Tag: M.W=150-200

Zhang, Xue-Zhen published the artcileSynthesis, Structures, and Fluorescence Properties of Dimeric Aluminum Oxo Clusters, COA of Formula: C11H8O3, the publication is Inorganic Chemistry (2021), 60(10), 7089-7093, database is CAplus and MEDLINE.

Aluminum is an important component for luminescence. However, the fluorescent aluminum complex with unambiguous structural information is still limited. Herein, we report a series of fluorescence aluminum oxo clusters (AlOCs). By introducing an addnl. coordination site to the aromatic conjugation ligand, cluster nuclearity increment and fluorescence variation are observed Al₈(OH)₂(μ₄-O)₂(1-NA)₂(OEt)₁₆ (AlOC-41, 1-NA = 1-naphthoic acid, OEt = ethanol) is made up of two tetrahedral subunits. By introducing an addnl. coordination site to the aromatic conjugation ligand, we isolate a high nuclearity compound Al₁₀(μ₃-O)₂(3-HNA)₂(OEt)₂₂ (AlOC-47, 3-HNA = 3-hydroxy-2-naphthoic acid). Correspondingly, their luminescence performance is different (blue fluorescence in AlOC-41 and green in AlOC-47). Present herein is a platform to illustrate the relationship between synthesis, structure, and fluorescence properties.

Inorganic Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C23H43NP2, COA of Formula: C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xu, Xi published the artcileStructure-Enabled Discovery of Novel Macrocyclic Inhibitors Targeting Glutaminase 1 Allosteric Binding Site, SDS of cas: 621-37-4, the publication is Journal of Medicinal Chemistry (2021), 64(8), 4588-4611, database is CAplus and MEDLINE.

The inhibition of glutaminase 1 (GLS1) represents a potential treatment of malignant tumors. Structural anal. led to the design of a novel series of macrocyclic GLS1 allosteric inhibitors. Through extensive structure-activity relationship studies, a promising candidate mol. 13b (LL202) was identified with robust GLS1 inhibitory activity (IC₅₀ = 6 nM) and high GLS1 binding affinity (SPR, K_d = 24 nM; ITC, K_d = 37 nM). The X-ray crystal structure of the 13b-GLS1 complex was resolved, revealing a unique binding mode and providing a novel structural scaffold for GLS1 allosteric inhibitors. Importantly, 13b clearly adjusted the cellular metabolites and induced an increase in the ROS level by blocking glutamine metabolism Furthermore, 13b exhibited a similar in vivo antitumor activity as CB839. This study adds to the growing body of evidence that macrocyclization provides an alternative and complementary approach for the design of small-mol. inhibitors, with the potential to improve the binding affinity to the targets.

Journal of Medicinal Chemistry published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C20H17FO4S, SDS of cas: 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Su, Chang published the artcileSynthesis of a novel ferrocene-contained polypyrrole derivative and its performance as a cathode material for Li-ion batteries, Quality Control of 23351-09-9, the publication is Electrochimica Acta (2013), 302-307, database is CAplus.

A novel ferrocene-contained pyrrole, 4-(1H-pyrrol-1-yl)-Ph-ferrocenecarboxylate (FcPy) was synthesized by esterification of 4-(1H-pyrrol-1-yl)-phenol (PLPY) and ferrocenecarboxylic acid. Then the homopolymer of FcPy (PFcPy), copolymer of FcPy and pyrrole (P(FcPy-co-Py)), polypyrrole (PPy) were prepared by chem. oxidative polymerization And the structure, morphol., electrochem. properties of prepared polymers were characterized by FTIR spectroscopy, SEM, cyclic voltammograms (CV) and electrochem. impedance spectra (EIS), resp. Also, the charge/discharge properties of the prepared polymers were studied by galvanostatic charge-discharge testing. The introduction of ferrocene to polypyrrole obviously improved the specific capacity of PPy cathode and gave a well-defined plateau at the potential rang of ∼3.5 V. Under the authors’ exptl. conditions, the discharge capacity of undoped PPy-based electrodes only presented 16.5 mAh g^-1 at 20 mA g^-1 between 2.5 and 4.2 V, while PFcPy-based electrodes exhibited an initial discharge capacity of up to 43.2 mAh g^-1. Specially, the P(FcPy-co-Py)-based electrodes even showed a discharge capacity of 68.1 mAh g^-1 and the improved discharge platform, which were ascribed to the resonance doping effect of pendant group, the advanced electrochem. nature of ferrocene moiety and the loose morphol. of copolymer.

Electrochimica Acta published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C7H7BN2O2, Quality Control of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Su, Chang published the artcileSyntheses and properties of pyrrole derivative as a cathode material for Li-ion batteries, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol, the publication is Applied Mechanics and Materials (2012), 731-735, database is CAplus.

A copolymer of 4-(1H-pyrrol-1-yl)phenol (PLPY) and pyrrole (P(PLPY-co-Py))was synthesized. And the chem. structure and battery performance of the prepared materials were characterized comparably by 1H NMR, FT-IR spectra and galvanostatic charge-discharge testing using simulant lithium ion half-cell method, resp. The results shows that the introduction of the phenol group to the pyrrole as a rigid side chain could prevent the polymer from agglomeration and optimize the particle morphol. of the resulting polymers, all of which made it demonstrate a significantly improved specific capacity (73.9 mAh·g^-1) compared with PPy (21.4 mAh·g^-1).

Applied Mechanics and Materials published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C8H10BNO3, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kang, Iou-Jiun published the artcileDesign, synthesis, and anti-HCV activity of thiourea compounds, Formula: C10H9NO, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(7), 1950-1955, database is CAplus and MEDLINE.

A series of thiourea derivatives, e.g., I, were synthesized and their antiviral activity was evaluated in a cell-based HCV subgenomic replicon assay. SAR studies revealed that the chain length and the position of the alkyl linker largely influenced the in vitro anti-HCV activity of this class of potent antiviral agents. Among this series of synthesized compounds, the thiourea derivative with a six-carbon alkyl linker at the meta-position of the central Ph ring was identified as the most potent anti-HCV inhibitor (EC₅₀ = 0.047 μM) with a selectivity index of 596.

Bioorganic & Medicinal Chemistry Letters published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Formula: C10H9NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liang, Hao published the artcileSelective Electrochemical Hydrolysis of Hydrosilanes to Silanols via Anodically Generated Silyl Cations, Synthetic Route of 17877-23-5, the publication is Angewandte Chemie, International Edition (2021), 60(4), 1839-1844, database is CAplus and MEDLINE.

The first electrochem. hydrolysis of hydrosilanes to silanols under mild and neutral reaction conditions is reported. The practical protocol employs com. available and cheap NHPI as a hydrogen-atom transfer (HAT) mediator and operates at room temperature with high selectivity, leading to various valuable silanols in moderate to good yields. Notably, this electrochem. method exhibits a broad substrate scope and high functional-group compatibility, and it is applicable to late-stage functionalization of complex mols. Preliminary mechanistic studies suggest that the reaction appears to proceed through a nucleophilic substitution reaction of an electrogenerated silyl cation with H₂O.

Angewandte Chemie, International Edition published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Synthetic Route of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shi, Lei published the artcileRapid and Efficient Microwave-Assisted Amination of Electron-Rich Aryl Halides without a Transition-Metal Catalyst, Related Products of alcohols-buliding-blocks, the publication is Organic Letters (2003), 5(19), 3515-3517, database is CAplus and MEDLINE.

A rapid and direct amination of aryl halides has been developed, in good to high yields, under microwave irradiation without a transition-metal catalyst. This reaction is a particularly powerful method for the coupling of electron-rich aryl halides with various amines. In some cases, excellent regioselectivity could be observed, which facilitated the preparation of meta-substituted anilines, e.g., I, from ortho- or para-substituted Ph halides. The proposed mechanism proceeds through a benzyne intermediate.

