Tag: M.W=150-200

Schaffert, Lena published the artcileEvaluation of vector systems and promoters for overexpression of the acarbose biosynthesis gene acbC in Actinoplanes sp. SE50/110, Name: Triisopropanolamine, the publication is Microbial Cell Factories (2019), 18(1), 1-16, database is CAplus and MEDLINE.

Background: Actinoplanes sp. SE50/110 is a natural producer of acarbose. It has been extensively studied in the last decades, which has led to the comprehensive anal. of the whole genome, transcriptome and proteome. First genetic and microbial techniques have been successfully established allowing targeted genome editing by CRISPR/Cas9 and conjugal transfer. Still, a suitable system for the overexpression of singular genes does not exist for Actinoplanes sp. SE50/110. Here, we discuss, test and analyze different strategies by the example of the acarbose biosynthesis gene acbC. Results: The integrative φC31-based vector pSET152 was chosen for the development of an expression system, as for the replicative pSG5-based vector pKC1139 unwanted vector integration by homologous recombination was observed Since simple gene duplication by pSET152 integration under control of native promoters appeared to be insufficient for overexpression, a promoter screening experiment was carried out. We analyzed promoter strengths of five native and seven heterologous promoters using transcriptional fusion with the gusA gene and glucuronidase assays as well as reverse transcription quant. This system will help altering transcript amounts of singular genes, that can be used to unclench metabolic bottlenecks and to redirect metabolic resources. Furthermore, an essential tool is provided, that can be transferred to other subspecies of Actinoplanes and industrially relevant derivatives

Microbial Cell Factories published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Name: Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Polucci, Paolo published the artcileAlkylsulfanyl-1,2,4-triazoles, a New Class of Allosteric Valosine Containing Protein Inhibitors. Synthesis and Structure-Activity Relationships, Recommanded Product: (4-(Methoxycarbamoyl)phenyl)boronic acid, the publication is Journal of Medicinal Chemistry (2013), 56(2), 437-450, database is CAplus and MEDLINE.

Valosine containing protein (VCP), also known as p97, is a member of AAA ATPase family that is involved in several biol. processes and plays a central role in the ubiquitin-mediated degradation of misfolded proteins. VCP is an ubiquitously expressed, highly abundant protein and has been found overexpressed in many tumor types, sometimes associated with poor prognosis. In this respect, VCP has recently received a great deal of attention as a potential new target for cancer therapy. In this paper, the discovery and structure-activity relationships of alkylsulfanyl-1,2,4-triazoles, a new class of potent, allosteric VCP inhibitors, are described. Medicinal chem. manipulation of 3-(isopropylthio)-5-(phenoxymethyl)-4-phenyl-1,2,4-triazole, identified via HTS, led to the discovery of potent and selective inhibitors with submicromolar activity in cells and clear mechanism of action at consistent doses. This represents a first step toward a new class of potential anticancer agents.

Journal of Medicinal Chemistry published new progress about 850568-17-1. 850568-17-1 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids, name is (4-(Methoxycarbamoyl)phenyl)boronic acid, and the molecular formula is C8H10BNO4, Recommanded Product: (4-(Methoxycarbamoyl)phenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Chunbao published the artcileEffect of triisopropanolamine on chloride binding of cement paste with ground-granulated blast furnace slag, Category: alcohols-buliding-blocks, the publication is Construction and Building Materials (2020), 119494, database is CAplus.

Chloride was one of important factors resulting in steel bar corrosion in reinforced concrete when using sea resources. In this paper, an attempt to promote the chloride binding capacity of the cement-ground-granulated blast furnace slag (GGBS) system was made by adding triisopropanolamine (TIPA). The paste was prepared by 70 wt% cement and 30 wt% GGBS, sodium chloride, TIPA (0.03%, 0.06% and 0.10%, by weight of binder) and water. The paste was cured for 7 d and 60 d, and the chloride binding ratio (CBR) were measured. The hydration heat and compressive strength were examined, then the hydrates and pore structure of the hardened paste were also analyzed; and the effect of TIPA on aluminum and ferric dissolution of GGBS was also studied. The results showed that TIPA could promote CBR at both 7 d and 60 d. The reason was ascribed to three aspects: (1) TIPA facilitate the formation of FS, which contribute to chem. binding; (2) TIPA promoted the formation of C-S(A)-H gel, which would increase the phys. binding; (3) TIPA refined the pore structure and increased fractal dimension, which could enhance the migration resistance. Furthermore, TIPA promoted cement hydration and pozzolanic reaction of GGBS by facilitated the dissolution of aluminum and ferric in GGBS. Addnl., the formation of Friedel’s salt was promoted due to the transformation of ettringite to AFm-like phase promoted by TIPA. Such results suggested a new way to improve chloride binding capacity of cementitious materials by adding alkanolamine.

Construction and Building Materials published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Xiaohai published the artcileImprovement in chloride immobilization of cement-metakaolin system by triisopropanolamine, Product Details of C9H21NO3, the publication is Applied Clay Science (2020), 105656, database is CAplus.

Metakaolin (MK) is a widely used admixture in chloride immobilization which is conducive to the durability of reinforced concrete. In this study, triisopropanolamine (TIPA) was added into cement-MK system to improve the chloride immobilization by expediting the pozzolanic reaction of MK. The effect of TIPA on hydration of binder composed of 90% Portland cement and 10% MK was investigated, and the hydration behavior was characterized by thermogravimetric anal., X-ray diffraction, NMR spectroscopy, and mercury intrusion porosimetry, based on the evaluation of pozzolanic reaction of MK by ion dissolution Results indicated that TIPA promoted the hydration of both MK and cement, and chloride immobilization was also improved. The mechanism for the improvement was involved in three aspects: a) TIPA facilitated the dissolution of aluminum from MK to obtain more chloroaluminate salts, strengthening chem. binding; b) TIPA accelerated hydration of cement and MK for more C-S-H gel, conducive to the phys. adsorption; c) TIPA increased the amount of hydrates to refine the pore structure, hindering the migration of chloride ion. This investigation provided one new method for improving the pozzolanic reaction of MK to enhance chloride immobilization of cement-MK system.

Applied Clay Science published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Product Details of C9H21NO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Jie published the artcileHydration and mechanical properties of cement-marble powder system incorporating triisopropanolamine, Related Products of alcohols-buliding-blocks, the publication is Construction and Building Materials (2021), 266(Part_B), 121068, database is CAplus.

This study aimed to improve the mech. properties of cement-marble powder (MP) mortar by incorporating triisopropanolamine (TIPA) to promote the optimal utilization of marble waste. In this research, the workability, compressive strength, capillary water absorption, hydration process and microstructure of cement-MP system were investigated. From the exptl. results, it was found that the incorporation of TIPA enhanced the mech. strength of cement-MP mortar. Moreover, the capillary water absorption of cement-MP mortar was improved when the TIPA dosage exceeded 0.06%. The enhancement of these properties was mainly due to the acceleration effect of TIPA on the cement-MP system hydration process, despite the fact that its air entraining effect would have a neg. effect. Incorporating TIPA in cement-MP system accelerated the dissolution of Fe3+ ions in ferrite phase to promote the hydration of cement, which certainly facilitated the consumption of SO2-4 ions, thus promoting the formation of calcium aluminocarbonate. Addnl., no obvious difference was observed in the workability and setting characteristics between cement-MP system with and without TIPA.

Construction and Building Materials published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C5H13Cl2N, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Ting published the artcileEffect of TIPA on mechanical properties and hydration properties of cement-lithium slag system, Recommanded Product: Triisopropanolamine, the publication is Journal of Environmental Management (2020), 111274, database is CAplus and MEDLINE.

Effect of triisopropanolamine (TIPA) on compressive strength and hydration properties of cement-lithium slag (LS, 30%) paste was studied. The results demonstrated that the addition of TIPA is advantageous for compressive strength at 7 d, 28 d and 60 d. The reason was related to the pore complexity and hydration process of cement and LS. TIPA reduced the total porosity, and increased the fractal dimension, making the pore structure more complicated. In addition, TIPA promoted the pozzolanic reaction of LS and the hydration of cement, expediting the formation of C-S(A)-H gel. TIPA accelerated the dissolution of aluminate ions, silicate ions and ferric ions in the pore solution, thereby accelerating the pozzolanic reaction of LS. During the hydration of cement-LS paste, TIPA facilitated the conversion of ettringite to the AFm-like phase and produced more C-A-S-H gel by promoting the dissolution of aluminate ions.

Journal of Environmental Management published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C15H20BNO2, Recommanded Product: Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

An, Zhi-min published the artcileStructural changes of 2-keto-L-gulonic acid studied by NMR spectroscopy, Formula: C6H10O7, the publication is Bopuxue Zazhi (2014), 31(3), 407-414, database is CAplus.

2-Keto-L-gulonic acid (2-KLG) changes its mol. structure in many solvents at room temperature A five-membered intramol. ring structure can easily be formed by the 2,5-hemiacetal reaction after the opening of the carbonyl group in 2-KLG (-C=O) to form a O-C-O interlinkage. In this study, we showed that the ¹³C chem. shift of the carbonyl changed from δ200 towards high field to about δ96 after forming the intramol. ring. Two-dimensional HMBC experiments revealed that 2-keto-L-gulonic acid formed five-membered ring 2,5-hemiacetal derivatives in seven solvents, instead of six-membered 2,6-hemiacetal derivatives

Bopuxue Zazhi published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Formula: C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kong, Xu-Dong published the artcileA Smart Library of Epoxide Hydrolase Variants and the Top Hits for Synthesis of (S)-β-Blocker Precursors, Name: 4-Morpholino-1,2,5-thiadiazol-3-ol, the publication is Angewandte Chemie, International Edition (2014), 53(26), 6641-6644, database is CAplus and MEDLINE.

Microtuning of the enzyme active pocket has led to a smart library of epoxide hydrolase variants with an expanded substrate spectrum covering a series of typical β-blocker precursors. Improved activities of 6- to 430-fold were achieved by redesigning the active site at two predicted hot spots. This study represents a breakthrough in protein engineering of epoxide hydrolases and resulted in enhanced activity toward bulky substrates.

Angewandte Chemie, International Edition published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C6H9N3O2S, Name: 4-Morpholino-1,2,5-thiadiazol-3-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Xia published the artcileBlue light-powered hydroxynaphthoic acid-titanium dioxide photocatalysis for the selective aerobic oxidation of amines, Recommanded Product: 1-Hydroxy-2-naphthoic acid, the publication is Journal of Colloid and Interface Science (2021), 534-543, database is CAplus and MEDLINE.

Solar photocatalysis is the key to resolve many environmental challenges but is usually hard to achieve over a metal oxide semiconductor. Therefore, assembling π-conjugated mols. onto semiconductors becomes an efficient approach to solar conversion via ligand-to-metal charge transfer. Here, a rational design of ligands for titanium dioxide (TiO₂) is presented to produce robust visible light photocatalysts. Three hydroxynaphthoic acids (HNAs) were selected as ligands by extending an extra benzene ring of salicylic acid (SA) at 3,4 or 4,5 or 5,6 positions. These ligands could regulate the performance of TiO₂ in which 2-hydroxy-1-naphthoic acid (2H1NA) endows the best outcome. In detail, blue light-powered cooperative photocatalysis of 2H1NA-TiO₂ with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO, 5 mol%) inaugurates the expeditious formation of imines by oxidation of amines with atm. oxygen (O₂). Interestingly, the increase of the O₂ pressure from 1 atm to 0.4 MPa promoted the selective oxidation of benzylamine but thereafter declined with a further boost to 0.6 MPa. Notably, an electron transfer between the oxidatively quenched 2H1NA-TiO₂ and TEMPO is established, offering a new pathway for environmental applications. This work presents a strategy in designing cutting-edge visible light photocatalysts via altering semiconductors with surface ligands.

Journal of Colloid and Interface Science published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Recommanded Product: 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Huanhuan published the artcileNovel ammonium dichloroacetates with enhanced herbicidal activity for weed control, Computed Properties of 122-20-3, the publication is RSC Advances (2020), 10(72), 44512-44521, database is CAplus and MEDLINE.

Dichloroacetic acid (DCA) exhibits great potential as an herbicide (nontoxic, easily biodegradable), but its application in agriculture has scarcely been investigated. Since DCA readily undergoes photolysis when exposed to natural light or UV irradiation, there is a large activity loss in controlling weeds. To improve the activity of DCA, we proposed the transformation of DCA into an ionic salt form by using an herbicidal ionic liquids (HILs) strategy. Herein, fifteen novel ammonium dichloroacetates were designed and achieved for the first time. When compared to the anionic precursor DCA, three salts with longer alkyl chains ranging from dodecyl to hexadecyl chains were found to enhance not only the post emergence herbicidal activity but also the rates of activity against some broadleaf weeds under greenhouse conditions. The enhancement was due to the synergistic effect of structural factors, such as the surface activity, solubility and stability arising from their ionic nature. In addition, IL 13 possesses a low phytotoxicity to cotton plants with a favorable selectivity index above 2. This study will be useful for the design of new, high-performance herbicidal formulations.

RSC Advances published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Computed Properties of 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts