Tag: M.W=100-150

Iona, Roberto; Bassetti, Mauro published the artcile< Dimerization of Aromatic Terminal Alkynes Featuring Hydrophilic Functional Groups under Ruthenium and Acid Promoted Catalysis. Competitive Alkyne Hydration upon Substituent Effect>, Formula: C9H8O, the main research area is dimeric diarylenyne stereoselective preparation; aryl terminal alkyne hydrophilic functional group dimerization ruthenium catalyst.

The self-coupling (hydroalkynylation) process of aromatic terminal alkynes RC6H4CCH to give dimeric 1,4-diaryl-1-en-3-yne products (trans-RC6H4CCCH=CHC6H4R) is catalyzed by the complex [{RuCl(μ-Cl)(η6-p-cymene)}2] with sodium acetate co-catalyst dissolved in neat acetic acid, the reaction proceeding with high trans-stereoselectivity under mild conditions (r.t.) even for substrates with protic or polar substituent groups (e. g. R = 3-OH, 4-CH2OH, 4-NHAc, -CHO, 4-tetra-O-acetyl-β-D-glucopyranoside). In presence of strongly electron donating arene substituents, NMe2 and NH2, the triple bond is activated toward exclusive triple bond hydration by reaction with acetic acid at room temperature also in absence of the ruthenium catalyst.

ChemistrySelect published new progress about Alkenynes Role: SPN (Synthetic Preparation), PREP (Preparation). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Formula: C9H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Carlson, Lars A.; Hedbom, Christina; Helgstrand, Erik; Misiorny, Alfons; Sjoberg, Berndt; Stjernstrom, Nils E.; Westin, Gertrud published the artcile< Potential hypolipidemic agents. VI. Syntheses of some new halo-substituted pyridine compounds. Effects on noradrenaline-stimulated free fatty acid mobilization>, Formula: C6H6ClNO, the main research area is pyridine halo hydroxy hypolipidemic; hypolipidemic halopyridine.

The pyridines I (R = CHO, CH2OH, CH2CN, CH2CO2H, CH2OCH2Ph, CH2O2CNHPh CH2O2CCMe2OC6H4Cl-p, etc.; R1 = 5-F, 6-F, 5-Cl, 6-Cl, 5-Br) were prepared Thus I (R = CH2OH, R1 = 5-F) was treated with SOCl2 and the product treated with KCN to give I (R = CH2CN, R1 = 5-F), which was hydrolyzed to give I (R = CH2CO2H, R1 = 5-F). 5-Fluoronicotinic acid and 5-fluoro-3-pyridylmethanol were oxidized with H2O2 to give the pyridine oxides (II, R = CO2H, R = CH2OH, resp.). The N-methylnicotinic acid (III) was also prepared The pharmacol. effects of the compounds on noradrenaline-induced free fatty acid mobilization in dogs was determined and related to nicotinic acid.

Acta Pharmaceutica Suecica published new progress about Lipids Role: RCT (Reactant), RACT (Reactant or Reagent). 22620-34-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H6ClNO, Formula: C6H6ClNO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

K. Bains, Amreen; Ankit, Yadav; Adhikari, Debashis published the artcile< Bioinspired Radical-Mediated Transition-Metal-Free Synthesis of N-Heterocycles under Visible Light>, Safety of 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is nitrogen heterocycle preparation; alc oxidation pyrene iminoquinone photocatalyst; amidine alc oxidation pyrene iminoquinone photocatalyst; carbonyl compound preparation; biomimetic catalysis; hydrogen atom transfer; pyrimidine; quinoline; topaquinone.

A redox-active iminoquinone motif connected with π-delocalized pyrene core has been reported that can perform efficient two-electron oxidation of a class of substrates. The design of the mol. was inspired by the organic redox cofactor topaquinone (TPQ), which executes amine oxidation in the enzyme, copper amine oxidase. Easy oxidation of both primary and secondary alcs. such as benzylalc., hexanol, 1-phenylethan-1-ol, cyclohexanol, etc. happened in the presence of catalytic KOtBu, which could reduce the ligand backbone to its iminosemiquinonate form under photoinduced conditions. Moreover, this easy oxidation of alcs. under aerobic condition could be elegantly extended to multi-component, one-pot coupling for the synthesis of quinolines e.g., I and pyrimidines II (R1 = Ph, 2-methylphenyl, 1-naphthyl, etc.; R2 = Ph, 4-chlorophenyl, 2-thienyl, etc.; R3 = H, Cl, Me, Br, etc.). This organocatalytic approach is very mild (70°C, 8 h) compared to a multitude of transition-metal catalysts that have been used to prepare these heterocycles e.g., I and II. A detailed mechanistic study proves the intermediacy of the iminosemiquinonate-type radical and a critical hydrogen atom transfer step to be involved in the dehydrogenation reaction.