Organic Letters published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C15H18BF3O4, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zeng, Weizhu published the artcileProduction of 2-keto-L-gulonic acid by metabolically engineered Escherichia coli, Product Details of C6H10O7, the publication is Bioresource Technology (2020), 124069, database is CAplus and MEDLINE.

The 2-keto-L-gulonic acid (2-KLG) is the direct precursor for industrial vitamin C production The main biosynthetic method for 2-KLG production is the classical two-step fermentation route. However, disadvantages of this method are emerging, including high consumption of energy, difficulties in strain screening, complex operation, and poor stability. In this study, five recombinant Escherichia coli strains overexpressing different sorbose/sorbosone dehydrogenases were constructed and used for 2-KLG production By optimizing catalytic conditions and further expressing pyrroloquinoline quinone in the recombinant strain, the titer of 2-KLG reached 72.4 g/L, with a conversion ratio from L-sorbose of 71.2% in a 5-L bioreactor. To achieve direct biosynthesis of 2-KLG from D-sorbitol, a co-culture system consisting of Gluconobacter oxydans and recombinant E. coli was designed. With this co-culture system, 16.8 g/L of 2-KLG was harvested, with a conversion ratio from D-sorbitol of 33.6%. The approaches developed here provide alternative routes for the efficient biosynthesis of 2-KLG.

Bioresource Technology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C3H5BN2O2, Product Details of C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Hong published the artcileSulfate adjustment for cement with triisopropanolamine: Mechanism of early strength enhancement, Application of Triisopropanolamine, the publication is Construction and Building Materials (2018), 516-522, database is CAplus.

This paper investigated the impacts of sulfate adjustment on strength, hydration and the microstructure of cement with triisopropanolamine (TIPA) to propose the mechanism of early strength enhancement from the microscopic point of view. The results showed that a single addition of TIPA was only good for cement strength promotion on 28 days. While an appropriate sulfate adjustment (∼0.6% in SO₃) was effective in enhancing the 1 day and 3 days strengths of cement with TIPA. When more sulfate was introduced, a clear delay in the AFt to AFm conversion and a steady increase of heat release could be observed during the early hydration of cement. QXRD analyses revealed that TIPA was able to promote the hydration of intermediate phases, particularly C₄AF, resulting in the fast formation of aluminate hydrates. The increased sulfate in cement with TIPA not only stabilized AFt formation but also promoted the silicate reaction in the early stages. SEM confirmed that the single addition of TIPA promoted the formation of coarse AFm clusters filling the pores of hardened cement paste. The increased sulfate restored the formation of fine AFt particles, which further refined the microstructure of the paste. Since the addition of TIPA and the adjustment of sulfate altered the hydration kinetics of intermediate phases, different aluminate hydrates intermixing with C-S-H could also be observed

Construction and Building Materials published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Application of Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Zhaochen published the artcileMetabolic mechanism of plant defense against rice blast induced by probenazole, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Metabolites (2021), 11(4), 246, database is CAplus and MEDLINE.

The probenazole fungicide is used for controlling rice blast (Magnaporthe grisea) primarily by inducing disease resistance of the plant. To investigate the mechanism of induced plant defense, rice seedlings were treated with probenazole at 15 days post emergence, and non-treated plants were used for the control. The plants were infected with M. grisea 5 days after chem. treatment and incubated in a greenhouse. After 7 days, rice seedlings were sampled. The metabolome of rice seedlings was chem. extracted and analyzed using gas chromatog. and mass spectrum (GC-MS). The GC-MS data were processed using anal. of variance (ANOVA), principal component anal. (PCA) and metabolic pathway elucidation. Results showed that probenazole application significantly affected the metabolic profile of rice seedlings, and the effect was proportionally leveraged with the increase of probenazole concentration Probenazole resulted in a change of 54 metabolites. Salicylic acid, γ-aminobutyrate, shikimate and several other primary metabolites related to plant resistance were significantly up-regulated and some metabolites such as phenylalanine, valine and proline were down-regulated in probenazole-treated seedlings. These results revealed a metabolic pathway of rice seedlings induced by probenazole treatment regarding the resistance to M. grisea infection.

Metabolites published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C4H3Cl2N3, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts