Tag: M.W=150-200

Tian, Zhenyu published the artcileSuspect and Nontarget Screening for Contaminants of Emerging Concern in an Urban Estuary, Safety of Triisopropanolamine, the publication is Environmental Science & Technology (2020), 54(2), 889-901, database is CAplus and MEDLINE.

This study used suspect and nontarget screening with high-resolution mass spectrometry to characterize the occurrence of contaminants of emerging concern (CECs) in the nearshore marine environment of Puget Sound (WA). In total, 87 non-polymeric CECs were identified; those confirmed with reference standards (45) included pharmaceuticals, herbicides, vehicle-related compounds, plasticizers, and flame retardants. Eight polyfluoroalkyl substances were detected; perfluorooctanesulfonic acid (PFOS) concentrations were as high as 72-140 ng/L at one location. Low levels of methamphetamine were detected in 41% of the samples. Transformation products of pesticides were tentatively identified, including two novel transformation products of tebuthiuron. While a hydrodynamic simulation, anal. results, and dilution calculations demonstrated the prevalence of wastewater effluent to nearshore marine environments, the identity and abundance of selected CECs revealed the addnl. contributions from stormwater and localized urban and industrial sources. For the confirmed CECs, risk quotients were calculated based on concentrations and predicted toxicities, and eight CECs had risk quotients >1. Dilution in the marine estuarine environment lowered the risks of most wastewater-derived CECs, but dilution alone is insufficient to mitigate risks of localized inputs. These findings highlighted the necessity of suspect and nontarget screening and revealed the importance of localized contamination sources in urban marine environments.

Environmental Science & Technology published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C4H12N2O2S, Safety of Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Agarwal, Sameer published the artcileDiscovery of a Potent and Orally Efficacious TGR5 Receptor Agonist, SDS of cas: 23351-09-9, the publication is ACS Medicinal Chemistry Letters (2016), 7(1), 51-55, database is CAplus and MEDLINE.

TGR5 is a G protein-coupled receptor (GPCR), activation of which promotes secretion of glucagon-like peptide-1 (GLP-1) and modulates insulin secretion. The 2-thio-imidazole derivative 6g was identified as a novel, potent, and selective TGR5 agonist (hTGR5 EC₅₀ = 57 pM, mTGR5 = 62 pM) with a favorable pharmacokinetic profile. The compound 6g was found to have potent glucose lowering effects in vivo during an oral glucose tolerance test in DIO C57 mice with ED₅₀ of 7.9 mg/kg and ED₉₀ of 29.2 mg/kg.

ACS Medicinal Chemistry Letters published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, SDS of cas: 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Frankowski, Kevin J. published the artcileDiscovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis, Application of 4,4-Diethoxybutan-1-amine, the publication is Journal of Medicinal Chemistry (2022), 65(12), 8303-8331, database is CAplus and MEDLINE.

A high-throughput, high-content assay was developed to identify novel small mols. that selectively reduce PNC prevalence in cancer cells. The pyrrolopyrimidine series able to reduce PNC prevalence in PC3M cancer cells at submicromolar concentrations without affecting cell viability was identified and further optimized. Structure-activity relationship exploration of the structural elements necessary for activity resulted in the discovery of several potent compounds Anal. of in vitro drug-like properties led to the discovery of the bioavailable analog, metarrestin, which has shown potent antimetastatic activity with improved survival in rodent models and is currently being evaluated in a first-in-human phase 1 clin. trial.

Journal of Medicinal Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Application of 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Roy, Ekta published the artcileCarbon dot/TAT peptide co-conjugated bubble nanoliposome for multicolor cell imaging, nuclear-targeted delivery, and chemo/photothermal synergistic therapy, Product Details of C9H21NO3, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2017), 144-157, database is CAplus.

A pioneering nucleus-targeting dual-functional thermosensitive bubble-generating liposome as drug carrier has been developed with conjugated cell penetrating peptide and photothermal agent (CDs) for multi-color cell imaging and combination (chemo- and photothermal) therapy of cancer, using doxorubicin as drug mol. The liposome was prepared by ‘inhouse’ synthesized precursors mols., to reduce the cost of production in comparison to the earlier reported liposomes. This drug carrier was proposed to target nucleus of the cancer cells, owing to specific and selective cell-penetrating property of TAT, followed by burst but stable drug release due to decomposition of bubble forming agent present inside the liposome core, by being subjected to near-IR (NIR) irradiation (i.e. photothermal conversion of radiation to heat). The in-vitro temperature and/or NIR-triggered release study indicated that liposome was sensitive towards heat and able to generate the sufficient temperature of 68 °C in the presence of NIR-laser source. The in vivo experiment was also performed to explore the NIR-responsive hyperthermia in the mice body. The as prepared bubble containing liposome-based drug delivery system exhibits superior stability, no drug leakage and enhanced in vitro and in vivo drug delivery with efficient cancer cell killing via combination therapy. The multicolor fluorescence obtained via CDs improves the accuracy of the cell imaging study as well as works as a key component for photothermal treatment of cancer. The results obtained in the study demonstrated that the designed smart drug carrier have great potential in the field of cancer theragnosis i.e. imaging, targeted drug delivery, and treatment.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Product Details of C9H21NO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chatzopoulou, Maria published the artcileDecreasing acidity in a series of aldose reductase inhibitors: 2-Fluoro-4-(1H-pyrrol-1-yl)phenol as a scaffold for improved membrane permeation, COA of Formula: C10H9NO, the publication is Bioorganic & Medicinal Chemistry (2014), 22(7), 2194-2207, database is CAplus and MEDLINE.

Targeting long-term diabetic complications, as well as inflammatory pathologies, aldose reductase inhibitors (ARIs) have been gaining attention over the years. In the present work, in order to address the poor membrane permeation of previously reported ARIs, derivatives of N-phenylpyrrole, bearing groups with putative pK_a ≥ 7.4, were synthesized and evaluated for aldose reductase inhibitory activity. The 2-fluorophenol group proved the most promising moiety, and further modifications were explored. The most active compound was identified as a submicromolar inhibitor (IC₅₀ = 0.443 μM), was also selective against the homologous enzyme aldehyde reductase. Cross-docking revealed that the above mentioned compound displays a peculiar interaction network that may be responsible for high affinity. Physicochem. profiling of it showed a pK_a of 7.64, rendering it less than 50% ionized in the physiol. pH range, with potentially favorable membrane permeation. The latter was supported from the successful inhibition of sorbitol formation in rat lenses and the ability to permeate rat jejunum.

Bioorganic & Medicinal Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, COA of Formula: C10H9NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hreczycho, Grzegorz published the artcileA new selective approach to unsymmetrical siloxanes and germasiloxanes via O-metalation of silanols with 2-methylallylsilanes and 2-methylallylgermanes, Recommanded Product: Triisopropylsilanol, the publication is New Journal of Chemistry (2011), 35(12), 2743-2746, database is CAplus.

A scandium(iii) trifluoromethanesulfonate-catalyzed O-metalation of silanols with 2-methylallylsilanes and 2-methylallylgermanes leading to siloxane or germasiloxane bond formation under mild conditions with evolution of isobutylene is described.

New Journal of Chemistry published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Recommanded Product: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Marciniec, Bogdan published the artcileSilylation of silanols with vinylsilanes catalyzed by a ruthenium complex, Name: Triisopropylsilanol, the publication is Tetrahedron Letters (2008), 49(8), 1310-1313, database is CAplus.

A new ruthenium complex-catalyzed O-silylation of silanols with vinylsilanes leading to siloxane bond formation with the evolution of ethylene is described. A maximum conversion of silanol is reached using an excess of vinylsilane which also yields the product of the homo-coupling of the latter. Under the optimum conditions, when a vinylsilane with at least one ethoxy substituent is used, the reaction gives exclusively unsym. siloxanes.

Tetrahedron Letters published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Name: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gagauzov, I. published the artcileDerivatives of 1,3-dimethylxanthine. I. Direct condensation of 1,3-dimethylxanthine with alkanolamines, Safety of 2-(Benzyl(methyl)amino)ethanol, the publication is Farmatsiya (Sofia, Bulgaria) (1977), 27(2), 1-6, database is CAplus.

Direct condensation of theophylline (I) with 1 equivalent HOCH₂CH2NRR¹ (R = Me, Et, Pr, Bu, CH₂CH₂CHMe₂, CH₂Ph, CH₂CH₂OH, CH₂CH₂OAc, CH₂CH₂OBz; R¹ = CH₂Ph, CH₂CH₂OH, CH₂CH₂OAc, CH₂CH₂OBz, CH₂CH₂O₂CH:CHPh) at 250-320° in a salt bath 50-90 min gave resinous II, which were taken up in EtOH and precipitated as the tartrates or saccharinates in 42-74% yield. The salts were H₂O-soluble and had bronchodilating, antihistaminic and diuretic effects, but were more toxic than I.

Farmatsiya (Sofia, Bulgaria) published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Safety of 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Xiaozhou published the artcileKlebsiella sp. PD3, a phenanthrene (PHE)-degrading strain with plant growth promoting properties enhances the PHE degradation and stress tolerance in rice plants, SDS of cas: 86-48-6, the publication is Ecotoxicology and Environmental Safety (2020), 110804, database is CAplus and MEDLINE.

Phenanthrene (PHE) is harmful to human health and is difficult to be eliminated from environment. In this study, an aerobic bacterium capable of use PHE as a sole carbon source and energy was isolated and classified as Klebsiella sp. PD3 according to 16S rDNA anal. The degradation efficiency of PHE reached to about 78.6% after 12 days of incubation with strain PD3. Identification of metabolites formed during PHE degradation process by this strain was carried out by GC-MS. The first degradation step of PHE by PD3 was proposed to generate 1-hydroxy-2-naphthoic acid. PD3 significantly improved growth performance, biomass production, seed germination rate, photosynthetic capacity, antioxidant levels, relative water content and chlorophyll accumulation in rice (Oryza sativa L.) plants under PHE stress conditions in comparison with non-inoculation treatment. Moreover, PD3-inoculated rice showed lower ROS accumulation, ethylene production, ACC content, ACC oxidase activity and electrolyte leakage under PHE treatment compared to non-inoculated ones. The combination use of rice plants and strain PD3 was also shown to enhance the removal efficiency of PHE from the soil and decline the PHE accumulation in plants. Synergistic use of plants and bacteria with PHE degradation ability and PGPR attributes to remediate the PHE-contaminated soil will be an important and effective way in the phytoremediation of PHE-contaminated soils.

Ecotoxicology and Environmental Safety published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, SDS of cas: 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Feng, Qiangqiang published the artcileKey variables prediction based on mechanism models of 2-KGA mixed culture fermentation, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Huagong Xuebao (Chinese Edition) (2013), 64(8), 2913-2917, database is CAplus.

2-Keto-L-gulonic acid (2-KGA), the precursor for vitamin C synthesis, is produced by the mixed culture of Ketogulonicigenium vulgare and Bacillus megaterium. In this paper, the previously established kinetic model for 2-KGA mixed culture was firstly tested with the data of 80 industrial batches. Based on sensitivity anal., it was found that some insensitive parameters might be assigned fixed values to minimize computing time. Then, the model was used to predict the most important state variables, i.e., substrate and product concentrations Moving data window technique and rolling parameter identification approach were used in the prediction process 4 h and 8 h ahead prediction errors for 2-KGA concentration were less than 5%.

Huagong Xuebao (Chinese Edition) published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts