Tag: M.W=150-200

Zhang, Qian published the artcileSiderophores of Bacillus pumilus promote 2-keto-L-gulonic acid production in a vitamin C microbial fermentation system, Synthetic Route of 526-98-7, the publication is Journal of Basic Microbiology (2022), 62(7), 833-842, database is CAplus and MEDLINE.

The precursor of vitamin C, 2-keto-L-gulonic acid (2-KLG), is bio-converted from L-sorbose by a microbial consortium of Ketogulonicigenium vulgare and a helper strain (Bacillus spp.). Most helper strains produce siderophores. To understand the effects of siderophores on promoting 2-KLG yield, the siderophores of Bacillus pumilus SY-A9 were purified and added to a monoculture fermentation system of K. vulgare 25B-1. The results revealed that the titer of 2-KLG reached 7.18 g/L within 60 h and increased by 71.45% when the added concentration of siderophores was 500μg/L. Moreover, the increased production of 2-KLG was accompanied by the overexpressed iron uptake system-related genes, electron transfer chain-related genes, ATP synthesis enzyme-related genes, antioxidant enzyme-related genes, and 2-KLG producing enzyme-related genes, which reduced oxidative stress and ensured the normal energy metabolism of K. vulgare 25B-1. This study demonstrated that siderophores of the helper strain play a key role in the enhancement of 2-KLG biosynthesis.

Journal of Basic Microbiology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C8H4FNO3, Synthetic Route of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Quan, Wei published the artcileMetabolic perturbations and health impact from exposure to a combination of multiple harmful Maillard reaction products on Sprague-Dawley rats, Computed Properties of 526-98-7, the publication is Food & Function (2022), 13(10), 5515-5527, database is CAplus and MEDLINE.

The present study aimed to investigate the metabolic perturbations and health impact of the co-accumulation of Maillard reaction products (MRPs), including acrylamide, harmane, and Nε-(carboxymethyl)lysine (CML), via serum biochem. and histopathol. examinations as well as metabolomic anal. Sprague-Dawley rats were treated with acrylamide (2 mg per kg body weight [bw]), harmane (1 mg per kg bw), CML (2 mg per kg bw), and combinations of these MRPs. Harmane did not cause adverse effects on the health of rats, whereas acrylamide and CML resulted in significantly (P < 0.05) decreased insulin sensitivity (HOMA-IR > 1), increased oxidative stress levels, and pathol. injuries to the pancreas, liver, and gastrocnemius. Owing to the antioxidant and anti-diabetic activities of harmane, the effects of the combination of the MRPs on oxidative stress levels, blood glucose metabolism, and pathol. injuries to the pancreas and gastrocnemius were relieved. However, new health problems, including pathol. injury of the kidneys and increased cancer risk, were observed Metabolomic anal. revealed that this may be related to the effects of MRPs on the arginine biosynthesis pathway, which resulted in the abnormal metabolism of fumaric acid and the tricarboxylic acid cycle. These results indicated that the mechanisms of the combined effect of MRPs and their effects on health cannot be predicted from the effects of individual MRPs.

Food & Function published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Computed Properties of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Cheng published the artcileIdentifying Key Metabolites Associated with Glucosinolate Biosynthesis in Response to Nitrogen Management Strategies in Two Rapeseed (Brassica napus) Varieties, Application In Synthesis of 90-64-2, the publication is Journal of Agricultural and Food Chemistry (2022), 70(2), 634-645, database is CAplus and MEDLINE.

A high glucosinolate (GSL) concentration, an undesirable substance, has severely restricted rapeseed (Brassica species) development. We performed widely targeted metabolomics anal. based on the ultra-high-performance liquid chromatog.-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS) technol. to analyze the metabolic profiles and identify the differential metabolites and GSL components in response to different nitrogen (N) levels in two rapeseed varieties. A total of 341 metabolites and 38 GSL components were detected in the seeds. A total of 188 differential metabolites, including 34 GSL components, were identified in response to different treatments, which were mapped into 2-oxocarboxylic acid metabolism, tryptophan metabolism, and GSL biosynthesis. Key indicators of GSL components highly responsible for different N levels under two contrasting varieties were recognized, i.e., 1-methylpropyl GSL and 4-methylthiobutyl GSL. This study suggests that the efficient N management and variety selection are important strategies for developing rapeseed with low GSLs.

Journal of Agricultural and Food Chemistry published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C4H5NS2, Application In Synthesis of 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Yanhong published the artcileIdentification of novel and selective non-peptide inhibitors targeting the polo-box domain of polo-like kinase 1, Synthetic Route of 1379356-00-9, the publication is Bioorganic Chemistry (2018), 278-288, database is CAplus and MEDLINE.

A series of non-peptide inhibitors targeting the polo-box domain (PBD) of polo-like kinase 1 (Plk1) was designed based on the potent and selective minimal tripeptide Plk1 PBD inhibitor. Seven compounds were designed, synthesized and evaluated for fluorescence polarization (FP) assay. The most promising compound 10 bound to Plk1 PBD with IC₅₀ of 3.37 μM and had no binding to Plk2 PBD or Plk3 PBD at 100 μM. Mol. docking study was performed and possible binding mode was proposed. MM/GBSA binding free energy calculation were in agreement with the observed exptl. results. These novel non-peptide selective Plk1 PBD inhibitors provided new lead compounds for further optimization.

Bioorganic Chemistry published new progress about 1379356-00-9. 1379356-00-9 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(3-(Aminomethyl)phenyl)ethanol, and the molecular formula is C9H13NO, Synthetic Route of 1379356-00-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lu, Xin-li published the artcileDetermination of 2-keto-l-gulonic acid in fermented broth by flow injection chemiluminescence, Synthetic Route of 526-98-7, the publication is Guangpu Shiyanshi (2013), 30(4), 1714-1717, database is CAplus.

A simple, rapid, accurate and sensitive method of flow injection chemiluminescence was developed for the determination of 2-keto-L-gulonic acid (2-KLG) in fermented broth. This method was based on enhance effect of 2-KLG on the chemiluminescence reaction between rhodamine B and potassium permanganate in acid medium. The optimized exptl. conditions were evaluated. Under the optimum conditions, calibration curve over the range of 0.2-60 mg·L^-1 was obtained. The detection limit of this method was 0.04 g·L^-1. The relative standard deviation was 3.4% for 2.0 mg·L^-1 2-KLG. The method is applied to the determination of studied 2-KLG in fermented broth with a satisfied result.

Guangpu Shiyanshi published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Synthetic Route of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Basch, Corey H. published the artcileHarnessing Alkyl Amines as Electrophiles for Nickel-Catalyzed Cross Couplings via C-N Bond Activation, Product Details of C8H19NO2, the publication is Journal of the American Chemical Society (2017), 139(15), 5313-5316, database is CAplus and MEDLINE.

We developed a strategy to harness alkyl amines as alkylating agents via C-N bond activation. This Suzuki-Miyaura cross coupling of alkylpyridinium salts, readily formed from primary amines, is the first example of a metal-catalyzed cross coupling via C-N bond activation of an amine with an unactivated alkyl group. This reaction enjoys broad scope and functional group tolerance. Primary and secondary alkyl groups can be installed. Preliminary studies suggest a Ni^I/Ni^III catalytic cycle.

Journal of the American Chemical Society published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Product Details of C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Luo, Nianhua published the artcileHighly Selective Hydroxylation and Alkoxylation of Silanes: One-Pot Silane Oxidation and Reduction of Aldehydes/Ketones, Application In Synthesis of 17877-23-5, the publication is Organometallics (2020), 39(1), 165-171, database is CAplus.

An efficient chemoselective iridium-catalyzed method for the hydroxylation and alkoxylation of organosilanes to generate hydrogen gas and silanols or silyl ethers was developed. A variety of sterically hindered silanes with alkyl, aryl, and ether groups were tolerated. Furthermore, this atom-economical catalytic protocol can be used for the synthesis of silanediols and silanetriols. A one-pot silane oxidation and chemoselective reduction of aldehydes/ketones was also realized.