ChemSusChem published new progress about Alcohols Role: PRP (Properties), RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Safety of 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Tun-Hui; Su, Zih-Syuan; Sung, Robert; Sung, Kuangsen published the artcile< Aza-ortho-Quinone Methide and Its Conjugated Acid: Reactivity, Stability and Acidity>, Quality Control of 5344-90-1, the main research area is quinone methide laser flash photolysis kinetics reactivity chem stability; acidity; aza-o-quinone methide; cycloaddition; drug metabolite; reactivity.

Aza-o-quinone methides and their conjugated acids are reactive drug metabolites that might react with nucleophilic sites of DNAs and proteins to cause cancer or immune responses, and their reactivity with water is the key information to judge if these metabolites are harmful in living systems. For the first time, aza-o-quinone methide (1) and its conjugated acid (2) are observed by laser flash photolysis, and their reactivity, stability and acidity in water are determined

ChemPhysChem published new progress about Absorption spectra. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Quality Control of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mondal, Rajarshi; Herbert, David E. published the artcile< Synthesis of Pyridines, Quinolines, and Pyrimidines via Acceptorless Dehydrogenative Coupling Catalyzed by a Simple Bidentate P^N Ligand Supported Ru Complex>, Related Products of 5344-90-1, the main research area is ruthenium catalyst dehydrogenative coupling multicomponent alc mol structure mechanism; pyridine quinoline pyrimidine preparation aldehyde adduct.

A ruthenium hydrido chloride complex supported by a simple, heteroleptic bidentate PN̂ ligand (I) containing a diarylphosphine and a benzannulated phenanthridine donor arm is reported. In the presence of base, the complex catalyzes multicomponent reactions using alc. precursors to produce structurally diverse mols. including pyridines, quinolines and pyrimidines via acceptorless dehydrogenative coupling pathways. Notably, I does not bear readily (de)protonated Bronsted acidic or basic groups common to transition metal catalysts capable of these sorts of transformations, suggesting metal-ligand cooperativity does not play a significant role in the catalytic reactivity of the complex. A rare example of an η2-aldehyde adduct of ruthenium was isolated and structurally characterized, and its role in acceptorless dehydrogenative coupling reactions is discussed.

Organometallics published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Related Products of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tressl, Roland; Wondrak, Georg T.; Krueger, Ralph-Peter; Rewicki, Dieter published the artcile< New Melanoidin-like Maillard Polymers from 2-Deoxypentoses>, Application In Synthesis of 52160-51-7, the main research area is melanoidin Maillard polymer deoxypentose oligomerization antioxidant.

In the 2-deoxy-D-ribose/methyl 4-aminobutyrate Maillard system a trapped N-substituted 2-(hydroxymethyl)pyrrole is one of the major products. However, nontrapped representatives of this type of compound were hitherto not found in other Maillard model systems, indicating their extraordinary reactivity. Model experiments with 2-deoxy-D-ribose/methylamine enabled the detection of N-methyl-2-(hydroxymethyl)pyrrole and some derived linear oligomers as minor components. Consequently, N-methyl-2-(hydroxymethyl)pyrrole was synthesized and its oligomerization was studied under very mild acidic conditions. The deformylated dimeric bis(N-methyl-2-pyrrolyl)methane and trimeric N-methyl-2,5-bis(N-methyl-2-pyrrolylmethyl)pyrrole were characterized by GC/MS and NMR. Higher regular oligomers up to 6 N-methyl-2-pyrrolylmethyl units as well as corresponding dehydro-oligomers up to 12 units were identified by MALDI-TOF-MS. A complementary experiment starting with N-methyl-2-hydroxy[13C]methylpyrrole confirmed the structure and the oligomerization pathway. The possible significance of this type of model oligomer for the melanoidin formation in Maillard reactions is discussed. The antioxidative activity of the isolated dimer and trimer was tested in Fe(III)-thiocyanate and DPPH assays.

Journal of Agricultural and Food Chemistry published new progress about Antioxidants. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Application In Synthesis of 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Choong, Ingrid C.; Serafimova, Iana; Fan, Junfa; Stockett, David; Chan, Erica; Cheeti, Sravanthi; Lu, Yafan; Fahr, Bruce; Pham, Phuongly; Arkin, Michelle R.; Walker, Duncan H.; Hoch, Ute published the artcile< A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties>, Synthetic Route of 6850-39-1, the main research area is diaminocyclohexyl analog SNS 032 preparation permeability bioavailability CDK inhibition.

The identification of a selective CDK2, 7, and 9 inhibitor (compound 4) with improved permeability is described. Compound 4 exhibits comparable CDK selectivity profile to SNS-032, but shows improved permeability and higher bioavailability in mice.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, Synthetic Route of 6850-39-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Azizi, Kobra; Akrami, Sedigheh; Madsen, Robert published the artcile< Manganese(III) Porphyrin-Catalyzed Dehydrogenation of Alcohols to form Imines, Tertiary Amines and Quinolines>, Application of C7H9NO, the main research area is manganese porphyrin chloride catalyst dehydrogenative coupling alcs amine; imine synthesis; tertiary amine synthesis; quinoline synthesis; alcohols; dehydrogenation; homogeneous catalysis; manganese; synthetic methods.

Manganese(III) porphyrin chloride complexes have been developed for the first time as catalysts for the acceptorless dehydrogenative coupling of alcs. and amines. The reaction has been applied to the direct synthesis of imines, tertiary amines and quinolines where only hydrogen gas and/or water are formed as the byproduct(s). The mechanism is believed to involve the formation of a manganese(III) alkoxide complex which degrades into the aldehyde and a manganese(III) hydride species. The latter reacts with the alc. to form hydrogen gas and thereby regenerates the alkoxide complex.

Chemistry – A European Journal published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application of C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Singh, Vivek Kumar; Donthireddy, S. N. R.; Pandey, Vipin K.; Rit, Arnab published the artcile< RuII-Complexes of heteroditopic chelating NHC ligands: effective catalysts for the β-alkylation of secondary alcohols and the synthesis of 2-alkylaminoquinoline derivatives following the dehydrogenative protocol>, Application In Synthesis of 5344-90-1, the main research area is ruthenium NHC imidazolylidene triazolylidene cymene complex preparation coupling catalyst; coupling primary secondary alc preparation aralkyl alc ruthenium catalyst; quinoline amine preparation cyclization amino alc nitrile ruthenium catalyst.

RuII-Complexes of chelating heteroditopic N-heterocyclic carbene ligands I·BF4 (1a-c; R = 2,4,6-Me3, 4-OMe, 4-CF3) featuring imidazol-2-ylidene (ImNHC) and 1,2,3-triazol-5-ylidene (tzNHC) donors connected via a CH2 spacer, were found to be very effective catalysts for the cross-coupling of secondary alcs. ArCH(OH)Me and primary alcs. RCH2OH with the elimination of H2O, yielding aralkyl alcs. ArCH(OH)CH2CH2R (Ar = substituted Ph, 2-naphthyl, 2-thienyl; R = aryl, hetaryl, C5H11). Diverse β-alkylated secondary alcs. were thus obtained by following this method in excellent yields of up to 95% by employing a very low catalyst 1a loading of 0.01-0.001 mol% along with the inexpensive base KOH. Mechanistically, the present protocol follows the borrowing hydrogen strategy which was established by various control experiments including deuterium labeling experiments and importantly, 1H NMR and ESI-MS analyses validated the participation of a Ru-H species in the catalytic cycle. Remarkably, the present system displayed the highest Ru-based TON of 396 000 for the β-benzylation of 1-phenylethanol with a catalyst loading of 1 ppm (0.0001 mol%). Addnl., diverse 2-alkylaminoquinoline derivatives were synthesized in a one-pot manner from 2-aminobenzyl alc., 2-arylacetonitrile, and various primary alcs.

Organic & Biomolecular Chemistry published new progress about Alkylation. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application In Synthesis of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Jing-xiu; Pan, Nan-lian; Chen, Jia-xi; Zhao, Jin-wu published the artcile< Visible-light-mediated oxidative cyclization of 2-aminobenzyl alcohols and secondary alcohols enabled by an organic photocatalyst>, Computed Properties of 5344-90-1, the main research area is photocatalysis photocyclization benzyl alc quinoline.

This paper describes a visible-light-mediated oxidative cyclization of 2-aminobenzyl alcs. and secondary alcs. to produce quinolines at room temperature This photocatalytic method employed anthraquinone as an organic small-mol. catalyst and DMSO as an oxidant. According to this present procedure, a series of quinolines were prepared in satisfactory yields.

Journal of Organic Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Computed Properties of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts