Tag: M.W=100-200

Related Products of 4728-12-5 ,Some common heterocyclic compound, 4728-12-5, molecular formula is C7H14O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To dichloromethane solution (100 ml) of 14 (6.38 g, 43.64 mmol), triethylamine (9.08 ml, 65.47 mmol) was added, and methane sulfonyl chloride (3.69 ml, 48.01 mmol) was dropped while cooling in ice with shaking, and stirred for 30 min at the same temperature. The reaction mixture was added cold water, and extracted with ethyl acetate. The extract was washed with water, dried, and evaporated to dryness under reduced pressure, and the residue was purified by silica gel column chromatography (solvent: ethyl acetate/n-hexane = 1/2), to obtain 15 (9.66 g, 99percent) of oily light yellow substance. APCI-MS m/z 225[M+H]+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4728-12-5, its application will become more common.

Reference:
Patent; Tohoku University; EP2103611; (2009); A1;,
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Synthetic Route of 27489-62-9 ,Some common heterocyclic compound, 27489-62-9, molecular formula is C6H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

4.2.31 8-(trans-4-Hydroxycyclohexylamino)-1-(3-morpholinopropyl)oxazolo[4,5-g]quinazolin-2(1H)-one (6e) Trans-4-aminocyclohexanol (148 mg, 1.28 mmol) and TEA (150 mg, 2.14 mmol) was added to a solution of compound 13 (300 mg, 1.07 mmol) in isopropanol (12 ml) and stirred at 60 C for 24 h. The mixture was cooled to room temperature and concentrated in vacuo, the residue was treated with aqueous NaHCO3 (10 ml) and extracted with EtOAc/MeOH (20:1, 30 ml). The organic layer was washed with brine, dried over MgSO4, and concentrated. Chromatography of the residue on silica gel with DCM-MeOH (90/1,v/v) gave 361 mg (yield, 79%) of the title compound as pale yellow solid: Mp: 312-315 C; HRMS, ESI+, m/z: Calcd for C22H30N5O4 (M + H)+, 428.2292; found, 428.2295; 1H NMR (500 MHz, DMSO-d6) delta:8.70 (1H, s), 7.80 (1H, s), 7.74 (1H, s), 4.14 (1H, s), 4.00 (2H, t, J = 6.4 Hz), 3.52 (4H, t, J = 4.2 Hz), 2.33 (2H, t, J = 6.3 Hz), 2.26 (4H, m), 2.00 (2H, p, J = 6.4 Hz); 13C NMR (75 MHz, DMSO-d6) delta:165.61, 159.43, 153.45, 153.26, 152.57, 152.00, 148.36, 148.27, 147.64, 147.03, 134.26, 132.23, 120.73, 112.49, 106.61, 106.06, 106.38, 101.58, 100.19, 66.00, 65.86, 55.01, 54.77, 54.15, 53.16, 53.12, 40.59, 40.33, 22.19, 22.91.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 27489-62-9, trans-4-Aminocyclohexanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Lin, Jinsheng; Shen, Wei; Xue, Jingwei; Sun, Juan; Zhang, Xue; Zhang, Can; European Journal of Medicinal Chemistry; vol. 55; (2012); p. 39 – 48,10;,
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Related Products of 623-04-1 , The common heterocyclic compound, 623-04-1, name is (4-Aminophenyl)methanol, molecular formula is C7H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 4-aminobenzyl alcohol (2.0g, 16.24mmol) in dry DMF (20mL) were added tert-butyldimethylsilyl chloride (3.67g, 24.35mmol) and imidazole (2.21g, 32.46mmol), the resulting mixture was further stirred for 5hat room temperature. The reaction mixture was then diluted with saturated brine solution and extracted with CH2Cl2. The organic layer was separated and washed with brine solution for several times, then dried over anhydrous Na2SO4, evaporated under vacuum, the obtained brown residue was purified by silica gel chromatography (petroleum ether-ethyl acetate), a brown oil was obtained (3.15g, 82%). 1H NMR (CDCl3, 400MHz) delta7.12 (d, 2H, J=8.4Hz), 6.67 (d, 2H, J=8.0Hz), 4.62 (s, 2H), 3.80 (brs, 2H), 0.91 (s, 9H), 0.08 (s, 6H).

The synthetic route of 623-04-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Fei, Qiang; Zhou, Li; Wang, Feiyi; Shi, Ben; Li, Chunbao; Wang, Rui; Zhao, Chunchang; Dyes and Pigments; vol. 136; (2017); p. 846 – 851;,
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Reference of 105-13-5 ,Some common heterocyclic compound, 105-13-5, molecular formula is C8H10O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure for selective mono PMB protection of diols: (Z)-4-((4-Methoxybenzyl)oxy)but-2-en-1-ol (Table 5, entry 1): A mixture of cis-2-butene-1,4-diol (200 mg, 2.3 mmol), p-anisyl alcohol (345 mg, 2.5 mmol), and catalytic amount (10% w/w, 20 mg) of Amberlyst-15 resin in anhydrous CH2Cl2 (10 mL) was refluxed. After 3 h, the crude reaction mixture was filtered through a Whatman filter paper and the residue washed with CH2Cl2, dried (over anhydrous Na2SO4), filtered and concentrated in vacuo and purified using flash chromatography (pet ether/ethyl acetate 70:30) to provide 401 mg (85%) of pure product as a colorless dense liquid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 105-13-5, (4-Methoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Chavan, Subhash P.; Harale, Kishor R.; Tetrahedron Letters; vol. 53; 35; (2012); p. 4683 – 4686;,
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Application of 6850-39-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6850-39-1, name is 3-Aminocyclohexanol. This compound has unique chemical properties. The synthetic route is as follows.

2- (t-butoxycarbonyl) amino) pyrazolo [1,5-a] pyrimidine-3-carboxylic acid (200mg, 0.72mmol)And 3-aminocyclohexanol (83 mg, 0.72 mmol)Dissolved in dichloromethane (8 mL)And 2- (7-azobenzotriazole) -N, N, N ‘, N’-tetramethyluronium hexafluorophosphate (334 mg, 0.88 mmol)And triethylamine (0.2 mL, 1.44 mmol).After the mixture was stirred at room temperature overnight,Quenched with water (30 mL)And extracted with ethyl acetate (100 mL x 3). The combined organic phases were washed with saturated brine (100 mL x 3), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate / petroleum ether (v / v) = 1 / 2) to give the title compound as a light yellow solid (200 mg, 74.0%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6850-39-1, 3-Aminocyclohexanol.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; (88 pag.)CN104650092; (2017); B;,
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Synthetic Route of 637031-88-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.637031-88-0, name is 3,3-Difluorocyclobutanol, molecular formula is C4H6F2O, molecular weight is 108.09, as common compound, the synthetic route is as follows.

To a 10-mL Schlenk tube were added Example 8f (240 mg, 0.8 mmol), Example lj (130 mg, 1.2 mmol), K2C03 (221 mg, 1.6 mmol) and DMF (4 mL). The tube was sealed and heated at 80C for 16 hours. The reaction was cooled to room temperature. Water (10 mL) was added, the mixture was extracted by EtOAc (10 mL*3). The combined organic phase was washed with brine, dried over Na2SO4, filtrated and concentrated under reduced pressure to give the crude product which was further purified by silica gel chromatography to give the pure product Example 8g (92 mg, yield 30%) as a white solid. ?H NMR (400 IVIHz, Chloroform-d) 7.36 (d, J 8.6 Hz, 1H), 6.86 (d, J 8.6 Hz, 1H), 4.77 (d, J= 9.3 Hz, 1H), 4.39-4.33 (m, 2H),4.28-4.23 (m, 2H), 3.13 (ddt, J 18.9, 12.3, 6.5 Hz, 2H), 2.94-2.81 (m, 2H).

Statistics shows that 637031-88-0 is playing an increasingly important role. we look forward to future research findings about 3,3-Difluorocyclobutanol.

Reference:
Patent; FRONTHERA U.S. PHARMACEUTICALS LLC; JIN, Bohan; DONG, Qing; HUNG, Gene; (151 pag.)WO2018/31680; (2018); A1;,
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Adding a certain compound to certain chemical reactions, such as: 17849-38-6, 2-Chlorobenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-Chlorobenzyl alcohol, blongs to alcohols-buliding-blocks compound. Quality Control of 2-Chlorobenzyl alcohol

General procedure: A mixture of the substrate (1 mmol), hexamethyldisilazane (0.70 mmol), and/or 3,4-dihydro-2H-pyran (1.4 mmol) and BiPy(SO3H)2(HSO4)2 (10 mg, 1.95 mol%) in CH3CN(3 mL) and/or CH2Cl2 (3 mL) was stirred at room temperature. The progress of thereaction was monitored by TLC (n-hexane: EtOAc; 10:1) and/or GC. After completion ofthe reaction, the mixture was filtered to separate the solid catalyst. Then the solution wasfiltered through a silica gel pad and washed with CH3CN (2 × 3 mL) and/or CH2Cl2 (2 ×3 mL). Evaporation of the solvent gave the desired products in high purity.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,17849-38-6, 2-Chlorobenzyl alcohol, and friends who are interested can also refer to it.

Reference:
Article; Shirini, Farhad; Abedini, Masoumeh; Mahmoodi, Nosratollah; Biglari, Mohammad; Safarpoor Nikoo Langrudi, Mohaddeseh; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 190; 11; (2015); p. 1912 – 1921;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1805-32-9, name is 3,4-Dichlorobenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 1805-32-9

Examples 204-206 were prepared according to the method described below: 6′-[(3R)-3-{[tert-Butyl(dimethyl)silyl]oxy}pyrrolidin-1-yl]-2-oxo-2H-1,3′-bipyridin-4-yl 4-bromobenzenesulfonate from Preparation 47 (197 mg, 0.324 mmol), the appropriate benzyl alcohol (0.982 mmol) and potassium hydroxide (55 mg) in DMSO (3 ml) were heated at 130 C. under nitrogen for 1 hour then allowed to stand at r.t. overnight. The reactions were diluted with methanol (3 ml) and passed down a SCX column, washed with methanol and the product eluted with 2M NH3 in methanol, evapourated to dryness. The residue was chromatographed on Biotage 12×150 mm silica column eluting with DCM/MeOH/NH3 98/2/0 to 93/7/1. Solvent removed in vacuo to give the title compound as solids. 204 LC-MS RT = 1.20 min m/z (APCI & ESI) 432 [MH+](2 min run)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1805-32-9, 3,4-Dichlorobenzyl alcohol.

Reference:
Patent; Pfizer Inc; US2008/85884; (2008); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 15258-73-8, name is (2,6-Dichlorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Safety of (2,6-Dichlorophenyl)methanol

[Example 10] Synthesis of sodium 2,6-dichlorobenzyloxymethyl trifluoroborate To the mixture of sodium hydride (61 %, 180 mg, 4.5 mmol) and tetrahydrofuran (6 ml), 2,6-dichlorobenzyl alcohol (740 mg, 4.2 mmol) was added at 0C (an outer temperature), and the obtained reaction mixture was stirred at room temperature for 1 hour. To the reaction mixture, 2-(bromomethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (92%, 500 mg, 2.1 mmol) synthesised in Production Example 2 and dissolved in tetrahydrofuran (4 ml) was added at 0C (an outer temperature), and the obtained mixture was stirred at 30C (an outer temperature) overnight. After cooling the reaction mixture to 0C (an outer temperature), sodium hydrogen fluoride (590 mg, 4.5 mmol) was added to the reaction mixture at the same temperature, followed by the dropwise addition of water (8 ml) at the same temperature. After stirring the reaction mixture for 30 minutes at room temperature, the solvents were evaporated under reduced pressure. Acetone (40 ml) was added to the obtained residue, followed by filtration. The solvents were evaporated under reduced pressure from the filtrate, and then the obtained residue was washed with diethyl ether, thereby obtaining the entitled compound (460 mg, 78%). 1H-NMR Spectrum (DMSO-d6) delta(ppm): 2.61(2H, q, J=5.4Hz), 4.46(2H, s), 7.30-7.35(1H, m), 7.44(2H, d, J=8.0Hz)

With the rapid development of chemical substances, we look forward to future research findings about 15258-73-8.

Reference:
Patent; Eisai R&D Management Co., Ltd.; EP2062901; (2009); A1;,
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Application of 53066-19-6, Adding some certain compound to certain chemical reactions, such as: 53066-19-6, name is 1-(2,6-Dichlorophenyl)ethanol,molecular formula is C8H8Cl2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 53066-19-6.

A solution of 1- (2,6-dichlorophenyl) ethanol (9.0 g, 47.11 mmol)Of tetrahydrofuran (200 mL)The solution was cooled to 0 C,Sodium hydride (60% dispersion in mineral oil, 2.45 g, 61.24 mmol) was added thereto in portions.When no bubbles are generated,A solution of 3-fluoro-2-nitropyridine (6.69 g, 47.11 mmol)In tetrahydrofuran (50 mL).The reaction was stirred at room temperature overnight, cooled to 0 C,Water (10 mL) was quenched and concentrated under reduced pressure. The residue was diluted with water (200 mL) and extracted with ethyl acetate(150 mL x 3). The combined organic phases were washed successively with saturated sodium bicarbonate solution (200 mL), brine (200 mL), anhydrous sulfurSodium sulfate, filtered, and concentrated under reduced pressure,The title compound was

According to the analysis of related databases, 53066-19-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Wang Ruyong; Wang Liang; (112 pag.)CN104016979; (2017); B;,
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