Tag: M.W=150-200

Choudhury, Anup published the artcileDinuclear dysprosium(III) complex derived from a multidentate bis-hydrazone Schiff base ligand: Synthesis, crystal structure and magnetic properties, SDS of cas: 90-64-2, the publication is Polyhedron (2022), 115603, database is CAplus.

Starting from phloroglucinol, a multidentate Schiff base ligand, H₃L N, N’-((1E, 1’E)-(5-acetyl-2,4,6-trihydroxy-1,3-phenylene)bis(ethan-1-yl-1-ylidene)bis(2-hydroxy-2-phenylacetohydrazide)), decorated with multiple coordination sites was designed. A dinuclear dysprosium complex, [{Dy(L)(H₂O)₂}₂]·4CH₃OH·3H₂O (1), was synthesized by employing this ligand and characterized by elemental anal., spectroscopic and structural investigations. Single crystal x-ray diffraction anal. reveals that 1 is a dinuclear Dy(III) complex with a large Dy^…Dy distance. Magnetic investigation shows the absence of slow relaxation of the magnetization in 1 owing to the lack of an axial crystal-field.

Polyhedron published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, SDS of cas: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Weinstock, Leonard M. published the artcileSynthesis of the β-adrenergic blocking agent timolol from optically active precursors, SDS of cas: 30165-97-0, the publication is Journal of Organic Chemistry (1976), 41(19), 3121-4, database is CAplus and MEDLINE.

The β-adrenergic blocking agent, trimolol (I), was prepared from R-glyceraldehyde via catalytic hydrogenation over Pd in the presence of Me3CNH2. Treating with PHCHO and then with II in the presence of Me3COK and acid hydrolysis gave 50% I.

Journal of Organic Chemistry published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C9H9NO, SDS of cas: 30165-97-0.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rahaman, Rubina published the artcileDioxygen reactivity of iron(II)-gentisate/1,4-dihydroxy-2-naphthoate complexes of N4 ligands: oxidative coupling of 1,4-dihydroxy-2-naphthoate, Synthetic Route of 86-48-6, the publication is Dalton Transactions (2019), 48(45), 16993-17004, database is CAplus and MEDLINE.

The influence of supporting ligands and co-ligands on the dioxygen reactivity of Fe(II) complexes, [(6-Me₃-TPA)Fe^II(GN-H)]⁺ (1), [(6-Me₃-TPA)Fe^II(DHN-H)]⁺ (1a), [(BPMEN)Fe^II(GN-H)]⁺ (2), [(BPMEN)Fe^II(DHN-H)]⁺ (2a), [(TBimA)Fe^II(GN-H)]⁺ (3), and [(TBimA)Fe^II(DHN-H)]⁺ (3a) (GN-H₂ = 2,5-dihydroxybenzoic acid and DHN-H₂ = 1,4-dihydroxy-2-naphthoic acid) of N4 ligands, is presented. The Fe(II)-gentisate complexes react with dioxygen to afford the corresponding Fe(III) species. On the contrary, DHN-H undergoes oxidative C-C coupling to form [2,2′-binaphthalene]-1,1′,4,4′-tetrone 3-hydroxy-3′-carboxylic acid (BNTHC) on 1a, and [2,2′-binaphthalene]-1,1′,4,4′-tetrone 3,3′-dicarboxylic acid (BNTD) on 2a and 3a. In each case, the reaction proceeds through an Fe(III)-DHN species. The x-ray single crystal structures of [(6-Me₃-TPA)Fe^II(BNTD)] (1^Ox) and [(BPMEN)Fe^II(BNTD)] (2^Ox) confirm the coupling of two DHN-H mols. The formation of Fe(III) product without any coupling of co-ligand from the complexes, [(BPMEN)Fe^II(HNA)]⁺ (2b) and [(BPMEN)Fe^II(5-OMeSA)]⁺ (2c) (HNA = 1-hydroxy-2-naphthoate, 5-OMeSA = 5-methoxysalicylate) confirms the importance of para-hydroxy group for the coupling reaction. The unusual coupling of DHN-H by the Fe(II) complexes of the neutral N4 ligands is distinctly different from the oxygenolytic aromatic C-C cleavage of DHN by the Fe(II) complex of a facial N3 ligand.

Dalton Transactions published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Synthetic Route of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ahfad, Neda published the artcileA naphthylamide based fluorescent probe for detection of Al³⁺, Fe³⁺, and CN^– with high sensitivity and selectivity, Product Details of C11H8O3, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (2020), 117753, database is CAplus and MEDLINE.

A naphthylamide based fluorescent chemosensor, N,N′-(1,2-phenylene)bis(1-hydroxy-2-naphthamide) (H₄L), for detection of Fe³⁺ and Al³⁺ cations as well as CN^– anion is reported. This compound has been synthesized by a novel and facile synthetic method with high yield and characterized by FT-IR, ¹H NMR, elemental anal., and UV-Vis spectroscopy. It could detect Fe³⁺ and Al³⁺ ions in different media with different excitation and emission wavelengths. In DMSO solution, H₄L showed selective ON-OFF quenching of its 451 nm emission in the presence of Fe³⁺. On the other hand, in DMF solution, H₄L exhibited selective OFF-ON fluorescence upon the addition of Al³⁺, the intensity at 429 nm increases drastically by 24-fold. Also, among the anions, the probe can selectively distinguish CN^– by deprotonation of OH and NH groups, as proved by ¹H NMR titration TD-DFT calculation supports the UV-Vis and fluorescence measurements of the chemosensor.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Product Details of C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mallah, Ramnath R. published the artcileNon-linear optical response of meso hybrid BODIPY: Synthesis, photophysical, DFT and Z scan study, COA of Formula: C11H8O3, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (2019), 126-140, database is CAplus and MEDLINE.

Hybrid meso BODIPY dyes are synthesized and their linear and nonlinear optical properties are studied. Time-resolved fluorescence lifetime decay is identical for all dyes irresp. of meso substituents. The Z-scan experiment performed to calculate the nonlinear absorption coefficient (β) and 3rd-order nonlinear susceptibility (χ³). Global hybrid (B3LYP and BHHLYP) and range-separated hybrid (CAM-B3LYP) functional with the basis set 6-311++G(d,p) was employed to determine the theor. linear and nonlinear optical properties. The computed β₀ value of all the 3 dyes is superior to that of urea (βo = 0.371 × 10^-30 esu). Introduction of meso substituent directly affects the polarizability and 2nd-order hyperpolarizability of the dyes. Thermal and reorientational effect of the studied NLOphoric dyes were studied.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, COA of Formula: C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Varma, Anil Kumar published the artcilePyrolysis of pine needles: effects of process parameters on products yield and analysis of products, Quality Control of 23351-09-9, the publication is Journal of Thermal Analysis and Calorimetry (2018), 131(3), 2057-2072, database is CAplus.

Pyrolysis of pine needles was carried out in a semi-batch reactor. The effects of pyrolysis parameters such as temperature (350-650°C), heating rate (10 and 50°C min^-1), nitrogen flow rate (50-200 cm³ min^-1) and biomass particle size (0.25-1.7 mm) were examined on products yield. Maximum bio-oil yield of 43.76% was obtained at pyrolysis temperature of 550°C with a heating rate of 50°C min^-1, nitrogen flow rate of 100 cm³ min^-1 for biomass particle size of 0.6 < d_p < 1 mm. The characterization of pyrolysis products (bio-oil, bio-char) has been made through different instrumental methods like Fourier transform IR spectroscopy, gas chromatog.-mass spectrometry, NMR spectroscopy (¹H NMR), X-ray powder diffraction, field emission scanning electron microscope and Brunauer-Emmett-Teller surface area anal. The empirical formula of the bio-oil and bio-char was found as CH_1.47O_0.36N_0.005 and CH_0.56O_0.28N_0.013 with heating value of 26.25 and 25.50 MJ kg^-1, resp. Results show that bio-oil can be potentially valuable as a renewable fuel after upgrading and can be used as a feedstock for valuable chems. production The properties of bio-char reveal that it can be used as solid fuels, as a cheap adsorbent and as a feedstock for activated carbon production

Journal of Thermal Analysis and Calorimetry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C13H10O2, Quality Control of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wiensch, Eric M. published the artcileNickel-Catalyzed Amination of Silyloxyarenes through C-O Bond Activation, Category: alcohols-buliding-blocks, the publication is Angewandte Chemie, International Edition (2018), 57(34), 11045-11049, database is CAplus and MEDLINE.

Silyloxyarenes were utilized as electrophilic coupling partners with amines in the synthesis of aniline derivatives A diverse range of amine substrates were used, including cyclic or acyclic secondary amines, secondary anilines, and sterically hindered primary anilines. Addnl., a range of sterically hindered and unhindered primary aliphatic amines were employed, which have previously been challenging with other classes of aryl ether electrophiles. Orthogonal couplings of silyloxyarenes with aryl Me ethers are illustrated, where selectivity between the two C-O electrophiles is determined by ligand control, thereby allowing complementary and selective late-stage diversification of either electrophile. Finally, a sequential coupling displays the utility of this amination method along with the reversal in intrinsic reactivity between aryl Me ethers and silyloxyarenes.

Angewandte Chemie, International Edition published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C9H8BNO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kim, Sung Phil published the artcileComposition of Herba Pogostemonis Water Extract and Protection of Infected Mice against Salmonella Typhimurium-Induced Liver Damage and Mortality by Stimulation of Innate Immune Cells, HPLC of Formula: 526-98-7, the publication is Journal of Agricultural and Food Chemistry (2012), 60(49), 12122-12130, database is CAplus and MEDLINE.

GC-MS anal. of a hot water extract of Herba Pogostemonis (HP) revealed the presence of 131 compounds HP slightly inhibited Salmonella Typhimurium bacteria in culture and stimulated uptake of the bacteria into RAW 264.7 murine macrophage cells as indicated by both increased fluorescence from internalized FITC-dextran and increased colony-forming unit (CFU) counts of the lysed macrophages. Postinfection, the HP-treated cells showed lower bacterial counts than the control. HP elicited altered morphol., elevated inducible NO synthase (iNOS) mRNA, and reduced pro-inflammatory cytokine expression in macrophage cells. Salmonella induced increased expression of iNOS mRNA, cognate polypeptides, and NO. Histol. of mice infected with a sublethal dose (1 × 10⁴ CFU) of Salmonella showed that i.p. administered HP protected against necrosis of the liver, a biomarker of in vivo salmonellosis. The lifespan of mice infected with a LD (1 × 10⁵ CFU) was significantly extended. These results suggest that the activity of HP against bacterial infection in mice occurs through the activation of innate immune macrophage cells. The relationship of composition of HP to bioactivity is discussed.

Journal of Agricultural and Food Chemistry published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, HPLC of Formula: 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rimnacova, Lucie published the artcileEthyl chloroformate mediated gas chromatographic-mass spectrometric biomonitoring of acidic biomarkers of occupational exposure and endogenous metabolites in human urine, Quality Control of 621-37-4, the publication is Journal of Chromatography A (2021), 462547, database is CAplus and MEDLINE.

Numerous industrial organic pollutants such as aromates, alkoxyalcs., other organic solvents and monomers are absorbed, metabolized, and finally excreted in urine mostly as carboxylic acids that are determined as biomarkers of exposure. For a number of these xenometabolites, biol. limits (levels of biomarkers in biol. material) have been established to prevent damage to human health. Till now, most of the anal. procedures used have been optimized for one or a few analytes. Here, we report a more comprehensive approach enabling rapid GC-MS screening of sixteen acidic biomarkers in urine that are metabolized in the human body from several important industrial chems.; benzene, toluene, styrene, xylenes, alkoxyalcs., carbon disulfide, furfural and N,N-dimethylformamide. The new method involves immediate in situ derivatization – liquid liquid microextraction of urine by an Et chloroformate-ethanol-chloroform-pyridine medium and GC-MS anal. of the derivatized analytes in the lower organic phase. The xenometabolite set represents diverse chem. structures and some of hippuric and mercapturic acids also provided unusual derivatives that were unambiguously elucidated by means of new Et chloroformates labeled with stable isotopes and by synthesis of the missing reference standards In the next step, an automated routine was developed for GC-MS/MS anal. using a MetaboAuto sample preparation workstation and the new method was validated for fourteen metabolites over the relevant concentration range of each analyte in the spiked pooled human urine. It shows good linearity (R2 ≥ 0.982), accuracy (from 85% to 120%), precision (from 0.7% to 20%) and recovery (from 89% to 120%). The method performance was further successfully proved by GC-MS/MS anal. of the certified IP45 and RM6009 reference urines. Moreover, we show that the new method opens up the possibility for biomonitoring of combined and cumulative occupational exposures as well as for urinary metabolite profiling of persons exposed to harmful industrial chems.

Journal of Chromatography A published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Quality Control of 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rimnacova, Lucie published the artcileEthyl chloroformate mediated gas chromatographic-mass spectrometric biomonitoring of acidic biomarkers of occupational exposure and endogenous metabolites in human urine, Category: alcohols-buliding-blocks, the publication is Journal of Chromatography A (2021), 462547, database is CAplus and MEDLINE.

Numerous industrial organic pollutants such as aromates, alkoxyalcs., other organic solvents and monomers are absorbed, metabolized, and finally excreted in urine mostly as carboxylic acids that are determined as biomarkers of exposure. For a number of these xenometabolites, biol. limits (levels of biomarkers in biol. material) have been established to prevent damage to human health. Till now, most of the anal. procedures used have been optimized for one or a few analytes. Here, we report a more comprehensive approach enabling rapid GC-MS screening of sixteen acidic biomarkers in urine that are metabolized in the human body from several important industrial chems.; benzene, toluene, styrene, xylenes, alkoxyalcs., carbon disulfide, furfural and N,N-dimethylformamide. The new method involves immediate in situ derivatization – liquid liquid microextraction of urine by an Et chloroformate-ethanol-chloroform-pyridine medium and GC-MS anal. of the derivatized analytes in the lower organic phase. The xenometabolite set represents diverse chem. structures and some of hippuric and mercapturic acids also provided unusual derivatives that were unambiguously elucidated by means of new Et chloroformates labeled with stable isotopes and by synthesis of the missing reference standards In the next step, an automated routine was developed for GC-MS/MS anal. using a MetaboAuto sample preparation workstation and the new method was validated for fourteen metabolites over the relevant concentration range of each analyte in the spiked pooled human urine. It shows good linearity (R2 ≥ 0.982), accuracy (from 85% to 120%), precision (from 0.7% to 20%) and recovery (from 89% to 120%). The method performance was further successfully proved by GC-MS/MS anal. of the certified IP45 and RM6009 reference urines. Moreover, we show that the new method opens up the possibility for biomonitoring of combined and cumulative occupational exposures as well as for urinary metabolite profiling of persons exposed to harmful industrial chems.

Journal of Chromatography A published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts