Tag: M.W=100-200

Electric Literature of 161446-90-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 161446-90-8, name is 3-Chloro-4-fluorobenzyl Alcohol. This compound has unique chemical properties. The synthetic route is as follows.

[00202] A solution of 3-chloro-4-fluorobenzaldehyde (3 g) in THF (40 ml) was added over 2 minutes to a stirred suspension of sodium borohydride (1.07 g) in methanol (40 ml) at 0 C. The mixture was allowed to warm to room temperature and then quenched with water. The resulting suspension was partitioned between water and diethyl ether and the combined organic extracts were dried and concentrated in vacuo. The residue was dissolved in dichloromethane (90 ml) and triphenylphosphine (4.62 g) and tetrabromomethane (6.64 g) were added at 0 C. The mixture was allowed to warm to room temperature overnight then concentrated in vacuo and the residue purified by column chromatography using iso-hexane as eluent to yield the desired product (3.57 g, 85%). NMR: delta 4.7 (s, 2H), 7.4 (m, 2H), 7.7 (m, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 161446-90-8, 3-Chloro-4-fluorobenzyl Alcohol.

Reference:
Patent; AstraZeneca AB; US6737435; (2004); B1;,
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Application of 2807-30-9, Adding some certain compound to certain chemical reactions, such as: 2807-30-9, name is 2-Propoxyethanol,molecular formula is C5H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2807-30-9.

Using toluene with CEP-0 No.: toluene = 1: 2 (w / w) as a solvent, First in low temperature (-5 ~ 0 ) under the conditions of absorption of phosgene,Then the temperature of 0 ~ 5 dropping CEP-0 for photochemical reaction,The dropwise addition of phosgene continued to the end of the photochemical reaction,Slowly warmed to 30 , 30 under the conditions of nitrogen to catch the light, the light after the end of the transfer into the CEP-1No. drop tank spare.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2807-30-9, 2-Propoxyethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Lier Chemical Co., Ltd.; Li Shihong; Cheng Ke; Wang Fuxiong; Zuo Xiang; (9 pag.)CN107311863; (2017); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 37729-18-3, name is 2-([1,1′-Biphenyl]-4-yl)ethanol. A new synthetic method of this compound is introduced below., Quality Control of 2-([1,1′-Biphenyl]-4-yl)ethanol

4-Biphenylethanol (see Kawasaki et al., Tetrahedron: Asymmetry 2001, 12, 585-596) (1.47 g, 7.41 mmol) and CBr4 (1.12 equiv) were dissolved in CH2Cl2 (25 mL), the mixture was cooled to 0 C and triphenylphosphine (1.1 equiv) was added in small portions. The reaction mixture was warmed at room temperature and stirred for 1 h before the solvent was removed in vacuo. Flash chromatography (0-5% EtOAc-hexanes) yielded 4-(2-bromoethyl)biphenyl (1.59 g, 82%). The title compound was prepared from S7 (55 mg, 0.27 mmol) and 4-(2-bromoethyl)biphenyl (280 mg, 1.07 mmol) by using general procedure D. Flash chromatography (SiO2, 1.5 x 18 cm, 50-100% EtOAc-hexanes) afforded the title compound (38 mg, 40%) as a white solid: 1H NMR (CDCl3, 500 MHz) delta 8.84 (dd, IH, J = 0.7, 4.7 Hz), 8.29 (d, IH, J = 7.9 Hz), 7.92 (dt, IH, J = 1.7, 7.8 Hz), 7.57 (m, 2H), 7.53 (m, 3H), 7.42 (t, 2H, J = 7.7 Hz), 7.33 (m, 3H), 3.60 (t, 2H, J = 7.5 Hz), 3.19 (t, 2H, J = 7.5 Hz); 13C NMR (CDCl3, 150 MHz) delta 186.2, 165.3, 161.3, 150.9, 142.7, 141.0, 139.6, 139.0, 137.5, 129.0, 128.9, 127.5, 127.3, 127.2, 126.9, 124.2, 41.7, 29.1 ; HRMS-ESI-TOF m/z 356.1392 ([M+H]+, C22H17N3O2 requires 356.1393).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 37729-18-3, 2-([1,1′-Biphenyl]-4-yl)ethanol.

Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; BOGER, Dale, L.; WO2010/5572; (2010); A2;,
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Electric Literature of 23147-58-2, Adding some certain compound to certain chemical reactions, such as: 23147-58-2, name is Glycerol aldehyde dimer,molecular formula is C4H8O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 23147-58-2.

Example 2 Preparation of 4-Hydroxy-2-methyl-but-2-enoic acid ethyl ester 886 g (2.44 mol) of 2-(triphenyl-phosphanylidene)-propionic acid ethyl ester in methylene chloride (4 L) was added dropwise into a refluxing solution of glycoaldehyde dimer (140 g, 1.17 mol) in methylene chloride (6 L). After refluxing for 4 h, the solvent was evaporated. Resulting crude product was fractionated (bp 108-114 C. at 2 mmHg) to give 304 g (90%) pure product as an oil. 1H-NMR (300 Hz CDCl3) delta 6.88 (t, 1H, CH), 4.35 (d, 2H, CH2OH), 4.20 (q, 2H, OCH2), 1.85 (s, 3H, CH3), 1.30 (t, 3H, CH3).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 23147-58-2, Glycerol aldehyde dimer, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Lockwood, Samuel F.; Tang, Peng Cho; Nadolski, Geoff; Jackson, Henry L.; Fang, Zhiqiang; Du, Yishu; Yang, Min; Geiss, William; Williams, Richard; Burdick, David; Braun, Cristi L.; US2008/221377; (2008); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.37585-25-4, name is (2-Amino-5-chlorophenyl)methanol, molecular formula is C7H8ClNO, molecular weight is 157.6, as common compound, the synthetic route is as follows.Recommanded Product: (2-Amino-5-chlorophenyl)methanol

General procedure: To a solution of 1a (1.2 g, 7.61 mmol) in CH2Cl2 (20 mL) was added MnO2 (2.6 g, 30.1 mmol) and stirred at rt under an Ar atmosphere. After 23 h with stirring, the reaction mixture was filtrated and evaporated. The residue was crystallized from AcOEt to give 7a (1.0 g, 85%) as a yellow needle crystal.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,37585-25-4, (2-Amino-5-chlorophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Article; Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi; Bioorganic and Medicinal Chemistry; vol. 20; 19; (2012); p. 5810 – 5831;,
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Synthetic Route of 50595-15-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 50595-15-8, name is tert-Butyl 2-hydroxyacetate, molecular formula is C6H12O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: The title compound was prepared according to the General procedure A using tert-butyl glycolate and intermediate A as starting materials. The crude product was purified by FCC (0 to 100 percent DCM in hexane). Y = 65 percent. MS ES+ ([M+Na]+): 354.4. NMR (400 MHz, DMSO-d6) delta 9.13 (s, 1H), 6.95 (s, 1H), 4.48 (s, 2H), 2.81 (t, J= 7 Hz, 4H), 2.72 (t, J= 7 Hz, 4H), 2.03 – 1.91 (m, 4H), 1.43 (s, 9H). The a-hydroxy ester or a-hydroxy acid (1 eq.) was dissolved in ACN (2 ml/mmol of a- hydroxy ester or a-hydroxy acid) and the solution was cooled down to 0° C. TEA (1 eq.) was added followed by dropwise addition of the isocyanate (1.2 eq.). The reaction mixture was allowed to warm up to room temperature and stirring was continued for 15 h under Ar. The reaction mixture was diluted with DCM and the solution was washed with 1M HCl. The aqueous layer was extracted twice with DCM and the combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by FCC (DCM or EtOAc gradient in hexane) or by preparative reverse-phase HPLC (ACN water, 0.1 percent formic acid buffer).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 50595-15-8, tert-Butyl 2-hydroxyacetate.

Reference:
Patent; NODTHERA LIMITED; BOCK, Mark G.; WATT, Alan Paul; PORTER, Roderick Alan; HARRISON, David; (229 pag.)WO2019/25467; (2019); A1;,
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Related Products of 346-06-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 346-06-5, name is (2-(Trifluoromethyl)phenyl)methanol. A new synthetic method of this compound is introduced below.

a) A solution of 30 ml of phosphorus tribromide in 60 ml of absolute toluene was added dropwise at 20°-30° C. to a solution of 14 g of o-trifluoromethylbenzyl alcohol in 80 ml of absolute toluene. Subsequently, the reaction mixture was stirred at room temperature for 2 hours, the toluene was distilled under reduced pressure, the residue was dissolved in methylene chloride, treated with water and the mixture was adjusted to pH 8.0 with potassium hydrogen carbonate. The aqueous phase was extracted three times with CH2 Cl2 and the organic phases were washed twice with water and once with saturated NaCl solution, dried over Na2 SO4 and evaporated under reduced pressure. o-Trifluoromethylbenzyl bromide was obtained as the residue.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,346-06-5, (2-(Trifluoromethyl)phenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Hoffmann-La Roche Inc.; US5270313; (1993); A;,
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Related Products of 5299-60-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5299-60-5, name is Ethyl 6-hydroxyhexanoate, molecular formula is C8H16O3, molecular weight is 160.21, as common compound, the synthetic route is as follows.

To an oven-dried 3-necked 10 mL round-bottom flask under nitrogen was added l-cyclopentyl-3-(2-(4-hydroxyphenyl)-l,l-bis(3- (trifluoromethoxy)phenyl)ethyl)urea, prepared as described in Procedure 11, 6, 2 and 59, (50 mg, 0.1 mmol ), triphenylphosphine (34 mg, 0.1 mmol), ethyl 6- hydroxyhexanoate (17 mg, 0.1 mmol ) and dry THF (0.5 mL ). The reaction mixture was cooled in an ice-methanol bath and diethylazodicarboxylate ( 23 mg, 0.13 mmol ) was added via syringe. The reaction was allowed to warm to rt and stirred overnight. The reaction mixture was concentrated in vacuo and purified by ISCO silica gel chromatography using a gradient of 5-25% EtOAc / hexanes as eluent to yield ethyl 6-(4-(2-(3-cyclopentylureido)-2,2-bis(3-(trifluoromethoxy)phenyl)ethyl)phenoxy)hexanoate (Example 313) was isolated as a white solid (43 mg, 61% yield). HPLC: RT = 4.69 minutes ( Phenomenex Luna C18 5mu column 4.6 x 50 mm eluting with 10-90% aqueous methanol containing 0.1% phosphoric acid over a 4 minute gradient monitoring at 220 nni). LC/MS [M+H] 711.3 ( Phenomenex Luna C18 5mu column 4.6 x 30 mm eluting with 10-90% aqueous methanol containing 0.1% TFA over a 4 minute gradient monitoring at 220 nm). 1H NMR (400MHz , CDCl3) delta ppm 7.33 (t, J= 7.9 Hz, 2 H), 7.20 (d, J= 7.9 Hz, 2 H), 7.12 (d, J= 7.9 Hz, 2 H), 7.07 (s, 2 H), 6.62 (d, J= 8.8 Hz, 2 H), 6.56 (d, J= 8.8 Hz, 2 H), 4.10 (q, J= 7.1 Hz, 2 H), 3.86 t, J = 6.1Hz, 2 H), 3.68 (s, 1 H), 3.62 (t, J= 6.6Hz, 1 H), 2.30-2.27 (m, 2 H), 1.82-1.14 (m, 17 H), 1.23 (t, J= 7.1Hz, 3 H).

The chemical industry reduces the impact on the environment during synthesis 5299-60-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2007/62308; (2007); A2;,
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Adding a certain compound to certain chemical reactions, such as: 86770-74-3, 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C8H19NO4, blongs to alcohols-buliding-blocks compound. Computed Properties of C8H19NO4

To a solution of 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethanol (0.50 g, 2.6 mmol) was added BCN-OSu (29-1 , 0.69 g, 2.3 mmol) and Et3N (0.97 ml_, 0.70 g, 7.0 mmol). The resulting mixture was mixture was stirred for 80 min and saturated aqueous NH4CI (60 ml_) was added. After separation, the aqueous phase was extracted with DCM (60 ml_). The combined organic layers were dried (Na2SC>4) and concentrated. The residue was purified with silica gel chromatography (DCM 10% MeOH in DCM), which yielded 578 mg (1.56 mmol, 67%) of the desired product. 1 H NMR (400 MHz, CDCIs) d (ppm) 5.98-5.85 (bs, 1 H), 4.14 (d, J = 8.0 Hz, 2H), 3.78-3.59 (m, 12H), 3.58-3.52 (m, 2H), 3.42-3.32 (m, 2H), 3.19-3.06 (bs, 1 H), 2.35-2.16 (m, 6H), 1 .70-1.50 (m, 2H), 1.36 (quintet, J = 8.6 Hz, 1 H), 0.99-0.87 (m, 2H).

The synthetic route of 86770-74-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SYNAFFIX B.V.; VERKADE, Jorge Merijn Mathieu; HOOGENBOOM, Jorin; VAN BERKEL, Maria Antonia; VAN DELFT, Floris Louis; (95 pag.)WO2019/110725; (2019); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.16700-55-3, name is (2,6-Dimethoxyphenyl)methanol, molecular formula is C9H12O3, molecular weight is 168.1898, as common compound, the synthetic route is as follows.Computed Properties of C9H12O3

Step A: Preparation of Ethyl 2-(3-(2,6-Dimethoxybenzyloxy)phenyl)acetate:; A solution of 2,6-Dimethoxylbenzyl alcohol (3.33 g, 19.8 mmol) and diisopropyl azodicarboxylate (DIAD, 4.36 g, 21.6 mmol) in THF (30 ml) was added drop wise to a solution of Ethyl 2-(3-hydroxyphenyl)acetate (4 g, 22.2 mmol) and triphenylphosphine (5.66g, 21.6 mmol) in THF (80 ml). The reaction mixture was stirred at room temperature for 8 hours, diluted with ether and washed with water and brine. The organic layer was dried over Na2SO4, filtered, concentrated, and purified by flash chromatography on a silica gel column (hex: ethyl acetate 4:1) to give the title compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,16700-55-3, (2,6-Dimethoxyphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; WELLSTAT THERAPEUTICS CORPORATION; WO2009/151695; (2009); A1;,
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