a high degree of selectivity when tested in a broad panel of G-protein-coupled receptors, ion channels, transporters, and enzymes, and 17 showed an acceptable pharmacokinetic profile and sufficient brain exposure in rodents in order to characterize the compound in vivo. Hence, in a rodent model of learning and memory, 17 reversed delay-induced natural forgetting, suggesting a procognitive potential of 17.

Journal of Medicinal Chemistry published new progress about 55346-97-9. 55346-97-9 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Nitro Compound,Benzene,Phenol, name is 4,5-Difluoro-2-nitrophenol, and the molecular formula is C6H3F2NO3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Noyola, Martha published the artcileSynthesis and smooth muscle relaxing activity of a series of 1,4-dihydropyridine nicardipine analogs, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Revista de la Sociedad Quimica de Mexico (2003), 47(1), 34-37, database is CAplus.

Nicardipine (I; R = NO₂) and five new analogs I (R = Cl, Br, F, Me, OMe) were synthesized and evaluated for their smooth muscle relaxing activity. All the compounds displayed significant relaxant activity and I (R = Br) was the most potent; the order of potency for the complete set of derivatives were: Br > NO₂ (nicardipine) > Cl ≈ F > Me ≈ OMe.

Revista de la Sociedad Quimica de Mexico published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts