Tag: M.W=100-200

Related Products of 4170-90-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4170-90-5, name is Mesitylmethanol, molecular formula is C10H14O, molecular weight is 150.2176, as common compound, the synthetic route is as follows.

To a 2-necked 500mL flask under nitrogen was added mesitylmethanol 1 (5g, 33.3mmol) to dichloromethane (133 mL, 0.25M) and all of the solid dissolved in the solvent. Zinc Iodide (5.3 lg, 16.64mmol) was added to the solution in one portion. The zinc iodide was not soluble in the solution, and white solid crashed out of the solution. Thioacetic acid (7.17mL, 100 mmol) was added to the solution in one portion causing the solution to turn pale yellow. The flask was affixed with a water condenser and was covered in aluminum foil. The solution was heated to reflux for 17 hours and was allowed to cool to room temperature. Once cool, the solution was then quenched with water (40mL) and this solution was transferred to a separatory funnel. The organic layer was collected and the aqueous layer was extracted with dichloromethane (4 x 7mL).The combined organic fractions were washed with brine (1 x lOOmL), dried over sodium sulfate, filtered, and concentrated on the high vacuum to give the title compound 2 as a brown oil, 7.7g, 111%. [00102] ¾ NMR (400MHz, CDC13) delta 6.84 (s, 2H), 4.18 (s, 2H), 2.35 (s, 3H), 2.30 (s, 6H), 2.25 (s, 3H).

The chemical industry reduces the impact on the environment during synthesis 4170-90-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; GREENCENTRE CANADA; UNIVERSITY OF OTTAWA; JESSOP, Philip; THORNTON, Paul David; DECKER, Shannon Marie; PRATT, Derek; ZHENG, Feng; LEGER, Donna Lynn; WO2013/75253; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 6966-10-5, Adding some certain compound to certain chemical reactions, such as: 6966-10-5, name is (3,4-Dimethylphenyl)methanol,molecular formula is C9H12O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6966-10-5.

General procedure: To a 25-mL Schlenk tube equipped with a magnetic stirrer, CuCl (0.05 mol, 5 mol%), DABCO (0.10 mol, 10 mol%), 4-HO-TEMPO (0.05 mmol, 5 mol%) were added. Substrates 1 (1 mmol) and NH3 (aq, 25-28%, 3 mmol, 3.0 equiv) in CH3CN (2 mL) were added subsequently. Then the reaction mixture was stirred at room temperature for 24 h in the presence of an air balloon. The progress of the reaction was monitored by TLC. After completion, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was dried over anhydrous MgSO4. Subsequently, the combined organic layer was concentrated under reduced pressure and the crude product was purified by column chromatography to afford the corresponding products.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6966-10-5, (3,4-Dimethylphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Hu, Yongke; Chen, Lei; Li, Bindong; Chinese Chemical Letters; vol. 29; 3; (2018); p. 464 – 466;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 623-61-0, Isopropyl glycolate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 623-61-0, blongs to alcohols-buliding-blocks compound. name: Isopropyl glycolate

General procedure: The nucleoside (3.21 mmol) was suspended in THF (25 ml). Under nitrogen and at 0 C., POCl3 (4.82 mmol) was added and the reaction mixture was allowed to reach at room temperature overnight. The reaction mixture was cooled down to 0 C. and a mixture of alcohol (3.53 mmol) and TEA (16.06 mmol) in CH3CN (10 ml) was added dropwise. The mixture was stirred at 0 C. during 1 hour. N-Methylimidazole (19.27 mmol) was added at 0 C. and after 15 min at 0 C., the reaction mixture was stirred at room temperature during 2 hours. The mixture was quenched on a solution 0.5M phosphate buffer (pH=7) and the product was extracted with CH2Cl2. The organic layer was dried on Na2SO4, filtered and concentrated under reduced pressure. The crude was purified by silica gel chromatography (eluent: CH2Cl2/CH3CH2OH 0 to 20%) and by preparative MS/HPLC to give the expected compounds as a mixture of diastereoisomers. For this reaction, the solvent was P(OEt)3. White solid; 4% yield; 1H NMR (DMSO-d6, 400 MHz) delta (ppm) 1.21-1.27 (m, 9H), 3.95-3.96 (m, 3H), 4.24-4.30 (m, 1H), 4.64-4.78 (m, 4H), 5.00 (septuplet, J=6.22 Hz, 1H), 6.26-6.33 (m, 1H), 6.52 (brs, 2H), 8.10 (brs, 1H); 31P NMR (DMSO-d6, 162 MHz) delta (ppm) -6.51 (s, 0.90P), -5.21 (s, 0.10P); 19F NMR (DMSO-d6, 376.50 MHz) delta (ppm) -158.57 (1F); MS (ESI) m/z=476.2 (MH+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,623-61-0, its application will become more common.

Reference:
Patent; PARSY, Christophe Claude; ALEXANDRE, Francois-Rene; DOUSSON, Cyril B.; DUKHAN, David; GOSSELIN, Gilles; RAHALI, Houcine; SURLERAUX, Dominique; US2013/315867; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1736-74-9, name is 4-(Trifluoromethoxy)benzyl alcohol, molecular formula is C8H7F3O2, molecular weight is 192.1352, as common compound, the synthetic route is as follows.COA of Formula: C8H7F3O2

1-(Bromomethyl)-4-(trifluoromethoxy)benzene: To a solution of (4-(trifluoromethoxy)phenyl)methanol (3.6 g, 18.8 mmol) in CH2Cl2 (60 mL) was added PBr3 (6 g, 22.2 mmol) dropwise with stirring, while cooling to a temperature of 0-10 C. over a time period of 30 min. The resulting mixture was stirred at room temperature for 3 h. Water (30 mL) was added and the mixture washed with aqueous NaHCO3 (2×30 mL) and brine (30 mL). The organic solution was dried (Na2SO4) and concentrated in vacuo to afford the title compound (3.5 g, 66%) as a yellow oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1736-74-9, 4-(Trifluoromethoxy)benzyl alcohol, and friends who are interested can also refer to it.

Reference:
Patent; KALYPSYS, INC.; US2007/270434; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 599-67-7, 1,1-Diphenylethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 599-67-7, blongs to alcohols-buliding-blocks compound. Computed Properties of C14H14O

General procedure: A solvent (5 mL) was placed in a 10 mL round bottom-flask equipped with a magnetic stirrerunder reflux, NXS (1.1 mmol) was then added and, after being dissolved, the substrate (1 mmol) wasadded and the solution was stirred for 4-24 h. The progress of the reaction mixture was monitoredby TLC, whilst the consumption of NXS was tested by KI (0.1 M). Upon completion of the reaction,the crude reaction mixture was cooled down at room temperature, diluted with EtOAc (15 mL),washed with aqueous Na2S2O3 (6 mL), NaHCO3 (6 mL), and water (10 mL), and dried over anhydrousNa2SO4. The solvent was evaporated under reduced pressure and the crude product obtained wasanalyzed by 1H-NMR. The pure final products were obtained after flash chromatography, columnchromatography or preparative thin layer chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,599-67-7, its application will become more common.

Reference:
Article; Ajvazi, Njomza; Stavber, Stojan; Molecules; vol. 21; 10; (2016);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 1777-82-8, (2,4-Dichlorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of (2,4-Dichlorophenyl)methanol, blongs to alcohols-buliding-blocks compound. Safety of (2,4-Dichlorophenyl)methanol

General procedure: Alcohol (1 mmol) was added to a mixture of MCM-41XANi(II) (0.03 g) and acetic anhydride (0.4 mL), and theresulting mixture was stirred at 50 C in solvent-free condition.After completion of the reaction (mentioned by TLC,ethylacetate: n-hexane, 3:7), dichloromethane (20 mL) wasadded and the catalyst was separated by filtration. Then, themixture was diluted with CH2Cl2.The organic phase washedwith 10% aqueous solution of sodium bicarbonate and driedover Na2SO4.Finally, the organic solvents were evaporatedand the product obtained with high to excellent yield.

The synthetic route of 1777-82-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Nazarzadeh, Somayeh; Ghorbani-Choghamarani, Arash; Tahanpesar, Elham; Journal of the Iranian Chemical Society; vol. 15; 3; (2018); p. 649 – 659;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 624-95-3 , The common heterocyclic compound, 624-95-3, name is 3,3-Dimethylbutan-1-ol, molecular formula is C6H14O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE III; Example III illustrates the oxidation of 3, 3-dimethyl-1-butanol to 3, 3-dimethyl-1- butanal using the catalyst system of the current invention: 170 mg ofFe (N03) 3′ 9H20 (0.416mmol), 66mg 2,2′-bipyridyl (0.416mmol), 85mg TEMPO (0.536mmol) and 80mg N-bromosuccinimide (0.45mmol) are dissolved in glacial acetic acid (7 cc) and the solution transferred into a jacketed glass reactor. The reactor is alternately evacuated and purged with oxygen at least five times and the temperature of the catalyst solution is raised to the target value of 45C under constant stirring of 1500RPM. When the temperature reached 45C, 8200 mg of 3, 3-dimethyl-1- butanol (76. 6mmol) are injected through the septum adapter using a gas tight syringe. The recorded oxygen uptake rate is 0. 205mmol 02/min and the GC analysis after 250min reaction time showed 95.2% conversion of the starting alcohol and 96.2% selectivity to the desired 3, 3-dimethyl-l-butanal. The graphical presentation of this reaction is also shown in the same Figure 01, curve 3, NS 10 16.EXAMPLE IV Example TV represents the potential of the catalyst composition to be used at even higher alcohol concentration in direct comparison with Example III. 170 mg of Fe (N03) 3 9H20 (0. 416mmol), 66mg 2,2′-bipyridyl (0. 416mmol), 85mg TEMPO (0. 536mmol) and 80mg N-bromosuccinimide (0. 45mmol) are dissolved in glacial acetic acid (7 cc) and the solution transferred into a jacketed glass reactor. The dissolution and thermostating of the catalyst solution is done as in Example III. When the temperature reached 45C, 9840 mg of3, 3-dimethyl-l-butanol (91. 9mmol) are injected through the septum adapter using a gas tight syringe. The recorded oxygen uptake rate was 0. 184mmol 02/min and the GC analysis after 420min reaction time showed 89.2% conversion of the starting alcohol and 97.4% selectivity to the desired 3, 3-dimethyl-1- butanal. The graphical presentation of this reaction is also shown in the same Figure 01, curve 4, NS1027. EXAMPLE V Example V represents addition protocol in which the catalysts solution and the alcohol are charged in the reactor prior purging the reactor with oxygen and raising the temperature. 170 mg ofFe (N03) 3′ 9H20 (0. 416mmol), 66mg 2, 2′-bipyridyl (0. (d416mmol), 85mg TEMPO (0. 536mmol), 80mg N-bromosuccinimide (0. 45mmol) and 8200 mg of 3, 3-Dimethyl-l-butanol (76. 6mmol) are dissolved in glacial acetic acid (7 cc) and the solution transferred into a jacketed glass reactor. The dissolution and therniostating of the catalyst solution is done as in Example III. When the temperature reached 45C the stirring rate was set to 1500RPM and at this point, monitoring of the oxygen uptake was initiated. The recorded oxygen uptake rate was 0. 220rrunol 02/min and the GC analysis after 230min reaction time showed 96.3% conversion of the starting alcohol and 98.5% selectivity to the desired 3, 3-dimethyl-1-butanal. The graphical presentation of this reaction is also shown in the same Figure 01, curve 5, NS1019.

The synthetic route of 624-95-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE NUTRASWEET COMPANY; WO2005/82825; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 346-06-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 346-06-5, name is (2-(Trifluoromethyl)phenyl)methanol. A new synthetic method of this compound is introduced below.

General procedure: Reactions were performed in a magnetically stirred round bottomed flask fitted with acondenser and placed in a temperature controlled oil bath. 1,2-Diamine (2 mmol)was added to alcohol (3 mmol) and the reaction mixture was allowed to stir at 135°C in an open (air) atmosphere. After disappearance of the diamine (reaction was monitored by TLC)or after the appropriate time, the reaction mixture was cooled to roomtemperature. The crude residue was further purified by column chromatography using silica gel (100-200 mesh) to afford pure products. All the products wereidentified on the basis of NMR and mass spectral data

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,346-06-5, its application will become more common.

Reference:
Article; Marri, Mahender Reddy; Peraka, Swamy; Macharla, Arun Kumar; Mameda, Naresh; Kodumuri, Srujana; Nama, Narender; Tetrahedron Letters; vol. 55; 48; (2014); p. 6520 – 6525;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 2173-69-5, Adding some certain compound to certain chemical reactions, such as: 2173-69-5, name is 2-Methyl-2-phenyl-1-propanol,molecular formula is C10H14O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2173-69-5.

A solution of 2-METHYL-2-PHENYLPROPAN-1-OL (160mg) (J. Org Chem 1982,47, 2476-2479) in DMF (8ml) under nitrogen was treated with sodium hydride (60% dispersion in mineral oil, 47mg) and the mixture stirred at 20 for 15min. (5R)-3-(6-Bromohexyl)-5-(2, 2- DIMETHYL-4H-1, 3-BENZODIOXIN-6-YL)-1, 3-OXAZOLIDIN-2-ONE (400mg) was then added and the mixture was stirred at 20 for 5h. Phosphate buffer solution (pH 6.5, 15MOI) and water (15ml) were added and the mixture was extracted with EtOAc. The extract was washed with water and dried (NA2SO4). The solvent was evaporated in vacuo and the residue purified by flash chromatography on silica gel. Elution with ETOAC-PETROLEUM ether (1: 4) then (1: 2) gave an oil which was further purified by preparative thin layer chromatography on a silica plate (20 x 20cm). Elution with isopropyl acetate-toluene (2: 3) gave the title compound (100mg). LCMS RT = 3.92 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2173-69-5, 2-Methyl-2-phenyl-1-propanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXO GROUP LIMITED; WO2004/37768; (2004); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 144-19-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 144-19-4, name is 2,2,4-Trimethyl-1,3-pentanediol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: EXAMPLE 7-1 Oxidation of 2,2-Dimethyl-5-phenylpentane-1,3-diol A sodium chlorite aqueous solution (81.0 mg, 0.717 mmol in H2O (0.4 ml)), and a sodium hypochlorite aqueous solution (0.0146 M, 0.16 ml) were separately and slowly dropped onto an acetonitrile (1.2 ml)-pH 6.8 phosphate buffer (1 M, 0.8 ml) of 2,2-dimethyl-5-phenylpentane-1,3-diol (49.7 mg, 0.239 mmol) and DMN-AZADO (3.97 mg, 0.024 mmol) at room temperature. The mixture was stirred at 25 C. for 1 h, and a pH 2.3 phosphate buffer was added until the mixture was brought to pH 4 or less. The aqueous layer was then saturated with a common salt, and extracted with dichloromethane. The organic layer was dried over sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was dissolved in a diethyl ether solution, and treated with an excess amount of a diazomethane diethyl ether solution to produce a methyl ester product. After evaporating the solvent under reduced pressure, the product was purified by silica gel column chromatography to give a hydroxy ester compound (51.0 mg, 90%)

According to the analysis of related databases, 144-19-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TOHOKU UNIVERSITY; Iwabuchi, Yoshiharu; Shibuya, Masatoshi; Doi, Ryusuke; US9114390; (2015); B2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts