Tag: M.W=100-200

Adding a certain compound to certain chemical reactions, such as: 1074-61-9, (4-Vinylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 1074-61-9, blongs to alcohols-buliding-blocks compound. SDS of cas: 1074-61-9

Step A 1-Bromomethyl-4-vinyl-benzene Bromine (16.4 g, 103 mmol) was slowly added to a solution of triphenylphosphine (28.87 g, 110.1 mmol) in CH2Cl2 (260 mL) at 0 C. After 10 minutes, 4-vinylbenzyl alcohol (12.5 g, 93.3 mmol) was added and the reaction mixture was stirred at 0 C. for 2 h. The reaction mixture was washed with water (1*) followed by brine (1*). The organic solution was dried over MgSO4, filtered, and concentrated in vacuo. The product was triturated with petroleum ether (3*), and the ethereal solution was concentrated in vacuo. The residue was purified by flash chromatography (hexanes) to afford 4-vinyl-benzyl bromide (6.23 g). 1H NMR (400 MHz, CDCl3) delta7.32-7.45 (m, 4H), 6.72 (dd, 1H), 5.77 (d, 1H), 5.28 (d, 1H), 4.50 (s, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1074-61-9, (4-Vinylphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Pfizer Inc.; US6344485; (2002); B1;,
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Synthetic Route of 929-06-6, Adding some certain compound to certain chemical reactions, such as: 929-06-6, name is 2-(2-Aminoethoxy)ethanol,molecular formula is C4H11NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 929-06-6.

To a round-bottomed flask containing dichloromethane (15 mL), 2-(2-aminoethoxy)ethanol1 (1.580 g, 15.03 mmol) was added. The solution was kept in ice bath (0 C). A dichloromethanesolution (9 mL) containing di-tert-butyl dicarbonate (3.726 g, 17.07 mmol) was added dropwise (25 min)to the round-bottomed flask. The progress of this amine protection reaction could be convenientlymonitored using TLC. The reaction was carried out at room temperature for 6.5 h.After the reaction, the mixture was washed first with 10 wt% citric acid (10 mL), then10 wt% NaHCO3 (10 mL 2), and finally with water (10 mL). The organic layer collected wasdried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residuewas purifed by column chromatography (ethyl acetate /hexane = 1:3, v/v) to aord tert-butyl(2-(2-hydroxyethoxy)ethyl)carbamate (2.646 g, 86% yield) as colorless liquid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 929-06-6, 2-(2-Aminoethoxy)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Li, Hsin-Yi; Chu, Yen-Ho; Molecules; vol. 25; 1; (2020);,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15258-73-8, name is (2,6-Dichlorophenyl)methanol, molecular formula is C7H6Cl2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: (2,6-Dichlorophenyl)methanol

To a solution of 2,6-dichlorobenzyl alcohol (22 mg, 0.13 mmol, 1.0 eq) in tetrahydrofuran (1.5mL) was added sodium hydride (25 mg, 0.99 mmol, 7.8 eq) and the resulting reaction mixturewas stirred at 23 C. After 10 minutes a solution of 4-{5-[3-chloro-4- (dimethylcarbamoyl)phenylj -3-cyanopyridin-2-yl } piperazine- 1 -carbonyl chloride (55 mg, 0.13 mmol, 1.0 eq) in dichloromethane (1.5 mL) was added and the reaction mixture was stirred at 23C for 16 hours. The excess sodium hydride was quenched with the dropwise addition of water(0.15 mL), the mixture was concentrated and the residue was dissolved in DMSO and purified byreverse phase liquid chromatography (Gemini-NX C18, 5 jim, 30 x 100 mm column; 0-100%CH3CN/H20 gradient w/ 0.10% TFA present) to yield 2,6-dichlorobenzyl 4-{5-[3-chloro-4-(dimethylcarbamoyl)phenylj -3-cyanopyridin-2-yl } piperazine- 1 -carboxylate. ?H NMR (400MHz, CD3OD): oe 8.69 (d, J = 2.5 Hz, 1 H); 8.29 (d, J = 2.5 Hz, 1 H); 7.79 (d, J = 1.7 Hz, 1 H);7.67 (dd, J = 8.0, 1.7 Hz, 1 H); 7.48-7.33 (m, 4 H); 5.44 (s, 2 H); 3.85-3.58 (m, 8 H); 3.13 (s, 3H); 2.92 (s, 3 H). LRMS m/z (M+H) 572.2 found, 572.1 required.

With the rapid development of chemical substances, we look forward to future research findings about 15258-73-8.

Reference:
Patent; MERCK SHARP & DOHME CORP.; RUDD, Michael, T.; BRNARDIC, Edward, J.; KIM, Yuntae; MEISSNER, Robert, S.; RADA, Vanessa; STACHEL, Shawn, J.; ZERBINATTI, Celina, V.; (125 pag.)WO2017/83216; (2017); A1;,
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Related Products of 6920-22-5 , The common heterocyclic compound, 6920-22-5, name is Hexane-1,2-diol, molecular formula is C6H14O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 1 – Deoxydehyd ration of 1,2-decanediol In the following examples, unless something else is stated, 40 mmol of diol, 2.0 mmol of catalyst (5 mol%, calculated with respect to the amount of vanadium), 500 mg of hexadecane (internal standard), and 100 ml of solvent were mixed in a 300 ml PTFE cup and placed in a 400 ml autoclave with a magnetic stir bar and computer-controlled heating plate. The autoclave was sealed, pressurized with 10-25 bar of H2, N2, or CO and heated to 230 C for 1000 min (corresponding to ~ 16 h at the reaction temperature); the temperature typically stabilized between 225 and 235 C. When the system had cooled to room temperature, the pressure was released, the reaction mixture was filtered to remove a black precipitate and analyzed by GC (for determination of conversion and yields) and GC-MS (for observation and identification of other products). Comparison of solvents A number of primary or secondary monohydric Ci-Cio alcohol solvents were tested together with NH4V03 as the catalyst. In addition, their performance was compared to that of acetone and hexane as solvents. The yields of 1-decene (C=C), 2-decanone (C=0), 2-decanol (2OH), and 1-decanol (lOH) are provided below in Table 1. It is evident that using a primary or secondary monohydric Ci-Cio alcohol as the solvent results in a better selectivity of 1-decene than any of the comparative solvents.

The synthetic route of 6920-22-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DANMARKS TEKNISKE UNIVERSITET; DETHLEFSEN, Johannes Rytter; FRISTRUP, Peter; (30 pag.)WO2016/101958; (2016); A1;,
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Related Products of 4728-12-5 , The common heterocyclic compound, 4728-12-5, name is (2,2-Dimethyl-1,3-dioxan-5-yl)methanol, molecular formula is C7H14O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred suspension of pyridinium chlorochromate (1.1 g) and diatomaceous earth (10 g) in dichloromethane (10 mL) was added (2,2-dimethyl-1,3-dioxan-5-yl)methanol (0.5 g) as a solution in dichloromethane (3 mL) dropwise. The mixture was stirred at room temperature for 2 hours. The suspension was filtered through diatomaceous earth and washed with ethyl acetate. The crude product was filtered through silica gel and concentrated to give the title compound. 1H NMR (501 MHz, chloroform-d) delta ppm 9.89 (s, 1H), 4.28? 4.17 (m, 4H), 2.42? 2.32 (m, 1H), 1.49 (s, 3H), 1.39 (s, 3H). MS (ESI) m/e 305.9 (2M+NH4)+.

The synthetic route of 4728-12-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABBVIE INC.; BENATUIL, Lorenzo; BRUNCKO, Milan; JUDD, Andrew, S.; LI, Yingchun; MCCLUSKEY, Andrew; PHILLIPS, Andrew, C.; PHILLIPS, Darren, C.; SEAGAL, Jane; SOUERS, Andrew, J.; (808 pag.)WO2017/214462; (2017); A2;,
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Electric Literature of 34957-73-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 34957-73-8 as follows.

Step 2; 9-Oxo-nonanoic acid methyl ester; To a solution of 5.2 g (28 mmol) 9-Hydroxy-nonanoic acid methyl ester in 350 mL DCM is added 9.1 g (41 mmol) Pyridinium chlorochromate and the reaction is stirred for 15 h at rt. The reaction is diluted with DCM, silica is added, the mixture is filtered through a pad of Hyflo and thoroughly washed with DCM. The solvent is removed in vacuo to give the title compound as a green oil, which is used without further purification. MS (method D): 204 [M+H2O]

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,34957-73-8, its application will become more common.

Reference:
Patent; NOVARTIS AG; WO2008/101665; (2008); A1;,
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Electric Literature of 1467-84-1, Adding some certain compound to certain chemical reactions, such as: 1467-84-1, name is (trans-4-Aminocyclohexyl)methanol,molecular formula is C7H15NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1467-84-1.

To a mixture of (4-aminocyclohexyl)methanol (6.62 g, 40 mmol) and K2C03 (11.04 g, 80 mmol) was in MeCN (60 mL) at 0 C was added Mel (5.6 g, 40 mmol) dropwise, the reaction mixture was stirred at rt for 7 h, filtered, and the filtrate was concentrated to afford the crude title compound. ESI-MS m/z 144 (MH)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1467-84-1, (trans-4-Aminocyclohexyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; VENATORX PHARMACEUTICALS, INC.; BURNS, Christopher, J.; CHU, Guo-Hua; HAMRICK, Jodie; BOYD, Steven, A.; CONDON, Stephen, M.; (0 pag.)WO2019/232053; (2019); A1;,
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Application of 1462-03-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1462-03-9, name is 1-Methylcyclopentanol, molecular formula is C6H12O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 3 4-(1-Methyl-1-cyclopentyl)resorcinol From 1-methylcyclopentanol as a solid. 1 H NMR (400 MHz, CDCl3 -MeOH): d 1.31 (3H, s); 1.74-1.89 (4H, m); 1.94-2.03 (4H, m); 6.33-6.34 (1H, m); 6.39 (1H, dd, J=2.5, 8.4 Hz); 7.10 (1H, m). M/Z (ES-ve) gives 191.6 (M-H).

According to the analysis of related databases, 1462-03-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Pfizer Inc.; US6132740; (2000); A;,
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Adding a certain compound to certain chemical reactions, such as: 67853-03-6, Methyl 3-(hydroxymethyl)benzoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

3-HYDROXYMETHYL-BENZOIC acid methyl ester (200 mg, 1.20 mmol) was dissolved in dichloromethane (5 ml). PCC (388 mg, 1.8 mmol) was added therein. The reaction mixture was stirred at room temperature for 3 hours to give 3-FORMYL-BENZOIC acid methyl ester (140 mg, yield: 72%, white solid).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,67853-03-6, Methyl 3-(hydroxymethyl)benzoate, and friends who are interested can also refer to it.

Reference:
Patent; JE IL PHARMACEUTICAL CO., LTD.; WO2004/113281; (2004); A1;,
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Reference of 558-42-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 558-42-9, name is 1-Chloro-2-methyl-2-propanol. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 1-chloro-2-methyl-propan-2-ol (10 mL ), 4-hydroxybenzonitrile (2 g, 16.8 mmol), K2CO3 (9.3 g, 67.3 mmol) in water (6 mL) and ethanol (60 mL) was heated at 80 °C for 16 hours. The reaction mixture was cooled and the solvent was concentrated in vacuo. The residue was diluted with ether (200 mL) and filtered and the filtrate was washed sequentially with water (50 mL) and brine solution (50 mL). The organics were separated and dried over MgSO4 and solvent was removed in vacuo to give a residue which was purified by silica gel column chromatography using (0-100percent) EtOAc/DCM as eluent to give 4-(2-hydroxy- 2-methyl-propoxy)benzonitrile (3.0 g, 94 percent) as a yellow solid. ESI-MS m/z calc. 191.1, found 192.3 (M+1)+; Retention time: 1.05 minutes (3 min run).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 558-42-9, 1-Chloro-2-methyl-2-propanol.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; HADIDA-RUAH, Sara, Sabina; ARUMUGAM, Vijayalaksmi; DENINNO, Michael, Paul; FRIEMAN, Bryan, A.; KALLEL, Edward, Adam; MILLER, Mark, Thomas; UY, Johnny; ZHOU, Jinglan; WO2013/109521; (2013); A1;,
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