Tag: M.W=150-200

Chadeayne, Andrew R. published the artcileThe Course of (R₂R’SiO)₃TaCl₂ (R = ^tBu, R’ = H, Me, Ph, ^tBu (silox); R = ⁱPr, R’ = ^tBu, ⁱPr) Reduction Is Dependent on Siloxide Size, Name: Triisopropylsilanol, the publication is Inorganic Chemistry (2004), 43(11), 3421-3432, database is CAplus and MEDLINE.

Various sized siloxides (Cy₃SiO > ^tBu₃SiO > ^tBu₂PhSiO > ^tBu₂MeSiO approx. ⁱPr₂^tBuSiO > ⁱPr₃SiO > ^tBu₂HSiO) were used to make (R₂R’SiO)₃TaCl₂ (R = ^tBu, R’ = H (1-H), Me (1-Me), Ph (1-Ph), 1–^tBu (1); R = ⁱPr, R’ = ^tBu (1–ⁱPr₂); R = R’ = ⁱPr (1–ⁱPr₃); R = R’ = cyclohexyl). Product analyses of Na amalgam reductions of several dichlorides suggest that [(R₂R’SiO)₃Ta]₂(μ-Cl)₂ may be a common intermediate. When the siloxide is large (1–^tBu), formation of the Ta(III) species (^tBu₃SiO)₃Ta (6) occurs via disproportionation. When the siloxide is small, the Ta(IV) intermediate is stable (e.g., [(ⁱPr₃SiO)₃Ta]₂(μ-Cl)₂ (2)), and when intermediate sized siloxides were used, solvent bond activation via unstable Ta(III) tris-siloxides probably occurs. Under H, reductions of 1-Me and 1-Ph provide Ta(IV) and Ta(V) hydrides [(^tBu₂MeSiO)₃Ta]₂(μ-H)₂ (4-Me) and (^tBu₂PhSiO)₃TaH₂ (7-Ph), resp.

Inorganic Chemistry published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Name: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Safitri, Baiq Firyal Salsabila published the artcileMorphology Modulation in Self-Assembly of Chiral 2-Hydroxy-2-Phenylacetic Acids in Polymeric Diluents, Formula: C8H8O3, the publication is Crystals (2022), 12(6), 807, database is CAplus.

This study focused on the chirality effects that control the lamellar bending sense in self-assembled crystals of chiral 2-hydroxy-2-phenylacetic acids. 2-Hydroxy-2-phenylacetic acid or mandelic acid (MA) was crystallized in the presence of poly(4-vinyl phenol) (PVPh), and its crystalline structures and morphologies were assessed using polarized optical microscopy and SEM . MA of two opposite chiral forms (S- and R-) was crystallized with PVPh as the morphol. modulator; with adjustment of the PVPh content, the morphol. of MA crystals transforms from ring-banded spherulites to highly dendritic spherulites. For MA/PVPh (50/50 weight/weight) blend and neat MA at same T_c, the dendritic spherulites are packed with single crystals where the lamellae bend at a specific direction varying with T_c and chirality. Contrary to conventional thought, the bending senses of the MA lamellae in the dendritic spherulites are not solely governed by the MA mol. chirality (S or R), but also by T_c. Only at high Tc (>65°C) is the lamellar bending direction in dendritic spherulites of (S)-MA or (R)-MA blended with PVPh dictated by the chirality, i.e., displaying counterclockwise and clockwise bending direction for (S)-MA/PVPh and (R)-MA/PVPh, resp. Nevertheless, at low T_c (45°C), the bending sense of dendritic spherulites displays an opposite direction from those at the higher T_c, which is to say that the chirality alone does not control the lamellar bending direction.

Crystals published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Elslager, Edward F. published the artcileSynthetic schistosomicides. XVI. 5-(Mono- and dialkylamino)-2-nitrosophenols, 2-amino-5-(dialkylamino)phenols, and related compounds, Formula: C10H13NO2, the publication is Journal of Medicinal Chemistry (1970), 13(3), 370-6, database is CAplus and MEDLINE.

Various 5-(mono- and dialkylamino)-2-nitrosophenols were prepared by nitrosation of the corresponding m-(mono- and dialkylamino)phenols, obtained by heating resorcinol with an excess of the appropriate amine at 200°, or by alkylation of m-aminophenol with an alkyl halide. 5-(Dimethylamino)-2-nitrosophenol, 5-(diethylamino)-2-nitrosophenol (I), 2-nitroso-5-(1-pyrrolidinyl)phenol, and 2-amino-5-(diethylamino)phenol, a potential metabolite of I, displayed strong schistosomicidal activity and effected a 70-100% reduction of adult Schistosoma mansoni in mice at daily doses of 177-568 mg/kg for 14 days. Structure-activity relationship are summarized, and information concerning potential metabolites and the possible mode of action of the nitrosophenols is discussed.

Journal of Medicinal Chemistry published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Formula: C10H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cavanagh, Joseph E. published the artcileOzonation byproducts: identification of bromohydrins from the ozonation of natural waters with enhanced bromide levels, Product Details of C5H11BrO, the publication is Environmental Science and Technology (1992), 26(8), 1658-62, database is CAplus.

Ozonization of 2 surface waters with enhanced levels of Br^– results in the formation of a group of previously unidentified, labile compounds identified as bromohydrins. The compounds are isolated by liquid-liquid extraction and identified by a combination of GC coupled with IR spectroscopy (GC/FT-IR) and GC coupled with mass spectrometry (GC/MS) using electron impact and chem. ionization sources, with 2% NH₃ in CH₄ as the reagent gas. The principal bromohydrin byproduct is 3-bromo-2-methyl-2-butanol, which was confirmed by independent synthesis and comparison of spectral data. At least 6 other bromohydrins are formed during the ozonization/bromination process. These compounds are also formed by reaction of the natural water with aqueous Br, irresp. of prior ozonization, but the nature of their precursors is unknown.

Environmental Science and Technology published new progress about 2588-77-4. 2588-77-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 2-Methyl-3-bromo-2-butanol, and the molecular formula is C5H11BrO, Product Details of C5H11BrO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Meng, Zhong-Lei published the artcileSynthesis of Terpineol from Alpha-Pinene Catalyzed by α-Hydroxy Acids, Quality Control of 90-64-2, the publication is Molecules (2022), 27(3), 1126, database is CAplus and MEDLINE.

We report the use of five alpha-hydroxy acids (citric, tartaric, mandelic, lactic and glycolic acids) as catalysts in the synthesis of terpineol from alpha-pinene. The study found that the hydration rate of pinene was slow when only catalyzed by alpha-hydroxyl acids. Ternary composite catalysts, composed of AHAs, phosphoric acid, and acetic acid, had a good catalytic performance. The reaction step was hydrolysis of the intermediate terpinyl acetate, which yielded terpineol. The optimal reaction conditions were as follows: alpha-pinene, acetic acid, water, citric acid, and phosphoric acid, at a mass ratio of 1:2.5:1:(0.1-0.05):0.05, a reaction temperature of 70°C, and a reaction time of 12-15 h. The conversion of alpha-pinene was 96%, the content of alpha-terpineol was 46.9%, and the selectivity of alpha-terpineol was 48.1%. In addition, the catalytic performance of monolayer graphene oxide and its composite catalyst with citric acid was studied, with acetic acid used as an additive.

Molecules published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Quality Control of 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cao, Zhan-fang published the artcileIn situ nano-Fe₃O₄/triisopropanolamine functionalized graphene oxide composites to enhance Pb²⁺ ions removal, Application of Triisopropanolamine, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (2019), 209-217, database is CAplus.

In this work, a kind of magnetic graphene oxide composite material (TI/GO@Fe₃O₄) for Pb²⁺ removal was successfully synthesized through in situ growth method. Briefly, metal ions (Fe³⁺) were fixed on GO surface by oxygen-containing functional groups and acted as growth centers of Fe₃O₄. Furthermore, the surface of GO and Fe₃O₄ nanoparticles were strengthened by the triisopropanolamine and its oxidnation products (TI), which can promote the removal of Pb²⁺ ions. The mass percentage of Fe₃O₄ particles in TI/GO@Fe₃O₄ was 54.31% by EDS datas. Average particle size of TI/GO@Fe₃O₄ is 19.03 nm. The adsorption experiments indicated that the adsorption capacity of TI/GO@Fe₃O₄ can reach 461.00 mg/g under optimized conditions (10 mg TI/GO@Fe₃O₄, 50 mL 500 mg/L Pb²⁺, pH 5.0, 293 K, 120 min). The XPS anal. results indicated that the TI/GO@Fe₃O₄ can adsorb the Pb²⁺ through the complexation between nitrogen and oxygen-containing functional groups and Pb²⁺ ions. Hence, the composite material is a superior material for the adsorption of Pb²⁺. Moreover, the synthesized adsorbent can be recycled by magnet quickly after adsorption.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Application of Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pein, Wesley L. published the artcileNickel-Catalyzed Ipso-Borylation of Silyloxyarenes via C-O Bond Activation, Application In Synthesis of 27292-49-5, the publication is Organic Letters (2021), 23(12), 4588-4592, database is CAplus and MEDLINE.

The conversion of silyloxyarenes to boronic acid pinacol esters via Ni catalysis is described. In contrast to other borylation protocols of inert C-O bonds, the method is competent in activating the C-O bond of silyloxyarenes in isolated aromatic systems lacking a directing group. The catalytic functionalization of benzyl silyl ethers was also achieved under these conditions. Sequential cross-coupling reactions were achieved by leveraging the orthogonal reactivity of silyloxyarenes, which could then be functionalized subsequently.

Organic Letters published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Application In Synthesis of 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Habtemariam, Abraha published the artcileControl of aminophosphine chelate ring-opening in Pt(II) and Pd(II) complexes: potential dual-mode anticancer agents, Formula: C10H15NO, the publication is Journal of the Chemical Society, Dalton Transactions (2001), 1306-1318, database is CAplus.

Bis(aminophosphine) complexes [M(R¹R²N(CH₂)_nPPh₂)₂]²⁺, M = Pt(II) or Pd(II), can exist in chelate ring-closed and ring-opened forms both in the solid state and in aqueous solution The equilibrium between them in solution can be controlled by the nature of the groups R¹ and R² (H, Me, Bz, cyclohexyl), by the bridge length n, and by the pH and Cl^– concentration X-ray crystal structures are reported for the ring-closed complexes cis-[Pt(H₂N(CH₂)₂PPh₂-P,N)₂]Cl₂, cis-[Pt(H₂N(CH₂)₃PPh₂-P,N)₂]Cl₂, and cis-[Pt(Me(H)N(CH₂)₂PPh₂-P,N)₂]Cl₂, the mono-ring-opened complex cis-Pd[(Me₂N(CH₂)₂PPh₂-N,P)Cl(Me₂NH(CH₂)₂PPh₂-P)](NO₃)₂, the di-ring-opened complex cis-[Pt(Me₂N(CH₂)₃PPh₂-P)₂Cl₂], and, for comparison, the monochelate cis-[Pd(Me₂N(CH₂)₃PPh₂-N,P)]Cl₂. These square-planar complexes exhibit varying degrees of distortion and variable M-N bond lengths dependent not only on the trans influence of P but also on steric effects within the complex. PH-induced chelate ring-opening of cis-[Pt(Me₂N(CH₂)₂PPh₂-P,N)₂]Cl₂ had an associated pK value of 6.9. In contrast, [M(R¹R²N(CH₂)_nPPh₂)₂]²⁺ complexes with R¹ and R² = H, n = 2 or 3 or R¹ = H and R² = Me, n = 2, are more difficult to ring-open. Thus cis-[Pt(Me(H)N(CH₂)₂PPh₂-P,N)₂]Cl₂ and cis-[Pt(H₂N(CH₂)₃PPh₂-P,N)₂]Cl₂ had associated pK values of 2.1 and 2.9, resp. These aminophosphine complexes may exhibit anticancer activity by two mechanisms: by disrupting mitochondrial membrane potentials as bis-chelated (ring-closed) lipophilic cations, or by direct binding to DNA bases as ring-opened complexes.

Journal of the Chemical Society, Dalton Transactions published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Formula: C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Ping published the artcileAdvanced continuous flow platform for on-demand pharmaceutical manufacturing, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Chemistry – A European Journal (2018), 24(11), 2776-2784, database is CAplus and MEDLINE.

As a demonstration of an alternative to the challenges faced with batch pharmaceutical manufacturing including the large production footprint and lengthy time-scale, we previously reported a refrigerator-sized continuous flow system for the on-demand production of essential medicines. Building on this technol., herein we report a second-generation, reconfigurable and 25% smaller (by volume) continuous flow pharmaceutical manufacturing platform featuring advances in reaction and purification equipment. Consisting of two compact [0.7 (L)×0.5 (D)×1.3 m (H)] stand-alone units for synthesis and purification/formulation processes, the capabilities of this automated system are demonstrated with the synthesis of nicardipine hydrochloride and the production of concentrated liquid doses of ciprofloxacin hydrochloride, neostigmine methylsulfate and rufinamide that meet US Pharmacopeia standards

Chemistry – A European Journal published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C12H17NO2, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Daqian published the artcileTris (2-chloroethyl) phosphate (TCEP) induces obesity and hepatic steatosis via FXR-mediated lipid accumulation in mice: Long-term exposure as a potential risk for metabolic diseases, Product Details of C8H8O3, the publication is Chemico-Biological Interactions (2022), 110027, database is CAplus and MEDLINE.

Tris (2-chloroethyl) phosphate (TCEP) is the most commonly detective organophosphate flame retardant in surroundings. TCEP is also evidenced as endocrine disrupting chems. and has potential adverse effects on metabolic diseases. In this study, we hypothesized that metabolic diseases are adverse outcomes of TCEP exposure. Adult ICR mice was daily treated with TCEP (20 mg/kg and 60 mg/kg, higher than expected level in people) by gavage administration for 9 wk. The results demonstrate that TCEP promoted body weight gain, hypertriglyceridemia, and hepatic steatosis, consistent with upregulation of hepatic lipogenesis-related gene expression. Moreover, TCEP altered the levels of several hepatic metabolites, especially bile acids and downregulated bile acid synthesis pathways. Intriguingly, we found a marked downregulation of the bile acid nuclear reporter, FXR, in TCEP-exposed livers. Mechanistically, TCEP directly interacted with FXR at Lys335 and Lys336. Further studies in this work elucidate the mechanisms of long-term TCEP exposure on hepatic steatosis and obesity in mice via FXR-mediated lipid accumulation. Our results provide insight into the possibility of intermediate TCEP exposure in causing metabolic diseases.

Chemico-Biological Interactions published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C19H15NO3, Product Details of C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts