Tag: M.W=100-200

Related Products of 1805-32-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1805-32-9, name is 3,4-Dichlorobenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: The oxidation of alcohols was performed in an autoclave reactor equipped with a magnetic stirrer, thermocouple, automatic temperature controller and a pressure gauge. After the addition of desired amount of reactant, catalyst, water and NaOH, the autoclave was sealed. The atmosphere over the mixture was replaced with O2 for three times. Then the reactor was heated to the desired temperature with stirring. Subsequently, the pressure of O2 was charged to 1.0 MPa and kept constant during the reaction through feeding O2. When the reaction was finished, the reactor was cooled down to the ambient temperature. The reaction mixture was diluted with acetone to dissolve the products. After the catalyst was separated, the filtrate was acidified to pH of 2.0 by hydrochloric acid. The oxidation products were analyzed by gas chromatography equipped with a flame ionization detector. The isolated yield of carboxyl acid was obtained with the following procedure. The solvent of the mixture after acidification was removed through rotary evaporation. The pH of the residual was adjusted to 10.0 with NaOH (2.0 M), and then it was extracted with ethyl acetate for three times. The aqueous layer was acidified to pH 2.0 using HCl (6.0 M) and extracted with ethyl acetate. The organic layer was removed ethyl acetate through rotary evaporation to get the carboxylic acid. The carboxylic acid was dried overnight for calculation of the isolated yield.

According to the analysis of related databases, 1805-32-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhou, Lipeng; Chen, Minzhu; Wang, Youqiang; Su, Yunlai; Yang, Xiaomei; Chen, Chen; Xu, Jie; Applied Catalysis A: General; vol. 475; (2014); p. 347 – 354;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1202577-61-4, name is trans-(4-(Trifluoromethyl)cyclohexyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of trans-(4-(Trifluoromethyl)cyclohexyl)methanol

[00173] To a mixture of oxalyl chloride (24.96 g, 13.84 mL, 197.7 mmol) in CH2C12 (250 mL) was added dropwise DMSO (20.72 g, 28 mL, 395.4 mmol) at -65 C. The mixture was stirred at -65 C for 30 min. (iraw5,-4-(trifluoromethyl)cyclohexyl)methanol (12 g, 65.9 mmol) dissolved in CH2C12 (50 mL) was added dropwise at -65 C and the mixture was stirred at -65 C for another 30 min. Triethylamine (66.4 g, 91.2 mL, 659 mmol) was added dropwise below -65 C. The mixture was stirred at -65 C for 30 min, then stirred at rt for 1.5 h. The mixture was quenched with water (200 mL) and separated. The aqueous layer was extracted with CH2C12 (2 x 300 mL). The combined organic layers were washed with water (200 mL) and brine (200 mL), dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. The residue was purified by silica gel chromatography (eluting with petroleum ether: ethyl acetate = 10: 1) to give trans-4- (trifluoromethyl)cyclohexanecarbaldehyde (8.9 g, 75%) as a slight yellow oil. 1H NMR (CDCI3, 400 MHz): delta 9.70 (s, 1H), 2.16-2.65 (m, 3H), 2.04-2.12 (m, 3H), 1.00-1.39 (m, 4H).

With the rapid development of chemical substances, we look forward to future research findings about 1202577-61-4.

Reference:
Patent; VITAE PHARMACEUTICALS, INC.; CLAREMON, David, A.; DILLARD, Lawrence, Wayne; DONG, Chengguo; FAN, Yi; JIA, Lanqi; LOTESTA, Stephen, D.; MARCUS, Andrew; SINGH, Suresh, B.; TICE, Colin, M.; YUAN, Jing; ZHAO, Wei; ZHENG, Yajun; ZHUANG, Linghang; (102 pag.)WO2016/61160; (2016); A1;,
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Application of 440-60-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 440-60-8, name is (Perfluorophenyl)methanol. A new synthetic method of this compound is introduced below.

Example 10 In a 30 ml two-necked flask were added 0.004 g of LiOH.H2O, 0.31 g of methyl 2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate, 1.00 g of (2,3,4,5,6-pentafluorophenyl)methyl alcohol and 0.6 g of toluene, and the mixture was stirred for 8 hours at a toluene refluxing temperature. Analysis of the reaction mixture by a gas chromatography showed that the yield of (2,3,4,5,6-pentafluorophenyl)methyl 2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate was 92% based on the starting ester.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,440-60-8, (Perfluorophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Sumitomo Chemical Company, Limited; US6441220; (2002); B1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 27489-62-9, name is trans-4-Aminocyclohexanol, the common compound, a new synthetic route is introduced below. Product Details of 27489-62-9

A mixture of Methyl 2-bromo-1 -methyl-1 H-benzimidazoIe-5-carboxylate (37.0 g, 0.137 mol), frans-4-aminocyclohexanol (38.0 g, 0.33 mol), cesium fluoride CsF (29.24 g, 0.29 mol), and DMSO (350 mL) was stirred at 110 C for 6 h and kept overnight at room temperature (TLC control, silica gel, chloroform/ethanol 20:1 ). The reaction mixture was poured into cold water (1.5 L). The precipitate was separated by filtration and recrystallized from acetonitrile (900 mL) to give the title compound in 84% (35.0 g) yield.

The synthetic route of 27489-62-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2007/69053; (2007); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4442-79-9, name is 2-Cyclohexylethanol. A new synthetic method of this compound is introduced below., category: alcohols-buliding-blocks

150 mg (1.17 mmol, 1 eq) of 2-cyclohexylethanol were diluted in 4 mL of DCM, 214 muL (1.52 mmol, 1.3 eq) of triethylamine were added. The mixture was cooled to 0C and 100 muL (1.29 mmol, 1.1 eq) of mesyl chloride were added. The mixture was stirred for 15 min at 00C then water was added. The aqueous phase was extracted with dichloromethane. The organic phase was washed with water, brine, dried over MgSO4, filtered and concentrated in vacuo. The crude product (241 mg) was used directly for synthesis of 2. TLC : Rf : 0.48 (eluant : Heptane/EtOAc : 1/1).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4442-79-9, 2-Cyclohexylethanol.

Reference:
Patent; AMGEN INC.; WO2009/9122; (2009); A2;,
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Reference of 873-76-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 873-76-7, name is (4-Chlorophenyl)methanol, molecular formula is C7H7ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a suspension of polymer-bound triphenylphosphine (1.2 mmol) in anhydrous acetonitrile (10 mL) were added iodine (1 mmol) and 1,6-hexanediol diol (1mmol). The reaction mixture was irradiated in microwave reactor at 120 C for 3 min. The reaction mixture was filtered over a filter paper and washed with chloroform.The filtrate was extracted with aqueous sodium thiosulfate solution and dried with anhydrous sodium sulfate.The reafter, solvent was removed under reduced pressure to obtain 6-iodohexan-1-ol (30) in 93%

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 873-76-7, (4-Chlorophenyl)methanol.

Reference:
Article; Das, Diparjun; Chanda, Tridib; Rokhum, Lalthazuala; Acta Chimica Slovenica; vol. 62; 4; (2015); p. 775 – 783;,
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Synthetic Route of 2240-88-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol. A new synthetic method of this compound is introduced below.

To the solution of 2.00 g Preparation 9a3 (8.61 mmol) in acetonitrile 2.38 g K2C03 (17.2 mmol), then 3,3,3-trifluoropropan-1-ol were added and the so obtained mixture was stirred for I Oh at 60°C. The reaction mixture was cooled, filtered and the filtrate concentratedunder reduced pressure. The residue was purified via flash chromatography using heptane and ethyl-acetate as eluents to give 4-(dimethoxymethyl)-2-(3,3,3-trifluoropropoxy) pyrimidine.?11 NMR (400 MHz, DMSO-d6): 8.68 (d, 111), 7.22 (d, 111), 5.22 (s, 111), 4.53 (t, 211), 3.33 (s, 611), 2.83 (m, 211).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2240-88-2, 3,3,3-Trifluoropropan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LIMITED; KOTSCHY, Andras; SZLAVIK, Zoltan; CSEKEI, Marton; PACZAL, Attila; SZABO, Zoltan; SIPOS, Szabolcs; RADICS, Gabor; PROSZENYAK, Agnes; BALINT, Balazs; BRUNO, Alain; GENESTE, Olivier; DAVIDSON, James Edward Paul; MURRAY, James Brooke; CHEN, I-Jen; PERRON-SIERRA, Francoise; WO2015/97123; (2015); A1;,
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Adding a certain compound to certain chemical reactions, such as: 67853-03-6, Methyl 3-(hydroxymethyl)benzoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 67853-03-6, blongs to alcohols-buliding-blocks compound. Product Details of 67853-03-6

To the solution of compound B4 (28 g, 0.168 mol) in 700 mL of Et2O was added PBr3 (17.4 mL, 0.185 mol) dropwise. The solution was stirred for 2 h, and then the reaction was poured into 500 mL of ice-water. The aqueous layer was extracted with Et2O. The combined organic layers were washed with sat. NaHCO3, water, and brine consecutively. The organic phase was dried over Na2SO4, filtered and concentrated under reduced pressure to give 34 g of compound B5 as an oil (yield: 70%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,67853-03-6, its application will become more common.

Reference:
Patent; PHENEX PHARMACEUTICALS AG; KREMOSER, Claus; ABEL, Ulrich; STEENECK, Christoph; KINZEL, Olaf; WO2011/20615; (2011); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 403-41-8, name is 1-(4-Fluorophenyl)ethyl Alcohol. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 1-(4-Fluorophenyl)ethyl Alcohol

To a stirred solution l-(4-fluorophenyl)ethan-l-ol (2, 0.5 g, 3.57 mmol) in DCM (5 mL), was added SOCl2(0.7 mL, 7.10 mmol) drop wise at 0 C and the reaction mixture was stirred at rt for 1 h (Reaction condition b). The reaction mixture was evaporated under vacuum and dried to afford the product as brown oil (3) (0.5 g, 89%, Yield).XHNMR (400 MHz, DMSO-d6) delta (ppm): 7.53-7.51 (m, 2H), 7.21-7.16 (m, 2H), 5.36-5.33 (m, 1H), 1.76 (d, = 6.8 Hz, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 403-41-8.

Reference:
Patent; JUBILANT BIOSYS LIMITED; HALLUR, Gurulingappa; DURAISWAMY, Athisayamani Jeyaraj; PURRA, Buchi Reddy; RAO, N.V.S.K.; RAJAGOPAL, Sridharan; KRISTAM, Rajendra; (200 pag.)WO2019/77631; (2019); A1;,
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Related Products of 1124-63-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1124-63-6, name is 3-Cyclohexylpropan-1-ol. A new synthetic method of this compound is introduced below.

To a stirred solution of 4-nitrophenol (4) (1.30 g, 8.35 mmol) and PPh3 (3.20 g, 12.2 mmol) in THF (30.0 mL) were added diisopropyl azodicarboxylate (2.40 mL, 12.2 mmol) and 3-cyclohexyl-1-propanol (1.91 mL, 12.2 mmol) at 0 C. After stirring for 2 h at ambient temperature, the reaction mixture was quenched with H2O and then extracted with EtOAc. The combined organic layers were dried over MgSO4 and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (EtOAc : n-hexane = 1 : 24 to 1 : 15) to afford 2.23 g (91%) of 18 as a colorless oil: 1H NMR (CDCl3, 400 MHz) delta 8.15 (d, 2H, J= 7.0 Hz), 6.91 (d, 2H, J = 7.0 Hz), 3.99 (t, 2H, J = 6.6 Hz), 1.80 (quintet, 2H, J = 7.2 Hz), 1.67 (m, 5H), 1.31 (m, 2H), 1.18 (m, 4H), 0.89 (m, 2H); 13C NMR (CDCl3, 100 MHz) delta 164.3, 141.3, 125.9, 114.4, 69.3, 37.4, 33.6, 33.3, 26.7, 26.4, 26.4.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1124-63-6, 3-Cyclohexylpropan-1-ol, and friends who are interested can also refer to it.

Reference:
Article; Jo, Jeyun; Kim, Heegyu; Oh, Ji Youn; Kim, Soyeong; Park, Yeong Hye; Choi, Hyeonjin; Jeong, Jee-Yeong; Jung, Young-Suk; Yun, Hwayoung; Bioorganic and Medicinal Chemistry Letters; vol. 29; 24; (2019);,
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