Tag: M.W=100-150

Xu, Jing-xiu; Pan, Nan-lian; Chen, Jia-xi; Zhao, Jin-wu published the artcile< Visible-light-mediated oxidative cyclization of 2-aminobenzyl alcohols and secondary alcohols enabled by an organic photocatalyst>, Computed Properties of 5344-90-1, the main research area is photocatalysis photocyclization benzyl alc quinoline.

This paper describes a visible-light-mediated oxidative cyclization of 2-aminobenzyl alcs. and secondary alcs. to produce quinolines at room temperature This photocatalytic method employed anthraquinone as an organic small-mol. catalyst and DMSO as an oxidant. According to this present procedure, a series of quinolines were prepared in satisfactory yields.

Journal of Organic Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Computed Properties of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Xiaoda; Gao, Yuan; Li, Chaoqun; Huang, Zhixian; Qiu, Ting published the artcile< Liquid-Liquid Equilibria for the Ternary Systems of Water + Thioglycolic Acid + 2-Ethyl-1-hexyl Thioglycolate and Water + 2-Ethyl-1-hexyl Thioglycolate + 2-Ethyl-1-hexanol at 293.15, 303.15, and 313.15 K under 101 kPa>, Formula: C8H18O, the main research area is liquid equilibrium ternary system; water thioglycolic acid ethylhexyl thioglycolate ethylhexanol.

Liquid-liquid equilibrium data were determined for the two ternary systems of water + thioglycolic acid (TGA) + 2-ethyl-1-hexyl thioglycolate (ETE) and water + 2-ethyl-1-hexyl thioglycolate (ETE) + 2-ethyl-1-hexanol (EHL) at 293.15, 303.15, and 313.15 K under 101 kPa. The nonrandom two-liquid (NRTL) and universal quasi-chem. (UNIQUAC) activity coefficient models were used to correlate the exptl. LLE data. The LLE data calculated by the NRTL and UNIQUAC models were in good agreement with the exptl. ones.

Journal of Chemical & Engineering Data published new progress about Liquid-liquid equilibrium. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Jianmin; Huitema, Carly; Niu, Chunying; Yin, Jiang; James, Michael N. G.; Eltis, Lindsay D.; Vederas, John C. published the artcile< Aryl methylene ketones and fluorinated methylene ketones as reversible inhibitors for severe acute respiratory syndrome (SARS) 3C-like proteinase>, Related Products of 22620-34-4, the main research area is aryl methylene ketone derivative preparation SARS 3C proteinase inhibitor; fluorinated methylene ketone derivative preparation SARS 3C proteinase inhibitor; structure activity SARS 3C like proteinase inhibiting ketone derivative.

The severe acute respiratory syndrome (SARS) virus depends on a chymotrypsin-like cysteine proteinase (3CLpro) to process the translated polyproteins to functional viral proteins. This enzyme is a target for the design of potential anti-SARS drugs. A series of ketones and corresponding mono- and di-fluoro ketones having two or three aromatic rings were synthesized as possible reversible inhibitors of SARS 3CLpro. The design was based on previously established potent inhibition of the enzyme by oxa analogs (esters), which also act as substrates. Structure-activity relationships and modeling studies indicate that three aromatic rings, including a 5-bromopyridin-3-yl moiety, are key features for good inhibition of SARS 3CLpro. 2-(5-Bromopyridin-3-yl)-1-(5-(4-chlorophenyl)furan-2-yl)ethanone and its α-monofluorinated analog, gave the best reversible inhibition with IC50 values of 13 μM and 28 μM, resp. In contrast to inhibitors having two aromatic rings, α-fluorination of compounds with three rings unexpectedly decreased the inhibitory activity.

Bioorganic Chemistry published new progress about Antiviral agents. 22620-34-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H6ClNO, Related Products of 22620-34-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Abdullah, Fuad Othman; Behrouzi, Leila; Kaboudin, Babak published the artcile< A novel synthesis of highly stable palladium nanoparticles and their application in the reduction of nitroaromatic compounds>, Synthetic Route of 5344-90-1, the main research area is aristolochia olivieri extract stabilized palladium nanoparticle catalyst preparation; nitroarom compound palladium catalyst reduction; aromatic amine preparation green chem.

A mild and efficient method for synthesis of highly stable palladium nanoparticles (PdNPs) on Aristolochia Olivieri (AO) extract as a support and reducing agent was described. Investigation of catalytically activity of obtained catalyst (AO@PdNPs) was performed for the reduction of nitroarom. compounds Of note were the functional group tolerance, fast rate, and the ability to apply a scope of nitro compounds (up to 30). The synthesized catalyst was characterized with UV-visible spectra, FE-SEM, EDS, XRD, AAS, FT-IR, and TEM techniques. The corresponding amine product was obtained excellent to high yields. The catalytic activity of AO@PdNPs for the hydrogenation of 4-methyl-2-nitroaniline and 4-methoxy-2-nitroaniline was pursued by UV-visible spectroscopy which presented excellent activity of catalyst.

Materials Research Express published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Synthetic Route of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tang, Shi; Ding, Shumin; Li, Dan; Li, Lianjie; Zhao, Haixia; Chai, Minxue; Wang, Jian published the artcile< Palladium-catalysed imidoylative spirocyclization of 3-(2-isocyanoethyl)indoles>, Recommanded Product: (2-Aminophenyl)methanol, the main research area is isocyanoalkyl indole organoiodide palladium catalyst tandem dearomative imidolylative spirocyclization; spiroindole azaarene preparation.

A palladium-catalyzed construction of spiroindolines through dearomative spirocyclization of 3-(2-isocyanoethyl)indoles was developed. 2′-Aryl-, vinyl-, and alkyl-substituted spiroindolines were accessed under mild conditions with excellent functional group tolerance. C1-tethered oxindole- and indole-spiroindoline bisheterocycles were generated in high yields via alkene/allene insertion and an imidoylative spirocyclization cascade. Addnl., a tandem dearomatization of two different indoles was realized with N-(2-bromobenzoyl)indoles as the electrophilic coupling partner of 3-(2-isocyanoethyl)indoles, affording polyindoline – spiroindoline bisheterocyclic scaffolds conveniently. Under the catalysis of Pd(OAc)2 and a spinol-derived phosphoramidite ligand, chiral spiroindolines were successfully accessed with up to 95% yield and 85% ee.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Recommanded Product: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Ling; Zhang, Shiqi; Deng, Xiongfei; Li, Guangxun; Tang, Zhuo; Zhao, Gang published the artcile< Preparation and Application of α-Imino Ketones through One-Pot Tandem Reactions Based on Heyns Rearrangement>, Related Products of 5344-90-1, the main research area is amine hydroxyketone regioselective diastereoselective tandem Heyns rearrangement oxidation; imino ketone preparation; hydroxyketone aminoalc regioselective diastereoselective tandem Heyns rearrangement oxidation; ketal preparation.

A metal-free and operationally simple strategy was developed to generate α-imino ketones with high regioselectivity. Meanwhile, the method allowed for the preparation of various N,O-ketals with high regioselectivities and diastereoselectivities through cascade reactions in one pot.

Organic Letters published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Related Products of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Poce, Giovanna; Cocozza, Martina; Alfonso, Salvatore; Consalvi, Sara; Venditti, Giulia; Fernandez-Menendez, Raquel; Bates, Robert H.; Barros Aguirre, David; Ballell, Lluis; De Logu, Alessandro; Vistoli, Giulio; Biava, Mariangela published the artcile< In vivo potent BM635 analogue with improved drug-like properties>, COA of Formula: C6H13NO, the main research area is pyrrolyl methanamine preparation antimycobacterial antitumor human SAR docking pharmacokinetics; Anti-mycobacterials; Drug discovery; MmpL3; Pyrroles; Tuberculosis.

Herein an efficient method was reported for the design, synthesis, biol. evaluation, pharmacokinetic anal. as well as in vivo TB mouse efficacy studies of novel (2-methyl-1H-pyrrol-3-yl)methanamines I [R = Me, 4-i-PrC6H4, 4-F3CC6H4, etc.; R1 = i-Pr, cyclohexyl, 4-FC6H4, etc.; R2 = 4-morpholinyl, 3-hydroxy-1-piperidyl, 3-methoxy-1-piperidyl] from 2-methyl-1H-pyrroles, formaldehyde and amines under Mannich reaction conditions. These BM635 analogs I showed improved physicochem. properties and excellent antimycobacterial activity. This hit-to-lead campaign led to the identification of a new compound I [R = 4-i-PrC6H4, R1 = i-Pr, R2 = 4-morpholinyl] that showed excellent activity (MIC = 0.15 μM; SI = 133) against drug-sensitive Mycobacterium tuberculosis strains as well as efficacy in a murine model of TB infection.

