Tag: M.W=100-200

Adding a certain compound to certain chemical reactions, such as: 14002-80-3, Methyl 3-hydroxy-2,2-dimethylpropanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: Methyl 3-hydroxy-2,2-dimethylpropanoate, blongs to alcohols-buliding-blocks compound. Recommanded Product: Methyl 3-hydroxy-2,2-dimethylpropanoate

A mixture of methyl 2,2-dimethyl-3-hydroxypropionate (100 g, 0.76 mol), 4-toluenesulfonyl chloride (151 g, 0.80 mol), 4-dimethylaminopyridine (4.6 g, 0.038 mol), and pyridine (200 mL) was stirred for 20 hrs and then was diluted with 200 mL toluene, stirred for 30 min and filtered. The filtrate was concentrated to 250 mL at aspirator pressure, diluted with 100 mL toluene, filtered, and concentrated. The residue was suspended in 200 mL hexanes, and the solvent was removed at aspirator pressure to yield the title compound (235 g, 100%) contaminated by a trace of toluenesulfonyl chloride.

The synthetic route of 14002-80-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Garst, Michael E.; Dolby, Lloyd Jay; Esfandiari, Shervin; MacKenzie, Vivian Rose; Avey JR., Alfred Arthur; Muchmore, David Charles; Cooper, Geoffrey Kenneth; Malone, Thomas C.; US2005/38076; (2005); A1;,
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Related Products of 61487-25-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.61487-25-0, name is (2-Amino-3-chlorophenyl)methanol, molecular formula is C7H8ClNO, molecular weight is 157.6, as common compound, the synthetic route is as follows.

Example 84 – Preparation of 2-benzyloxymethyl-6-chloro aniline This material was prepared from 2-amino-3-chlorobenzyl alcohol and benzyl bromide by the general procedure outlined in Example 82. The product was purified by Kugelrohr distillation to yield an oil, bp 118-125C (0.1 mm). The product was characterized by IR and 1H NMR spectroscopy.

The chemical industry reduces the impact on the environment during synthesis 61487-25-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; THE DOW CHEMICAL COMPANY; EP142152; (1991); B1;,
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Related Products of 1875-88-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1875-88-3, name is 2-(4-Chlorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Step a. 1-chloro-2-(4-chlorophenyl)ethane. To a solution of 4-chlorophenethyl alcohol (5 ml, 37 mmol) and pyridine (3.0 ml, 37.0 mmol) in a two-necked flask, equipped with a dropping funnel and a reflux condenser fitted with calcium chloride drying tube, was added thionyl chloride (5.39 ml, 74.0 mmol) dropwise over 1 h. The reaction was heated at reflux for 1.5 h before being cooled in an ice-bath. This led to the precipitation of a white solid which was filtered off rapidly and washed with a small quantity of cold diethyl ether. The organic material was then washed cautiously with water (1*30 ml), 2N sodium hydroxide solution (2*30 ml) and water (1*30 ml), dried over magnesium sulfate, filtered and the solvent evaporated to give the desired product as a pale yellow oil (5.73 g): 1H NMR (300 MHz, CDCl3) 7.29 (2H, d), 7.16 (2H, d), 3.70 (2H, t), 3.05 (2H, t).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1875-88-3, 2-(4-Chlorophenyl)ethanol.

Reference:
Patent; James Black Foundation Limited; US6355665; (2002); B1;,
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Application of 2568-33-4, Adding some certain compound to certain chemical reactions, such as: 2568-33-4, name is 3-Methylbutane-1,3-diol,molecular formula is C5H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2568-33-4.

General procedure: In the Schlenk reaction vessel,Methyltri n-octylphosphonium methyl carbonate([Me (n-octyl) 3P] + [OCO2Me]-,Charge the catalyst (C1a), 55.8 muL, 0.12 mmol),Methyl methacrylate (MMA, 4 mL) was added and stirred at room temperature for 1 to 2 minutes. Then, 3-methylbutane-1,3-diol (compound (3a), 21 3 muL, 2.0 mmol), internal standard substance (4,4′-di-tert-butylbiphenyl, 53.3 mg, 0.20 mmol), 1.0 g of dried powdery molecular sieves 5A (MS 5A) was added, and the mixture was stirred at room temperature (25 C.) for 3 hours to carry out an ester exchange reaction represented by the following formula. During the reaction, the progress of the reaction was confirmed by thin layer chromatography (TLC) as appropriate. The reaction mixture was passed through a celite pad to remove MS 5A, MMA was distilled off from the mixture under reduced pressure, and after concentration, the yield of the reaction product was measured by 1H NMR (internal standard method). The concentrate was subjected to silica gel column chromatography (n-hexane: ethyl acetate = 50: 1 to 10: 1) to isolate a carboxylic acid monoester (compound (4a)). The yield and yield of the reaction product are shown in Table 1. In the reaction system, the reaction between the catalyst (C1a) and the alcohol derived from the raw material (compound (3a)) causes Me (n-octyl) 3P] + [OR5]-as a catalytically active species.(Most R5 is 3-hydroxy-3-methylbutyl).

According to the analysis of related databases, 2568-33-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Nagoya University; Ishihara, Kazuaki; Hatano, Manabu; (20 pag.)JP2019/26618; (2019); A;,
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Synthetic Route of 2807-30-9 ,Some common heterocyclic compound, 2807-30-9, molecular formula is C5H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Examples 3 to 14 – synthesis of 2-amino-4-substituted-6-(4-fluorophenyl)-pyrido(3,2-d) pyrimidinesTo a solution of the 2-amino-4-thiomethyl-6-(4-fluorophenyl)-pyrido(3,2- d)pyrimidine of example 2 (56 mg) in a suitable alcohol (5 ml) was added a 2 M solution of lithium diisopropylamide (LDA) in tetrahydrofuran (1 ml). The reaction mixture was stirred at room temperature for 3 days. The excess alcohol was evaporated in vacuo and the crude residue was purified by preparative thin layer chromatography on silica using a mixture of toluene and acetonitrile as the mobile phase (in a volume ratio of 1 :1 ). If necessary a second purification was performed by HPLC on a C18-RP column (100 x30mm Gemini 5 mum) with a gradient of H2O, 0.05% TEA-acetonitrile. The resulting compounds were isolated in yields varying from 30 to 50%, depending on the alcohol used, and were characterized by their mass spectra MS as indicated below.2-amino-4-(2-propoxyethoxy)-6-(4-fluorophenyl)pyrido(3,2-d)pyrimidine (example 3) was obtained from 2-propoxyethanol; MS (m/z) : 343 ([M+H]+, 100).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2807-30-9, its application will become more common.

Reference:
Patent; GILEAD SCIENCES, INC.; WO2008/77650; (2008); A1;,
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Adding a certain compound to certain chemical reactions, such as: 4461-39-6, N-(2-Hydroxyethyl)-1,3-propanediamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 4461-39-6, blongs to alcohols-buliding-blocks compound. Safety of N-(2-Hydroxyethyl)-1,3-propanediamine

In a nitrogen purged glove box, a 3-Liter, 4-neck round-bottom flask, fitted with a mechanical stirrer, thermocouple, nitrogen inlet adapter and septum, was charged with 2-(3- aminopropylamino)ethanol (144 g; 1.22 mol) and sulfolane (1.00 L; 10.5 mol). This was brought to a fume hood where it was attached to a nitrogen line and the septum was replaced with an adapter holding a 1/8 inch diameter Teflon tube attached to a HBr lecture bottle. While stirring, the hydrogen bromide (HBr) gas was admitted subsurface at a rate that allowed the temperature to rise to about 1300C. Addition was discontinued after heat evolution ceased and HBr was no longer absorbed; two equivalents had reacted, giving the dihydrobromide salt of the starting alcohol. The adapter on the reaction flask was replaced with a pressure-equalized dropping funnel containing phosphorus tribromide (PBr3) (132 g, 0.487 mol, 1.2 equiv) which was added over about 10 minutes at a temperature of between about 110 to about 130C. The solution was then stirred under nitrogen at 1200C for 20 minutes, after which time the product had crystallized into a thick cake. Additional sulfolaiie (380 mL) was added, resulting in a slurry which could be stirred at 120C. After a period of time, the hot slurry was transferred through a 3/8 ” polypropylene tube and was dropped into 2 L of acetone, stirring in a 4 L beaker (in three approximately equal portions) to precipitate the product. After each portion, the solid was filtered and rinsed with acetone and the beaker was charged with 2 L of fresh acetone for the next portion. Finally, the round bottom flask was rinsed with acetone and the resulting solid was combined with other portions. The solid was dried by passing nitrogen through the filtration bed overnight, giving 391 g (1.14 mol, 94%) of pale yellow hygroscopic powder. The 1H NMR showed that it contained residual sulfolane in a 0.023:1 mol ratio (Figure 1).[00032] Subsequent studies showed that less PBr3 is needed for this reaction, the 0.33:1 mol ratio required by the stoichiometry is nearly adequate and excess PBr3 contributes to the formation of colored impurities which are removed from the final product as described below. It was also found that the buildup of product cake after PBr3 addition can be prevented by increasing the initial sulfolane charge and by maintaining the reactor temperature at about 120C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4461-39-6, its application will become more common.

Reference:
Patent; ALBEMARLE CORPORATION; WO2007/53730; (2007); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5456-63-3, name is trans-2-Aminocyclohexanol hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

(0746) A solution of 6-(2′-hexyldecanoyloxy)hexan-l-al (2.4 g) and trans-2- aminocyclohexanol hydrochloride (0.35 g) in methylene chloride (10 (0747) mL)/tetrahydrofuran (10 mL) was treated with sodium triacetoxyborohydride (1.3 g) for 1.5 hours. The solution was washed with aqueous sodium hydrogen carbonate solution. The organic phase was dried over anhydrous magnesium sulfate, filtered and the solvent removed. The residue was passed down a silica gel column using a (0748) methanol/methylene chloride (0-8/100-92%)) gradient, yielding compound III-9 as colorless oil (0.6 g

With the rapid development of chemical substances, we look forward to future research findings about 5456-63-3.

Reference:
Patent; ACUITAS THERAPEUTICS, INC.; LIN, Paulo, Jia Ching; TAM, Ying; (211 pag.)WO2018/191719; (2018); A1;,
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Reference of 456-47-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 456-47-3, name is 3-Fluorobenzyl alcohol, molecular formula is C7H7FO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2-ChIoro- l-(3-fluorobenzyIoxy)-4-nitrob enzene (14) was prepared from (3-fluoro-phenyl)-methanol (13)(Aldrich) and 2-chloro-l-fluoro-4-nitro- benzene (12) (Aldrich) according to Wallace et al. (Preparation of cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors. 2005). Yield (20.Og; 85%) yellow crystals. 1H- NMR (DMSO-[D6]): delta (ppm) = 5.41 (s, 2H), 7.18-7.25 (m, H), 7.31-7.35 (m, 2H), 7.43-7.50 (m, 2H), 8.26 (dd, IH, J = 9.2 Hz, 4J – 2.8 Hz), 8.35 (d, IH, 4J = 2.8 Hz).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 456-47-3, 3-Fluorobenzyl alcohol.

Reference:
Patent; 4SC AG; WO2009/63054; (2009); A1;,
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Adding a certain compound to certain chemical reactions, such as: 2807-30-9, 2-Propoxyethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2807-30-9, blongs to alcohols-buliding-blocks compound. Formula: C5H12O2

Dimethyl 4-nitro-1H-pyrazole-3, 5-dicarboxylate (WO00/24745, page 48, preparation 2) (15g, 60mmol), 2-propoxyethanol (8.2mL,70mmol) and triphenylphosphine(18. 9g,70mmol) were dissolved in tetrahydrofuran(150mL) and the solution cooled to0 C. The solution was treated withdiisopropyl azodicarboxylate (14.2mL,70mmol) and the reaction mixture stirred at0 C for 3 hours before being allowed to warm to room temperature. The reaction mixture was concentrated in vacuo and the residue purified by column chromatography on silica gel eluting with ethyl acetate: pentane 15: 85 and then againeluting withdichloromethane to yield the title product. ‘H NMR (CD30D, 400MHz) a : 0.82 (t, 3H), 1.47 (q, 2H), 3.34 (t, 2H), 3.78 (t, 2H), 3.91 (s, 6H), 4.76 (t, 2H). MS APCI+ m/z 316 [MH] +

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2807-30-9, its application will become more common.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/49616; (2005); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 115-20-8, name is Trichloroethanol. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 115-20-8

Compound 1 (2g, 13.4mmol) was dissolved intetrahydrofuran (15ml) was added triethylamine (176mg), Was added dropwise to asolution of compound 2 (2.1g, 24.8mmol), dropwise addition was heated to 60 C under reflux, stirringStirred overnight. The reaction was stopped, after the reaction mixture wascooled added saturated citric acid (20ml), extracted with methylene chloride,The organic layer was washed with water, brine, dried over anhydrous NaSO 4,isolated by column chromatography to give compound 3 (2.2g, 71% yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 115-20-8, Trichloroethanol.

Reference:
Patent; ARROMAX PHARMATECH SUZHOU CO LTD; JIAN, HONG; XU, XIN; (12 pag.)CN104230792; (2016); B;,
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