Tag: M.W=100-200

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 597-31-9, name is 3-Hydroxy-2,2-dimethylpropanal, the common compound, a new synthetic route is introduced below. Product Details of 597-31-9

The hydroxypivalaldehyde and sodium hydroxide solution obtained in the step (3) were added to a four-necked flask, heated and refluxed for 2 hours with stirring at 85 to 95 C,The weight ratio of the BaO / SiO2 core-shell microsphere catalyst was 27: 5: 270: 15, the weight ratio of the catalyst was 4: Stirring to 60 C while adding ammonia to keep the pH of the reaction solution 7-9, 8 hours after the stop reaction, the reaction solution suction filter, the filtrate concentration adjusted with concentrated hydrochloric acid ph value 3-4, extracted with acetone , After evaporation of acetone standing, precipitation crystallization is hydroxy pivalic acid, the yield was 91%

The synthetic route of 597-31-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Suzhou Yi Dike Pharmaceutical Chemical Co; Hu, Haiwei; Ding, Jing; Yan, Yongping; Zheng, Hui; Yan, Hui; (7 pag.)CN105753684; (2016); A;,
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Application of 623-50-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.623-50-7, name is Ethyl 2-hydroxyacetate, molecular formula is C4H8O3, molecular weight is 104.1045, as common compound, the synthetic route is as follows.

Example 34[0196] Preparation of allyloxy-acetic acid ethyl ester. EMI61.2[0197] A round-bottom flask was charged with NaH (1.76 g, 44 mmol, 60% dispersion in mineral oil) and flushed with argon. Hexane (10 ml x 2) was added and decanted. DMF (10 ml) was added into the flask and the resulting solution was cooled to 0 C. Ethyl glycolate (4.16 g, 40.0 mmol) was added over 10 min. The solution was allowed to gradually warm to 25 C and was maintained at that temperature for 2 h. The solution was cooled to 0 C and allyl bromide (5. 32 g, 44.0 mmol) was added over 10 min. The solution was allowed to gradually warm to 25 C and stirred at that temperature for 2h. Aqueous solutionNH4Cl(10 ml) was added to the reaction and the mixture was diluted with EtOAc (60 ml). The organic layer was separated and washed withH20 (20 ml x 2), dried overNa2S04 and concentratedin vacuo. The crude product was purified by distillation under reduced pressure. [0198] Yield = 4.29 g, 75%; colorless liquid; bp = 38-39 C, 2 mmHg. IR (neat): 1985,1756, 1724,1203, 1130 cm-l. IH NMR (CDC13, 400 MHz): 6 5.90-5. 70 (m, 1H), 5.25-5. 00 (m, 2H), 4.10-4. 20 (m, 2H), 3.92-4. 05 (m, 4H), 1.21 (t, J = 7Hz, 3H). 13C NMR (CDCl3, 100 MHz): 8 170.09 (C), 133.62 (CH), 117.78 (CH2), 72.10 (CH2), 66.99 (CH2), 60.53 (CH2), 13. 94 (CH3). MS (m/z, relative intensity): 144 (M+, 14), 115 (22), 103 (100), 83 (85); HRMS: calculated for C7HI203 (M+): 144.0786 ; found 144.0783.

Statistics shows that 623-50-7 is playing an increasingly important role. we look forward to future research findings about Ethyl 2-hydroxyacetate.

Reference:
Patent; AUSPEX PHARMACEUTICALS, INC.; WO2005/49582; (2005); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 623-50-7, name is Ethyl 2-hydroxyacetate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: Ethyl 2-hydroxyacetate

EXAMPLE 10(i) N-(1-azabicyclo[2.2.1]hept-3-yl)-furo[2,3-b]pyridine-2-carboxamide: Ethyl glycolate (35.5 mL, 375 mmol) is slowly added (over 20 minutes) to a slurry of NaOH (15.8 g, 394 mmol) in 1,2-dimethoxyethane (400 mL) under N2 with the flask being in an ice bath. The mixture is allowed to warm to rt, is stirred for 30 min, and ethyl 2-chloronicotinate (27.84 g, 150 mmol) in 1,2-dimethoxyethane (50 mL) is added over 10 minutes. The reaction is warmed to 65 C. for 15 h in an oil bath. The mixture is concentrated to dryness, the residue is dissolved in H2O (500 mL), washed with hexane (500 mL), acidified to pH 3 with 5% HCl, and extracted with CHCl3 (4*400 mL). The combined organic layer is dried over MgSO4, filtered, and concentrated to a yellow solid. The solid is suspended in ether (200 mL) and heated on a steam bath until concentrated to a volume of 40 mL. The material is allowed to crystallize overnight, then filtered to afford ethyl 3-hydroxyfuro[2,3-b]pyridine-2-carboxylate (C40) as a pale orange solid (41% yield). Additional material is obtained by concentrating the filtrate.

With the rapid development of chemical substances, we look forward to future research findings about 623-50-7.

Reference:
Patent; Walker, Daniel Patrick; Piotrowski, David W.; Jacobsen, Eric Jon; Acker, Brad A.; Wishka, Donn G.; Reitz, Steven Charles; Groppi JR., Vincent E.; US2003/153595; (2003); A1;,
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Adding a certain compound to certain chemical reactions, such as: 454-91-1, 1-[3-(Trifluoromethyl)phenyl]ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 1-[3-(Trifluoromethyl)phenyl]ethanol, blongs to alcohols-buliding-blocks compound. Safety of 1-[3-(Trifluoromethyl)phenyl]ethanol

At room temperature, in a 50 ml round-bottom flask is sequentially added in 3 – trifluoromethyl -1 – phenethyl alcohol (0.19 g, 1 mmol), benzoic acid (0.183g, 1.5 mmol), NBS (0.356g, 2 mmol) and 1, 4 – dioxane (2 ml). In the 60 C stirring 1 hour, then adding DBU (0.304 g, 2 mmol), continue to reaction 4 hours (TLC detection reaction). Then, stopping the reaction, concentrated under reduced pressure, to obtain crude product. Finally petroleum ether and ethyl acetate mixed eluent flushing, rapid column chromatography (silica gel column) to obtain the corresponding product alpha – acyloxy ketone compound (white solid 0.170, yield 55%)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,454-91-1, 1-[3-(Trifluoromethyl)phenyl]ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Qufu Normal University; Wang, Hua; Wei, Wei; Zhu, Minghui; Cui, Huanhuan; (19 pag.)CN106518663; (2017); A;,
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Reference of 402-63-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.402-63-1, name is 1-(3-Fluorophenyl)ethanol, molecular formula is C8H9FO, molecular weight is 140.1549, as common compound, the synthetic route is as follows.

General procedure: In a round-bottom flask, a benzyl alcohol 2 (1.0 mmol), a sulfonamide1 (1.8 mmol) and BF3·OEt2 (151 muL, 1.2 mmol) were dissolved in CHCl3 (2.0 mL). The mixture was stirred for 2 h under reflux in air atmosphere, then the solvent was removed under reduced pressure using a rotary evaporator. The product was isolated by column chromatography of the residue on silica gel (EtOAc-PE, 1:10 to 1:2, v/v) to give the desired mono- and di-N-benzylated products 3 and 4.

The chemical industry reduces the impact on the environment during synthesis 402-63-1, I believe this compound will play a more active role in future production and life.

Reference:
Article; Pan, Jing; Li, Jia-Qiang; Huang, Ruo-Feng; Zhang, Xiao-Hui; Shen, Hang; Xiong, Yan; Zhu, Xiang-Ming; Synthesis; vol. 47; 8; (2015); p. 1101 – 1108;,
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Adding a certain compound to certain chemical reactions, such as: 702-23-8, 2-(4-Methoxyphenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-(4-Methoxyphenyl)ethanol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 2-(4-Methoxyphenyl)ethanol

Production Example 7 Synthesis of 4-methoxyphenethyl bromide 4-Methoxyphenethyl alcohol (0.61 g) was treated as in Production Example 1 to give the title compound (0.838 g) as a pale yellow oil (yield: 97.4%). 1H-NMR (400 MHz, CDCl3): delta(ppm) 3.10(2H, t, J=7.6Hz), 3.53(2H, t, J=7.6Hz), 3.80(3H, s), 6.86(2H, d, J=8.2Hz), 7.13(2H, d, J=8.2Hz).

The synthetic route of 702-23-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Eisai Co., Ltd.; US2002/19531; (2002); A1;,
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Synthetic Route of 23147-58-2, Adding some certain compound to certain chemical reactions, such as: 23147-58-2, name is Glycerol aldehyde dimer,molecular formula is C4H8O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 23147-58-2.

A mixture of 2-(l-piperazinyl)- 5-pyrimidinecarboxylic acid, ethyl ester (0.016 mol),(2-phenylethenyl)- boronic acid (0.016 mol) and l,4-dioxane-2,5-diol (0.016 mol) inEtOH (250 ml) was stirred for 2 days at room temperature and then the solvent wasevaporated (vac.), The residue was taken up in DCM and water and the organic layerwas separated, dried (MgSO4), filtered and the solvent was evaporated. The residue waspurified by column chromatography over silica gel (15-40/xm) (eluent: DCM/MeOH97/1). The pure fractions were evaporated, yielding 4g (61%) of intermediate 1, meltingpoint 128C.Esters, corresponding to intermediate 1, can be separated by chiral chromatography.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 23147-58-2, Glycerol aldehyde dimer, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2006/10749; (2006); A2;,
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Electric Literature of 27129-87-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.27129-87-9, name is (3,5-Dimethylphenyl)methanol, molecular formula is C9H12O, molecular weight is 136.191, as common compound, the synthetic route is as follows.

General procedure: A glass vial fitted with magnetic stirrer and a magnetic bar containing a reaction mixture of alcohol (0.1 mmol), NH4SCN (3 eq.), catalyst (5 mol%) and 2 ml of solvent. The vial was closed with rubber septum and O2 was bubbling for 15 minutes using needles. The reaction mixture was irradiated under a 23W CFL lamp for a certain time period. Reaction progress was monitored by TLC. After, completion of the reaction, a yellow solid was formed. The reaction mixture of three vials with the same content were combined and filter it through whatman filter paper. The mixture was evaporated under reduced pressure and purified by column chromatography using hexane/ethyl acetate as eluent. Further, the reaction mixture was run on a GC-MS instrument for characterisation. Yield, conversion and selectivity were calculated using following equations.

Statistics shows that 27129-87-9 is playing an increasingly important role. we look forward to future research findings about (3,5-Dimethylphenyl)methanol.

Reference:
Article; Sheriff Shah, Sk; Pradeep Singh; Tetrahedron Letters; vol. 59; 3; (2018); p. 247 – 251;,
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Electric Literature of 79418-41-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 79418-41-0, name is 3-Amino-7-hydroxy-2H-chromen-2-one, molecular formula is C9H7NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

3-Amino-7-hydroxy-2H-chromen-2-one (3) (0.56 g, 31 mmol) and O-(4-formylphenyl)dimethylcarbamothioate (0.65 g, 31 mmol) were dissolved in absoluteEtOH (10 mL) and refluxed for 2 h, during which time a precipitate formed.After cooling, the solid was collected and washed with an excess of hot EtOH:yellow solid, 0.85 g, 80 %. m.p. 240-242 C; 1H NMR (DMSO-d6): delta 8.59 (s, 1H, N=C-Ar), 7.94-7.92 (d, 1H, Ar-H, J = 8.6 Hz), 7.78 (s, 1H, =C-H),7.56-7.54 (d, 1H, Ar-H, J = 8.0 Hz),7.22-7.20 (d, 1H, Ar-H, J = 8.0 Hz),6.81 (dd, 1H, Ar-H, J = 8.0, 2.0 Hz),6.75(d, 1H, Ar-H, J = 2.0 Hz), 3.36(s, 3H, N(CH3)2), 3.32 (s, 3H, N(CH3)2);13C NMR (DMSO-d6):delta 39.1, 43.3, 102.3, 112.4, 114.0, 123.9, 130.0, 130.1, 132.3, 132.4, 133.8,154.0, 156.7, 158.5, 161.1, 161.8, 186.3; m/z obsd 369.0895; calcd for [M+H]+369.4143.

According to the analysis of related databases, 79418-41-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Garcia-Beltran, Olimpo; Rodriguez, Alejandra; Trujillo, Ariel; Canete, Alvaro; Aguirre, Pabla; Gallego-Quintero, Sebastian; Nunez, Marco T.; Aliaga, Margarita E.; Tetrahedron Letters; vol. 56; 42; (2015); p. 5761 – 5766;,
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Adding a certain compound to certain chemical reactions, such as: 62058-03-1, trans-4-Aminoadamantan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 62058-03-1, blongs to alcohols-buliding-blocks compound. Quality Control of trans-4-Aminoadamantan-1-ol

General procedure: To a solution of ethyl 1-phenyl-5-(2-methyl-4-oxobutan-2-yl)-1H-pyrazole-4-carboxylate 14b (45 mg, 0.15 mmol) in CHCl3 (9 mL) was added trans-5-hydroxy-2-adamantylamine (25 mg, 0.15 mmol), acetic acid (0.025 mL, 0.45 mmol) and sodium triacetoxyborohydride (85 mg, 0.45 mmol) at room temperature. After stirring at ambient temperature for 16 hours, the reaction mixture was quenched with aq. NaHCO3, extracted with CHCl3, and washed with aq. NaCl. The combined organic layer was dried over Na2SO4 and concentrated in vacuo. The residue was dissolved in methanol (0.30 mL), and added 1.0 N NaOH (0.22 mL, 0.22 mmol) at room temperature. After stirring at ambient temperature for 16 hours, the solvent was removed under vacuum. The mixture of the residue in CHCl3 (1.5 mL) and DIPEA (0.078 mL, 0.45 mmol) and HBTU (35 mg, 0.15 mmol) was stirred at room temperature. After 16 hours, the reaction mixture was quenched with aq. NaHCO3, extracted with CHCl3, and washed with aq. NaCl., then purified with column chromatography (silica gel, eluting with CHCl3/methanol) to give the title compound as a white solid (0.025 g, 42 percent yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,62058-03-1, its application will become more common.

Reference:
Article; Udagawa, Shuji; Sakami, Satoshi; Takemura, Takahiro; Sato, Mikiya; Arai, Takahiro; Nitta, Aiko; Aoki, Takumi; Kawai, Koji; Iwamura, Tomokatsu; Okazaki, Seiji; Takahashi, Takehiro; Kaino, Mie; Bioorganic and Medicinal Chemistry Letters; vol. 23; 6; (2013); p. 1617 – 1621;,
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