European Journal of Medicinal Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, COA of Formula: C6H13NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chakraborty, Gargi; Sikari, Rina; Das, Siuli; Mondal, Rakesh; Sinha, Suman; Banerjee, Seemika; Paul, Nanda D. published the artcile< Dehydrogenative Synthesis of Quinolines, 2-Aminoquinolines, and Quinazolines Using Singlet Diradical Ni(II)-Catalysts>, Application of C7H9NO, the main research area is quinoline biomimetic synthesis; aminoquinoline biomimetic synthesis; quinazoline biomimetic synthesis; nickel complex diamine singlet diradical oxidative condensation coupling catalyst.

Simple, straightforward, and atom economic methods for the synthesis of quinolines, 2-aminoquinolines, and quinazolines via biomimetic dehydrogenative condensation/coupling reactions, catalyzed by well-defined inexpensive and easy to prepare singlet diradical Ni(II)-catalysts featuring two antiferromagnetically coupled singlet diradical diamine type ligands are described. Various polysubstituted quinolines, 2-aminoquinolines, and quinazolines were synthesized in moderate to good yields from different low-cost and readily accessible starting materials. Several control experiments were carried out to get insight into the reaction mechanism which shows that the nickel and the coordinated diamine ligands participate in a synergistic way during the dehydrogenation of alcs.

Journal of Organic Chemistry published new progress about Acetonitriles Role: RCT (Reactant), RACT (Reactant or Reagent) (phenylacetonitriles). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application of C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yadav, Anamika; Ambule, Mayur D.; Kant, Ruchir; Srivastava, Ajay K. published the artcile< Silver/Palladium Relay Catalyzed Cross-Coupling of N'-Acetyl-8-quinolinesulfonylhydrazide with Alcohols: An Easy Access to 8-Quinolinesulfinate Esters>, Application In Synthesis of 5344-90-1, the main research area is silver palladium catalyzed cross coupling quinolinesulfonyl hydrazide alc; quinolinesulfinate ester preparation.

An efficient strategy for the synthesis of unexplored 8-quinolinesulfinate esters has been reported. The method involves in situ generation of quinoline sulfinate from N’-acetylquinoline-8-sulfonohydrazide via silver mediated cleavage followed by palladium-catalyzed cross-coupling with 1° and 2° alcs. to yield sulfinate esters. A variety of substituted alcs. were successfully employed in the reaction. Control experiments performed to understand the mechanism, revealed that the transformation follows a radical pathway and the alc. oxygen get incorporated in the resulting sulfinate esters. Two of the chirally pure alcs. were also used in the transformation to study the diastereoselectivity in the reaction. In order to demonstrate the synthetic utility, a representative allyl quinoline-8-sulfinate (I) was successfully converted into the 8-(allylsulfonyl)quinoline (II) via palladium(II) acetate mediated isomerization.

European Journal of Organic Chemistry published new progress about Hydrazides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application In Synthesis of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Verma, Ashutosh; Hazra, Susanta; Dolui, Pritam; Elias, Anil J. published the artcile< Ruthenium-Catalyzed Synthesis of α-Alkylated Ketones and Quinolines in an Aqueous Medium via a Hydrogen-Borrowing Strategy Using Ketones and Alcohols>, Category: alcohols-buliding-blocks, the main research area is ruthenium catalyst preparation; aryl ketone alc ruthenium catalyst green alkylation; phenyl arylpropanone preparation; arylquinoline preparation.

A simple, efficient, and sustainable method for the synthesis of α-alkylated ketones and quin50556012Aolines using a hydrogen-borrowing strategy was reported, which has emerged as a greener alternative in organic transformation reactions. Synthesis of a range of α-alkylated ketones and quinoline derivatives was achieved by using the water-soluble [Ru(8-AQ)Cl(p-cym.)]+Cl- [Ru]-1 (AQ=aminoquinoline) catalyst with water as the reaction medium. By adopting this strategy, α-alkylated ketones and quinolines was synthesized using ketones or secondary alcs. as starting materials and the primary alc. as a green and naturally abundant alkylating agent.

Asian Journal of Organic Chemistry published new progress about Alkylation. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts