Tag: M.W=100-200

Synthetic Route of 63478-76-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.63478-76-2, name is 6-Heptyn-1-ol, molecular formula is C7H12O, molecular weight is 112.1696, as common compound, the synthetic route is as follows.

A solution of Dess-Martin-periodinane (5.09 g, 12.0 mmol, 2.0 equiv) in dry DCM (27 mL) was cooled to 0 C, 6-heptyn-1-ol (673 mg, 6.00 mmol, 1.0 equiv) in DCM (3 mL) was added and the mixture was stirred at 23 C for 5 h. DCM (5 mL) was added, the mixture was washed with sat. aq. Na2S2O3-sol. (30 mL), 1 M NaOH (30 mL), and sat. aq. NaCl (30 mL). The aq. phase was extracted with DCM (90 mL), the combined organic layers were washed with brine, dried over anhydrous Na2SO4, filtered and the solvent was removed under reduced pressure. The residue was purified on silica gel (n-pentane/Et2O, 9:1) to yield the title compound as a colourless oil (337 mg, 3.06 mmol, 51%).

Statistics shows that 63478-76-2 is playing an increasingly important role. we look forward to future research findings about 6-Heptyn-1-ol.

Reference:
Article; Rode, Katharina; Palomba, Martina; Ortgies, Stefan; Rieger, Rene; Breder, Alexander; Synthesis; vol. 50; 19; (2018); p. 3875 – 3885;,
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Application of 5299-60-5 ,Some common heterocyclic compound, 5299-60-5, molecular formula is C8H16O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a stirred solution of esters 2a-2j (70 mmol) in MeOH (30 mL) cooled in an ice-water bath was added dropwise 80% aqueous hydrazine hydrate (6.26 g, 100 mmol). The resulting solution was stirred at room temperature (2a-2b or 2d-2j), or reflux (2c), until the completion of reaction as indicated by TLC analysis (typically within 5 h). The reaction mixture was evaporated on a rotary evaporator to give a residue, which was purified by column chromatography through a short silica gel column to yield 3a-3k after trituration with n-hexane if possible.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5299-60-5, Ethyl 6-hydroxyhexanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Tian, He; Liu, Wei; Zhou, Zhixing; Shang, Qian; Liu, Yuqiang; Xie, Yafei; Liu, Changying; Xu, Weiren; Tang, Lida; Wang, Jianwu; Zhao, Guilong; Molecules; vol. 21; 11; (2016);,
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Application of 627-18-9, Adding some certain compound to certain chemical reactions, such as: 627-18-9, name is 3-Bromopropan-1-ol,molecular formula is C3H7BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-18-9.

Bromopropanol (1.38g, 0.01mol) and sodium azide (0.975g, 0.015mol) were dissolved in N,N-dimethylformamide (DMF) and reacted under nitrogen for 90 h at 12 C. . After the reaction is completed, the solution is cooled to room temperature, diluted with a certain amount of water, and the aqueous layer is washed with a large amount of diethyl ether. The ether solution is collected and dried overnight with anhydrous NaS04. The crude product after filtration is purified by column chromatography. The residual DMF organic solvent is removed, and the developing solvent is ethyl acetate: petroleum ether = 1:5, and the obtained colorless liquid is the product azidopropanol.The yield was 0.873 g and the yield was 86.4%. Azido hexanol (0.69 g, 89.2%) and azido undecanol (0.98 g, 91.7%) were prepared by the same procedure.

According to the analysis of related databases, 627-18-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shanghai Jiao Tong University; Zhu Xinyuan; Zhang Jun; Fan Wenbin; Zhang Chuan; Xue Feng; Tong Gangsheng; (15 pag.)CN109912528; (2019); A;,
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Electric Literature of 33036-62-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 33036-62-3, name is 4-Bromo-1-butanol, molecular formula is C4H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation 9 1-Tetrahydropyranyloxy-4-bromobutane (Formula XXIII: A is trimethylene) Concentrated hydrobromic acid (75 drops of 48%) is added with stirring to a mixture of 4-bromobutanol (150 ml.) and dihydropyran (300 ml.) at 0. This mixture is stirred and allowed to warm slowly to 25 C. during 15 hours. Evaporation under reduced pressure gives a residue which is divided into two equal parts, each part being chromatographed on 1.5 kg. of silica gel, each column being eluted with 7.5 l. of 5% ethyl acetate in Skellysolve, B, and then with 4 l. of 7.5% ethyl acetate in Skellysolve B, collecting 500 ml. frations. Fractions 5- 11 from each column are evaporated to give a total of 240 g. of 1-tetrahydropyranyloxy-4-bromobutane.

According to the analysis of related databases, 33036-62-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; The Upjohn Company; US3959346; (1976); A;,
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Electric Literature of 10602-04-7 ,Some common heterocyclic compound, 10602-04-7, molecular formula is C9H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 4 (2.04 g, 15.44 mmol) in 1 ml of DCM (Dichlormethane) was cooled to 0¡ã C. MsCl methanesulfonyl chloride (1.383 ml, 17.75 mmol) and Triethylamine (2.474 ml, 17.75 mmol) were added and the mixture was heated in a microwave oven at 100¡ã C. for 20 min. The mixture was quenched with saturated NaHCO3 (0.8 ml) and extracted with DCM. The organic layers were washed with water, dried over MgSO4, filtered and concentrated under vacuum to afford 5 (2.004 g, 13.31 mmol, 86percent yield) as a yellow oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10602-04-7, (4-Ethynylphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; UNIVERSITE DE FRIBOURG; Fromm, Katharina; Bochet, Christian; (27 pag.)US9758545; (2017); B2;,
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Reference of 107-75-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 107-75-5 as follows.

General procedure: A solution of amine 14 in methanol (4 mL) was addedunder stirring to the corresponding aldehyde. After 3 hours NaBH4 was added to reaction mixture and stirred for an additional 1.5 hours, then the reaction mixture was treated with8 ml of saturated NaCl solution and allowed to stand for 30 minutes. The product was extracted with ether (6×10 ml).Isolation of amines 15a-d from the reaction mixture wasaccomplished by precipitation from solution in ether in theform of hydrochloric salts by adding to a solution of ethylacetatesaturated with hydrogen chloride. The precipitatewas filtered off, washed with ether and treated with saturatedsodium bicarbonate solution. The product was extractedfrom the aqueous solution with ether.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,107-75-5, its application will become more common.

Reference:
Article; Ponomarev, Konstantin; Morozova, Ekaterina; Pavlova, Alla; Suslov, Evgeniy; Korchagina, Dina; Nefedov, Andrej; Tolstikova, Tat’yana; Volcho, Konstantin; Salakhutdinov, Nariman; Medicinal Chemistry; vol. 13; 8; (2017); p. 773 – 779;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111-90-0, name is Diethylene Glycol Monoethyl Ether. This compound has unique chemical properties. The synthetic route is as follows. Safety of Diethylene Glycol Monoethyl Ether

EXAMPLE 14 10.7 g (0.08 mole) of ethyl carbitol was added dropwise to a mixture consisting of 1.5 g (0.04 mole) of sodium borohydride and 15 ml of xylene at 120 C. for 1.5 hours. The mixture was agitated at 120 C. for one hour. A mixture consisting of 3 g (0.02 mole) of N,N-dimethyl benzamide and 10 ml of xylene was added dropwise to the mixture over 0.5 hours. Subsequently, the resulting mixture was agitated at 120 C. for 20 hours. After cooling to room temperature, the mixture was neutralized with dilute sulfuric acid. As a result, N,N-dimethylbenzylamine was obtained in 51% yield and benzyl alcohol in 47% yield, respectively.

With the rapid development of chemical substances, we look forward to future research findings about 111-90-0.

Reference:
Patent; Kao Corporation; US5196601; (1993); A;,
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Application of 33893-85-5, Adding some certain compound to certain chemical reactions, such as: 33893-85-5, name is 4-(Hydroxymethyl)cyclohexanol,molecular formula is C7H14O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33893-85-5.

Operation steps: The four-necked flask is equipped with a stirring paddle, a thermometer, a water separator, and a reflux condenser is connected to the upper part of the water separator. 150.2g of p-methylolcyclohexanol and 92g of acrylic acid were placed in a 500mL four-necked flask, and 4.2g of p-hydroxyanisole, 8.6g of p-toluenesulfonic acid, 1.95g of hypophosphorous acid, and 80g of toluene were added. After stirring, the vacuum pump was started at 30KPa When the temperature is raised to 86 C, the reflux flow rate of the solvent in the reflux condenser is stable, and a water layer appears in the water separator. The water output is recorded once every hour. When the water output is less than 0.1g / h, the reaction is completed and the reaction time is 16 ~ 18h.After the reaction, the temperature was lowered to 45 C., 80 g of toluene was added to the product after the reaction, and 50 g of water was added for washing. After stirring at 40 C. for 5 minutes, it was placed in a separating funnel and allowed to stand for water separation. At 40 C, 50g of 1N sodium bicarbonate and 1N sodium hydroxide aqueous solution were added to neutralize, and the mixture was left standing to separate water. This operation was repeated 3 times. After neutralization is completed, add 0.3g of p-hydroxyanisole, spin-dry the solvent,Obtained colorless transparent viscous monomer A3,

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 33893-85-5, 4-(Hydroxymethyl)cyclohexanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Guangdong Boxing New Materials Technology Co., Ltd.; Huang Lijiang; Pang Laixing; Li Zhiyun; Wang Hui; Su Hang; Tan Haiding; Li Lin; (11 pag.)CN110452191; (2019); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol, the common compound, a new synthetic route is introduced below. Formula: C3H6F3NO

A solution of 150 mg intermediate 17, 1 12 mg 3-amino-1 ,1 ,1 -trifluoropropan-2-ol, 248 mg HATU and 0.23 mL ethyldiisopropylamine in 7.5 mL of DMF was stirred at room temperature for 14 hours. Then the reaction was quenched by water, and the mixture was extracted with dichloromethane two times. The combined organic phases were dried over sodium sulfate and evaporated to dryness. The residue was subjected to RP-HPLC ((column: X-Bridge C18 5muetaiota 100x30mm, mobile phase: acetonitrile / water (0.1 Vol% formic acid)-gradient)) to yield 130 mg 6-(4-chlorophenyl)-2-(3-fluorophenyl)-3-oxo-/V-(3,3,3-trifluoro-2-hydroxypropyl)-2,3- dihydropyridazine-4-carboxamide. 1H-NMR (400 MHz, DMSO-de): delta = 3.47 (ddd, 1 H); 3.75 (ddd, 1 H); 4.17-4.27 (m, 1 H); 6.66 (d, 1 H); 7.39 (ddt, 1 H); 7.53-7.66 (m, 5H); 8.00 (d, 2H); 8.67 (s, 1 H); 9.64 (t, 1 H).

The synthetic route of 431-38-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ); SCHMEES, Norbert; GUTCHER, Ilona; IRLBACHER, Horst; BADER, Benjamin; ZHAO, Na; PLATTEN, Michael; (437 pag.)WO2017/202816; (2017); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19819-98-8, name is 2-(o-Tolyl)ethanol. A new synthetic method of this compound is introduced below., SDS of cas: 19819-98-8

The phenylacetaldehydes 6a-n were prepared by oxidation of the corresponding phenylethyl alcohols using dipyridine chromium (VI) oxide (Collin’s reagent) in dry dichloromethane at 25 C. according to reported procedures.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 19819-98-8, 2-(o-Tolyl)ethanol.

Reference:
Patent; The Governors of the University of Alberta; US2011/9492; (2011); A1;,
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