Tag: M.W=100-200

Related Products of 612-16-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.612-16-8, name is (2-Methoxyphenyl)methanol, molecular formula is C8H10O2, molecular weight is 138.16, as common compound, the synthetic route is as follows.

Add 2-methylquinoline (1mmol), 2-methoxybenzyl alcohol (2.5mmol), TEMPO (0.1mmol), Fe (NO3) 3.9H2O (0.1mmol) andt-BuOK (2mmol) was sequentially added to a flask containing 2mL of THF,The air in the flask was replaced with oxygen, and the reaction was stirred at 50 C.The reaction process was monitored by thin layer chromatography. After the reaction was completed, it was quenched with water (10 mL).The reaction product was extracted with ethyl acetate (3 × 20 mL), washed with saturated brine (20 mL), dried over anhydrous Na2SO4, filtered, and the resulting filtrate was concentrated, and passed through silica gel column chromatography (200-300 mesh, the developing solvent was petroleum ether). (20: 1 mixed solution with ethyl acetate in volume ratio) yielded 215.0 mg of product with a yield of 82%.

Statistics shows that 612-16-8 is playing an increasingly important role. we look forward to future research findings about (2-Methoxyphenyl)methanol.

Reference:
Patent; Hebei University of Science and Technology; Zhang Zhiguang; Zhang Yong; Li Ling; Dai Siwei; Li Xingxi; (18 pag.)CN110804015; (2020); A;,
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Reference of 16369-21-4 ,Some common heterocyclic compound, 16369-21-4, molecular formula is C5H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A stirred solution of 2-[bis(2-chloroethyl)amino]-3,5-dinitrobenzoic acid (22) (5.00 g, 14.20 mmol) in SOCl2 (50 mL) and DMF (5 drops) was heated under reflux for 3 h, then cooled to room temperature and the excess SOCl2 was removed under reduced pressure. The resulting crude 2- [bis(2-chloroethyl)amino]-3,5-dinitrobenzoyl chloride was dissolved in THF (40 mL) and slowly added to a stirred solution of 2-(propylamino)ethanol (4.60 g, 44.63 mmol) in THF (40 mL) at -10 C. The mixture was stirred for 20 min at -10 0C, then treated with aqueous HCl (0.5 M, 40 mL) to pH ~ 3 before being extracted with EtOAc. The combined organic layers were washed with brine, dried with Na2SO4 and concentrated under reduced pressure. The residue was purified by flash column chromatography on silica gel eluting with CH2Cl2/MeOH (99:1) to give 2-[bis(2-chloroethyl) amino]-iV-(2-hydroxyethyl)-3,5-dinitro-iJ-propylbenzamide (26) (3.73 g, 60%) as a yellow oil. 1HNMR [(CDj)2SO] (mixture of rotamers) delta 8.71, 8.68 (2dJ = 2.8 Hz, IH), 8.38, 8.24 (2dJ = 2.8 Hz, IH), 4.84, 4.80 (2tJ = 5.2 Hz, IH), 3.72-3.65 (m, 5H), 3.63-3.42 (m, 4H), 3.39-3.31 (m, 2H),3.24-3.12 (m, 2H), 1.66, 1.55 (2m, 2H), 0.94, 0.73 (2tJ = 7.4 Hz, 3H). HRMS(ESI) calcd for C16H23 Cl2N4O6 [M+H]+ m/z 437.0989: found 437.0993.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 16369-21-4, 2-(Propylamino)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AUCKLAND UNISERVICES LIMITED; PATTERSON, Adam, Vorn; SMAILL, Jeffrey, Bruce; DENNY, William, Alexander; WILSON, William, Robert; SYDDALL, Sophie; ASHOORZADEH, Amir; WO2010/44685; (2010); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 702-23-8, name is 2-(4-Methoxyphenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-(4-Methoxyphenyl)ethanol

6 (2.0 g, 13.1 mmol) was dissolved in dry toluene (50mL), dry CaCO3 (3.94 g, 39.4 mmol), PCl5 (5.47 g, 26.3 mmol) were added slowly over a period of 40 min under argon atmosphere at 0 C; temperature in the mixture was allowed to reach RT and stirred for another 3 h. The mixture was poured into ice-cold saturated NaHCO3 solution (20 mL) and extracted twice with diethyl ether (100 mL). The organic layer was dried with Na2SO4 and evaporated. Purification by silica gel column chromatography (n-hexane-ethyl acetate 9:1 (v/v)) yielded a yellow oil:7 (1.95 g, 87 %).

With the rapid development of chemical substances, we look forward to future research findings about 702-23-8.

Reference:
Article; Blaess, Markus; Bibak, Nelly; Claus, Ralf A.; Kohl, Matthias; Bonaterra, Gabriel A.; Kinscherf, Ralf; Laufer, Stefan; Deigner, Hans-Peter; European Journal of Medicinal Chemistry; vol. 153; (2018); p. 73 – 104;,
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Electric Literature of 148043-73-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.148043-73-6, name is 4,4,5,5,5-Pentafluoropentan-1-ol, molecular formula is C5H7F5O, molecular weight is 178.1, as common compound, the synthetic route is as follows.

General procedure: 10653] General Procedure 12 for the preparation of 12 with exclusion of moisture: 1 molar equivalent of alcohol was dissolved in 5 molar equivalents of pyridine, and 1.1 molar equivalents of tosyl chloride were added at 0-5 C. The mix- tare was then stirred at 00 C. for 2.5 hours and at room temperature for 1-2 hours or overnight. The reaction mixture was stirred into a mixture of ice-water and concentrated sulphuric acid (10 ml: 1 ml). Here, per 10 ml of pyridine 29-53 ml of water were used as base. The mixture was extracted three times with diethyl ether, and the combined organic phases were washed once with water and with saturated sodium chloride solution, dried over sodium sulphate ormagnesium sulphate and concentrated.4,4,5,5,5-Pentafluoropentyl 4-methylbenzenesulphonate 40 g (224.6 mmol) of 4,4,5,5,5-pentafluorpentan-1-ol were reacted with 47.04 g of tosyl chloride according to General Procedure 12. 39.5 g (53% of theory) of product were obtained. 1H NMR (400 MHz, chloroform-d1): delta=1.90-2.00 (m, 2H), 2.01-2.17 (m, 2H), 2.46 (s, 3H), 4.10 (t, 2H), 7.37 (d, 2H), 7.80 (d, 2H).

The chemical industry reduces the impact on the environment during synthesis 148043-73-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; Wintermantel, Tim; Moeller, Carsten; Bothe, Ulrich; Nubbemeyer, Reinhard; Zorn, Ludwig; Ter Laak, Antonius; Bohlmann, Rolf; Wortmann, Lars; US2015/80438; (2015); A1;,
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Reference of 38514-05-5 ,Some common heterocyclic compound, 38514-05-5, molecular formula is C9H20O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

6-Methyloctanoic acid (10 g, 63 mmol) was reduced by lithium aluminum hydride (2.4 g, 1.0 eq.) in dry diethylether (150 mL) at 0 C and then left at room temperature overnight to yield after work-up the corresponding alcohol (7.4 g, GC purity 97%). Acetylation of 6-methyloctanol (2.4 g, 16.6 mmol) was performed by using acetyl chloride (1.57 g, 1.2 eq.) and DIEA (4.3 g, 2.0 equiv.) in ethyl acetate (50 mL). After the usual work-up, the crude product was distilled under vacuum (?84 C, ?5 mmHg) to yield 6-methyloctyl acetate (2.2 g, 72%, GC purity 98.7%). 1H NMR (400 MHz, CDCl3): 4.05 (t, J = 6.7, 2H); 2.05 (s, 3H); 1.59-1.66 (m, 2H); 1.25-1.38 (m, 7H); 1.08-1.16 (m, 2H); 0.86 (t, J = 7.1, 3H); 0.85 (d, J = 6.5, 3H). 13C NMR (100 MHz, CDCl3): delta 171.2 (C); 64.7 (CH2); 36.5 (CH2); 34.3 (CH); 29.5 (CH2); 28.7 (CH2); 26.7 (CH2); 26.3 (CH2); 21.0 (CH3); 19.2 (CH3); 11.4 (CH3). MS (EI, 70 eV), m/z (%): 186 (0, M+); 98 (22); 97 (100); 83 (17); 71 (15); 70 (54); 69 (39); 68 (11); 61 (41); 57 (27); 56 (31); 55 (75); 43 (72); 42 (10); 41 (29); 29 (10). LRI (SPB-1) 1264; LRI (SWax) 1544. In cv. Alstonville extract, LRI (SPB-1) 1263; LRI (SWax) 1543.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,38514-05-5, its application will become more common.

Reference:
Article; Delort, Estelle; Jaquier, Alain; Decorzant, Erik; Chapuis, Christian; Casilli, Alessandro; Frerot, Eric; Phytochemistry; vol. 109; (2015); p. 111 – 124;,
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Related Products of 6971-51-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6971-51-3, name is (3-Methoxyphenyl)methanol, molecular formula is C8H10O2, molecular weight is 138.16, as common compound, the synthetic route is as follows.

General procedure: In a 25 mL round bottomed flask were placed 0.1 mol % of copper(I) catalyst, 1 mmol of alcohol, 1 mmol of amine, 0.2 mmol of KOH and 2 mL of toluene. The reaction flask was heated at 100 C for 12 h in an oil bath. Upon completion (as monitored by TLC), the reaction mixture was cooled at ambient temperature, H2O (3 mL) was added and the organic layer was extracted with CH2Cl2 (3 10 mL). The combined organic layers were dried with magnesium sulphate and concentrated. The crude product was purified by column chromatography (ethyl acetate/hexane). Reported isolated yields are an average of two runs

The chemical industry reduces the impact on the environment during synthesis 6971-51-3, I believe this compound will play a more active role in future production and life.

Reference:
Article; Ramachandran, Rangasamy; Prakash, Govindan; Vijayan, Paranthaman; Viswanathamurthi, Periasamy; Grzegorz Malecki, Jan; Inorganica Chimica Acta; vol. 464; (2017); p. 88 – 93;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52244-70-9, name is 4-(4-Methoxyphenyl)-1-butanol, molecular formula is C11H16O2, molecular weight is 180.24, as common compound, the synthetic route is as follows.Formula: C11H16O2

4-Methylphenylsulfonic Acid 4-(4-Methoxyphenyl)butyl Ester (1) Pyridine (15 mL) was added drop wise to a cooled (0° C.) solution of 4-(4-methoxyphenyl)butanol (10.0 g, 0.055 mol) and p-toluenesulfonyl chloride (13.6 g, 0.072 mol) in dry chloroform (100 mL) under stirring. The reaction mixture was stirred overnight at room temperature. After this time, the reaction was quenched with 10percent HCl (300 mL) and extracted with chloroform. The organic fraction was washed with saturated NaHCO3, water and dried over magnesium sulfate. The solvent was removed under reduced pressure and the residue purified by flash chromatography (eluent:hexane/ethyl acetate 15:1) to provide 12.9 g (66percent) of 1 as clear oil. 1H NMR (360 MHz, CDCl3) delta 1.61 (m, 4H), 2.44 (s, 3H), 2.52 (m, 2H), 3.78 (s, 3H), 4.05 (m, 2H), 6.77 (d, 2H), 7.05 (d, 2H), 7.34 (d, 2H), 7.78 (d, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,52244-70-9, 4-(4-Methoxyphenyl)-1-butanol, and friends who are interested can also refer to it.

Reference:
Patent; CYFI, INC.; US2003/199456; (2003); A1;,
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Related Products of 2240-88-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol, molecular formula is C3H5F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

methyl 6-hydroxypyrazolo[1,5-a]pyridine-3-carboxylate (0,100 g, 0.520 mmol), 3,3,3-trifluoropiOpan-l -ol (0.096 mL, 1.0 mmol), and l, -(azodicarbonyl)dipiperidine (0.394 g, 1.56 mmol) were placed in a pressure vial. Anhydrous toluene (5 mL) and tri-N-butylphosphine (0,390 mL, 1,56 mmol) were added, and the reaction mixture was stirred at 140 °C under microwave irradiation for 15 min. The reaction mixture was quenched by the addition of MeOH (1 mL), diluted with EtOAc (50 mL), Celite was added, and solvent was removed under reduced pressure. The residue was purified by ISCO (solid loading on Celite, 0-60percent EtOAc/DCM gradient) to give Intermediate 8 (0,064 g, 42 percent yield) as a white solid. MS (ESI) m/z; 289.0 (M+H)+. ‘H-NMR: (500 MHz, DMSO-d6) delta ppm 8.70 (d, 7=1.9 Hz, IH), 8.38 (s, IH), 7.98 (d, J=9.6 Hz, IH), 7.40 (dd, J=9.6, 2.2 Hz, 1H), 4.33 (t, J-5.9 Hz, 2H), 3.82 (s, 3H), 2.85 (qt, J=11.3, 5.8 Hz, 2H). 19F-NMR: (471 MHz, DMSO-d6) delta ppm -63.03 (s, 3F).

According to the analysis of related databases, 2240-88-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; GLUNZ, Peter W.; LADZIATA, Vladimir; DE LUCCA, Indawati; TORA, George O.; MAISHAL, Tarun Kumar; TANGIRALA, Raghuram; THIYAGARAJAN, Kamalraj; (216 pag.)WO2019/14308; (2019); A1;,
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Related Products of 52273-77-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52273-77-5, name is 2-(3-Aminophenyl)ethanol, molecular formula is C8H11NO, molecular weight is 137.179, as common compound, the synthetic route is as follows.

Step A: 2-{3-[(5-Chloro-4-{[2-(3-methoxyphenyl)ethyl]amino}pyrimidin-2-yl)amino]phenyl}ethanol To a solution of 2,5-dichloro-N-[2-(3-methoxyphenyl)ethyl]pyrimidin-4-amine (0.50 g, 1.7 mmol) (prepared according to Example 8, step A) and 2-(3-aminophenyl)ethanol (0.31 g, 2.3 mmol) (prepared according to Example 22, Step B) in 1,4-dioxane (14.3 mL) was added p-toluenesulfonic acid monohydrate (0.12 g, 0.61 mmol). The mixture was heated at 100 C. for 16 h and the reaction was complete. To the mixture was added NaHCO3 (saturated aqueous solution). The organic solvent was removed under vacuum and water/EtOAc was added. After layer separation, the aqueous layer was extracted with EtOAc twice. The combined organic layers were dried over Na2SO4, filtered, and concentrated (then triturated with cold EtOAc) to give the desired product as a light brown powder (0.64 g, 96%). LCMS for C21H24ClN4O2 (M+H)+: m/z=399.1.

Statistics shows that 52273-77-5 is playing an increasingly important role. we look forward to future research findings about 2-(3-Aminophenyl)ethanol.

Reference:
Patent; INCYTE CORPORATION; US2010/190804; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6240-11-5, name is 1-Adamantaneethanol, molecular formula is C12H20O, molecular weight is 180.2866, as common compound, the synthetic route is as follows.Quality Control of 1-Adamantaneethanol

A solution of 1-adamantylethanol (3 g, 16.64 mmol) in methylen chloride (50 mL) and triethylamine (2.8 mL, 19.95 mmol) was stirred for 10 minutes. Then methanesulfonyl chloride (1.55 mL, 20.03 mmol) was added and the resulting reaction mixture was stirred at room temperature for 72 hours. The crude was partitioned between methylen chloride and a solution of sodium hydrogen carbonate (4%). The organic layer was washed with water and brine and the solvent was removed under reduced pressure to give the title compound as a yellow oil (4.1 g, 96%), which was used in the next step without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6240-11-5, 1-Adamantaneethanol, and friends who are interested can also refer to it.

Reference:
Patent; LABORATORIOS ALMIRALL, S.A.; WO2009/68177; (2009); A1;,
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