Organometallics published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Application In Synthesis of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bender, Christoph published the artcileStereoselective 1-arylation of isoquinolines via chiral N-acylisoquinolinium salts, Quality Control of 27292-49-5, the publication is ARKIVOC (Gainesville, FL, United States) (2008), 111-136, database is CAplus.

Reaction of isoquinolines with (R)-menthyl chlorocarbonate or (S)-α-Cbz-aminoacyl fluorides and arenes or heteroarenes gave access to the corresponding 2-R¹-1-R²-1,2-dihydroisoquinolines I [R¹ = H, Br, Ph, 4-ClC₆H₄; R² = menthyloxycarbonyl, N-benzyloxycarbonyl-2-amino-3-phenylpropionyl, N-benzyloxycarbonyl-2-amino-propionyl; R³ = 4-(1-dimethylaminonaphthyl), 4-Et₂NC₆H₄, 3-indolyl, etc.] in a Mannich-type reaction via intermediate N-acylisoquinolinium salts. As an alternative, aryl metal compounds could be used. Modest stereoselectivities were achieved. Further reduction and hydrolysis of the products gave access to 1,2,3,4-tetrahydroisoquinolines II (R² = H, Me; R³ = Ph, 4-Et₂NC₆H₄, 3-MeOC₆H₄, 4-MeOC₆H₄, 3-indolyl).

ARKIVOC (Gainesville, FL, United States) published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Quality Control of 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xu, Zhiqiang published the artcileResearch on cement hydration and hardening with different alkanolamines, Product Details of C9H21NO3, the publication is Construction and Building Materials (2017), 296-306, database is CAplus.

In this work, six types of alkanolamines (i.e., TEA, TIPA, DEIPA, EDIPA, THEED and THPED) were added into Portland cement as chem. additives, and their effects on phys. properties and hydration of Portland cement as well as mechanism were investigated. The results show that all the alkanolamines expect TEA can effectively improve the degree of cement hydration. TEA delays the hydration of alite because the formation of the TEA-Ca2+ complex inhibits the growth of CH. TIPA accelerates the hydration of C4AF at late stage, but reduce the early strength due to its air-entraining effect. The lower dosages of DEIPA and EDIPA have the advantages of TEA and TIPA, which increase not only the early strength but also the late strength. They promote both the hydration of the aluminum and ferrite phase as well as catalyze the conversion of AFt to AFm, which lead to the optimization of pore size distribution. The effects of THEED and THPED on hydration of Portland cement are similar though their mol. structure are different which improve the late strength and have larger suitable dosage range.

Construction and Building Materials published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C10H23N, Product Details of C9H21NO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xu, Zhiqiang published the artcileHydration of Portland cement with alkanolamines by thermal analysis, Product Details of C9H21NO3, the publication is Journal of Thermal Analysis and Calorimetry (2018), 131(1), 37-47, database is CAplus.

Four types of alkanolamines (i.e., traditional alkanolamines represented by TEA and TIPA and new alkanolamines represented by DEIPA and EDIPA) were added to Portland cement as chem. additives, and their effects on the cement properties and hydration process were investigated. An isothermal calorimeter was used to track the hydration heat flow of the cement pastes with or without alkanolamines. Thermogravimetric analyses were performed to measure the degree of hydration over the course of 28 days. In addition, X-ray diffraction, MIP anal. and SEM were used as auxiliary tests. The results indicated that alkanolamines improved the compressive strength of the cement mortars. It was found that TEA increased the rate of the second hydration of C₃A, and TIPA accelerated the hydration of C₄AF. DEIPA and EDIPA promoted the hydration of both the aluminum and ferrite phases as well as catalyzed the conversion of AFt to the AFm phase. By contrast, the new alkanolamines represented by DEIPA and EDIPA expressed more superior properties.

Journal of Thermal Analysis and Calorimetry published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Product Details of C9H21NO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts